We derive the discontinuities of banana integrals using the dispersion relation iteratively,and find a series of identities between the parameterized discontinuities of banana integrals(p-DOBIs).Similar to elliptic in...We derive the discontinuities of banana integrals using the dispersion relation iteratively,and find a series of identities between the parameterized discontinuities of banana integrals(p-DOBIs).Similar to elliptic integrals,these identities enable the reduction of various p-DOBIs to be a linear combination of some fundamental ones.We present a practical application of p-DOBIs for deriving the Picard–Fuchs operator.Then we establish the expression of generalized dispersion relation,which enables us to obtain the dispersion relation representation of arbitrary banana integrals.Moreover,we propose a hypothesis for generalized dispersion relation and p-DOBIs,which provides a simple way to calculate the discontinuities and transform dispersion relation representation to p-DOBIs.展开更多
This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward m...This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward mathematical formulation for the luminosity distance as function of the transverse comoving distance for all cosmology cases with a non-zero cosmological constant by adopting a different mindset. The applied method deals with incomplete elliptical integrals of the first kind associated with the polynomial roots admitted in the comoving distance integral according to the scientific literature. The outcome shows that the luminosity distance can be obtained by the combination of an analytical solution followed by a numerical integration in order to account for the redshift. This solution is solely compared to the current Gaussian quadrature method used as basic recognized algorithm in standard cosmology.展开更多
Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quan...Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.展开更多
Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have ...Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.展开更多
Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have ...Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.展开更多
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.展开更多
Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were appli...Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were applied in the derivation. Results and Conclusion The principle of virtual work, Betti's reciprocal theorem and the uniqueness theorem of quasicrystal elasticity theory are proud, and some conservative integrals in quasicrystal elasticty theory are obtained.展开更多
Based on protein-DNA complex crystal structural data in up-to-date Nucleic Acid Database,the related parameters of DNA Kinetic Structure were investigated by Monte-Carlo Multiple Integrals on the base of modified DNA ...Based on protein-DNA complex crystal structural data in up-to-date Nucleic Acid Database,the related parameters of DNA Kinetic Structure were investigated by Monte-Carlo Multiple Integrals on the base of modified DNA structure statistical mechanical model,and time complexity and precision were analyzed on the calculated results.展开更多
Refer to the Hamiltonian system, first integrals of the Birkhoffian system can be found by using of the perfect differential method. Through these first integrals, the order of the Birkhoffian system can be reduced. T...Refer to the Hamiltonian system, first integrals of the Birkhoffian system can be found by using of the perfect differential method. Through these first integrals, the order of the Birkhoffian system can be reduced. Then according to the alternate of the coordinate, a kind of new partial differential operator was defined in order to hold the Birkhoff form. The result shows that the Birkhoffian system has generalized energy integrals and cyclic integrals. Furthermore, each integral can reduce the order of equations two degrees.展开更多
Boundedness of multilinear singular integrals and their commutators from products of variable exponent Lebesgue spaces to variable exponent Lebesgue spaces are obtained. The vector-valued case is also considered.
We establish the monotonicity and convexity properties for several special functions involving the generalized elliptic integrals, and present some new analytic inequalities.
