Pretreated Oenan the Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils

Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia.However,neuroprotective mechanisms of OJE have not been fully identified.Thus,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral ischemia.We treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral ischemia.Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade B.Immunohistochemistry of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,respectively.To investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory function.When we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 area.We also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ischemia.However,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal neurons.Our findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 and-13.The experimental plan of this study was reviewed and approved by the Institutional Animal Care and Use Committee(IACUC)in Kangwon National University(approval No.KW-160802-1)on August 10,2016.

Culture Self- Consciousness in Transmission of Chinese Philosophy from the Perspective of English Globalization -- Taking the Belt and Road Initiative for Example

The Belt and Road Initiative contains the aspiration of Chinese nation to pursue ideological freedom and desire of strengthening international exchanges and cooperation. This paper takes the Belt and Road Initiative for example,emphasizing the interpretation of the inheritance and development of Chinese culture so as to study the importance of Culture Self-Consciousness in Chinese Philosophy,in the context of English globalization. That is to say,this paper stresses the spirits and the stand of nation 's demonstration on pursuing peace,cooperation and sustainable development in the civilization continuity from traditional China to the contemporary China,with practical philosophic view.

基于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯电化学免疫传感器检测Anti-IgG含量的研究

应用物理吸附法将羊抗人IgG抗原直接固定于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯修饰的金电极表面,制备电化学免疫传感器。采用循环伏安法和交流阻抗法对传感器进行表征,结果表明该传感器适合检测Anti-IgG浓度。同时探讨了缓冲液pH值、扫描速度、免疫反应温度、抗原与抗体配比对循环伏安峰电流的影响,结果表明在5-100mV/s扫速范围内,峰电流与扫速呈线性。孵育最优条件为25℃,h-IgG与Anti-IgG配比为1∶1。循环伏安法研究还表明Anti-IgG浓度在0.01-260μg/L范围内,线性关系良好,相关系数r^2=0.993,检出限（S/N=3）为0.006μg/L,据此建立了检测Anti-IgG浓度的新方法。

信号分子IRAK1/4在antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF中的作用探讨

目的:探讨IRAK1和IRAK4在antiβ-2GPI/β2GPI复合物诱导单核细胞株THP-1表达组织因子(TF)中的作用。方法:利用荧光定量PCR(Real-time PCR)、TF活性试剂盒分别检测THP-1细胞表达TF mRNA及TF活性;Western blot检测anti-β2GPI/β2GPI复合物诱导THP-1细胞表达IRAK1、磷酸化-IRAK1(p-IRAK1)、IRAK4情况;观察IRAK1/4抑制物是否干预anti-β2GPI/β2GPI复合物诱导THP-1表达TF。结果:Antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1细胞表达TF显著增加(P<0.05 vs control);Antiβ-2GPI/β2GPI复合物(100μg/ml)刺激THP-1细胞表达IRAK1、p-IRAK1、IRAK4(蛋白)显著升高(P<0.05 vscontrol);IRAK1/4抑制物(50μmol/L)能够阻断antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1表达TF及IRAK1磷酸化的效应。结论:antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF过程中,信号分子IRAK1/4被激活进而发挥重要作用。

三维Anti de Sitter空间中Lorentzian曲面的S_t^1×S_s^1-值光锥Gauss映射的奇点分类

利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.

Future Changes in Extreme High Temperature over China at 1.5℃-5℃ Global Warming Based on CMIP6 Simulations

Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the latest Coupled Model Intercomparison Project Phase 6(CMIP6),this study assesses future EHT changes across China at five specific global warming thresholds(1.5℃-5℃).The results indicate that global mean temperature will increase by 1.5℃/2℃ before 2030/2050 relative to pre-industrial levels(1861-1900)under three future scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5),and warming will occur faster under SSP5-8.5 compared to SSP1-2.6 and SSP2-4.5.Under SSP5-8.5,global warming will eventually exceed 5℃ by 2100,while under SSP1-2.6,it will stabilize around 2℃ after 2050.In China,most of the areas where warming exceeds global average levels will be located in Tibet and northern China(Northwest China,North China and Northeast China),covering 50%-70%of the country.Furthermore,about 0.19-0.44 billion people(accounting for 16%-41%of the national population)will experience warming above the global average.Compared to present-day(1995-2014),the warmest day(TXx)will increase most notably in northern China,while the number of warm days(TX90p)and warm spell duration indicator(WSDI)will increase most profoundly in southern China.For example,relative to the present-day,TXx will increase by 1℃-5℃ in northern China,and TX90p(WSDI)will increase by 25-150(10-80)days in southern China at 1.5℃-5℃ global warming.Compared to 2℃-5℃,limiting global warming to 1.5℃ will help avoid about 36%-87%of the EHT increases in China.

