Aim: The relationship between apolipoprotein B, LDL/ApoB,ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent < 45 years) was studied in 46 children compared with ...Aim: The relationship between apolipoprotein B, LDL/ApoB,ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent < 45 years) was studied in 46 children compared with 64 controls. Methods:19 children came out of families with a myocardial infarction(MI) of the father and 27 children with MI of a grandparent. Results:In the whole risk group LDL-C,ApoB and ApoB/ApoA-1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL-C and LDL/ApoB.Conclusio-n: Our results show that levels of ApoB, LDL-C and ApoB/ApoA-1 might be better predictors in children from families of very early MI as compared with ApoA-1, HDL-C and LDL/ApoB.展开更多
We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group ...We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.展开更多
Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coro...Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coronary artery disease （CAD） in elderly. Methods 498 participants aged over 65 years with chest pain had been subsumed from Sep. 2009 to April 2011 of Guangdong General Hospital. Clinic informations of gender, age, history of hypertension, diabetes mellitus, smoking was collected. Simultaneously, serum lipids should be phlebotomized in 24 hours after be inpatient. ApoB100/ApoA1 ratio, LDL-C/HDL-C ratio. TC/HDL-C ratio, non-HDL-C were calculated using the above data. Accroding to the mean of ApoB100/ApoA1 ratio, ApoB100, non-HDL-C, all individuals were divided into two groups： high level group and low level group, while all individuals were divided into two groups whether the level of LDL-C was achieve 2.06 mmol/L. We classified the participants into CAD group and non-CAD group on the basis of CAG. The incidence of CAD was compared between the two groups of four different lipid indicators. The ability of estimating CAD was described by Reciever Operating Characteristic curve （ROC curve）. Result There were significantly statistical differences in the incidence of CAD between the high level group and low level group of ApoB100/ApoA1 ratio （75.0% vs. 55.9%, %2 = 19.681, P 〈 0.001）. By logistic regression analysis, odds ratio of ApoB100/ApoA1 ratio was 2.142, 95% CI （1.437, 3.195）（P 〈 0.001）. The AUC （area under curve） of ApoB100/ApoA1 ratio were 0.66. There were significant for diagnosis of CAD （P 〈 0.001）. Conclusion The ApoB100/ApoA1 ratio was an independent risk factor of CAD in elderly population, and it is better than traditional lipid indicators, and can be used for the ability of estimating CAD.展开更多
Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among t...Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among the urban population. Methods: A cross sectional study was done among Kodava population by conducting health camps in Mysore district. Metabolic syndrome was defined according to Joint Interim Statement criteria. Anthropometry was done and blood pressure readings were noted. Clinical markers like fasting glucose, triglyceride, high density lipoprotein, CVD markers and uric acid levels were analyzed. Results: The prevalence of metabolic syndrome was 60.77% and the utmost occurrence was in 41 - 60 age groups. Women were more affected than men (31.58%) and MetS became pronounced with advance of age. Biochemical levels of C-reactive protein, ApolipoproteinB/ApolipoproteinA1 ratio and uric acid wereraised (P < 0.05) and the severity correlated with the number of components of metabolic syndrome. Conclusions: This study helped in identifying new subjects with metabolic syndrome wherein, abdominal obesity was the most common abnormality followed by elevated fasting glucose. Female subjects and subjects with increased waist circumference along with mid aged people are more susceptible to MetS which amplified their CVD risk factors and hyperuricemic conditions. Life style modifications and therapeutic approach are critical prerequisite. However, there is an urgent need for further health camps for the awareness, and prevention of MetS and its associated risk factors among Kodavas.展开更多
Background: Correlations between CRP and serum lipids are weak, and there are conflicting and incomplete results in the literature. The aim of the present study was to clarify the strength and independence of relation...Background: Correlations between CRP and serum lipids are weak, and there are conflicting and incomplete results in the literature. The aim of the present study was to clarify the strength and independence of relationships between CRP and serum lipids in outpatients. Methods: Inclusion criteria were outpatients where all the following analyses were requested in clinical routine: high sensitivity CRP, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ApoB, ApoA-1 and Lp(a). Data for patients meeting the above criteria during a period of six years (2004-2010) were copied from Aleris Medilab’s Laboratory Information System to the software Statistica. Basic statistics and correlations were calculated for 2771 patients. In patients with two (n = 959) or more sampling times changes over time were calculated. The study was a quality assurance project without access to patient files. Results: Median age was 59 years and median serum CRP concentration was 1.5 mg/L. The strongest correlations (Spearman R) were seen between CRP and triglycerides (0.25), ApoB/ApoA-1 ratio (0.21) and HDL-cholesterol (−0.18). Stepwise regression analysis showed that ApoB, total cholesterol, log triglycerides and log Lp(a) together explained 8% of the variation in log CRP. Unfavourable time trends for CRP and triglycerides counteracted a significant decrease in LDL-cholesterol and total cholesterol. Conclusion: In a large cohort of outpatients CRP showed stronger correlation with triglycerides and ApoB/ApoA-1 ratio than with LDL-cholesterol and Lp(a). LDL-cholesterol concentrations changed favorably over time whereas CRP and triglycerides did not.展开更多
文摘Aim: The relationship between apolipoprotein B, LDL/ApoB,ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent < 45 years) was studied in 46 children compared with 64 controls. Methods:19 children came out of families with a myocardial infarction(MI) of the father and 27 children with MI of a grandparent. Results:In the whole risk group LDL-C,ApoB and ApoB/ApoA-1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL-C and LDL/ApoB.Conclusio-n: Our results show that levels of ApoB, LDL-C and ApoB/ApoA-1 might be better predictors in children from families of very early MI as compared with ApoA-1, HDL-C and LDL/ApoB.
