Anterior cerebral artery is the smaller terminal branch of the internal carotid artery. It is one of the arteries involved in the formation of the arterial circle of Willis at the base of the brain. Its hypoplasia or ...Anterior cerebral artery is the smaller terminal branch of the internal carotid artery. It is one of the arteries involved in the formation of the arterial circle of Willis at the base of the brain. Its hypoplasia or absence can cause serious problems during neurosurgery or in the vascular dynamics of the brain. We found a rare variation of the right anterior cerebral artery during the dissection of the brain. The initial segment of the artery was hypoplastic and plexiform. The anterior communicating artery was absent. The right and left anterior cerebral arteries fused with each other for a distance of about 1 cm. The course, size and distribution of the distal part of the right anterior cerebral artery were normal. This case may be of special importance to neurosurgeonsand radiologists. Obstructionor rupture of the left anterior cerebral artery in such cases might result in infarct of the medial surfaces of both cerebral hemispheres.展开更多
Background: In the previous study, we established an ischemia-prone gerbil population(IG), which was selectively bred to increase the incidence of unilateral carotid arterial occlusion(UCO)-induced ischemia in Mongoli...Background: In the previous study, we established an ischemia-prone gerbil population(IG), which was selectively bred to increase the incidence of unilateral carotid arterial occlusion(UCO)-induced ischemia in Mongolian gerbils. However, if the characteristics of ischemia model in IG are the same as those in general gerbils(GG), and if the neurological symptoms are associated with the neurological insults in IG is still unclear.Methods: In the present study, we evaluated the UCO model in IG by analyzing neurological symptoms, neurological injury in the hippocampal CA1 region and compared with GG.Results: The data showed that the ratios of neurological symptom scores ≥ 2 in the IG and GG groups were 65.0% vs 30.0%, respectively, and were significantly different(P <.01).The neuronal damage following a UCO ischemic insult in the IG group was more severe compared to the GG group. There was a high correlation between the neurological insults' scale and the neurological symptom score in the IG and GG groups(r =.979 and.943 in the IG and GG groups, respectively). In animals with mild neurological symptom scores(2 and 3), the neuronal insults were significantly different between female and male gerbils in both IG and GG.Conclusion: Our findings suggest that IG population would likely be more advantageous to establish an ischemic model.展开更多
文摘Anterior cerebral artery is the smaller terminal branch of the internal carotid artery. It is one of the arteries involved in the formation of the arterial circle of Willis at the base of the brain. Its hypoplasia or absence can cause serious problems during neurosurgery or in the vascular dynamics of the brain. We found a rare variation of the right anterior cerebral artery during the dissection of the brain. The initial segment of the artery was hypoplastic and plexiform. The anterior communicating artery was absent. The right and left anterior cerebral arteries fused with each other for a distance of about 1 cm. The course, size and distribution of the distal part of the right anterior cerebral artery were normal. This case may be of special importance to neurosurgeonsand radiologists. Obstructionor rupture of the left anterior cerebral artery in such cases might result in infarct of the medial surfaces of both cerebral hemispheres.
基金Key Projects in the National Science&Technology Pillar Program,Grant/Award Number:2015BAI09B01
文摘Background: In the previous study, we established an ischemia-prone gerbil population(IG), which was selectively bred to increase the incidence of unilateral carotid arterial occlusion(UCO)-induced ischemia in Mongolian gerbils. However, if the characteristics of ischemia model in IG are the same as those in general gerbils(GG), and if the neurological symptoms are associated with the neurological insults in IG is still unclear.Methods: In the present study, we evaluated the UCO model in IG by analyzing neurological symptoms, neurological injury in the hippocampal CA1 region and compared with GG.Results: The data showed that the ratios of neurological symptom scores ≥ 2 in the IG and GG groups were 65.0% vs 30.0%, respectively, and were significantly different(P <.01).The neuronal damage following a UCO ischemic insult in the IG group was more severe compared to the GG group. There was a high correlation between the neurological insults' scale and the neurological symptom score in the IG and GG groups(r =.979 and.943 in the IG and GG groups, respectively). In animals with mild neurological symptom scores(2 and 3), the neuronal insults were significantly different between female and male gerbils in both IG and GG.Conclusion: Our findings suggest that IG population would likely be more advantageous to establish an ischemic model.
