Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

Discussion on the application prospect of the transient electromagnetic method based on the dual launcher and mine advanced detection

The dual transmitter implements the equivalent anti-magnetic flux transient electromagnetic method, which can effectively reduce the scope of the transient electromagnetic detection blind area. However, this method is rarely reported in the detection of pipelines in urban geophysical exploration and the application of coal mines. Based on this, this paper realizes the equivalent anti-magnetic flux transient electromagnetic method based on the dual launcher. The suppression effect of this method on the blind area is analyzed by physical simulation. And the detection experiment of underground pipelines is carried out outdoors. The results show that the dual launcher can significantly reduce the turn-off time, thereby effectively reducing the impact of the blind area on the detection results, and the pipeline detection results verify the device’s effectiveness. Finally, based on the ground experimental results, the application prospect of mine advanced detection is discussed. Compared with other detection fields, the formation of blind areas is mainly caused by the equipment. If the dual launcher can be used to reduce the blind area, the accuracy of advanced detection can be improved more effectively. The above research results are of great significance for improving the detection accuracy of the underground transient electromagnetic method.

A Review of Knowledge Graph in Traditional Chinese Medicine:Analysis,Construction,Application and Prospects

As an advanced data science technology,the knowledge graph systematically integrates and displays the knowledge framework within the field of traditional Chinese medicine(TCM).This not only contributes to a deeper comprehension of traditional Chinese medical theories but also provides robust support for the intelligent decision systems and medical applications of TCM.Against this backdrop,this paper aims to systematically review the current status and development trends of TCM knowledge graphs,offering theoretical and technical foundations to facilitate the inheritance,innovation,and integrated development of TCM.Firstly,we introduce the relevant concepts and research status of TCM knowledge graphs.Secondly,we conduct an in-depth analysis of the challenges and trends faced by key technologies in TCM knowledge graph construction,such as knowledge representation,extraction,fusion,and reasoning,and classifies typical knowledge graphs in various subfields of TCM.Next,we comprehensively outline the current medical applications of TCM knowledge graphs in areas such as information retrieval,diagnosis,question answering,recommendation,and knowledge mining.Finally,the current research status and future directions of TCM knowledge graphs are concluded and discussed.We believe this paper contributes to a deeper understanding of the research dynamics in TCM knowledge graphs and provides essential references for scholars in related fields.

Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases

Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.

Potential prospects of Chinese medicine application in diabetic retinopathy

Current treatment strategies for diabetic retinopathy(DR),an eye condition that can lead to blindness,have mainly focused on proliferative DR,including vitreous injection,retinal photocoagulation,and vitrectomy.Vitreous injections mainly depend on anti-vascular endothelial growth factor therapy.In this editorial,we comment on the article by Sun et al.We focus specifically on the mechanisms of the protective effect of genipin on the retina.Genipin is a gardenia extract used in traditional Chinese medicine(TCM).In their study,the authors suggest that controlling advanced glycosylation by the intraocular injection of genipin may be a strategy for preventing retinopathy.The innovative use of a Chinese medicine extract injected into the eye to achieve a curative effect has attracted our attention.Although TCM is effective in treating DR,the topical application of DR,especially intraocular injections,is not yet feasible.Herein,we present a brief analysis of effective Chinese medicines for the treatment of DR.The effectiveness of local injections of TCM applied directly into the eyes holds promise as an effective treatment approach for DR.

Survey and Application Prospect Analysis of Spontaneous Plants in Urban Park Lawn in Hangzhou

The spontaneous plants in the lawn not only improve the biodiversity of the lawn,but also provide food and shelter for insects,amphibians and birds,as well as pleasant sensory experience for people.The spontaneous plants in eight different types of parks in Hangzhou were investigated in detail by field survey.A total of 89 species of 27 families of spontaneous plants were found in Hangzhou urban parks,of which Asteraceae,Fabaceae and Poaceae were the dominant families.The life forms are mainly perennial herbs,and the growth forms are mostly erect.According to the screening criteria,20 spontaneous plants,such as Ranunculus sieboldii,Taraxacum mongolicum and Corydalis decumbens,were recommended for potential exploitation.According to the spontaneous plants of lawn,three application models of flower lawn,semi-natural succession of lawn and natural grassland were put forward.

