We introduce anticipating quadrant and symmetric integrals in the plane, and establish the associated chain rules which are the same as the deterministic ones. In particular, we deduce the relation between quadrant in...We introduce anticipating quadrant and symmetric integrals in the plane, and establish the associated chain rules which are the same as the deterministic ones. In particular, we deduce the relation between quadrant integrals, symmetric integral, and Skorohod integral with respect to two-parameter Wiener processes.展开更多
How to predict the dynamics of nonlinear chaotic systems is still a challenging subject with important real-life applications. The present paper deals with this important yet difficult problem via a new scheme of anti...How to predict the dynamics of nonlinear chaotic systems is still a challenging subject with important real-life applications. The present paper deals with this important yet difficult problem via a new scheme of anticipating synchronization. A global, robust, analytical and delay-independent sufficient condition is obtained to guarantee the existence of anticipating synchronization manifold theoretically in the framework of the Krasovskii-Lyapunov theory. Different from 'traditional techniques (or regimes)' proposed in the previous literature, the present scheme guarantees that the receiver system can synchronize with the future state of a transmitter system for an arbitrarily long anticipation time, which allows one to predict the dynamics of chaotic transmitter at any point of time if necessary. Also it is simple to implement in practice. A classical chaotic system is employed to demonstrate the application of the proposed scheme to the long-term prediction of chaotic states.展开更多
A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradati...A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradation or degeneracy in state estimator performance.The proposed approach leverages efficient numerical techniques in nonlinear observability analysis and motion primitive-based planning technique to realize the local observability prediction with real-time performance.The degradation of the state estimation performance can be readily predicted with the local observability evaluation result.The proposed approach is specialized to a representative optimization-based monocular visual-inertial state estimation formulation and evaluated through simulation and experiments.The experimental results demonstrated the ability of the proposed methodology to correctly anticipate the potential state estimation degradation.展开更多
This paper introdnces some concepts of conditional stability of stochasticVolterra equations with anticipating kernel. Snfficient conditions of these types of sta-bility are established via Lyapunov funciton.
For a backward stochastic differential equation(BSDE,for short),when the generator is not progressively measurable,it might not admit adapted solutions,shown by an example.However,for backward stochastic Volterra inte...For a backward stochastic differential equation(BSDE,for short),when the generator is not progressively measurable,it might not admit adapted solutions,shown by an example.However,for backward stochastic Volterra integral equations(BSVIEs,for short),the generators are allowed to be anticipating.This gives,among other things,an essential difference between BSDEs and BSVIEs.Under some proper conditions,the well-posedness of such BSVIEs is established.Further,the results are extended to path-dependent BSVIEs,in which the generators can depend on the future paths of unknown processes.An additional finding is that for path-dependent BSVIEs,in general,the situation of anticipating generators is not avoidable,and the adaptedness condition similar to that imposed for anticipated BSDEs by Peng−Yang[22]is not necessary.展开更多
In the 2010 State of the Union Address in January, U.S. President Barack Obama set a goal of doubling U.S. exports over the next five years, "an increase that will support 2 million jobs
Chen Muhua (L4), Vice Chairperson of the Standing Committee of the National People’s Congress and President of the ACWF, Wang Zhaoguo (R3), Minister of United Front, Lu Ping (L3), Director of the Hong Kong and Macao ...Chen Muhua (L4), Vice Chairperson of the Standing Committee of the National People’s Congress and President of the ACWF, Wang Zhaoguo (R3), Minister of United Front, Lu Ping (L3), Director of the Hong Kong and Macao Affairs Office of the State Council, Huang Qizao (L2), Vice President and first member of the ACWF Secretariat, and Zhao Di (R2), Vice President and member of the ACWF Secretariat with Ms. Peggyp Lam, head of the Hona Kona and Macao Women’s Visitina Group.展开更多
