To evaluate the action of Apium graveolens L. on the growth and differentiation of neural stem cells （NSCs）, cells culture and animal experiment were performed. NSCs were isolated from the striatum of SD rat embryo ...To evaluate the action of Apium graveolens L. on the growth and differentiation of neural stem cells （NSCs）, cells culture and animal experiment were performed. NSCs were isolated from the striatum of SD rat embryo were cultured in the medium containing aqueous extract from Apium graveolens L（AAG）.and/or the serum derived from mice treated with Apium graveolens L （SAG）. The results show that AAG promoted the survival and growth of NSCs in low concentration. Apium graveolens L. leaves aqueous extract promoted the proliferation of NSCs in relatively high concentration. SAG significantly accelerated the differentiation of NSCs.展开更多
Apium graveolens,an annual herb belonging to the family of Apiaceae,is widely distributed in North and South America,Southern Europe,Africa and Asia.Apium graveolens seeds have a rich history in traditional Chinese me...Apium graveolens,an annual herb belonging to the family of Apiaceae,is widely distributed in North and South America,Southern Europe,Africa and Asia.Apium graveolens seeds have a rich history in traditional Chinese medicine for treating hypertension,headaches,vertigo and epilepsy.N-butylphthalide,originally extracted from Apium graveolens seeds,represents a first-in-class drug developed independently in China.Its broad pharmacological activities on nervous system disorders have garnered significant attention from researchers globally.This review focuses on the pharmacological research of n-butylphthalide on central nervous system diseases,including ischemic stroke,Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis.The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.展开更多
文摘To evaluate the action of Apium graveolens L. on the growth and differentiation of neural stem cells （NSCs）, cells culture and animal experiment were performed. NSCs were isolated from the striatum of SD rat embryo were cultured in the medium containing aqueous extract from Apium graveolens L（AAG）.and/or the serum derived from mice treated with Apium graveolens L （SAG）. The results show that AAG promoted the survival and growth of NSCs in low concentration. Apium graveolens L. leaves aqueous extract promoted the proliferation of NSCs in relatively high concentration. SAG significantly accelerated the differentiation of NSCs.
文摘Apium graveolens,an annual herb belonging to the family of Apiaceae,is widely distributed in North and South America,Southern Europe,Africa and Asia.Apium graveolens seeds have a rich history in traditional Chinese medicine for treating hypertension,headaches,vertigo and epilepsy.N-butylphthalide,originally extracted from Apium graveolens seeds,represents a first-in-class drug developed independently in China.Its broad pharmacological activities on nervous system disorders have garnered significant attention from researchers globally.This review focuses on the pharmacological research of n-butylphthalide on central nervous system diseases,including ischemic stroke,Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis.The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.
