In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in ...In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.展开更多
The idea of intrinsic value is pervasive in environmental ethics and animal ethics.In fact,the view that certain non-human animals and the environment have intrinsic value is the basis of many ethicists’claim that we...The idea of intrinsic value is pervasive in environmental ethics and animal ethics.In fact,the view that certain non-human animals and the environment have intrinsic value is the basis of many ethicists’claim that we are morally obligated to treat these non-human animals and the environment well.In this paper,I argue that these ethicists often conflate intrinsic and final value.If something is finally valuable,then it is valuable for its own sake or in its own right either in virtue of its internal or external properties.To be intrinsically valuable is just to be finally valuable in virtue of one’s internal or intrinsic properties.Given this understanding of intrinsic value,many animal and environmental ethicists end up committing themselves to the view that the source of the moral status of certain non-human animals and the environment is some set of their respective internal or intrinsic properties.However,I argue that the value that they are often concerned with is based on non-human animals’and the environment’s external or extrinsic properties(sentience,rareness,uniqueness,diversity,etc.).This means that these ethicists need only defend the claim that certain non-human animals and the environment are extrinsically finally valuable as opposed to intrinsically valuable.展开更多
基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000)the National Natural Science Foundation of China(31130051)
文摘In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats （CRISPR） adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.
文摘The idea of intrinsic value is pervasive in environmental ethics and animal ethics.In fact,the view that certain non-human animals and the environment have intrinsic value is the basis of many ethicists’claim that we are morally obligated to treat these non-human animals and the environment well.In this paper,I argue that these ethicists often conflate intrinsic and final value.If something is finally valuable,then it is valuable for its own sake or in its own right either in virtue of its internal or external properties.To be intrinsically valuable is just to be finally valuable in virtue of one’s internal or intrinsic properties.Given this understanding of intrinsic value,many animal and environmental ethicists end up committing themselves to the view that the source of the moral status of certain non-human animals and the environment is some set of their respective internal or intrinsic properties.However,I argue that the value that they are often concerned with is based on non-human animals’and the environment’s external or extrinsic properties(sentience,rareness,uniqueness,diversity,etc.).This means that these ethicists need only defend the claim that certain non-human animals and the environment are extrinsically finally valuable as opposed to intrinsically valuable.