Application of nanotechnology to dentistry:Impact of graphene nanocomposites on clinical air quality

Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection technologies.This editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene nanocomposites.The potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains unexplored.The recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental clinics.The study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional methods.Despite these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical practice.Therefore,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.

Clinical Application and Prospect of New Radiotherapy Technology in Cancer Treatment

Objective: Carbon ion therapy, a new radiotherapy technology, has shown its remarkable efficacy and potential in cancer treatment, especially in the treatment of refractory tumors. Methods: This paper clarifies the physical basis, technological change, and clinical practice effect of carbon ion therapy, comprehensively discusses the future prospects, and evaluates the clinical application effect. Results: The technology has significantly improved the treatment effectiveness and received a positive response from patients. Conclusion: Carbon ion therapy technology has become a major innovation in the field of cancer treatment. It not only has a profound impact on many current cancer therapy methods but also indicates the application blueprint for a wider range of cancer types in the future, showing a new chapter of medical technology advancement.

Efficient Green Modern Agriculture of Fenlong Cultivation and Its Application Prospects

Based on the evolution of farming revolution in Fengyan aiming to create a healthier and more beautiful human existence and a harmonious coexistence with nature, this study introduced Fenlong green agriculture, which had the characteristics of natural yield increase of more than 10% with zero fertilization, and yield increase of 10%-30%, quality improvement of 5% and doubled land water holding capacity with the conventional fertilization in over 20 crops in more than 20 provinces, and significant reforming efficiency on salinized land and grassland; for the first time made a comprehensive description of high efficient application of Fenlong green modern agriculture to explore natural resources, realizing the sustainable develop- ment of quality improvement, yield increase and efficiency enhancement; for the first time clarified the scientific basis and theoretical system of the green efficient mod- ern agricultural technique-Fenlong cultivation, as well as the basic connotations and concepts of Fenlong cultivation, green efficient modern agricultural technical system; created a new model of efficient modern agricultural production and new technology system, and 6 major technical projects like cultivated land improvement to increase yield and transformation of salinized land and grassland, which could play a role in relieving the climatic disasters like haze, transformation of farmland with medium to low yield as well as the construction of high standard farmland, sucrose industry and ＂One Road One Belt＂ strategy; for the first time proposed Fenlong cultivation as the ＂China technology card＂ in China and even the whole world, so as to make people understand the particular significance of this technology to green develop- ment, which could benefit the future generations.

Review and Application Prospect of Agricultural Film for Protected Horticulture

The development of Chinese agriculture is now facing the grim situation of decreasing farmland area, increasing population and social demands, so the devel- opment of protected horticulture becomes necessary to solve the issue. This paper reviewed the characteristics of traditional horticulture films and application prospects of new functional films.

Breeding and Application Prospects of a New Quinoa Variety Longli 1

Longli 1 （ Chenopod/um qu/noa Willd） was the first new quinoa variety in China, which was bred by Pasture and Green Agriculture Institute of Gansu Academy of Agricultural Sciences through the methods of line breeding, cultivation and domestication. In muhipeint regional test, the average yield of Longli 1 was 2 100. （30 kg/hm2, which was increased by 9.6% compared to Jingle qulnoa. Langli 1 was a mid-late mature quinoa variety. The plant was brcom-shape, with the plant height of 181.2 - 223.6 cm, the growth period of 128 - 140 d, and the branch number of 23 - 27. The seeds were round pill shaped, with 1 000-grain weight of 2.40 -3.46 g. The contents of crude protein, fat, proline and total phosphorus in seeds were 171.5 -187.8, 56.5 -59.3, 5.5 -6.9 and 4.5 -6.8 g/kg, re- spectively. I_ongli 1 presented resistance against downy mildew and leaf spot, with strong disease-resistant ability. In multipeint regional test and production test, Longli 1 displayed lodging resistance with strong regeneration ability. It also presented resistance to cold, drought, saline and alkaline, and barren, with wide adaptability. Longh 1 was suitable for planting in mountains, plain field and irrigation area with frost-free period greater than 120 d, rainfall more than 250 mm, and altitude 1 500 -3 000 m. The application prospects of quinoa were also put forward in the paper.

