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Facing ethical concerns in the age of precise gene therapy:Outlook on inherited arrhythmias
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作者 Federico Carbone Fabrizio Montecucco 《World Journal of Cardiology》 2024年第2期64-66,共3页
This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of Cardiology.We here provide an outlook on potential ethical concerns related to the future application of ... This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of Cardiology.We here provide an outlook on potential ethical concerns related to the future application of gene therapy in the field of inherited arrhythmias.As monogenic diseases with no or few therapeutic options available through standard care,inherited arrhythmias are ideal candidates to gene therapy in their treatment.Patients with inherited arrhythmias typically have a poor quality of life,especially young people engaged in agonistic sports.While genome editing for treatment of inherited arrhythmias still has theoretical application,advances in CRISPR/Cas9 technology now allows the generation of knock-in animal models of the disease.However,clinical translation is somehow expected soon and this make consistent discussing about ethical concerns related to gene editing in inherited arrhythmias.Genomic off-target activity is a known technical issue,but its relationship with ethnical and individual genetical diversity raises concerns about an equitable accessibility.Meanwhile,the costeffectiveness may further limit an equal distribution of gene therapies.The economic burden of gene therapies on healthcare systems is is increasingly recognized as a pressing concern.A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems,but potential concerns for universal healthcare systems in the long term as well.Altogether,those aspects strongly indicate a need of regulatory entities to manage those issues. 展开更多
关键词 ETHICS Inherited arrhythmias CRISPR/Cas9 Gene therapy Equitable accessibility
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Amiodarone Therapy for Cardiac Arrhythmias: Is It Associated with the Development of Cancers? 被引量:1
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作者 Padmavathi Mali Michele M. Henry Salzman +1 位作者 Humberto J. Vidaillet Shereif H. Rezkalla 《World Journal of Cardiovascular Diseases》 2014年第3期109-118,共10页
Amiodarone is used worldwide to treat cardiac arrhythmias, as well as highly symptomatic cases of atrial fibrillation. With this expanded use, especially following its 1985 United States Food and Drug Administration a... Amiodarone is used worldwide to treat cardiac arrhythmias, as well as highly symptomatic cases of atrial fibrillation. With this expanded use, especially following its 1985 United States Food and Drug Administration approval, and its use as a long-term therapy in common practice, reports of cancers temporarily related to amiodarone have begun to increase. Animal studies, several clinical trials, numerous case reports, and a population-based cohort study have suggested that cancers may be associated with amiodarone use. This review focuses on the ever increasing evidence in the literature that suggests amiodarone therapy, especially with long-term use, may increase the potential risk of cancer development. It also expresses the need for more definitive studies to be conducted to provide clinicians with a clear answer to this important question. 展开更多
关键词 AMIODARONE arrhythmias Cancer/Lung Skin THYROID cardiac
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Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage 被引量:3
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作者 Yong-Fu Xiao 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2011年第3期147-158,共12页
Action potentials generated in the sinoatrial node (SAN) dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormali... Action potentials generated in the sinoatrial node (SAN) dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormalities of impulse generation and/or propagation in a heart can cause arrhythmias. For example, SAN dysfunction or conduction block of the atrioventricular node can lead to serious bradycardia which is currently treated with an implanted electronic pacemaker. On the other hand, conduction damage may cause reentrant tachyarrhythmias which are primarily treated pharmacologically or by medical device-based therapies, including defibrillation and tissue ablation. However, drug therapies sometimes may