Anticipating others’actions is innate and essential in order for humans to navigate and interact well with others in dense crowds.This ability is urgently required for unmanned systems such as service robots and self...Anticipating others’actions is innate and essential in order for humans to navigate and interact well with others in dense crowds.This ability is urgently required for unmanned systems such as service robots and self-driving cars.However,existing solutions struggle to predict pedestrian anticipation accurately,because the influence of group-related social behaviors has not been well considered.While group relationships and group interactions are ubiquitous and significantly influence pedestrian anticipation,their influence is diverse and subtle,making it difficult to explicitly quantify.Here,we propose the group interaction field(GIF),a novel group-aware representation that quantifies pedestrian anticipation into a probability field of pedestrians’future locations and attention orientations.An end-to-end neural network,GIFNet,is tailored to estimate the GIF from explicit multidimensional observations.GIFNet quantifies the influence of group behaviors by formulating a group interaction graph with propagation and graph attention that is adaptive to the group size and dynamic interaction states.The experimental results show that the GIF effectively represents the change in pedestrians’anticipation under the prominent impact of group behaviors and accurately predicts pedestrians’future states.Moreover,the GIF contributes to explaining various predictions of pedestrians’behavior in different social states.The proposed GIF will eventually be able to allow unmanned systems to work in a human-like manner and comply with social norms,thereby promoting harmonious human-machine relationships.展开更多
Objective To make early diagnosis of IT15 gene mutation in a Wuhan juvenile-onset Huntington disease (HD) family, for providing them with genetic counseling, and making preparation for the further research on pathog...Objective To make early diagnosis of IT15 gene mutation in a Wuhan juvenile-onset Huntington disease (HD) family, for providing them with genetic counseling, and making preparation for the further research on pathogenesis and experimental therapy of HD. Methods According to the principle of informed consent, we extracted genomic DNA from peripheral blood samples and carried genetic diagnosis of pathogenic exon 1 of IT15 gene by modified touchdown PCR and DNA sequencing methods. Results Eight of twenty-five family members carried abnormal allele: Ⅲ10 Ⅲ12, IIIt4, Ⅳ3, and Ⅴ2 carded (CAG) 48, Ⅳ11 and Ⅳ12 carried (CAG) 67, and Ⅳ14 carried (CAG) 63, in contrast with the 8-25 CAG trinucleotides in the members of control group. Ⅳ14 carried 15 more CAG trinucleotides than her father Ⅲ10. Conclusion The results definitely confirm the diagnosis of HD and indicate the CAG trinucleotide repeat expansion of IT15 gene in this HD family. In addition, CAG expansion results in juvenile-onset and anticipation (characterized by earlier age of onset and increasing severity) of the patientⅣ12.展开更多
Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of inf...Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of information. This paper willputs forward some skills for reading comprehension.展开更多
The full velocity difference model proposed by Jiang et al. [2001 Phys. Rev. E 64 017101] has been improved by introducing velocity anticipation. Velocity anticipation means the follower estimates the future velocity ...The full velocity difference model proposed by Jiang et al. [2001 Phys. Rev. E 64 017101] has been improved by introducing velocity anticipation. Velocity anticipation means the follower estimates the future velocity of the leader. The stability condition of the new model is obtained by using the linear stability theory. Theoretical results show that the stability region increases when we increase the anticipation time interval. The mKdV equation is derived to describe the kink-antikink soliton wave and obtain the coexisting stability line. The delay time of car motion and kinematic wave speed at jam density are obtained in this modeh Numerical simulations exhibit that when we increase the anticipation time interval enough, the new model could avoid accidents under urgent braking cases. Also, the traffic jam could be suppressed by considering the anticipation velocity. All results demonstrate that this model is an improvement on the full velocity difference model.展开更多
AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalenc...AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),respectively.Thehighest levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in DR.The lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in DR.In the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with DR.CONCLUSION:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2diabetics.Prevention of oxidative stress and abdominal obesity is needed.Supplementation in vitamin C,D,and E should be recommended as complement therapies of T2DM.展开更多
AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a...AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o’clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o’clock by anti-glaucoma drugs,but their IOPs would elevate 】21mmHg after 12 o’clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.展开更多
This paper investigates robust unified (lag, anticipated, and complete) synchronization of two coupled chaotic systems, By introducing the concepts of positive definite symmetrical matrix and Riccati inequality and ...This paper investigates robust unified (lag, anticipated, and complete) synchronization of two coupled chaotic systems, By introducing the concepts of positive definite symmetrical matrix and Riccati inequality and the theory of robust stability, several criteria on robust synchronization are established. Extensive numerical simulations are also used to confirm the results.展开更多