On the Construction of Deepening Anti - corruption Mechanism

It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.

Does the Global Warming Pause in the Last Decade:1999-2008?

Issues related to the pause of global warming in the last decade are reviewed.It is indicated that:(1) The decade of 1999-2008 is still the warmest of the last 30 years,though the global temperature increment is near zero;(2) Natural factors such as volcanism,solar radiation,ENSO,and thermohaline circulation can have impact on the inter-annual and inter-decadal variability of global mean temperatures.However,it will not mask the global warming trend for a long time;(3) Temperatures of China continue to increase in 1999-2008 with an increment of 0.4-0.5℃per 10 years.

Existence and Exponential Stability of the Anti-Periodic Solutions for a Class of Impulsive CohenGrossberg Neural Networks with Mixed Delays

In this paper,we study the anti-periodic solutions for a class of impulsive Cohen-Grossberg neural networks with mixed delays.By using analysis techniques,some sufficient conditions are obtained which guarantee the existence and global exponential stability of the anti-periodic solutions.The criteria extend and improve some earlier results.Moreover,we give an examples to illustrate our main results.

Anti-Bacterial and Flame Retardant for Cotton Fabric by One-Bath Finishing

A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products

Testing of Anti-stripping Property of Friction Spun Core Yarn

Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.

西方发达国家留学生教育政策的演化逻辑与现实审视

第二次世界大战以来,西方发达国家的留学生教育政策经历了导向发展援助、转向出口贸易和成为国家战略三个阶段。为维持留学生教育的主导地位,西方发达国家围绕着“人道的善举”、“双赢的交易”和“自由的竞争”三种隐喻进行留学生教育政策的话语构建,借此推介以发展援助为名的文化价值渗透、以掠夺资本为要的国际教育合作和以维持优势为基的国际人才之战,使不平等的权力关系得以延续。伴随世界多极化的深入发展以及国际局势的日趋紧张与复杂,传统“中心—边缘”的留学生教育格局受到冲击,留学生教育的数字化形态加速发展。人类命运共同体理念的提出为留学生教育政策提供了新阐释,其鼓励更多边缘、新兴形态的教育的传播,推动着融合多元视域的“新留学生教育图景”的生成。

逆全球化背景下区域协同创新网络抗毁性评价——以长江经济带城市群为例

从结构抗毁性和功能抗毁性两个维度构建区域协同创新网络抗毁性评价指标体系,进而提出改进的AHPCRITIC组合赋权法确定指标权重,并采用TOPSIS方法对长江经济带3个城市群协同创新网络的抗毁性水平进行综合评价。结果表明,长三角城市群的协同创新网络抗毁性水平最强,成渝城市群次之,中游城市群最低;随着时间推移,长三角城市群的抗毁性持续增强,成渝城市群呈现“V”型减弱趋势,中游城市群呈现“V”型增强趋势;从结构抗毁性看,长三角城市群持续增强,成渝城市群与中游城市群呈现“V”型增强趋势但增幅较小;从功能抗毁性看,长三角城市群与中游城市群均呈现“V”型增强趋势,而成渝城市群呈现“V”型减弱趋势。

欧盟对中国电动汽车实施反补贴调查的影响及对策

中国逐步掌握了全球汽车产业电气化和智能化转型话语权,对以美日欧为主的传统汽车产业格局产生了冲击,难免会遭遇各种形式的贸易保护主义。欧盟作为我国主要电动汽车企业出口目的地,已于2023年9月13日宣布对中国电动汽车展开反补贴调查。虽然此举无法从根本上阻止我国电动汽车产业全球化进程,但可能在短期内会破坏市场预期,干扰我国电动汽车企业的经营决策和业务布局并提高未来进入欧盟市场门槛和成本,需要警惕并在窗口期内做好应对准备。

反倾销嵌入全球生产网络的级联效应仿真研究

本研究将复杂网络理论应用于投入产出模型并将其引入宏观经济学生产函数理论模型,对反倾销嵌入全球生产网络的内在机理与其产生的级联效应展开探讨与仿真模拟分析.研究发现:基于网络视角与投入产出关系,反倾销冲击对中间产品的贸易抑制作用要明显大于最终产品,多次跨境的中间品将会累积增加反倾销带来的贸易成本;反倾销带来的行业引致需求量降低与出口贸易受到抑制以及行业与国家总产出水平的波动等影响,会沿着以中间品贸易为基础的全球生产网络中的投入产出关系进行传播,从而产生显著的级联效应,并且该效应会随着不同国家-部门节点之间的联系紧密程度(贸易量)的降低而衰减;反倾销产生的级联效应不仅涉及全球生产网络中直接关联节点即涉案国(调查国与被调查国)的国内上下游行业,而且波及间接关联节点即非涉案国的第三方国家和地区,进而影响全球多边贸易发展,同时,级联效应也阻碍了网络节点参与全球价值链生产分工,导致了节点隶属国(地区)的国内价值链被拉长;反倾销嵌入全球生产网络后,会通过整个生产网络产生总量波动效应,从而改变全球生产网络的拓扑结构,即全球生产网络变的相对稀疏、节点间网络距离拉长等.