not be effective or are associated with serious side effects. Device-based therapies for cardiac arrhythmias, even with well developed technology, still face inadequacies, limitations, hardware complications, and other challenges. Therefore, scientists are actively seeking other alternatives for antiarrhythmic therapy. In particular, cells and genes used for repairing cardiac conduction damage/defect have been investigated in various studies both in vitro and in vivo. Despite the complexities of the excitation and conduction systems of the heart, cell and gene-based strategies provide novel alternatives for treatment or cure of cardiac arrhythmias. This review summarizes some highlights of recent research progress in this field. 展开更多
关键词 cell therapy gene therapy conduction repair arrhythmia
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Cardiac arrhythmias detection in an ECG beat signal using fast fourier transform and artificial neural network 被引量:4
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作者 Himanshu Gothwal Silky Kedawat Rajesh Kumar 《Journal of Biomedical Science and Engineering》 2011年第4期289-296,共8页
Cardiac Arrhythmias shows a condition of abnor-mal electrical activity in the heart which is a threat to humans. This paper presents a method to analyze electrocardiogram (ECG) signal, extract the fea-tures, for the c... Cardiac Arrhythmias shows a condition of abnor-mal electrical activity in the heart which is a threat to humans. This paper presents a method to analyze electrocardiogram (ECG) signal, extract the fea-tures, for the classification of heart beats according to different arrhythmias. Data were obtained from 40 records of the MIT-BIH arrhythmia database (only one lead). Cardiac arrhythmias which are found are Tachycardia, Bradycardia, Supraventricular Tachycardia, Incomplete Bundle Branch Block, Bundle Branch Block, Ventricular Tachycardia. A learning dataset for the neural network was obtained from a twenty records set which were manually classified using MIT-BIH Arrhythmia Database Directory and docu- mentation, taking advantage of the professional experience of a cardiologist. Fast Fourier transforms are used to identify the peaks in the ECG signal and then Neural Networks are applied to identify the diseases. Levenberg Marquardt Back-Propagation algorithm is used to train the network. The results obtained have better efficiency then the previously proposed methods. 展开更多
关键词 cardiac arrhythmias Neural Network ELECTROCARDIOGRAM (ECG) Fast FOURIER Transform (FFT)
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Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults 被引量:1
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作者 Lingyan Liu Yutong Zhu +12 位作者 Hongbing Xu Yang Wang Tong Wang Qian Zhao Yi Zhang Jie Chen Shengcong Liu Tieci Yi Rongshan Wu Shuo Liu Xiaoming Song Jianping Li Wei Huang 《Global Health Journal》 2022年第1期6-18,共13页
Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains unclear.In this study,we aim to examine the impacts of O3 exposure on car... Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains unclear.In this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial injury.Methods Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014‒2016.Generalized additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome measurements.Results During the study period,24-hour average concentrations of ambient O3 were 47.4µg/m3(ranging from 1.0 to 165.9µg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant's clinic visit,with relative risks of 2.14(95%confidence interval[CI]:1.95 to 2.32)and 5.47(95%CI:3.51 to 7.43),respectively.Mediation analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74%of the risks of arrhythmias attributable to O3 exposure.Conclusion Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden. 展开更多
关键词 OZONE cardiac arrhythmias cardiac autonomic function Myocardial injury Panel study
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Control of cardiac excitability and arrhythmias by microRNAs
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作者 Zhiguo Wang (Department of Medicine,Montreal Heart Institute, University of Montreal,Montreal,Canada) 《岭南心血管病杂志》 2011年第S1期22-23,共2页