基金supported by National High-Tech Research and Development Program of China (No.2006AA02A406)Natural Science Foundation of China (No.30871042)
文摘We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
基金supportet by the grants from The Science and Techonlogy Planning Project of Gungdong Prvince (2010B060900105) and (2011B061300034)
文摘Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coronary artery disease （CAD） in elderly. Methods 498 participants aged over 65 years with chest pain had been subsumed from Sep. 2009 to April 2011 of Guangdong General Hospital. Clinic informations of gender, age, history of hypertension, diabetes mellitus, smoking was collected. Simultaneously, serum lipids should be phlebotomized in 24 hours after be inpatient. ApoB100/ApoA1 ratio, LDL-C/HDL-C ratio. TC/HDL-C ratio, non-HDL-C were calculated using the above data. Accroding to the mean of ApoB100/ApoA1 ratio, ApoB100, non-HDL-C, all individuals were divided into two groups： high level group and low level group, while all individuals were divided into two groups whether the level of LDL-C was achieve 2.06 mmol/L. We classified the participants into CAD group and non-CAD group on the basis of CAG. The incidence of CAD was compared between the two groups of four different lipid indicators. The ability of estimating CAD was described by Reciever Operating Characteristic curve （ROC curve）. Result There were significantly statistical differences in the incidence of CAD between the high level group and low level group of ApoB100/ApoA1 ratio （75.0% vs. 55.9%, %2 = 19.681, P 〈 0.001）. By logistic regression analysis, odds ratio of ApoB100/ApoA1 ratio was 2.142, 95% CI （1.437, 3.195）（P 〈 0.001）. The AUC （area under curve） of ApoB100/ApoA1 ratio were 0.66. There were significant for diagnosis of CAD （P 〈 0.001）. Conclusion The ApoB100/ApoA1 ratio was an independent risk factor of CAD in elderly population, and it is better than traditional lipid indicators, and can be used for the ability of estimating CAD.
文摘Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among the urban population. Methods: A cross sectional study was done among Kodava population by conducting health camps in Mysore district. Metabolic syndrome was defined according to Joint Interim Statement criteria. Anthropometry was done and blood pressure readings were noted. Clinical markers like fasting glucose, triglyceride, high density lipoprotein, CVD markers and uric acid levels were analyzed. Results: The prevalence of metabolic syndrome was 60.77% and the utmost occurrence was in 41 - 60 age groups. Women were more affected than men (31.58%) and MetS became pronounced with advance of age. Biochemical levels of C-reactive protein, ApolipoproteinB/ApolipoproteinA1 ratio and uric acid wereraised (P < 0.05) and the severity correlated with the number of components of metabolic syndrome. Conclusions: This study helped in identifying new subjects with metabolic syndrome wherein, abdominal obesity was the most common abnormality followed by elevated fasting glucose. Female subjects and subjects with increased waist circumference along with mid aged people are more susceptible to MetS which amplified their CVD risk factors and hyperuricemic conditions. Life style modifications and therapeutic approach are critical prerequisite. However, there is an urgent need for further health camps for the awareness, and prevention of MetS and its associated risk factors among Kodavas.
文摘Background: Correlations between CRP and serum lipids are weak, and there are conflicting and incomplete results in the literature. The aim of the present study was to clarify the strength and independence of relationships between CRP and serum lipids in outpatients. Methods: Inclusion criteria were outpatients where all the following analyses were requested in clinical routine: high sensitivity CRP, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ApoB, ApoA-1 and Lp(a). Data for patients meeting the above criteria during a period of six years (2004-2010) were copied from Aleris Medilab’s Laboratory Information System to the software Statistica. Basic statistics and correlations were calculated for 2771 patients. In patients with two (n = 959) or more sampling times changes over time were calculated. The study was a quality assurance project without access to patient files. Results: Median age was 59 years and median serum CRP concentration was 1.5 mg/L. The strongest correlations (Spearman R) were seen between CRP and triglycerides (0.25), ApoB/ApoA-1 ratio (0.21) and HDL-cholesterol (−0.18). Stepwise regression analysis showed that ApoB, total cholesterol, log triglycerides and log Lp(a) together explained 8% of the variation in log CRP. Unfavourable time trends for CRP and triglycerides counteracted a significant decrease in LDL-cholesterol and total cholesterol. Conclusion: In a large cohort of outpatients CRP showed stronger correlation with triglycerides and ApoB/ApoA-1 ratio than with LDL-cholesterol and Lp(a). LDL-cholesterol concentrations changed favorably over time whereas CRP and triglycerides did not.
