A kind of functional liquid was extracted from compound Chinese traditional medicine over 20 different varieties such as ginseng, danggui and so on. The anti-anoxic effects were observed by the ways of oxygen lack in ...A kind of functional liquid was extracted from compound Chinese traditional medicine over 20 different varieties such as ginseng, danggui and so on. The anti-anoxic effects were observed by the ways of oxygen lack in normal atmosphere of mice, decapitation and erythrocyte count and hemoglobin in the mice. Experiments done in this study included observing the best dose and the best time of appearing anti-anoxic effects in mice. Results were found that the functional liquid could prolong not only the survival time and the brain survival time of the mouse, but also increasing the number of erythrocytes (RBC) and the content of hemoglobin (Hb); and the functional liquid has markedly protecting cardio-cerebral function; If the dosage of the functional liquid control on the 0.3ml/day for each mouse, the best effects should appear after four hour. And the functional liquid had no obvious effect on the weight of the mice within thirty days.展开更多
Objective. This study is to investigate the functional mimicry by using antiidiotypic antibodies of enzymes. Methods.Monoclonal antiidiotypic antibodies against antiHEL(hen eggwhite lysozyme, HEL) antibodies were obta...Objective. This study is to investigate the functional mimicry by using antiidiotypic antibodies of enzymes. Methods.Monoclonal antiidiotypic antibodies against antiHEL(hen eggwhite lysozyme, HEL) antibodies were obtained by fusion of Sp2/0 myeloma cells with spleen cells of syngeneic mice immunized with monoclonal antiHEL antibodies against HELs different antigenic epitopes. Then bacteriolysis of the antiidiotypic antibodies were observed. Results.Eight hybridomas strains secreting antiidiotypic antibodies were selected and characterized. It was shown that two of eight antiidiotypic antibodies secreted by two hybridomas(1A 10 C 9 and 2A 11 C 1B 3) could mimic HEL catalytic activity to lyse Micrococcus lysodeikticus and that the catalytic effect of mixed antiidiotypic antibodies of 1A 10 C 9 and 2A 11 C 1B 3 was stronger than that of one of them, but less than HEL. Conclusion. The results demonstrated that the antiidiotypic antibodies that could mimic enzyme activity existed in the idiotype network during antienzymatic immune response.展开更多
Patients with cancer have a high inherent risk of infectious complications.In addition,the incidence of acute and chronic kidney dysfunction rises in this population.Antiinfective drugs often require dosing modificati...Patients with cancer have a high inherent risk of infectious complications.In addition,the incidence of acute and chronic kidney dysfunction rises in this population.Antiinfective drugs often require dosing modifications based on an estimate of kidney function,usually the glomerular filtration rate(GFR).However,there is still no preferential GFR formula to be used,and in acute kidney injury there is always a considerable time delay between true kidney function and estimated GFR.In most cases,the anti-infective therapy should start with an immediate and high loading dose.Pharmacokinetic as well as pharmacodynamic principles must be applied for further dose adjustment.Anti-infective drugs with time-dependent action should be given with the target of high trough concentrations(e.g.,beta lactam antibiotics,penems,vancomycin,antiviral drugs).Anti-infective drugs with concentration-dependent action should be given with the target of high peak concentrations(e.g.,aminoglycosides,daptomycin,colistin,quinolones).Our group created a pharmacokinetic database,called NEPharm,hat serves as a reference to obtain reliable dosing regimens of anti-infective drugs in kidney dysfunction as well as renal replacement therapy.To avoid the risk of either too low or too infrequent peak concentrations,we prefer the eliminated fraction rule for dose adjustment calculations.展开更多
The special case of a crack under mode Ⅲ conditions was treated, lying parallel to the edges of an infinite strip with finite width and with the shear modulus varying exponentially perpendicular to the edges. By usin...The special case of a crack under mode Ⅲ conditions was treated, lying parallel to the edges of an infinite strip with finite width and with the shear modulus varying exponentially perpendicular to the edges. By using Fourier transforms the problem was formulated in terms of a singular integral equation. It was numerically solved by representing the unknown dislocation density by a truncated series of Chebyshev polynomials leading to a linear system of equations. The stress intensity factor （SIF） results were discussed with respect to the influences of different geometric parameters and the strength of the non-homogeneity. It was indicated that the SIF increases with the increase of the crack length and decreases with the increase of the rigidity of the material in the vicinity of crack. The SIF of narrow strip is very sensitive to the change of the non-homogeneity parameter and its variation is complicated. With the increase of the non-homogeneity parameter, the stress intensity factor may increase, decrease or keep constant, which is mainly determined by the strip width and the relative crack location. If the crack is located at the midline of the strip or if the strip is wide, the stress intensity factor is not sensitive to the material non-homogeneity parameter.展开更多