Recent studies revealing the important roles of microRNAs(miRNAs) in regulating expression of ion channel genes have opened up a research field for extending and deepening our investi- gation into the cardiac excita... Recent studies revealing the important roles of microRNAs(miRNAs) in regulating expression of ion channel genes have opened up a research field for extending and deepening our investi- gation into the cardiac excitability and the associated arrhythmogenesis.Cardiac excitability,the fundamental property of the cardiac myocytes,defines the cardiac conduction,repolarization,automaticity,intracellular calcium handling,and their regional heterogeneity. Our previous and ongoing studies and the work from other laboratories have demonstrated the significant involvement of miRNAs in regulating every aspects of cardiac excitability.We have found earlier that the muscle-specific miRNA miR-1 boosts up the arrhythmogenic potential through targeting gap junction channel connexin 43 in myocardial infarction.A subsequent study revealed that miR-1 can also cause arrhythmias by impairing Ca<sup>2+</sup> handling by targeting phosphatase.We then identified another muscle-specific miRNA miR-133 promotes abnormal QT prolongation by repressing HERG K<sup>+</sup> channel expression in diabetic cardiomyopathy. Subsequently,we discovered that both miR- 1 and miR-133 are involved in the reexpression of pacemaker channels HCN2/HCN4 to enhance abnormal automaticity in cardiac hypertrophy.Recently, we further identified miR-328 as an important determinant for atrial fibrillation(AF) and the associated adverse atrial electrical remodeling via targeting L-type Ca<sup>2+</sup> channels.While all the above-mentioned miRNAs are proarrhythmic,we have newly identified for the first time a natural antiarrhythmic miRNA miR-26.We found that all three members of the miR-26 family is downregulated in their expression in AF tissues and this downregulation increases AF vulnerability as a result of removal of an endogenous antiarrhythmic factor.miR-26 downregulation shortens atrial action potential favoring AF by increasing inward rectifier K<sup>+</sup> current(IK1) density. This is caused by an upregulation of Kir2.1 K<sup>+</sup> channel subunit due to derepression of its encoding gene KCNJ2 as we have validated KCNJ2 as a target gene for miR-26.Administration of a LNA-modified antimiR-26 antisense through tail vein injection increases AF vulnerability as indicated by increased number of mice with AF induction by intracardiac pacing.And this effect is blunted by co-injection of either an adenovirus vector carrying miR-26 precursor sequence or a LNA-modified miR-26 mimic to specifically target KCNJ2.We further discovered that the activity of NFAT transcription factor is enhanced in AF which represses the transcription of miR-26. We characterized the promoter region of the host genes of all three members of the miR-26 miRNA family and identified a common cis-acting element for NFAT binding.Thus,our study unraveled a novel miRNA signaling pathway AF NFAT miR-26 KC-NJ2 /Kir2.1/I<sub>K1</sub> AF as a positive feedback loop favoring AF and the remodeling process. 展开更多
关键词 Control of cardiac excitability and arrhythmias by microRNAs
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Cardiac arrhythmias and cardiac arrest related to mushroom poisoning: A case report 被引量:5
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作者 Shu Li Qing-Bian Ma +7 位作者 Ci Tian Hong-Xia Ge Yang Liang Zhi-Guo Guo Cheng-Duo Zhang Bei Yao Jia-Ning Geng Fran Riley 《World Journal of Clinical Cases》 SCIE 2019年第16期2330-2335,共6页
BACKGROUND Mushroom exposure is a global health issue.The manifestations of mushroom poisoning (MP) may vary.Some species have been reported as rhabdomyolytic,hallucinogenic,or gastrointestinal poisons.Critical or eve... BACKGROUND Mushroom exposure is a global health issue.The manifestations of mushroom poisoning (MP) may vary.Some species have been reported as rhabdomyolytic,hallucinogenic,or gastrointestinal poisons.Critical or even fatal MPs are mostly attributable to Amanita phalloides,with the development of severe liver or renal failure.Myocardial injury and even cases mimicking ST-segment elevation myocardial infarction (STEMI) have been previously reported,while cardiac arrhythmia or cardiac arrest is not commonly seen.CASE SUMMARY We report a 68-year-old woman with MP who suffered from delirium,seizure,long QT syndrome on electrocardiogram (ECG),severe cardiac arrhythmias of multiple origins,and cardiac arrest.She was intubated and put on blood perfusion.Her kidney and liver functions were intact;creatine kinase-MB was mildly elevated,and then fell within normal range during her hospital stay.We sent the mushrooms she left for