By introducing the traffic anticipation effect in the real world into the original lattice hydrodynamic model, we present a new anticipation effect lattice hydrodynamic (AELH) model, and obtain the linear stability ...By introducing the traffic anticipation effect in the real world into the original lattice hydrodynamic model, we present a new anticipation effect lattice hydrodynamic (AELH) model, and obtain the linear stability condition of the model by applying the linear stability theory. Through nonlinear analysis, we derive the Burgers equation and Korteweg-de Vries (KdV) equation, to describe the propagating behaviour of traffic density waves in the stable and the metastable regions, respectively. The good agreement between simulation results and analytical results shows that the stability of traffic flow can be enhanced when the anticipation effect is considered.展开更多
In this paper, a bidirectional partial generalized (lag, complete, and anticipated) synchronization of a class of continuous-time systems is defined. Then based on the active control idea, a new systematic and concr...In this paper, a bidirectional partial generalized (lag, complete, and anticipated) synchronization of a class of continuous-time systems is defined. Then based on the active control idea, a new systematic and concrete scheme is developed to achieve bidirectional partial generalized (lag, complete, and anticipated) synchronization between two chaotic systems or between chaotic and hyperchaotic systems. With the help of symbolic-numerical computation, we choose the modified Chua system, Lorenz system, and the hyperchaotic Tamasevicius Namajunas-Cenys system to illustrate the proposed scheme. Numerical simulations are used to verify the effectiveness of the proposed scheme. It is interesting that partial chaos synchronization not only can take place between two chaotic systems, but also can take place between chaotic and hyperchaotic systems. The proposed scheme can also be extended to research bidirectional partial generalized (lag, complete, and anticipated) synchronization between other dynamical systems.展开更多
AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polypos...AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polyposisand their 7465 first-degree relatives who weremembers of 750 families registered at ourPolyposis Registry.The ages at death andcumulative mortality rates in the parent,theproband,and the child generations werecompared for both all subjects and the patientsalone.RESULTS In the patients over 5 years of age,the mean age at death was 50.9 years for theparent,42.3 years for the proband,and 33.3years for the child generations,respectively(P【0.001).The deceased rates in the threegenerations were 90.7%,51.3% and 23.1% ofthe patients,respectively,and this differencewas the main cause of the anticipation measuredby parent-child paring method.The cumulativemortality rates for all subjects failed to showanticipation,however the cumulative mortalityrates for the patients showed the anticipation.The anticipation phenomenon was shown by anyparent-child pairing methods for the deceasedpatients.Other important causes of theanticipation were different proportion of causesof death between generations(P【0.001),and alow proportion of detected or deceased patients (P【0.001)in the child generation.CONCLUSION Anticipation in familialadenomatous polyposis may be caused byparent-child paring methods as well as severalintergenerational biases.展开更多
This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables...This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables.By virtue of the duality method and the generalized anticipated backward stochastic differential equations,we establish a necessary maximum principle and a sufficient verification theorem.In particular,we deal with the controlled stochastic system where the distributed delays enter both the state and the control.To explain the theoretical results,we apply them to a dynamic advertising problem.展开更多
A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new ma...A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new macroscopic traffic flow model based on the transition velocity distribution is proposed which characterizes traffic alignment under adverse weather conditions. Two examples are considered to illustrate the effect of the transition velocity behavior on traffic velocity and density. Simulation results are presented which show that this model provides a more accurate characterization of traffic flow behavior than the well known Payne-Whitham model. The proposed model can be used to reduce accidents and improve road safety during adverse weather conditions.展开更多
文摘We introduce anticipating quadrant and symmetric integrals in the plane, and establish the associated chain rules which are the same as the deterministic ones. In particular, we deduce the relation between quadrant integrals, symmetric integral, and Skorohod integral with respect to two-parameter Wiener processes.