This paper describes an approximated-scalar-sign-function-based anti-windup digital control design for analog nonlinear systems subject to input constraints. As input saturation occurs, the non-smooth saturation const...This paper describes an approximated-scalar-sign-function-based anti-windup digital control design for analog nonlinear systems subject to input constraints. As input saturation occurs, the non-smooth saturation constraint is modeled with the approximated scalar sign function which is a smooth nonlinear function. The resulting nonlinear model is further linearized at any operating point with the optimal linearization technique, and Linear Quadratic Regulator (LQR) is then applied for a state-feedback controller optimal for each operating point. As input saturation is encountered, an iterative procedure is developed to adjust control gains by systematically updating LQR weighting matrices until the inputs lie within the saturation limits. Through global digital redesign, the analog LQR controller is converted to an equivalent digital one for keeping the essential control performance, and moreover, delay compensation is taken into account during digital redesign for compensating the potential time delays in a control loop. The swing-up and stabilization control of single rotary inverted pendulum system is used to illustrate and verify the proposed method.展开更多
In expansions of arbitrary functions in Bessel functions or Spherical Bessel functions, a dual partner set of polynomials play a role. For the Bessel functions, these are the Chebyshev polynomials of first kind and fo...In expansions of arbitrary functions in Bessel functions or Spherical Bessel functions, a dual partner set of polynomials play a role. For the Bessel functions, these are the Chebyshev polynomials of first kind and for the Spherical Bessel functions the Legendre polynomials. These two sets of functions appear in many formulas of the expansion and in the completeness and (bi)-orthogonality relations. The analogy to expansions of functions in Taylor series and in moment series and to expansions in Hermite functions is elaborated. Besides other special expansion, we find the expansion of Bessel functions in Spherical Bessel functions and their inversion and of Chebyshev polynomials of first kind in Legendre polynomials and their inversion. For the operators which generate the Spherical Bessel functions from a basic Spherical Bessel function, the normally ordered (or disentangled) form is found.展开更多
文摘A kind of functional liquid was extracted from compound Chinese traditional medicine over 20 different varieties such as ginseng, danggui and so on. The anti-anoxic effects were observed by the ways of oxygen lack in normal atmosphere of mice, decapitation and erythrocyte count and hemoglobin in the mice. Experiments done in this study included observing the best dose and the best time of appearing anti-anoxic effects in mice. Results were found that the functional liquid could prolong not only the survival time and the brain survival time of the mouse, but also increasing the number of erythrocytes (RBC) and the content of hemoglobin (Hb); and the functional liquid has markedly protecting cardio-cerebral function; If the dosage of the functional liquid control on the 0.3ml/day for each mouse, the best effects should appear after four hour. And the functional liquid had no obvious effect on the weight of the mice within thirty days.
文摘Objective. This study is to investigate the functional mimicry by using antiidiotypic antibodies of enzymes. Methods.Monoclonal antiidiotypic antibodies against antiHEL(hen eggwhite lysozyme, HEL) antibodies were obtained by fusion of Sp2/0 myeloma cells with spleen cells of syngeneic mice immunized with monoclonal antiHEL antibodies against HELs different antigenic epitopes. Then bacteriolysis of the antiidiotypic antibodies were observed. Results.Eight hybridomas strains secreting antiidiotypic antibodies were selected and characterized. It was shown that two of eight antiidiotypic antibodies secreted by two hybridomas(1A 10 C 9 and 2A 11 C 1B 3) could mimic HEL catalytic activity to lyse Micrococcus lysodeikticus and that the catalytic effect of mixed antiidiotypic antibodies of 1A 10 C 9 and 2A 11 C 1B 3 was stronger than that of one of them, but less than HEL. Conclusion. The results demonstrated that the antiidiotypic antibodies that could mimic enzyme activity existed in the idiotype network during antienzymatic immune response.
