Anisotanols A—D(1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus tanguticus.Their structures were elucidated by com...Anisotanols A—D(1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus tanguticus.Their structures were elucidated by comprehensive spectroscopic techniques,and the absolute configurations were confirmed via ECD calculations and single-crystal X-ray diffractions.A putative biosynthetic pathway for these compounds was proposed.Biological evaluation disclosed that compound 3 showed anti-angiogenic activity by inhibiting the viability,migration,and tube formation in HUVECs.展开更多
基金This work was supported by the National Natural Science Foundation of China(NNSFC,Grant Nos.82022072 and 81891012)the Fok Ying Tung Education Foundation(Grant No.171037)+1 种基金the Sichuan Science and Technology Program(Grant No.2018JZ0081)the"Xinglin Scholar"Plan of Chengdu University of TCM(Grant Nos.YXRC2018005,BSH2018009,and QNXZ2019030).
文摘Anisotanols A—D(1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus tanguticus.Their structures were elucidated by comprehensive spectroscopic techniques,and the absolute configurations were confirmed via ECD calculations and single-crystal X-ray diffractions.A putative biosynthetic pathway for these compounds was proposed.Biological evaluation disclosed that compound 3 showed anti-angiogenic activity by inhibiting the viability,migration,and tube formation in HUVECs.
