Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiat...Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR spectroscopy.The copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) methods.Average molecular weight,as well as intrinsic viscosity,was obtained by vapor pressu...展开更多
2,4-Dichlorophenoxyacetic acid(2,4-D)is a board-leaf selective herbicide and globally used in agricultural activities.Complexation mode,spectroscopic investigations and biological properties of complexes formed betwee...2,4-Dichlorophenoxyacetic acid(2,4-D)is a board-leaf selective herbicide and globally used in agricultural activities.Complexation mode,spectroscopic investigations and biological properties of complexes formed between 2,4-D(C_(6)H_(3)Cl_(2)OCH_(2)·COOH;HL)with Zn(Ⅱ),Cu(Ⅱ),Ni(Ⅱ),Co(Ⅱ),and Mn(Ⅱ)metal ions were investigated.To characterize the binding mode between 2,4-D and the metal ions,many physicochemical approaches were employed.The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis,FTIR spectroscopy,UV-Vis spectroscopy,1H-NMR,and magnetic susceptibility measurements.Results of these approaches suggested that the gross formula of the complexes obtained with the metal ions were[ZnL_(2)](2H_(2)O(1),[CuL_(2)(H_(2)O)_(2)](2),[NiL_(2)](3H_(2)O(3),[CoL_(2)(H_(2)O)_(2)](4),and[MnL_(2)(H_(2)O)_(2)](5).In all complexes,two L-anion were coordinated the metal ion by their bidentate carboxylate groups.From the spectral study,all the complexes obtained as monomeric structure and the metals center moieties are six-coordinated with octahedral geometry except Ni(Ⅱ)and Zn(Ⅱ)complexes which existed as a tetrahedral and square pyramidal geometry respectively.The complexes were screened in vitro against several microbes(fungi and bacteria)using Kirby-Bauer disc diffusion method,and data has demonstrated that complex 3 showed excellent antifungal activity.展开更多
Acacia nilotica （L.） Delile, commonly known as ＂Babul＂, is reported for its medicinal property since ages. Plant is recognized for its medicinal use in traditional practices. For the study, phytochemicals were ext...Acacia nilotica （L.） Delile, commonly known as ＂Babul＂, is reported for its medicinal property since ages. Plant is recognized for its medicinal use in traditional practices. For the study, phytochemicals were extracted as well as identified from four different solvents and their antibacterial property was determined. The fingerprinting was accomplished using HPTLC and the MIC （Minimum Inhibitory Concentration） was elucidated using standard protocols. Two Gram positive （Staphylococcus aureus and Bacillus subtilis） and two Gram negative （Escherichia coli and Pseudomonas aeruginosa） bacteria were selected for the antibacterial screening. The major phytochemicals identified in the extract of the bark of A. nilotica were catechin/epicatechin, ellagic acid and m-digallic acid. Excellent antimicrobial activity was found in chloroform （40 ~tg/mL） and methanol （60 ~g/mL） extracts against Pseudomonas aeruginosa. The chloroform extracts consist of higher number of phytochemicals/bands as compared with other extracts and demonstrated significant antibacterial activity against all the test bacterial species.展开更多
New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus...New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.展开更多
文摘Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR spectroscopy.The copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) methods.Average molecular weight,as well as intrinsic viscosity,was obtained by vapor pressu...
基金the deanship of scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding program。
文摘2,4-Dichlorophenoxyacetic acid(2,4-D)is a board-leaf selective herbicide and globally used in agricultural activities.Complexation mode,spectroscopic investigations and biological properties of complexes formed between 2,4-D(C_(6)H_(3)Cl_(2)OCH_(2)·COOH;HL)with Zn(Ⅱ),Cu(Ⅱ),Ni(Ⅱ),Co(Ⅱ),and Mn(Ⅱ)metal ions were investigated.To characterize the binding mode between 2,4-D and the metal ions,many physicochemical approaches were employed.The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis,FTIR spectroscopy,UV-Vis spectroscopy,1H-NMR,and magnetic susceptibility measurements.Results of these approaches suggested that the gross formula of the complexes obtained with the metal ions were[ZnL_(2)](2H_(2)O(1),[CuL_(2)(H_(2)O)_(2)](2),[NiL_(2)](3H_(2)O(3),[CoL_(2)(H_(2)O)_(2)](4),and[MnL_(2)(H_(2)O)_(2)](5).In all complexes,two L-anion were coordinated the metal ion by their bidentate carboxylate groups.From the spectral study,all the complexes obtained as monomeric structure and the metals center moieties are six-coordinated with octahedral geometry except Ni(Ⅱ)and Zn(Ⅱ)complexes which existed as a tetrahedral and square pyramidal geometry respectively.The complexes were screened in vitro against several microbes(fungi and bacteria)using Kirby-Bauer disc diffusion method,and data has demonstrated that complex 3 showed excellent antifungal activity.
文摘Acacia nilotica （L.） Delile, commonly known as ＂Babul＂, is reported for its medicinal property since ages. Plant is recognized for its medicinal use in traditional practices. For the study, phytochemicals were extracted as well as identified from four different solvents and their antibacterial property was determined. The fingerprinting was accomplished using HPTLC and the MIC （Minimum Inhibitory Concentration） was elucidated using standard protocols. Two Gram positive （Staphylococcus aureus and Bacillus subtilis） and two Gram negative （Escherichia coli and Pseudomonas aeruginosa） bacteria were selected for the antibacterial screening. The major phytochemicals identified in the extract of the bark of A. nilotica were catechin/epicatechin, ellagic acid and m-digallic acid. Excellent antimicrobial activity was found in chloroform （40 ~tg/mL） and methanol （60 ~g/mL） extracts against Pseudomonas aeruginosa. The chloroform extracts consist of higher number of phytochemicals/bands as compared with other extracts and demonstrated significant antibacterial activity against all the test bacterial species.
文摘New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.