translation elongation factor subunit 1α,ribosomal RNA gene sequence,and internal transcribed spacer sequence analyses.There were four kinds of mushrooms identified,two of which were found to be toxic.CONCLUSION This is the first time that we found cardiac toxicity caused by Panaeolus subbalteatus and Conocybe lactea,which were believed to be toxic to the liver,kidney,and brain.We suggest that intensive monitoring and ECG follow-up are essential to diagnose prolonged QT interval and different forms of tachycardia in MP patients,even without the development of severe liver or renal failure.The mechanisms need to be further investigated and clarified based on animal experiments and molecular signal pathways. 展开更多
关键词 MUSHROOM POISONING arrhythmia cardiac ARREST SEIZURE Case report
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Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis 被引量:1
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作者 Ahmed Bayoumy Meng-Qi GONG +9 位作者 Ka Hou Christien Li Sunny Hei Wong William KK Wu Guang-Ping LI George Bazoukis Konstantinos P Letsas Wing Tak Wong Yun-Long XIA Tong LIU Gary Tse 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第10期639-643,共5页
Brugada syndrome (BrS) is primary electrical disorder characterized by ST segment elevation with right bundle branch block morphology in patients with apparent structurally normal hearts, It predisposes affected in... Brugada syndrome (BrS) is primary electrical disorder characterized by ST segment elevation with right bundle branch block morphology in patients with apparent structurally normal hearts, It predisposes affected individuals to ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD).A number of studies have identified risk factors that are associated with a more malignant course of disease. These include male gender, syncope, a spontaneous type 1 ECG pattern, family history of SCD, family history of Brugada syndrome, 展开更多
关键词 Brugada syndrome Risk stratification Spontaneous type 1 Sudden cardiac death Ventricular arrhythmia
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Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account? 被引量:1
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作者 Michael Spartalis Eleftherios Spartalis Gerasimos Siasos 《World Journal of Cardiology》 2023年第12期623-626,共4页
Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology.In the past half-century,there has been significant advan-cement in the development and implementation of inn... Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology.In the past half-century,there has been significant advan-cement in the development and implementation of innovative ablation treatments and approaches.However,the treatment of arrhythmias continues to be inade-quate.Several arrhythmias,such as ventricular tachycardia and atrial fibrillation,pose significant challenges in terms of therapeutic efficacy,whether through interventional procedures or the administration of antiarrhythmic drugs.Cardio-logists are engaged in ongoing research to explore innovative methodologies,such as genome editing,with the purpose of effectively managing arrhythmias and meeting the growing needs of patients afflicted with rhythm disturbances.The field of genome editing has significant promise and has the potential to serve as a highly effective personalized therapy for rhythm disorders in patients.However,several ethical issues must be considered. 展开更多
关键词 arrhythmia Sudden cardiac death Genome editing Long QT Channelo-pathies Mutation
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Athletes and Arrhythmias
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作者 Michael J.Jansen,MD,FACC,FHRS Floyd W.Burke,MD,FACC,FACP,FASNC 《Cardiovascular Innovations and Applications》 2016年第B02期211-219,共9页
Sudden cardiac death related to athletic competition is a rare but tragic event.The victims are typically young with no previous cardiovascular symptoms or limitations.The majority of sudden cardiac death events in at... Sudden cardiac death related to athletic competition is a rare but tragic event.The victims are typically young with no previous cardiovascular symptoms or limitations.The majority of sudden cardiac death events in athletes are due to ventricular arrhythmias as a result of underlying molecular and/or structural level pathologic substrate.In this article,we will review the physiologic cardiac adaptations to exercise along with arrhythmias seen in athletes with a focus on those commonly associated with sudden cardiac death. 展开更多