文摘Patients with cancer have a high inherent risk of infectious complications.In addition,the incidence of acute and chronic kidney dysfunction rises in this population.Antiinfective drugs often require dosing modifications based on an estimate of kidney function,usually the glomerular filtration rate(GFR).However,there is still no preferential GFR formula to be used,and in acute kidney injury there is always a considerable time delay between true kidney function and estimated GFR.In most cases,the anti-infective therapy should start with an immediate and high loading dose.Pharmacokinetic as well as pharmacodynamic principles must be applied for further dose adjustment.Anti-infective drugs with time-dependent action should be given with the target of high trough concentrations(e.g.,beta lactam antibiotics,penems,vancomycin,antiviral drugs).Anti-infective drugs with concentration-dependent action should be given with the target of high peak concentrations(e.g.,aminoglycosides,daptomycin,colistin,quinolones).Our group created a pharmacokinetic database,called NEPharm,hat serves as a reference to obtain reliable dosing regimens of anti-infective drugs in kidney dysfunction as well as renal replacement therapy.To avoid the risk of either too low or too infrequent peak concentrations,we prefer the eliminated fraction rule for dose adjustment calculations.
基金Project supported by the National Natural Science Foundation of China (No.90305023)
文摘The special case of a crack under mode Ⅲ conditions was treated, lying parallel to the edges of an infinite strip with finite width and with the shear modulus varying exponentially perpendicular to the edges. By using Fourier transforms the problem was formulated in terms of a singular integral equation. It was numerically solved by representing the unknown dislocation density by a truncated series of Chebyshev polynomials leading to a linear system of equations. The stress intensity factor （SIF） results were discussed with respect to the influences of different geometric parameters and the strength of the non-homogeneity. It was indicated that the SIF increases with the increase of the crack length and decreases with the increase of the rigidity of the material in the vicinity of crack. The SIF of narrow strip is very sensitive to the change of the non-homogeneity parameter and its variation is complicated. With the increase of the non-homogeneity parameter, the stress intensity factor may increase, decrease or keep constant, which is mainly determined by the strip width and the relative crack location. If the crack is located at the midline of the strip or if the strip is wide, the stress intensity factor is not sensitive to the material non-homogeneity parameter.
文摘This paper describes an approximated-scalar-sign-function-based anti-windup digital control design for analog nonlinear systems subject to input constraints. As input saturation occurs, the non-smooth saturation constraint is modeled with the approximated scalar sign function which is a smooth nonlinear function. The resulting nonlinear model is further linearized at any operating point with the optimal linearization technique, and Linear Quadratic Regulator (LQR) is then applied for a state-feedback controller optimal for each operating point. As input saturation is encountered, an iterative procedure is developed to adjust control gains by systematically updating LQR weighting matrices until the inputs lie within the saturation limits. Through global digital redesign, the analog LQR controller is converted to an equivalent digital one for keeping the essential control performance, and moreover, delay compensation is taken into account during digital redesign for compensating the potential time delays in a control loop. The swing-up and stabilization control of single rotary inverted pendulum system is used to illustrate and verify the proposed method.
文摘In expansions of arbitrary functions in Bessel functions or Spherical Bessel functions, a dual partner set of polynomials play a role. For the Bessel functions, these are the Chebyshev polynomials of first kind and for the Spherical Bessel functions the Legendre polynomials. These two sets of functions appear in many formulas of the expansion and in the completeness and (bi)-orthogonality relations. The analogy to expansions of functions in Taylor series and in moment series and to expansions in Hermite functions is elaborated. Besides other special expansion, we find the expansion of Bessel functions in Spherical Bessel functions and their inversion and of Chebyshev polynomials of first kind in Legendre polynomials and their inversion. For the operators which generate the Spherical Bessel functions from a basic Spherical Bessel function, the normally ordered (or disentangled) form is found.