Evolution,progress,and prospects of research on transjugular intrahepatic portosystemic shunt applications

Transjugular intrahepatic portosystemic shun(TIPS)is an effective procedure for the treatment of portal hypertension complications such as esophagogastric variceal bleeding and refractory ascites.To date,its use by many experts and scholars at home and abroad has benefitted countless patients.In order to further promote the development and innovation of TIPS in China,this paper briefly reviews the development process of TIPS at home and abroad,objectively analyzes the bottlenecks and breakthrough achievements in the development of TIPS,and discusses the application status and research progress of TIPS technology for different indications.Finally,we provide an outlook about the development and application of TIPS in China.

Research and Application Prospect of Computer Simulation on Heat Treatment Process

In this paper, a modified temperature-phase transformation-stress/strain field coupled 3D non-linear mathematical model was used in the computer simulation on heat treatment processes of workpieces including catch jaw, anchor ring, cold roller, large-scale bearing roller, nitriding crank shaft, etc. The simulation on complicated technologies such as pre-cooled quenching, double media quenching, self-tempering, difference temperature heating, nitriding distortion was carried out. The optimum design of heat treatment technology has been realized. The successful application of computer simulation on heat treatment have also been demonstrated.

Preparation of Light-burned MgO by Microcrystalline Magnesite and Its Application Prospect Analysis

In order to widen the application of microcrystalline magnesite, the microcrystalline magnesite in Sichuan and Tibet area was used as the raw material to prepare light-burned MgO at 700,800,900, 1 000, 1 100 and I 200 ~C for 3 h, respectively. Then the physical and chemical properties of the light-burned MgO were detec- ted, and its application prospect was analyzed. The re- sults show that： （1） microcrystalline magnesite com- pletely decomposes forming light-burned MgO calcined at the temperature range of 700 - 1 200 ~C ; the MgO con- tent of the light-burned MgO is higher than 96. 51% ; the chemical activity is 88 - 130 s and the grain size is 40 - 200 nm ; it has the advantages of high purity, high activity and fine grain; （2） the light-burned MgO pre- pared with microcrystalline magnesite can be widely used in many industries; it can be used in refractories indus- try to prepare high-purity sintered magnesia and large crystal fused magnesia, or as an additive for refractory products, etc. ; it can also be used in magnesium chemi- cal industry to prepare electrical grade magnesia, sili- con-steel magnesia, environmental friendly flame retard- ant magnesium hydroxide, magnesium sulfate fertilizer, pharmaceutical grade magnesia, food grade magnesia, etc.

Application Status and Prospect of <i>Pinus massoniana</i>Sawdust as the Substrate for the Cultivation of Edible Fungi

In this paper, the research status of using Pinus massoniana sawdust for the cultivation of edible fungi was analyzed and discussed. It was found that Pinus massoniana sawdust contained the material base of edible fungi with sufficient cellulose, hemicellulose and lignin and a small amount of nitrogen, phosphorus, potassium, calcium, magnesium, other mineral salts, and some vitamins for the growth of edible fungi. However, the Pinus massoniana wood contained a significant amount of terpenoids, which are detrimental to the growth of edible fungus and mycelial. The major and current detoxification methods for Pinus massoniana sawdust were analyzed, such as steaming method, distillation method, lime water immersion method, outdoor piling fermentation method, and chemical method. Their advantages and disadvantages were discussed and reviewed. Finally, the major issues in the application of Pinus massoniana sawdust as the cultivation substrate of edible fungi were analyzed, and the application prospect of Pinus massoniana sawdust as the substrate for the cultivation of edible fungi was also reviewed.