关键词 ATHLETES cardiac REMODELING arrhythmias SUDDEN cardiac DEATH
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Recent impact study of automatic search function of the pacemaker atrial hysteresis on atrial arrhythmias
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作者 Yongdong Li Zhiping Ge +1 位作者 Huihua Wen Anjie Xu 《Discussion of Clinical Cases》 2016年第4期14-17,共4页
Objective:To explore the recent influences of pacemaker with automatic search function of atrial hysteresis on atrial arrhythmias,and to evaluate it clinical efficacy and safety.Methods:Indentify ADx DDD 5286 implante... Objective:To explore the recent influences of pacemaker with automatic search function of atrial hysteresis on atrial arrhythmias,and to evaluate it clinical efficacy and safety.Methods:Indentify ADx DDD 5286 implanted dual chamber pacemaker for sick sinus syndrome in 43 cases.Automatic search of atrial lag was not opened with after pacemaker implantation,and the pacemaker settings were kept.Follow-up program after 3 months,DDD mode with automatic search of atrial lag was opened,and this mode was followed up for 6 months,comparing the atrial pacing percentage and DCG atrial tachyarrhythmias of pacemaker implantation to opening atrium lag mode.Results:Compared with the preoperative and operative 3 months later,dynamic electrocardiogram(DCG)24 h showed that the number of atrial premature beats(APB)and atrial tachycardia,atrial fibrillation(AF)array increased(p<.05);the cases of APB,atrial tachycardia and AF episodes were also increased(p<.05).Compared with the automatic search function in atrial hysteresis model opened with and not opened:atrial pacing percentage decreased[0.54(0.41,0.71)vs.0.82(0.65,0.93),p<.05];DCG 24 h showed that the number of APB,AF episodes was reduced(p<.05).Conclusions:Automation search function in atrial hysteresis model can obviously reduce the proportion of atrial pacing,reduce the occurrence of atrial arrhythmias;opened with automatic search function in atrial hysteresis model was safe and reliable. 展开更多
关键词 PACEMAKER Artificial arrhythmias cardiac Automatic search Atrial delayed
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Dysglycemia and arrhythmias 被引量:1
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作者 Dong-Kun Sun Nan Zhang +5 位作者 Ying Liu Jiu-Chun Qiu Gary Tse Guang-Ping Li Leonardo Roever Tong Liu 《World Journal of Diabetes》 SCIE 2023年第8期1163-1177,共15页
Disorders in glucose metabolism can be divided into three separate but interrelated domains,namely hyperglycemia,hypoglycemia,and glycemic variability.Intensive glycemic control in patients with diabetes might increas... Disorders in glucose metabolism can be divided into three separate but interrelated domains,namely hyperglycemia,hypoglycemia,and glycemic variability.Intensive glycemic control in patients with diabetes might increase the risk of hypoglycemic incidents and glucose fluctuations.These three dysglycemic states occur not only amongst patients with diabetes,but are frequently present in other clinical settings,such as during critically ill.A growing body of evidence has focused on the relationships between these dysglycemic domains with cardiac arrhythmias,including supraventricular arrhythmias(primarily atrial fibrillation),ventricular arrhythmias(malignant ventricular arrhythmias and QT interval prolongation),and bradyarrhythmias(bradycardia and heart block).Different mechanisms by which these dysglycemic states might provoke cardiac arrhythmias have been identified in experimental studies.A customized glycemic control strategy to minimize the risk of hyperglycemia,hypoglycemia and glucose variability is of the utmost importance in order to mitigate the risk of cardiac arrhythmias. 展开更多
关键词 DYSGLYCEMIA HYPERGLYCEMIA HYPOGLYCEMIA Glucose variability cardiac arrhythmia
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Influence of the Right Ventricular Lead Location on Ventricular Arrhythmias in Cardiac Resynchronization Therapy 被引量:1
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作者 Hao Su Pei Bao +4 位作者 Kang-Yu Chen Ji Yan Jian Xu Fei Yu Dong-Mei Yang 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第20期2402-2409,共8页