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10472091 and 10502042) and the Scientific and Technological Innovation Foundation for Young Teachers of Northwestern Polytechnical University, China.
文摘How to predict the dynamics of nonlinear chaotic systems is still a challenging subject with important real-life applications. The present paper deals with this important yet difficult problem via a new scheme of anticipating synchronization. A global, robust, analytical and delay-independent sufficient condition is obtained to guarantee the existence of anticipating synchronization manifold theoretically in the framework of the Krasovskii-Lyapunov theory. Different from 'traditional techniques (or regimes)' proposed in the previous literature, the present scheme guarantees that the receiver system can synchronize with the future state of a transmitter system for an arbitrarily long anticipation time, which allows one to predict the dynamics of chaotic transmitter at any point of time if necessary. Also it is simple to implement in practice. A classical chaotic system is employed to demonstrate the application of the proposed scheme to the long-term prediction of chaotic states.
文摘A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradation or degeneracy in state estimator performance.The proposed approach leverages efficient numerical techniques in nonlinear observability analysis and motion primitive-based planning technique to realize the local observability prediction with real-time performance.The degradation of the state estimation performance can be readily predicted with the local observability evaluation result.The proposed approach is specialized to a representative optimization-based monocular visual-inertial state estimation formulation and evaluated through simulation and experiments.The experimental results demonstrated the ability of the proposed methodology to correctly anticipate the potential state estimation degradation.
基金Supported by Natural Science Foundation of Beijing (1022004)
文摘This paper introdnces some concepts of conditional stability of stochasticVolterra equations with anticipating kernel. Snfficient conditions of these types of sta-bility are established via Lyapunov funciton.
基金Hanxiao Wang would like to thank Chenchen Mou(of City University of Hong Kong)for some useful discussionsJiongmin Yong is supported in part by NSF(Grant No.DMS-1812921)+1 种基金Chao Zhou is supported by NSFC(Grant No.11871364)Singapore MOE AcRF(Grant Nos.A-800453-00-00,R-146-000-271-112 and R-146-000-284-114).
文摘For a backward stochastic differential equation(BSDE,for short),when the generator is not progressively measurable,it might not admit adapted solutions,shown by an example.However,for backward stochastic Volterra integral equations(BSVIEs,for short),the generators are allowed to be anticipating.This gives,among other things,an essential difference between BSDEs and BSVIEs.Under some proper conditions,the well-posedness of such BSVIEs is established.Further,the results are extended to path-dependent BSVIEs,in which the generators can depend on the future paths of unknown processes.An additional finding is that for path-dependent BSVIEs,in general,the situation of anticipating generators is not avoidable,and the adaptedness condition similar to that imposed for anticipated BSDEs by Peng−Yang[22]is not necessary.
文摘In the 2010 State of the Union Address in January, U.S. President Barack Obama set a goal of doubling U.S. exports over the next five years, "an increase that will support 2 million jobs
文摘Chen Muhua (L4), Vice Chairperson of the Standing Committee of the National People’s Congress and President of the ACWF, Wang Zhaoguo (R3), Minister of United Front, Lu Ping (L3), Director of the Hong Kong and Macao Affairs Office of the State Council, Huang Qizao (L2), Vice President and first member of the ACWF Secretariat, and Zhao Di (R2), Vice President and member of the ACWF Secretariat with Ms. Peggyp Lam, head of the Hona Kona and Macao Women’s Visitina Group.
基金supported in part by the National Natural Science Foundation of China (NSFC,62125106,61860206003,and 62088102)in part by the Ministry of Science and Technology of China (2021ZD0109901)in part by the Provincial Key Research and Development Program of Zhejiang (2021C01016).