Let b = (b1,…,bm) be a finite family of locally integrable functions. Then, we introduce generalized higher commutator of Marcinkiwicz integral as follows:( μΩ^b^→(f)(x)=(∫ 0^∞|FΩ^b^→,t(f)(x)|^2...Let b = (b1,…,bm) be a finite family of locally integrable functions. Then, we introduce generalized higher commutator of Marcinkiwicz integral as follows:( μΩ^b^→(f)(x)=(∫ 0^∞|FΩ^b^→,t(f)(x)|^2t/dt)^1/2,where(FΩ^b^→,t(f)(x)=1/t∫|x-y|≤t Ω(x-y)/|x-y|^n-1 Лj=1^m(bj(x)-bj(y))f(y)dy.)When(bj∈Aβj,1≤j≤m,0〈βj〈1∑j=1^mβj=β〈n)and Ω is homogeneous of degreezero and satisfies the cancelation condition, we prove that μΩ^b^→is bounded from L^p(R^n)to L^8(R^n),where1〈p〈βand 1/s=1/p-β/n,Moreover,if Ω also satisties some L^q -Dini condition,then μΩ^b^→ isbounded from L^p(R^n)to Fp^β,∞(R^n)and on certain Hardy spaces.The article extends some known results.展开更多
This paper presents a discrete vaxiational principle and a method to build first-integrals for finite dimensional Lagrange-Maxwell mechanico-electrical systems with nonconservative forces and a dissipation function. T...This paper presents a discrete vaxiational principle and a method to build first-integrals for finite dimensional Lagrange-Maxwell mechanico-electrical systems with nonconservative forces and a dissipation function. The discrete variational principle and the corresponding Euler-Lagrange equations are derived from a discrete action associated to these systems. The first-integrals are obtained by introducing the infinitesimal transformation with respect to the generalized coordinates and electric quantities of the systems. This work also extends discrete Noether symmetries to mechanico-electrical dynamical systems. A practical example is presented to illustrate the results.展开更多
In the present paper, we consider the boundedness of Marcinkiewicz integral operator μΩ,h,Ф along a surface Г = {x = Ф(|y|)y/|y|)} on the Triebel-Lizorkin space Fq,q^α(R^n ) for Ω belonging to H1 (Sn-...In the present paper, we consider the boundedness of Marcinkiewicz integral operator μΩ,h,Ф along a surface Г = {x = Ф(|y|)y/|y|)} on the Triebel-Lizorkin space Fq,q^α(R^n ) for Ω belonging to H1 (Sn-1) and some class WFα(S^n-1), which relates to Grafakos-Stefanov class. Some previous results are extended and improved.展开更多
In this article, certain Marcinkiewicz integral operators associated to surfaces of revolution on product domains were studied. The Lp boundedness for these operators are established under some rather weak conditions ...In this article, certain Marcinkiewicz integral operators associated to surfaces of revolution on product domains were studied. The Lp boundedness for these operators are established under some rather weak conditions on kernels. The main results essentially improve and extend some known results.展开更多
Some new inequalities involving improper integrals are established in the paper which generalize the related results due to Pachpatte and Rodrigues.Discrete analogues of the integral inequalities obtained are also der...Some new inequalities involving improper integrals are established in the paper which generalize the related results due to Pachpatte and Rodrigues.Discrete analogues of the integral inequalities obtained are also derived.An example is given to show that the bound in Theorem 1 is not improvable.展开更多
In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauch...In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauchy-type integral taken over a smooth surface by rather simple method.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12175318)the Natural Science Foundation of Guangdong Province of China(Grant No.2022A1515011922).
文摘We derive the discontinuities of banana integrals using the dispersion relation iteratively,and find a series of identities between the parameterized discontinuities of banana integrals(p-DOBIs).Similar to elliptic integrals,these identities enable the reduction of various p-DOBIs to be a linear combination of some fundamental ones.We present a practical application of p-DOBIs for deriving the Picard–Fuchs operator.Then we establish the expression of generalized dispersion relation,which enables us to obtain the dispersion relation representation of arbitrary banana integrals.Moreover,we propose a hypothesis for generalized dispersion relation and p-DOBIs,which provides a simple way to calculate the discontinuities and transform dispersion relation representation to p-DOBIs.
文摘This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward mathematical formulation for the luminosity distance as function of the transverse comoving distance for all cosmology cases with a non-zero cosmological constant by adopting a different mindset. The applied method deals with incomplete elliptical integrals of the first kind associated with the polynomial roots admitted in the comoving distance integral according to the scientific literature. The outcome shows that the luminosity distance can be obtained by the combination of an analytical solution followed by a numerical integration in order to account for the redshift. This solution is solely compared to the current Gaussian quadrature method used as basic recognized algorithm in standard cosmology.
基金supported by the NSF of Hebei Province(A2022208007)the NSF of China(11571089,11871191)the NSF of Henan Province(222300420397)。
文摘Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.
基金supported by NIH-NIA (1F31AG057155-01A1)University of Minnesota Doctoral Dissertation Fellowship (to JL)
文摘Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.
文摘Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.
基金Supported by National Natural Science Foundation of China,No.82174461Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
文摘BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.
文摘Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were applied in the derivation. Results and Conclusion The principle of virtual work, Betti's reciprocal theorem and the uniqueness theorem of quasicrystal elasticity theory are proud, and some conservative integrals in quasicrystal elasticty theory are obtained.
基金Supported by Inner Mongolia Natural Science Foundation(200711020112)Innovation Fundation of Inner Mongolia University of Science and Technology (2009NC064)~~
文摘Based on protein-DNA complex crystal structural data in up-to-date Nucleic Acid Database,the related parameters of DNA Kinetic Structure were investigated by Monte-Carlo Multiple Integrals on the base of modified DNA structure statistical mechanical model,and time complexity and precision were analyzed on the calculated results.