Research Progress and Application Prospects of Mulching Technology

This article mainly covers the agricultural technology and traditional technology of plastic film mulching in China through the contrast and analysis. The mechanism and effect of plastic mulching technology is expounded, and the main use, positive role and development prospects of the technology in agricultural production, as well as the technology of agricultural soil conservation are introduced. In addition, existing problems and countermeasures are put forward to promote the development of agriculture in arid areas.

Research Status and Application Prospects of Monascus sp.

Monascus sp. has been widely applied for a long time in China. In recent years, the effective physiological active substances produced by Monascus sp. have been extensively investigated. The classification, cultivation characteristics, physiological and biochemical properties, primary metabolites, secondary metabolites and application prospects of Monascus sp. were summarized and discussed in this paper.

Application Research Status and Development Prospect of Microbial Flocculant

Microbial flocculant （MBF） is a kind of novel flocculant, which is widely used for the food industry, highly concentrated organic waste water treatment and the urban water supply technology. Due to its characteristics of superior flocculation effect, without secondary pollution to the environment and being easily degraded, MBF has been emerging as a hotspot of water treatment research in recent years. In this paper, the latest progress of the preparation of MBFs and the flocculating mechanism were presented. The practical application research of MBFs for water treatment was reviewed. Finally, suggestions and development prospect of research on MBFs were discussed.

Recentadvancesincarbon‐basedmaterials for solar‐driven interfacial photothermal conversion water evaporation:Assemblies,structures,applications,and prospective

The shortage of fresh water in the world has brought upon a serious crisis to human health and economic development.Solar‐driven interfacial photothermal conversion water evaporation including evaporating seawater,lake water,or river water has been recognized as an environmentally friendly process for obtaining clean water in a low‐cost way.However,water transport is restricted by itself by solar energy absorption capacity's limits,especially for finite evaporation rates and insufficient working life.Therefore,it is important to seek photothermal conversion materials that can efficiently absorb solar energy and reasonably design solar‐driven interfacial photothermal conversion water evaporation devices.This paper reviews the research progress of carbon‐based photothermal conversion materials and the mechanism for solar‐driven interfacial photothermal conversion water evaporation,as well as the summary of the design and development of the devices.Based on the research progress and achievements of photothermal conversion materials and devices in the fields of seawater desalination and photothermal electric energy generation in recent years,the challenges and opportunities faced by carbon‐based photothermal conversion materials and devices are discussed.The prospect of the practical application of solar‐driven interfacial photothermal conversion evaporation technology is foreseen,and theoretical guidance is provided for the further development of this technology.

Industrial application prospects and key issues of the pure-hydrogen reduction process

The industrial application prospect and key issues in basic theory and application are discussed by the methods of theoretical analysis and calculation to promote the development of the pure-hydrogen reduction process.According to the discussion of thermodynamics and kinetics of pure-hydrogen reduction reaction,the reduction reaction of iron oxide by pure hydrogen is an endothermic reaction,and the reaction rate of hydrogen reduction is significantly faster than that of carbon reduction.To explore the feasibility of the industrial applications of pure-hydrogen reduction,we design the hydrogen reduction reactor and process with reference to the industrialized hydrogen-rich reduction process and put forward the methods of appropriately increasing the reduction temperature,pressure,and temperature of iron ore into the furnace to accelerate the reaction rate and promote the reduction of iron oxide.The key technical parameters in engineering applications,such as hydrogen consumption,circulating gas volume,and heat balance,are discussed by theoretical calculations,and the optimized parameter values are proposed.The process parameters,cost,advantages,and disadvantages of various current hydrogen production methods are compared,and the results show that hydrogen production by natural gas reforming has a good development prospect.Through the discussion of the corrosion mechanism of high-temperature and high-pressure hydrogen on heat-resistant steel materials and the corrosion mechanism of H_2S in the hydrogen gas on steel,the technical ideas of developing new metal temperature-resistant materials,metal coating materials,and controlling gas composition are put forward to provide guidance for the selection of heater and reactor materials.Finally,the key factors affecting the smooth operation of the hydrogen reduction process in engineering applications are analyzed,offering a reference for the industrial application of the purehydrogen reduction process.