文摘Anticipating others’actions is innate and essential in order for humans to navigate and interact well with others in dense crowds.This ability is urgently required for unmanned systems such as service robots and self-driving cars.However,existing solutions struggle to predict pedestrian anticipation accurately,because the influence of group-related social behaviors has not been well considered.While group relationships and group interactions are ubiquitous and significantly influence pedestrian anticipation,their influence is diverse and subtle,making it difficult to explicitly quantify.Here,we propose the group interaction field(GIF),a novel group-aware representation that quantifies pedestrian anticipation into a probability field of pedestrians’future locations and attention orientations.An end-to-end neural network,GIFNet,is tailored to estimate the GIF from explicit multidimensional observations.GIFNet quantifies the influence of group behaviors by formulating a group interaction graph with propagation and graph attention that is adaptive to the group size and dynamic interaction states.The experimental results show that the GIF effectively represents the change in pedestrians’anticipation under the prominent impact of group behaviors and accurately predicts pedestrians’future states.Moreover,the GIF contributes to explaining various predictions of pedestrians’behavior in different social states.The proposed GIF will eventually be able to allow unmanned systems to work in a human-like manner and comply with social norms,thereby promoting harmonious human-machine relationships.
文摘Objective To make early diagnosis of IT15 gene mutation in a Wuhan juvenile-onset Huntington disease (HD) family, for providing them with genetic counseling, and making preparation for the further research on pathogenesis and experimental therapy of HD. Methods According to the principle of informed consent, we extracted genomic DNA from peripheral blood samples and carried genetic diagnosis of pathogenic exon 1 of IT15 gene by modified touchdown PCR and DNA sequencing methods. Results Eight of twenty-five family members carried abnormal allele: Ⅲ10 Ⅲ12, IIIt4, Ⅳ3, and Ⅴ2 carded (CAG) 48, Ⅳ11 and Ⅳ12 carried (CAG) 67, and Ⅳ14 carried (CAG) 63, in contrast with the 8-25 CAG trinucleotides in the members of control group. Ⅳ14 carried 15 more CAG trinucleotides than her father Ⅲ10. Conclusion The results definitely confirm the diagnosis of HD and indicate the CAG trinucleotide repeat expansion of IT15 gene in this HD family. In addition, CAG expansion results in juvenile-onset and anticipation (characterized by earlier age of onset and increasing severity) of the patientⅣ12.
文摘Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of information. This paper willputs forward some skills for reading comprehension.
基金Project supported by the National Basic Research Program of China (Grant No. 2006CB705500)the National Natural Science Foundation of China (Grant Nos. 70501004, 70701004 and 70631001)the Program for New Century Talents in University,Ministry of Education, China (Grant No. NCET-07-0057)
文摘The full velocity difference model proposed by Jiang et al. [2001 Phys. Rev. E 64 017101] has been improved by introducing velocity anticipation. Velocity anticipation means the follower estimates the future velocity of the leader. The stability condition of the new model is obtained by using the linear stability theory. Theoretical results show that the stability region increases when we increase the anticipation time interval. The mKdV equation is derived to describe the kink-antikink soliton wave and obtain the coexisting stability line. The delay time of car motion and kinematic wave speed at jam density are obtained in this modeh Numerical simulations exhibit that when we increase the anticipation time interval enough, the new model could avoid accidents under urgent braking cases. Also, the traffic jam could be suppressed by considering the anticipation velocity. All results demonstrate that this model is an improvement on the full velocity difference model.
文摘AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),respectively.Thehighest levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in DR.The lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in DR.In the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with DR.CONCLUSION:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2diabetics.Prevention of oxidative stress and abdominal obesity is needed.Supplementation in vitamin C,D,and E should be recommended as complement therapies of T2DM.
基金Medical Scientific Research Foundation of Guangdong Province(No.A2013215)
文摘AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o’clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o’clock by anti-glaucoma drugs,but their IOPs would elevate 】21mmHg after 12 o’clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.
基金Project supported by the National Natural Science Foundation of China (Grant No 10372054).