文摘Refer to the Hamiltonian system, first integrals of the Birkhoffian system can be found by using of the perfect differential method. Through these first integrals, the order of the Birkhoffian system can be reduced. Then according to the alternate of the coordinate, a kind of new partial differential operator was defined in order to hold the Birkhoff form. The result shows that the Birkhoffian system has generalized energy integrals and cyclic integrals. Furthermore, each integral can reduce the order of equations two degrees.
基金supported by the Scientific Research Fund of Hunan Provincial Education Department (09A058)
文摘Boundedness of multilinear singular integrals and their commutators from products of variable exponent Lebesgue spaces to variable exponent Lebesgue spaces are obtained. The vector-valued case is also considered.
基金supported by the Natural Science Foundation of China(11701176,61673169,11301127,11626101,11601485)the Science and Technology Research Program of Zhejiang Educational Committee(Y201635325)
文摘We establish the monotonicity and convexity properties for several special functions involving the generalized elliptic integrals, and present some new analytic inequalities.
基金Supported by National 973 Project(G.19990751)the SEDF of China(20040027001)
文摘Let b = (b1,…,bm) be a finite family of locally integrable functions. Then, we introduce generalized higher commutator of Marcinkiwicz integral as follows:( μΩ^b^→(f)(x)=(∫ 0^∞|FΩ^b^→,t(f)(x)|^2t/dt)^1/2,where(FΩ^b^→,t(f)(x)=1/t∫|x-y|≤t Ω(x-y)/|x-y|^n-1 Лj=1^m(bj(x)-bj(y))f(y)dy.)When(bj∈Aβj,1≤j≤m,0〈βj〈1∑j=1^mβj=β〈n)and Ω is homogeneous of degreezero and satisfies the cancelation condition, we prove that μΩ^b^→is bounded from L^p(R^n)to L^8(R^n),where1〈p〈βand 1/s=1/p-β/n,Moreover,if Ω also satisties some L^q -Dini condition,then μΩ^b^→ isbounded from L^p(R^n)to Fp^β,∞(R^n)and on certain Hardy spaces.The article extends some known results.
基金Project supported by State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences and the National Natural Science Foundation of China (Grant Nos 10672143 and 10471145) and the Natural Science Foundation of Henan Province Government, China (Grant Nos 0311011400 and 0511022200).
文摘This paper presents a discrete vaxiational principle and a method to build first-integrals for finite dimensional Lagrange-Maxwell mechanico-electrical systems with nonconservative forces and a dissipation function. The discrete variational principle and the corresponding Euler-Lagrange equations are derived from a discrete action associated to these systems. The first-integrals are obtained by introducing the infinitesimal transformation with respect to the generalized coordinates and electric quantities of the systems. This work also extends discrete Noether symmetries to mechanico-electrical dynamical systems. A practical example is presented to illustrate the results.
基金partially supported by Grant-in-Aid for Scientific Research(C)(No.23540228),Japan Society for the Promotion of Science
文摘In the present paper, we consider the boundedness of Marcinkiewicz integral operator μΩ,h,Ф along a surface Г = {x = Ф(|y|)y/|y|)} on the Triebel-Lizorkin space Fq,q^α(R^n ) for Ω belonging to H1 (Sn-1) and some class WFα(S^n-1), which relates to Grafakos-Stefanov class. Some previous results are extended and improved.
基金Supported by the NSF of China (G10571122) the NFS of Fujian Province of China (Z0511004)
文摘In this article, certain Marcinkiewicz integral operators associated to surfaces of revolution on product domains were studied. The Lp boundedness for these operators are established under some rather weak conditions on kernels. The main results essentially improve and extend some known results.
基金Supported by the Natural Science Foundation of Guangdong Pronvince( 0 1 1 471 ) and Education Bu-reau( 0 1 76)
文摘Some new inequalities involving improper integrals are established in the paper which generalize the related results due to Pachpatte and Rodrigues.Discrete analogues of the integral inequalities obtained are also derived.An example is given to show that the bound in Theorem 1 is not improvable.
基金Project supported by NNSF of China(10471107)RFDP of Higher Eduction of China(20060486001)
文摘In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauchy-type integral taken over a smooth surface by rather simple method.