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An Experimental Study of the Mechanism of Andrographis Paniculata Nees(APN) in Alleviating the Ca^(2+)-overloading In the Process of Myocardial Ischemic Reperfusion
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作者 郭志凌 赵华月 郑信华 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1995年第4期205-208,共4页
The aim of this experiment is to study the mechanism of APN in alleviating the Ca2+-overloading in dog model during the process of ischemic reperfusion. In comparison with the sustained ischemic group, the parameters ... The aim of this experiment is to study the mechanism of APN in alleviating the Ca2+-overloading in dog model during the process of ischemic reperfusion. In comparison with the sustained ischemic group, the parameters in the ischemic reperfusion group demonstrated: Ca2+ of ischemic region of myocardial cell increased (P<0.05) , Na+ increased remarkably(P<0. 01), the activity of Ca2+-ATPase dropped remarkably(P<0. 01),and MDA increased significantly(P<0. 01). Whereas in the group pretreated with APN, the Ca2+ in the relevant area reduced (P<0.05), Na+ decreased significantly(P<0. 01), the activity of Ca2+-ATPase and Na+-K+ ATPase increased remarkably(P<0.01) ,and MDA decreased significantly (P<0. 01). These findings indicate that APN may improve the activity of sarcolemma ATPase in alleviating the Ca2+ and Na+-overloading by decreasing the harmful effect of oxygen free radicals. 展开更多
关键词 myocardial ischemia reperfusion andrographis paniculata nees (APN) calcium
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The Effect of Andrographis Paniculata Nees(APN)in Alleviating the Myocardial Ischemic Reperfunion Injury
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作者 郭志凌 赵华月 郑信华 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1994年第1期49-51,共3页
In experimental dogs,the effect of APN in alleviating the ischemiareperfusion injury was prominent.Compared with the sustained isthmian group,superoxide dismutast(SOD)in the ischemic region of myocardial tissue in the... In experimental dogs,the effect of APN in alleviating the ischemiareperfusion injury was prominent.Compared with the sustained isthmian group,superoxide dismutast(SOD)in the ischemic region of myocardial tissue in the ischemiareperfusion group was significantly decreased and malondialdehyde(MDA)marktdly increased Ca2+in myocardial cells was increased. and ultrastructural changes of myocardial tisstes were severe in the APN-pretreated ischemia-reperfusion group ,on the contrary,all the above parameters showed reversely,i,e.,SOD increased ,MDA and intracellular Ca2+ decreased.the ultrastructure changes were less distorted. 展开更多
关键词 andrographis paniculata nees (APN) myocardial ischemiareperfusion
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穿心莲种质产量性状与药用成分分析 被引量:2
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作者 王雨霞 邹秀崽 +6 位作者 李春雨 张可 梁梓珊 王宏斌 段礼新 靳红磊 沈奇 《中山大学学报(自然科学版)(中英文)》 CAS CSCD 北大核心 2023年第3期100-108,共9页
穿心莲(Andrographis paniculata(Burm.f.)Nees)是我国传统的中药材,应用广泛。为了评价穿心莲种质的遗传多样性,收集了广东湛江和广西贵港两个主要产区的种质材料,对其产量性状和主要药用成分进行调查和分析。结果表明,同一来源穿心莲... 穿心莲(Andrographis paniculata(Burm.f.)Nees)是我国传统的中药材,应用广泛。为了评价穿心莲种质的遗传多样性,收集了广东湛江和广西贵港两个主要产区的种质材料,对其产量性状和主要药用成分进行调查和分析。结果表明,同一来源穿心莲材料的产量性状及药用成分均呈现较大变异。产量性状中,单株生物量变幅最大为100~624 g,其余从大到小依次为叶片质量、叶面积、一次分枝数、生育期、株高。药用成分性状中,穿心莲内酯变幅最大为1.5385~6.5944 mg/g,其余依次为新穿心莲内酯、14-去氧穿心莲内酯、脱水穿心莲内酯。供试材料分析发现种质纯和度差,具有显著的遗传多样性,为材料鉴选及遗传育种提供了丰富的材料基础。此外,相关性分析表明,穿心莲主要产量性状与主要药用成分含量间呈显著负相关。材料选育时需要注重产量性状和药用成分之间的平衡。最后,进一步按产量性状及药用成分指标进行聚类分析,筛选重要材料。本研究结果可为穿心莲的种质资源保护及良种选育提供育种研究材料基础。 展开更多
关键词 穿心莲(andrographis paniculata(Burm.f.)nees) 遗传多样性 产量性状 药用成分 相关性分析 聚类分析
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Role of semi-purified andrographolide from Andrographis paniculata extract as nano-phytovesicular carrier for enhancing oral absorption and hypoglycemic activity 被引量:1
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作者 Vinod Kumar Verma Md.Kamaruz Zaman +2 位作者 Shekhar Verma Santosh Kumar Verma Khomendra Kumar Sarwa 《Chinese Herbal Medicines》 CAS 2020年第2期142-155,共14页
Objective:Andrographis paniculata is a well-known medicinal plant in Southeast Asia,India and China.The plant contains andrographolide(AN),a very important phytochemical used in various health problems.However,AN is l... Objective:Andrographis paniculata is a well-known medicinal plant in Southeast Asia,India and China.The plant contains andrographolide(AN),a very important phytochemical used in various health problems.However,AN is low in oral absorption bioavailability of AN due to the rapid clearance and high protein binding capacity.Methods:The present study was aimed to develop a nano-phytovesicular formulation of semi-purified AN extracts from a naturally occurring phospholipid(soya phosphatidylcholine)in order to increase the oral absorption and antihyperglycemic activity in rats.Results:The nano-phyto vesicle of semi-purified AN extracts equivalent to 25 mg/kg AN significantly protected the hyperglycemic condition of rats.The in vitro and in vivo experiments results proved that the nano-phytovesicular system of plant extracts containing AN produced better oral absorption,bioavailability and improved antihyperglycemic activity compared with that of free AN at dose of 50 mg/kg.Conclusion:Hence,the prepared semi-purified extract nano-phytovesicular system is helpful in solving the problem of rapid clearance of AN. 展开更多
关键词 andrographis paniculata(Burm.f.)nees ANDROGRAPHOLIDE hypoglycemic activity liquid dispersion nano-phyto vesicle soya phosphatidylcholine
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