Background: The influence of different right ventricular lead locations on ventricular arrhythmias (VTA) in patients with a cardiac resynchronization therapy (CRT) is not clear. This study aimed to evaluate the i... Background: The influence of different right ventricular lead locations on ventricular arrhythmias (VTA) in patients with a cardiac resynchronization therapy (CRT) is not clear. This study aimed to evaluate the influence on VTA in patients with a CRT when right ventricular lead was positioned at the right ventricular middle septum (RVMS) and the right ventricular apical (RVA). Methods: A total of 352 patients implanted with a CRT-defibrillator (CRT-D) between May 2012 and July 2016 in the Department of Cardiology of Anhui Provincial Hospital were included. Two-year clinical and pacemaker follow-up data were collected to evaluate the influence of the right ventricular lead location on VTA. Patients were divided into the RVMS group (n = 155) and the RVA group (n = 197) based on the right ventricular lead position. The VTA were compared between these two groups using a Kaplan-Meier curve and Cox multivariate analysis. Results: When the left ventricular lead location was not considered, RVMS and RVA locations did not affect VTA. However, the subgroup analysis results showed that when the left ventricular lead was positioned at the anterolateral cardiac vein (ALCV), the RVMS group had an increased risk ofventricular arrhythmias and appropriate defibrillation (hazard ratio [HR] - 3.29, P = 0.01 and HR = 4.33, P 〈 0.01, respectively); when the left ventricular lead was at the posterolateral cardiac vein (PLCV), these risks in the RVMS group decreased (HR = 0.45, P = 0.02 and HR = 0.33, P 〈 0.01, respectively), and when the lett ventricular lead was at the lateral cardiac vein, there was no difference between the two groups. In regard to inappropriate defibrillation, there was no significant difference among all these groups. Conclusions: When the left ventricular lead was positioned at ALCV or PLCV, the right ventricular lead location was associated with VTA and appropriate defibrillation after CRT. Greater distances between leads not only improved cardiac function but also may reduce the risk of VTA. 展开更多
关键词 cardiac Resynchronization therapy Heart Failure Ventricular Remodeling Ventricular arrhythmias
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Nonalcoholic Fatty Liver Disease (NAFLD) and Risk of Cardiac Arrhythmias: A New Aspect of the Liver-heart Axis 被引量:9
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作者 Alessandro Mantovani 《Journal of Clinical and Translational Hepatology》 SCIE 2017年第2期134-141,共8页
Nonalcoholic fatty liver disease (NAFLD) is a pathologic condition frequently observed in clinical practice.To date,the prevalence of NAFLD is approximately 25-30% among adults of the general population in Western cou... Nonalcoholic fatty liver disease (NAFLD) is a pathologic condition frequently observed in clinical practice.To date,the prevalence of NAFLD is approximately 25-30% among adults of the general population in Western countries but increases to approximately 70-75% among patients with type 2 diabetes mellitus.In the last decade,accumulating evidence has clearly demonstrated that patients with NAFLD have not only an increased liver-related morbidity and mortality but also an increased risk of fatal and non-fatal cardiovascular events.In particular,several studies have documented the existence of an independent association among NAFLD and cardiac changes in structure and function in both non-diabetic and diabetic patients.In addition,mounting evidence also suggests that there is a strong relationship between NAFLD and cardiac arrhythmias,such as atrial fibrillation,QTc prolongation and ventricular arrhythmias.This is of clinical interest,as it could explain,at least in part,the increased risk of death for cardiovascular disease in patients with NAFLD.Therefore,seeing that cardiovascular disease complications are the leading cause of disability and death in NAFLD patients,the recent European clinical practice guidelines advised to check the cardiovascular system in all patients with NAFLD.This clinical mini review will briefly describe the increasing body of evidence regarding the association between NAFLD and cardiac arrhythmias,and discuss the potential biological mechanisms underlying this association. 展开更多
关键词 Nonalcoholic fatty liver disease Cardiovascular disease cardiac arrhythmias cardiac complications
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Expert Consensus on Wenxin Granule for Treatment of Cardiac Arrhythmias 被引量:6
