common maize synthetic rate( Photosynthetic characteristics were probed by sweet maize, waxy maize, high starch maize and The results revealed that leaf area index (LAI), chlorophyll a content, chlorophyll b cont...common maize synthetic rate( Photosynthetic characteristics were probed by sweet maize, waxy maize, high starch maize and The results revealed that leaf area index (LAI), chlorophyll a content, chlorophyll b content,photo-PR) showed single peak curve at the whole growth stage. The stages of peak were different according to different varieties. NEAUS4 had the lowest peak and while SIDAN 19 had the highest among all stages. Ratio of chlorophyll a to b was low at seedling stage, reached the peak atjointing stage and then declined. SIDAN 19 had the lower level at the last stages.展开更多
Based on the theory of three living spaces,taking the characteristic rural areas of Shiye Town in Zhenjiang City as the research object,the study analyzed its constituent elements in production,life and ecological spa...Based on the theory of three living spaces,taking the characteristic rural areas of Shiye Town in Zhenjiang City as the research object,the study analyzed its constituent elements in production,life and ecological space (three living spaces) and put forward the strategy of space optimization.The overall optimization design of the village is made according to the problems by combining with the current situation of pilot villages such as Yongmaowei,Huanqingzhou and group 1 of Xianfeng Village.In addition,special reconstruction measures were formulated for the existing problems of agricultural houses and public spaces in various typical villages.展开更多
AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent...AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.展开更多
Based on data on taxed-cropland area and on the number of households in historical documents, a probabilistic model of cropland distribution and a cropland area allocation model were designed and validated. Cropland a...Based on data on taxed-cropland area and on the number of households in historical documents, a probabilistic model of cropland distribution and a cropland area allocation model were designed and validated. Cropland areas for the years AD976, 997, 1066, and 1078 were estimated at the level of Lu(an administrative region of the Northern Song Dynasty). The results indicated that(1) the cropland area of the whole study region for AD976, 997, 1066, and 1078 was about 468.27 million mu(a Chinese unit of area, with1 mu=666.7m2), 495.53 million mu, 697.65 million mu, and 731.94 million mu, respectively. The fractional cropland area(FCA) increased from 10.7% to 16.8%, and the per capita cropland area decreased from 15.7 mu to 8.4 mu.(2) With regard to the cropland spatial pattern, the FCA of the southeast, north, and southwest regions of the Northern Song territory increased by 12.0%, 5.2%, and 1.2%, respectively. The FCA of some regions in the Yangtze River Plain increased to greater than 40%, and the FCA of the North China Plain increased to greater than 20%. However, the FCA of the southwest region(except for the Chengdu Plain) in the Northern Song territory was less than 6%.(3) There were 84.2% Lus whose absolute relative error was smaller than 20% in the mid Northern Song Dynasty. The validation results indicate that our models are reasonable and that the results of reconstruction are credible.展开更多
Background: Cirrhosis is a common complication of chronic hepatitis B. It remains unclear if viral and biochemical parameters at baseline affect virological response to entecavir and therefore warrant investigation. ...Background: Cirrhosis is a common complication of chronic hepatitis B. It remains unclear if viral and biochemical parameters at baseline affect virological response to entecavir and therefore warrant investigation. In the present study, we aimed to eval uate the efficacy of entecavir therapy by monitoring virological response at the end of the 3^rd month of treatment and try to figure out whether baseline factors could help predict it in a cohort of hepatitis B virus (HBV) compensated cirrhosis patients and to determine the cut-off value of a predicting parameter.Methods: A total of 91 nucleos(t)ide-naive patients with HBV induced cirrhosis (compensatory stage) were enrolled in a prospective cohort. HBV DNA and alanine aminotransferase (ALT) were tested at baseline and