In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-N...In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid(AA)- and adenosine diphosphate(ADP)-induced platelet aggregation in vitro, with 3.8- and 7.0-fold more effectiveness than(S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2 S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release(S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.展开更多
Background: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event ...Background: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder (LRD) with dosimetric, anatomic, and clinical factors in patients with prostate cancer who underwent three-dimensional conformal radiation therapy (3D-CRT). Methods: We retrospectively analyzed 104 patients undergoing 3D-CRT between January 2009 and October 2011. Thirty patients were administered anticoagulation/antiplatelet (AC/AP) agents. The standard dose was 74 Gy. Uni- and multi-va,iate analyses we,e performed to identify factors predictive of LRD after 3D-CRT. Results: The median follow-up period was 66 (range: 14 87) months. LRD occurred in 10.6% (11/104) of patients. The median time fi'om RT to LRD was 15 months (range: 7MI months). Sixty-four percent of those with LRD (7/11 patients) had been given AC/AP agents. Fitly-five (6/11 ) patients had severe internal iliac artery calcification. By univariate analysis, significant predictors of LRD were internal iliac artery calcification, administration of AC/AP agents, and age. Being very elderly was the significant predictor identified by multivariate analysis (P = 0.0276). For patients receiving AC/AP agents and those with severe internal iliac artery calcification, the LRD incidences were 23.3% (7/30 patients) and 23.1% (6/26 patients), respectively, and being 75 years of age or older was a significant predictor in these subsets. Conclusions: Our results suggest advanced age, administration of AC/AP agents, and severe internal iliac artery calcification to be risk factors tbr LRD in patients undergoing standard RT. Therefore, it is necessary to administer radiation with particular caution in the very elderly, especially those receiving AC/AP agents and/or with severe internal iliac artery calcification.展开更多
Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered fro...Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered from atypical initial symptoms.Here,in this case report,a 12-year-old patient was initially diagnosed as encephalitis.However,it was later noticed that this was a misdiagnosis for the following reasons:the echocardiography showed a vegetation attached to his mitral valves;the cranial magnetic resonance imaging showed lesions that were consistent with a cardioembolic distribution.The final diagnosis was IE.展开更多
基金supported by the National Natural Science Foundation for Young Scientists of China(Nos:21502071 and 21302068)the Natural Science Foundation of Jiangsu Province,China(Nos:BK20140154 and BK20130127)the Fundamental Research Funds for the Central Universities(Nos:JUSRP51411B and JUSRP51629B)
文摘In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid(AA)- and adenosine diphosphate(ADP)-induced platelet aggregation in vitro, with 3.8- and 7.0-fold more effectiveness than(S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2 S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release(S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.
文摘Background: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder (LRD) with dosimetric, anatomic, and clinical factors in patients with prostate cancer who underwent three-dimensional conformal radiation therapy (3D-CRT). Methods: We retrospectively analyzed 104 patients undergoing 3D-CRT between January 2009 and October 2011. Thirty patients were administered anticoagulation/antiplatelet (AC/AP) agents. The standard dose was 74 Gy. Uni- and multi-va,iate analyses we,e performed to identify factors predictive of LRD after 3D-CRT. Results: The median follow-up period was 66 (range: 14 87) months. LRD occurred in 10.6% (11/104) of patients. The median time fi'om RT to LRD was 15 months (range: 7MI months). Sixty-four percent of those with LRD (7/11 patients) had been given AC/AP agents. Fitly-five (6/11 ) patients had severe internal iliac artery calcification. By univariate analysis, significant predictors of LRD were internal iliac artery calcification, administration of AC/AP agents, and age. Being very elderly was the significant predictor identified by multivariate analysis (P = 0.0276). For patients receiving AC/AP agents and those with severe internal iliac artery calcification, the LRD incidences were 23.3% (7/30 patients) and 23.1% (6/26 patients), respectively, and being 75 years of age or older was a significant predictor in these subsets. Conclusions: Our results suggest advanced age, administration of AC/AP agents, and severe internal iliac artery calcification to be risk factors tbr LRD in patients undergoing standard RT. Therefore, it is necessary to administer radiation with particular caution in the very elderly, especially those receiving AC/AP agents and/or with severe internal iliac artery calcification.
文摘Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered from atypical initial symptoms.Here,in this case report,a 12-year-old patient was initially diagnosed as encephalitis.However,it was later noticed that this was a misdiagnosis for the following reasons:the echocardiography showed a vegetation attached to his mitral valves;the cranial magnetic resonance imaging showed lesions that were consistent with a cardioembolic distribution.The final diagnosis was IE.