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作者 Guo, Ji-Hong Yan, Gan-Xin +20 位作者 Wu, Lin Zhao, Bu-Chang Wang, Yi-Min Gu, Fu-Sheng Zhou, Yu-Ping Antzelevitch, Charles Guo, Jing-Xuan Yang, Jie-Fu Yang, Xin-Chun Ding, Yan-Sheng Zhang, Ping Zhang, Hai-Cheng Liu, Hong-Xu Lu, Wei-Xing Xing, Yan-Wei Fan, Jian-Feng Ze, Feng Li, Guang-ping Li, Yi-Gang Liao, De-Ning Xue, Xiao-Lin 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第2期203-210,共8页
INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, ... INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, Class Ⅰ and Ⅲ antiarrhythmic drugs have been shown to be associated with the development of proarrhythmias and an increase in the likelihood of causing higher mortality by inducing torsade de pointes ventricular tachycardia and other serious adverse reactions. Consequently, the development of safe and effective antiarrhythmic regimens remains a primary focus of contemporary cardiovascular research. 展开更多
关键词 cardiac arrhythmias TREATMENT Wenxin Granule
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Automatic Classification of Cardiac Arrhythmias Based on Hybrid Features and Decision Tree Algorithm 被引量:5
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作者 Santanu Sahoo Asit Subudhi +1 位作者 Manasa Dash Sukanta Sabut 《International Journal of Automation and computing》 EI CSCD 2020年第4期551-561,共11页
Accurate classification of cardiac arrhythmias is a crucial task because of the non-stationary nature of electrocardiogram(ECG)signals.In a life-threatening situation,an automated system is necessary for early detecti... Accurate classification of cardiac arrhythmias is a crucial task because of the non-stationary nature of electrocardiogram(ECG)signals.In a life-threatening situation,an automated system is necessary for early detection of beat abnormalities in order to reduce the mortality rate.In this paper,we propose an automatic classification system of ECG beats based on the multi-domain features derived from the ECG signals.The experimental study was evaluated on ECG signals obtained from the MIT-BIH Arrhythmia Database.The feature set comprises eight empirical mode decomposition(EMD)based features,three features from variational mode decomposition(VMD)and four features from RR intervals.In total,15 features are ranked according to a ranker search approach and then used as input to the support vector machine(SVM)and C4.5 decision tree classifiers for classifying six types of arrhythmia beats.The proposed method achieved best result in C4.5 decision tree classifier with an accuracy of 98.89%compared to cubic-SVM classifier which achieved an accuracy of 95.35%only.Besides accuracy measures,all other parameters such as sensitivity(Se),specificity(Sp)and precision rates of 95.68%,99.28%and 95.8%was achieved better in C4.5 classifier.Also the computational time of 0.65 s with an error rate of 0.11 was achieved which is very less compared to SVM.The multi-domain based features with decision tree classifier obtained the best results in classifying cardiac arrhythmias hence the system could be used efficiently in clinical practices. 展开更多
关键词 Electrocardiogram(ECG) cardiac arrhythmias empirical mode decomposition(EMD) variational mode decomposition(VMD) hybrid features decision tree classifier
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Left bundle branch pacing set to outshine biventricular pacing for cardiac resynchronization therapy? 被引量:2
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作者 Akash Batta Juniali Hatwal 《World Journal of Cardiology》 2024年第4期186-190,共5页
The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP... The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that still our opinions on this technique are largely based on observational data and there is a dire need for larger RCTs to ascertain the position of LBBPCRT in management of heart failure patients with left bundle branch block. 展开更多
关键词 Biventricular pacing cardiac resynchronization therapy Conduction system pacing Left bundle branch-area pacing Left bundle branch block Electromechanical dssynchrony
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Mechanistic and therapeutic perspectives for cardiac arrhythmias:beyond ion channels 被引量:5
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作者 Yufei Wu Jun Li +2 位作者 Liang Xu Li Lin Yi-Han Chen 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第4期348-355,共8页