monitored every 3-6 months after starting therapy. Results: Of all 91 patients, the median follow-up time was 12 (9-24) months. Overall, 64 patients (70.3%) achieved virological response in the 3^rd month. Univariate analysis showed that the 3^rd month virological response can be predicted by baseline HBV DNA levels (P 〈 0.001, odds ratio [OR]: 2.13, 95% confidence interval [CI]: 1.44-3.15), ALT value (P = 0.023, OR: 1.01, 95% CI: 1.00 1.01 ) and hepatitis B e antigen (HBeAg) negativity (P = 0.016, OR: 0.30, 95% CI: 0.11-0.80). Multiple regression analysis showed baseline H BV DNA level was the only parameter related to full virological response. Higher baseline HBV DNA strata indicated a higher probability that HBV DNA remains detectable at the 3^rd month (P = 0.001). Area under receiver operating characteristic curve for determining the 3^rd month virological response by baseline HBV DNA was 77.6% (95% CI: 66.7-85.2%), with a best cut-offvalue of 5.8 log10. Conclusions: Baseline HBV DNA, HBeAg negativity, and ALT were independent factors contributing to virological response at the 3^rt month. Further, multiple regression showed that HBV DNA level was the only parameter predicting full virological response as early as the 3^rd month, in this cirrhosis cohort.展开更多
Chinese men should have a higher prostate-specific antigen (PSA) "gray zone" than the traditional value of 2.5-10.0 ng ml-1 since the incidence of prostate cancer (PCa) in Chinese men is relative low. We hypothe...Chinese men should have a higher prostate-specific antigen (PSA) "gray zone" than the traditional value of 2.5-10.0 ng ml-1 since the incidence of prostate cancer (PCa) in Chinese men is relative low. We hypothesized that PSA density (PSAD) could improve the rate of PCa detection in Chinese men with a PSA higher than the traditional PSA "gray zone." A total of 461 men with a PSA between 2.5 and 20.0 ng ml-1, who had undergone prostatic biopsy at two Chinese centers were included in the analysis. The men were then further divided into groups with a PSA between 2.5-10.0 ng ml-1 and 10.1-20.0 ng ml-1. Receiver operating characteristic (ROC) curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis of PCa. In men with a PSA of 2.5-10.0 ng ml-1 or 10.1-20.0 ng ml-z, the areas under the ROC curve were higher for PSAD than for PSA. This was consistent across both centers and the cohort overall. When the entire cohort was considered, the optimal PSAD cut-off for predicting PCa in men with a PSA of 2.5-10.0 ng m1-1 was 0.15 ng ml-2 ml-2, with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 10.1-20.0 ng m1-1 was 0.33 ng ml-1 ml-1, with a sensitivity of 60.3% and specificity of 82.7%. PSAD can improve the effectiveness for PCa detection in Chinese men with a PSA of 2.5-10.0 ng ml-1 (traditional Western PSA "gray zone") and 10.1-20.0 ng ml-2 (Chinese PSA "gray zone").展开更多
文摘common maize synthetic rate( Photosynthetic characteristics were probed by sweet maize, waxy maize, high starch maize and The results revealed that leaf area index (LAI), chlorophyll a content, chlorophyll b content,photo-PR) showed single peak curve at the whole growth stage. The stages of peak were different according to different varieties. NEAUS4 had the lowest peak and while SIDAN 19 had the highest among all stages. Ratio of chlorophyll a to b was low at seedling stage, reached the peak atjointing stage and then declined. SIDAN 19 had the lower level at the last stages.
文摘Based on the theory of three living spaces,taking the characteristic rural areas of Shiye Town in Zhenjiang City as the research object,the study analyzed its constituent elements in production,life and ecological space (three living spaces) and put forward the strategy of space optimization.The overall optimization design of the village is made according to the problems by combining with the current situation of pilot villages such as Yongmaowei,Huanqingzhou and group 1 of Xianfeng Village.In addition,special reconstruction measures were formulated for the existing problems of agricultural houses and public spaces in various typical villages.
基金Supported by the Ministerio de Ciencia e Innovación(SAF:2010/21805,partially)CIBERehd(Instituto de Salud CarlosⅢ,Madrid)+1 种基金Fundación Mutua Madrile■a(to Moreno-Otero R)a grant from Asociación Espa■ola Contra el Cáncer(AIO 2010,AECC,to Sanz-Cameno P)
文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.