文摘This paper investigates robust unified (lag, anticipated, and complete) synchronization of two coupled chaotic systems, By introducing the concepts of positive definite symmetrical matrix and Riccati inequality and the theory of robust stability, several criteria on robust synchronization are established. Extensive numerical simulations are also used to confirm the results.
基金supported by the Fundamental Research Funds for the Central Universities (Grant No. CDJZR11170002)the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090191110022)
文摘By introducing the traffic anticipation effect in the real world into the original lattice hydrodynamic model, we present a new anticipation effect lattice hydrodynamic (AELH) model, and obtain the linear stability condition of the model by applying the linear stability theory. Through nonlinear analysis, we derive the Burgers equation and Korteweg-de Vries (KdV) equation, to describe the propagating behaviour of traffic density waves in the stable and the metastable regions, respectively. The good agreement between simulation results and analytical results shows that the stability of traffic flow can be enhanced when the anticipation effect is considered.
基金The author thanks the referees for their valuable suggestions and is very grateful to Dr. Yan Zhen-Ya for his enthusiastic guidance and help.
文摘In this paper, a bidirectional partial generalized (lag, complete, and anticipated) synchronization of a class of continuous-time systems is defined. Then based on the active control idea, a new systematic and concrete scheme is developed to achieve bidirectional partial generalized (lag, complete, and anticipated) synchronization between two chaotic systems or between chaotic and hyperchaotic systems. With the help of symbolic-numerical computation, we choose the modified Chua system, Lorenz system, and the hyperchaotic Tamasevicius Namajunas-Cenys system to illustrate the proposed scheme. Numerical simulations are used to verify the effectiveness of the proposed scheme. It is interesting that partial chaos synchronization not only can take place between two chaotic systems, but also can take place between chaotic and hyperchaotic systems. The proposed scheme can also be extended to research bidirectional partial generalized (lag, complete, and anticipated) synchronization between other dynamical systems.
基金Foundation for Promotion of Cancer Research in JapanGrant in Aid from the Ministry of Health and WelfareJapanese Society for Cancer of the Colon and Rectum
文摘AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polyposisand their 7465 first-degree relatives who weremembers of 750 families registered at ourPolyposis Registry.The ages at death andcumulative mortality rates in the parent,theproband,and the child generations werecompared for both all subjects and the patientsalone.RESULTS In the patients over 5 years of age,the mean age at death was 50.9 years for theparent,42.3 years for the proband,and 33.3years for the child generations,respectively(P【0.001).The deceased rates in the threegenerations were 90.7%,51.3% and 23.1% ofthe patients,respectively,and this differencewas the main cause of the anticipation measuredby parent-child paring method.The cumulativemortality rates for all subjects failed to showanticipation,however the cumulative mortalityrates for the patients showed the anticipation.The anticipation phenomenon was shown by anyparent-child pairing methods for the deceasedpatients.Other important causes of theanticipation were different proportion of causesof death between generations(P【0.001),and alow proportion of detected or deceased patients (P【0.001)in the child generation.CONCLUSION Anticipation in familialadenomatous polyposis may be caused byparent-child paring methods as well as severalintergenerational biases.
基金supported by the National Natural Science Foundation of China(11701214)Shandong Provincial Natural Science Foundation,China(ZR2019MA045).
文摘This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables.By virtue of the duality method and the generalized anticipated backward stochastic differential equations,we establish a necessary maximum principle and a sufficient verification theorem.In particular,we deal with the controlled stochastic system where the distributed delays enter both the state and the control.To explain the theoretical results,we apply them to a dynamic advertising problem.
基金Project supported by Higher Education Commission,Pakistan/National Center of Big Data and Cloud Computing
文摘A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new macroscopic traffic flow model based on the transition velocity distribution is proposed which characterizes traffic alignment under adverse weather conditions. Two examples are considered to illustrate the effect of the transition velocity behavior on traffic velocity and density. Simulation results are presented which show that this model provides a more accurate characterization of traffic flow behavior than the well known Payne-Whitham model. The proposed model can be used to reduce accidents and improve road safety during adverse weather conditions.