Cardiac arrhythmias are among the most common causes of death in the world. Foundational studies established the critical role of ion channel disorders in arrhythmias, yet defects in ion channels themselves, such as m... Cardiac arrhythmias are among the most common causes of death in the world. Foundational studies established the critical role of ion channel disorders in arrhythmias, yet defects in ion channels themselves, such as mutations, may not account for all arrhythmias. Despite the progress made in recent decades, the antiarrhythmic drugs currently available have limited effectiveness,and the majority of these drugs can have proarrhythmic effects. This review describes novel knowledge on cellular mechanisms that cause cardiac arrhythmias, focuses on the dysfunction of subcellular organelles and intracellular logistics, and discusses potential strategies and challenges for developing novel, safe and effective treatments for arrhythmias. 展开更多
关键词 beyond intracellular mitochondria suppress currently potentially logistics arrhythmia themselves targeted
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The Effect of Predictive Nursing Intervention on Cardiac Function and Clinical Outcomes in CCU Patients with Acute Myocardial Infarction After Interventional Therapy
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作者 Tingting Wang Cui Xia 《Journal of Clinical and Nursing Research》 2024年第8期237-242,共6页
Objective:To evaluate the impact of predictive nursing on the care of acute myocardial infarction(AMI)patients in the Coronary Care Unit(CCU)after interventional therapy.Methods:From September 2021 to September 2023,8... Objective:To evaluate the impact of predictive nursing on the care of acute myocardial infarction(AMI)patients in the Coronary Care Unit(CCU)after interventional therapy.Methods:From September 2021 to September 2023,84 AMI patients admitted to the CCU were randomly divided into two groups:the experimental group(42 patients)received predictive nursing,and the reference group(42 patients)received conventional nursing.Cardiac function and clinical outcomes were compared between the groups.Results:Before nursing,there was no difference in cardiac function between the two groups(P>0.05).After nursing,the cardiac function of the experimental group was better than that of the reference group(P<0.05).The clinical outcomes of the experimental group were better than those of the reference group(P<0.05).Before nursing,there was no difference in psychological scores between the two groups(P>0.05).After nursing,the psychological scores of the experimental group were lower than those of the reference group(P<0.05).Conclusion:Predictive nursing can improve the cardiac function and clinical outcomes of AMI patients after interventional therapy and can also regulate patients’negative psychological states. 展开更多
关键词 Predictive nursing CCU Acute myocardial infarction Interventional therapy cardiac function
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Diagnostic Dilemma of Intracardiac Mass: Tumor versus Thrombus-Case Series and Systematic Review
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作者 Indira Acharya Ashik Pokharel +1 位作者 Raktim Ghosh Christopher J. Haas 《Journal of Biosciences and Medicines》 2024年第7期141-150,共10页
Background: The differential diagnosis for intracavitary cardiac masses is limited, typically including vegetations, tumors, or thrombi. Cardiac thrombi can often mimic cardiac tumors on imaging, creating a diagnostic... Background: The differential diagnosis for intracavitary cardiac masses is limited, typically including vegetations, tumors, or thrombi. Cardiac thrombi can often mimic cardiac tumors on imaging, creating a diagnostic challenge. Primary cardiac tumors are rare and usually benign, whereas most cardiac tumors result from metastases, commonly originating from malignancies in the breast, lung, or melanoma. Aim: This report highlights the importance of distinguishing various cardiac masses based on clinical presentations, clinical courses, and radiological features. Case Presentation: We describe two cases of cardiac masses with unique and diverse clinical features. Each case posed significant diagnostic challenges due to their distinct presentations and clinical progressions. Conclusion: These cases underscore the importance of considering both benign and metastatic origins in the differential diagnosis of intracavitary cardiac masses. Accurate differentiation between thrombi and tumors is crucial for appropriate management and treatment. 展开更多
关键词 ECHOCARDIOGRAPHY cardiac Masses arrhythmias cardiac Magnetic Resonance Imaging cardiac Thrombi
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