In 2003, a 61-year old highly respected director of the Surgery Department of Dongfang Hospital Affiliated to Beijing University of Chinese Medicine was diagnosed as advanced lung cancer, moderately differentiated ade...In 2003, a 61-year old highly respected director of the Surgery Department of Dongfang Hospital Affiliated to Beijing University of Chinese Medicine was diagnosed as advanced lung cancer, moderately differentiated adenocarcinoma, coverinqmore than two thirds of the thoracic aorta, multiple mediastinal nodal metastases, pleural effusion ＂Only 3 months could be expected＂, a cruel fact came out after deliberation of many seasoned medical specialists. In the whole career of this surgery professor, he used the lancet as his weapon to save lives. But this time after weighing the pros and cons again and again, he required a ＂tender＂ plan with no lancet.展开更多
Chemotherapy is still the effective strategy for treating cancer.It is important to explore anticancer agents from Traditional Chinese Medicine and Natural products.Different cancer cell lines were included in our res...Chemotherapy is still the effective strategy for treating cancer.It is important to explore anticancer agents from Traditional Chinese Medicine and Natural products.Different cancer cell lines were included in our research,such as HL60,K562,K562/ADR,KB,KBv200 cells.Cell growth inhibition assay,Annexin V-FITC/PI double-staining assay,measurement of reactive展开更多
Recent progress in the studies of anticancer drugs originating from plants in China is reviewed in this paper. Guided by the experience of traditional Chinese medicine (TCM), several new anticancer drugs have been fou...Recent progress in the studies of anticancer drugs originating from plants in China is reviewed in this paper. Guided by the experience of traditional Chinese medicine (TCM), several new anticancer drugs have been found. Indirubin from indigofera tinctoria (青黛) is useful for the treatment of chronic myelocytic leukemia. On the basis of structure-activity relationship studies of these compounds, a second generation drug (N-methyl isoindigotin) has been developed. Clinical studies demonstrated that it is more effective than indirubin, 1O-hydroxy campothecin derived from Camptotheca acuminata (喜树) have exhibited definite activity on rodent tumors and it is used for phase Ⅱ studies. Iris latea pallasi Fischer var. Chinensis (马蔺子) may serve as展开更多
Malignant cancer is the leading cause of death in man,exceeding cerebrovascular disease and heart disease.More than half of the total mortality due to malignant cancer is from lung,liver,intestinal and gastric cancer....Malignant cancer is the leading cause of death in man,exceeding cerebrovascular disease and heart disease.More than half of the total mortality due to malignant cancer is from lung,liver,intestinal and gastric cancer.Chemotherapy is one of the effective treatments for cancer.However,the great majority of Western anticancer medicines have considerable side effects.Herbal medicines offer many more advantages than synthesized compounds because they are made from purely natural compounds and have less adverse effects.However,the single administration methods used as standard in herbal medicine,and deficient drug targeting,severely limit their anticancer activity.Single-walled carbon nanotubes（SWNTs）can be used as drug carriers.They have been modified to form Chinese anticancer medicine-SWNT compounds which can specifically target tumors,thereby significantly increasing the therapeutic effectiveness of these medicines.Water-soluble SWNTs have high stability.As a drug carrier,SWNTs functional modification of the anticancer medicine may improve the targeting and killing of tumor cells.SWNTs have been attached to the Chinese antitumor medicines paclitaxel and plumbagin and have achieved excellent therapeutic effects.Furthermore,choosing the best administration methods such as internal iliac arterial infusion,intravesical infusion and embedment of a hypodermic chemotherapeutic pump,may also improve the anticancer effects of Chinese medicine.展开更多
基金Supported by the 2018 Capital Health Development Research Key ProjectBeijing Municipal Commission of Health and Fanmily Planning(No.2018-1-4201)National Natural Science Foundation of China(No.81403250)
文摘In 2003, a 61-year old highly respected director of the Surgery Department of Dongfang Hospital Affiliated to Beijing University of Chinese Medicine was diagnosed as advanced lung cancer, moderately differentiated adenocarcinoma, coverinqmore than two thirds of the thoracic aorta, multiple mediastinal nodal metastases, pleural effusion ＂Only 3 months could be expected＂, a cruel fact came out after deliberation of many seasoned medical specialists. In the whole career of this surgery professor, he used the lancet as his weapon to save lives. But this time after weighing the pros and cons again and again, he required a ＂tender＂ plan with no lancet.
文摘Chemotherapy is still the effective strategy for treating cancer.It is important to explore anticancer agents from Traditional Chinese Medicine and Natural products.Different cancer cell lines were included in our research,such as HL60,K562,K562/ADR,KB,KBv200 cells.Cell growth inhibition assay,Annexin V-FITC/PI double-staining assay,measurement of reactive
文摘Recent progress in the studies of anticancer drugs originating from plants in China is reviewed in this paper. Guided by the experience of traditional Chinese medicine (TCM), several new anticancer drugs have been found. Indirubin from indigofera tinctoria (青黛) is useful for the treatment of chronic myelocytic leukemia. On the basis of structure-activity relationship studies of these compounds, a second generation drug (N-methyl isoindigotin) has been developed. Clinical studies demonstrated that it is more effective than indirubin, 1O-hydroxy campothecin derived from Camptotheca acuminata (喜树) have exhibited definite activity on rodent tumors and it is used for phase Ⅱ studies. Iris latea pallasi Fischer var. Chinensis (马蔺子) may serve as
文摘Malignant cancer is the leading cause of death in man,exceeding cerebrovascular disease and heart disease.More than half of the total mortality due to malignant cancer is from lung,liver,intestinal and gastric cancer.Chemotherapy is one of the effective treatments for cancer.However,the great majority of Western anticancer medicines have considerable side effects.Herbal medicines offer many more advantages than synthesized compounds because they are made from purely natural compounds and have less adverse effects.However,the single administration methods used as standard in herbal medicine,and deficient drug targeting,severely limit their anticancer activity.Single-walled carbon nanotubes（SWNTs）can be used as drug carriers.They have been modified to form Chinese anticancer medicine-SWNT compounds which can specifically target tumors,thereby significantly increasing the therapeutic effectiveness of these medicines.Water-soluble SWNTs have high stability.As a drug carrier,SWNTs functional modification of the anticancer medicine may improve the targeting and killing of tumor cells.SWNTs have been attached to the Chinese antitumor medicines paclitaxel and plumbagin and have achieved excellent therapeutic effects.Furthermore,choosing the best administration methods such as internal iliac arterial infusion,intravesical infusion and embedment of a hypodermic chemotherapeutic pump,may also improve the anticancer effects of Chinese medicine.