国内马克思主义全球化理论研究热点与趋势展望——基于CiteSpace知识图谱的可视化分析(1998—2023)

马克思主义全球化理论明确指出了全球化发展的历史特征和可能走向,为当前我国应对全球化挑战提供了思想武器,对该议题的探讨成为我国马克思主义研究的重要组成部分。在利用CiteSpace对国内马克思主义全球化理论研究235篇文献样本进行可视化分析时发现:25年来该议题在发展态势上呈波浪式摇摆趋势,并形成了一定的研究力量,但仍存在核心研究群体不稳定、期刊力量分布不均衡等问题。就研究热点而言,社会主义、世界历史、世界市场、资本主义、共产主义、逆全球化等是该领域的研究热词,学者们聚焦马克思主义全球化理论的实质和内涵、该理论视域下的逆全球化研究及其与世界主义思想的关系研究等热点议题进行深度阐释,并逐渐形成了本土化的马克思主义全球化理论研究体系,进一步推动了马克思主义中国化的发展。在发展趋势上,今后围绕逆全球化和民族国家前途命运的马克思主义全球化理论研究将持续深化。

贸易政策不确定性与全球生产网络——基于内外资企业异质性视角

在逆全球化与贸易保护主义抬头的背景下,区分内外资企业在全球生产网络中的不同角色地位,以及有效应对不确定性贸易政策带来的冲击,对于探索内外资企业的差异化发展路径具有重要意义。基于反倾销发起方和非涉案方(第三方)视角,采用能够反映内外资企业异质性的AMNE数据库,考察反倾销引致的贸易政策不确定性对内外资企业全球生产网络地位的影响效应。研究发现:以反倾销调查衡量的贸易政策不确定性会促进反倾销发起方及非涉案方的外资企业生产网络地位攀升,其中对发达国家、制造业与反倾销发起方境内的外资企业生产网络地位促进作用更显著;贸易政策不确定性会对发起方及非涉案方的内资企业生产网络地位产生负向影响,其中对发展中国家、非制造业与反倾销非涉案方境内的内资企业生产网络地位抑制作用更显著;被调查国的OFDI会增强贸易政策不确定性对外资企业全球生产网络地位的正向效应以及对内资企业全球生产网络地位的负向效应。

海南自贸港建设国际教育创新岛的机遇、挑战与路径

建设国际教育创新岛是时代赋予海南自贸港建设的光荣使命。教育部支持海南创新开展“在地国际化”模式,建设国际教育创新岛。当前,国际形势面临百年未有之大变局,海南国际教育创新岛建设面临着逆全球化浪潮的影响,机遇与挑战并存。海南要积极用好用足政策优势,继续深入探索建设国际教育创新岛的实现路径,全方位、深层次、高质量推进国际教育创新岛建设,打响“学在海南,留学国外”的金字招牌,全面提升教育国际化水平,为中国乃至世界教育发展贡献海南智慧与力量。

新一轮逆全球化浪潮下的南北经济一体化关系走向--基于美国退出TPP和重谈NAFTA的分析

特朗普上任后,将"美国第一"或"美国优先"的全球利益再分配作为"特朗普主义"的核心,宣布美国退出TPP,要求重新谈判NAFTA,甚至威胁退出WTO。这些行动成为当前新一轮逆全球化的重要表现。此轮逆全球化浪潮是由一系列现实问题助推而成,不仅呈现出新的趋势和特点,还给国际经济一体化进程带来了挑战与机遇并存的影响。而美国作为全球唯一的超级大国,在涉及TPP和NAFTA的国际区域经济一体化战略上所作的调整,引起了包括其在内的发达成员和发展中成员之间经济关系的变化。

驯服全球化的药方是否适合逆全球化?--再读《驯服全球化:国际法、美国宪法和新的全球秩序》

全球化正在遭遇逆全球化,陷入逆全球化陷阱。全球法治和国际治理体系也随之陷入举步维艰和停滞不前的困境。早在全球化盛行的时代,美国国际法学者就有观点认为全球化侵蚀了美国宪法和宪法确立的三权分立原则,并提出驯服全球化的药方。全球金融危机之后,逆全球化逐渐抬头,全球化遇到重大挫折,国际法、国际规则和国际经济治理体系均受到不同程度的削弱甚至是动摇。本文试图寻找驯服逆全球化的药方,在逆全球化的进程中,理解国际法、国际规则和国际治理体系的发展逻辑。