A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone(1), 1β,6α-dihydroxyeudesma-4(15)-en...A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone(1), 1β,6α-dihydroxyeudesma-4(15)-ene(2), carainterol A(3), oplodiol(4), douglanin(5), 1α-hydroxyisodauc-4-en-15-al(6), 3α,6α-dihydroxybisabola-4,10-diene(7), 4α,5β-dihydroxybisabola-2,10-diene(8), opposit-4(15)-ene-1β,7-diol(9), and saniculamoid D(10), respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.展开更多
基金National Natural Science Foundation of China(NSFC,Grant No.81373294)National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2018ZX09711001-008-003)
文摘A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone(1), 1β,6α-dihydroxyeudesma-4(15)-ene(2), carainterol A(3), oplodiol(4), douglanin(5), 1α-hydroxyisodauc-4-en-15-al(6), 3α,6α-dihydroxybisabola-4,10-diene(7), 4α,5β-dihydroxybisabola-2,10-diene(8), opposit-4(15)-ene-1β,7-diol(9), and saniculamoid D(10), respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.