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Relationship between Host Survival and the Type of Immune Response in Different Organs during Disseminated Candidiasis
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作者 曹菲 李家文 +2 位作者 严小枫 邬炎卿 张德美 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2005年第2期141-143,184,共4页
Summary: To examine the relationship between host survival and the type of immune response in different organs during disseminated candidiasis, the murine model of disseminated candidiasis was established by injecti... Summary: To examine the relationship between host survival and the type of immune response in different organs during disseminated candidiasis, the murine model of disseminated candidiasis was established by injection with Candida albicans via tail vein. The survival time was observed for up to 60 days. And the expression levels of cytokines in the spleen and kidney, including IFN-γ and IL-4, were determined with RT-PCR. Our results showed that in the spleen, both non-fatal and fatal inoculum caused a type Ⅱimmune response with steady expression levels of IFN-γ and the obviously increased levels of IL-4. While in the kidney, non-fatal inoculum induced a typeⅠimmune response with the obviously increased levels of IFN-γ and the steady expression levels of IL-4. However, fatal inoculum induced a type Ⅱ immune response with a constant expression of IFN-γ and the evidently increased levels of IL-4. It is concluded that in disseminated candidiasis, host survival is associated with the type of immune responses in the kidney, but not in the spleen. 展开更多
关键词 disseminated candidiasis INTERFERON-Γ INTERLEUKIN-4 animal testing alternatives
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