基金National Natural Science Foundation of China,No.41271227 The Special Program for Basic Work of the Ministry of Science and Technology,China,No.2014FY210900
文摘Based on data on taxed-cropland area and on the number of households in historical documents, a probabilistic model of cropland distribution and a cropland area allocation model were designed and validated. Cropland areas for the years AD976, 997, 1066, and 1078 were estimated at the level of Lu(an administrative region of the Northern Song Dynasty). The results indicated that(1) the cropland area of the whole study region for AD976, 997, 1066, and 1078 was about 468.27 million mu(a Chinese unit of area, with1 mu=666.7m2), 495.53 million mu, 697.65 million mu, and 731.94 million mu, respectively. The fractional cropland area(FCA) increased from 10.7% to 16.8%, and the per capita cropland area decreased from 15.7 mu to 8.4 mu.(2) With regard to the cropland spatial pattern, the FCA of the southeast, north, and southwest regions of the Northern Song territory increased by 12.0%, 5.2%, and 1.2%, respectively. The FCA of some regions in the Yangtze River Plain increased to greater than 40%, and the FCA of the North China Plain increased to greater than 20%. However, the FCA of the southwest region(except for the Chengdu Plain) in the Northern Song territory was less than 6%.(3) There were 84.2% Lus whose absolute relative error was smaller than 20% in the mid Northern Song Dynasty. The validation results indicate that our models are reasonable and that the results of reconstruction are credible.
文摘Background: Cirrhosis is a common complication of chronic hepatitis B. It remains unclear if viral and biochemical parameters at baseline affect virological response to entecavir and therefore warrant investigation. In the present study, we aimed to eval uate the efficacy of entecavir therapy by monitoring virological response at the end of the 3^rd month of treatment and try to figure out whether baseline factors could help predict it in a cohort of hepatitis B virus (HBV) compensated cirrhosis patients and to determine the cut-off value of a predicting parameter.Methods: A total of 91 nucleos(t)ide-naive patients with HBV induced cirrhosis (compensatory stage) were enrolled in a prospective cohort. HBV DNA and alanine aminotransferase (ALT) were tested at baseline and monitored every 3-6 months after starting therapy. Results: Of all 91 patients, the median follow-up time was 12 (9-24) months. Overall, 64 patients (70.3%) achieved virological response in the 3^rd month. Univariate analysis showed that the 3^rd month virological response can be predicted by baseline HBV DNA levels (P 〈 0.001, odds ratio [OR]: 2.13, 95% confidence interval [CI]: 1.44-3.15), ALT value (P = 0.023, OR: 1.01, 95% CI: 1.00 1.01 ) and hepatitis B e antigen (HBeAg) negativity (P = 0.016, OR: 0.30, 95% CI: 0.11-0.80). Multiple regression analysis showed baseline H BV DNA level was the only parameter related to full virological response. Higher baseline HBV DNA strata indicated a higher probability that HBV DNA remains detectable at the 3^rd month (P = 0.001). Area under receiver operating characteristic curve for determining the 3^rd month virological response by baseline HBV DNA was 77.6% (95% CI: 66.7-85.2%), with a best cut-offvalue of 5.8 log10. Conclusions: Baseline HBV DNA, HBeAg negativity, and ALT were independent factors contributing to virological response at the 3^rt month. Further, multiple regression showed that HBV DNA level was the only parameter predicting full virological response as early as the 3^rd month, in this cirrhosis cohort.
文摘Chinese men should have a higher prostate-specific antigen (PSA) "gray zone" than the traditional value of 2.5-10.0 ng ml-1 since the incidence of prostate cancer (PCa) in Chinese men is relative low. We hypothesized that PSA density (PSAD) could improve the rate of PCa detection in Chinese men with a PSA higher than the traditional PSA "gray zone." A total of 461 men with a PSA between 2.5 and 20.0 ng ml-1, who had undergone prostatic biopsy at two Chinese centers were included in the analysis. The men were then further divided into groups with a PSA between 2.5-10.0 ng ml-1 and 10.1-20.0 ng ml-1. Receiver operating characteristic (ROC) curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis of PCa. In men with a PSA of 2.5-10.0 ng ml-1 or 10.1-20.0 ng ml-z, the areas under the ROC curve were higher for PSAD than for PSA. This was consistent across both centers and the cohort overall. When the entire cohort was considered, the optimal PSAD cut-off for predicting PCa in men with a PSA of 2.5-10.0 ng m1-1 was 0.15 ng ml-2 ml-2, with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 10.1-20.0 ng m1-1 was 0.33 ng ml-1 ml-1, with a sensitivity of 60.3% and specificity of 82.7%. PSAD can improve the effectiveness for PCa detection in Chinese men with a PSA of 2.5-10.0 ng ml-1 (traditional Western PSA "gray zone") and 10.1-20.0 ng ml-2 (Chinese PSA "gray zone").