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Synthesis and biological evaluation of nitric oxide(NO)-hydrogen sulfide(H2S) releasing derivatives of(S)-3-n-butylphthalide as potential antiplatelet agents 被引量:8
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作者 WANG Xiao-Li WANG Zhao-Ya +2 位作者 LING Jing-Jing ZHANG Yi-Hua YIN Jian 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2016年第12期946-953,共8页
In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-N... In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid(AA)- and adenosine diphosphate(ADP)-induced platelet aggregation in vitro, with 3.8- and 7.0-fold more effectiveness than(S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2 S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release(S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke. 展开更多
关键词 (S)-3-n-butylphthalide Nitric oxide Hydrogen sulfide antiplatelet agents
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Factors Predicting Late Rectal Disorders after Radiation Therapy for Prostate Cancer
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作者 Toshiya Maebayashi Naoya Ishibashi +6 位作者 Takuya Aizawa Masakuni Sakaguchi Hideki Sato Katsuhiko Sato Tsuyoshi Matsui Kenya Yamaguchi Satoru Takahashi 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第20期2441-2446,共6页
Background: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event ... Background: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder (LRD) with dosimetric, anatomic, and clinical factors in patients with prostate cancer who underwent three-dimensional conformal radiation therapy (3D-CRT). Methods: We retrospectively analyzed 104 patients undergoing 3D-CRT between January 2009 and October 2011. Thirty patients were administered anticoagulation/antiplatelet (AC/AP) agents. The standard dose was 74 Gy. Uni- and multi-va,iate analyses we,e performed to identify factors predictive of LRD after 3D-CRT. Results: The median follow-up period was 66 (range: 14 87) months. LRD occurred in 10.6% (11/104) of patients. The median time fi'om RT to LRD was 15 months (range: 7MI months). Sixty-four percent of those with LRD (7/11 patients) had been given AC/AP agents. Fitly-five (6/11 ) patients had severe internal iliac artery calcification. By univariate analysis, significant predictors of LRD were internal iliac artery calcification, administration of AC/AP agents, and age. Being very elderly was the significant predictor identified by multivariate analysis (P = 0.0276). For patients receiving AC/AP agents and those with severe internal iliac artery calcification, the LRD incidences were 23.3% (7/30 patients) and 23.1% (6/26 patients), respectively, and being 75 years of age or older was a significant predictor in these subsets. Conclusions: Our results suggest advanced age, administration of AC/AP agents, and severe internal iliac artery calcification to be risk factors tbr LRD in patients undergoing standard RT. Therefore, it is necessary to administer radiation with particular caution in the very elderly, especially those receiving AC/AP agents and/or with severe internal iliac artery calcification. 展开更多
关键词 Anticoagulation/antiplatelet agents Late Rectal Disorder Prostate Cancer Radiation Therapy Severe Internal lliac Artery Calcification
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Infective endocarditis with brain lesions misdiagnosed as viral encephalitis
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作者 Jing-Jing Zhang Guo-Dong Feng 《Neuroimmunology and Neuroinflammation》 2016年第1期48-50,共3页
Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered fro... Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered from atypical initial symptoms.Here,in this case report,a 12-year-old patient was initially diagnosed as encephalitis.However,it was later noticed that this was a misdiagnosis for the following reasons:the echocardiography showed a vegetation attached to his mitral valves;the cranial magnetic resonance imaging showed lesions that were consistent with a cardioembolic distribution.The final diagnosis was IE. 展开更多
关键词 antiplatelet agents embolic events infective endocarditis
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