Evaluation of artificial tears on cornea epithelium healing

AIM： To observe the efficacy of different artificial eye drops on corneal epithelium healing in rabbit. METHODS： Thirty-five rabbits with 6 mm diameter central corneal epithelium removed were randomly assigned to six groups： 0.9% normal saline（NS） group, 0.1% hyaluronate（HA） group, 0.3% HA group, Tears Naturale Free？（TNF） group, 0.4% polyethylene glycol（PEG） group, 0.5% carboxymethyl cellulose（CMC） group and blank control group. Treatments were administered topically four times daily. Corneal epithelium healing was evaluated by the percentage reduction in wound area at 24, 36, 48, 60, and 72 h after removal of the corneal epithelium. Cornea re-epithelialization was also assessed by histological analysis and electron microscopy. RESULTS： All corneal wounds completely re-epithelialized in less than 72 h. The average re-epithelialization time was 47.61±4.25 h in the 0.3% HA group and 49.72±1.05 h in the 0.9% NS group, followed by 0.1% HA, TNF, 0.4% PEG, 0.5% CMC, and lastly by the control group. Compared to the control group, there were significant differences among 0.3% HA, 0.9% NS, PEG, and TNF（P〈0.05） groups. At the first 24 h, re-epithelialization at the 0.3% HA, TNF, and 0.9% NS treatment groups were significantly faster than the other groups. At 48 h post-wounding, corneal epithelium is nearly completing re-epithelialization at 0.3% HA and 0.9% NS treatment groups. Electron microscopy revealed that there were a large number of vacuoles in the cells of the 0.9% NS group at 72 h. CONCLUSION： Artificial tears promote corneal reepithelium varied in the efficacy. Obviously, all artificial eye drops better than blank group. In the process of corneal healing, corneal epithelium cells suffered from hypoxia caused by NS.

Clinical Comparison and Analysis of Decoction of Traditional Chinese Medicine Combined with Ear Acupoint Application and Simple Artificial Tears in the Treatment of Dry Eye Syndrome

OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P < 0.05). At 2 weeks, 4 weeks, and 8 weeks after the treatment, the amelioration level of BUT, SIT, and FL indicators in the observation group was better than that of the control group(P < 0.05). CONCLUSION: Compared with the artificial tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.

Role of artificial tears with and without hyaluronic acid in controlling ocular discomfort following PRK: a randomized clinical trial

AIM:To compare outcomes of applying preservative free artificial tears(PFAT)with and without hyaluronic acid(HA)in early postoperative course following photorefractive keratectomy(PRK).METHODS:In this triple-blinded randomized clinical trial,PRK procedure was performed on both eyes of 230 patients.Following PRK,patients were divided into three groups:the HA^(+)group,44 patients PFAT containing HA;the HA-group,71 patients PFAT without HA were administered 5 times per day(every 4 h);the third group,115 patients received no PFAT before lens removal.On the 1st and 4th postoperative day,Visual Analogue Score(VAS)was utilized to evaluate patient’s level of pain.Participants were asked to complete a questionnaire about the severity of eye discomfort ranked from 0 to 10(0=no complaint;10=most severe complaint experienced).RESULTS:In eyes receiving PFAT with or without HA(Drop group),mean scores for epiphora,foreign body sensation,and blurred vision on the 1st postoperative day were statistically lower(P<0.05).Filamentous keratitis(FK)was detected in 11(4.7%)eyes,and recurrent corneal erosion(RCE)was observed in 5(2.1%)eyes.In the control group,FK was noted in 16(6.9%)eyes while 13(5.6%)eyes had RCE and 5(2.1%)eyes had corneal haze.The rate of complications was statistically lower in Drop group(P=0.009).However,the aforementioned scores were not statically different between HA^(+)and HA-group one and two(P=0.29).CONCLUSION:Following PRK,applying PFAT with and without HA yields faster visual recovery,decreases postoperative ocular discomfor t and haze formation;however there is no additive effect for HA.

Review on artificial intelligence techniques for improving representative air traffic management capability

The use of artificial intelligence(AI)has increased since the middle of the 20th century,as evidenced by its applications to a wide range of engineering and science problems.Air traffic management(ATM)is becoming increasingly automated and autonomous,making it lucrative for AI applications.This paper presents a systematic review of studies that employ AI techniques for improving ATM capability.A brief account of the history,structure,and advantages of these methods is provided,followed by the description of their applications to several representative ATM tasks,such as air traffic services(ATS),airspace management(AM),air traffic flow management(ATFM),and flight operations(FO).The major contribution of the current review is the professional survey of the AI application to ATM alongside with the description of their specific advantages:(i)these methods provide alternative approaches to conventional physical modeling techniques,(ii)these methods do not require knowing relevant internal system parameters,(iii)these methods are computationally more efficient,and(iv)these methods offer compact solutions to multivariable problems.In addition,this review offers a fresh outlook on future research.One is providing a clear rationale for the model type and structure selection for a given ATM mission.Another is to understand what makes a specific architecture or algorithm effective for a given ATM mission.These are among the most important issues that will continue to attract the attention of the AI research community and ATM work teams in the future.

基于虚拟仪器的装备ATS系统硬件平台设计与实现

在对现有维修检测设备存在不足分析的基础上,结合武器装备的维修技术保障需求,利用分块设计思想,采用虚拟仪器、人工智能、计算机通讯与控制等技术,搭建了基于虚拟仪器的装备自动测试系统硬件平台整体架构,在对系统各功能模块原理进行分析之后,对系统主控电路、电磁兼容性进行了设计;采用虚拟仪器的装备自动测试系统硬件平台,具有智能化、通用化、可视化的特点,通过试验结果分析,测试系统硬件平台能够实现装备的性能检测和故障诊断,测试数据符合任务要求,能满足各级修理机构维修测试需求。

Impact of 0.1% sodium hyaluronate and 0.2% sodium hyaluronate artificial tears on postoperative discomfort following cataract extraction surgery: a comparative study

Background:Recent artificial tear preparations have provided 0.2%concentration of sodium hyaluronate.However,no published data exist on their potential superiority against 0.1%in alleviating dry-eye-disease symptoms in cataract extraction surgery.Methods:A total of 180 patients that underwent cataract extraction surgery were randomly divided into 2 groups according to their postoperative regime:Study group(SG)received fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks,and additionally 0.2%sodium hyaluronate provided in the COMOD®device quid for 6 weeks.Control group(CG)received fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks,and additionally 0.1%sodium hyaluronate provided in the COMOD®device quid for 6 weeks.The following indexes were evaluated at 3 postoperative checkpoints:(1)Surface discomfort index(SDI)which was derived by four direct 10-scale Likert-type questions that were addressed to the patient and pertained to:(a)foreign body sensation(FBS),(b)blinking discomfort(BD),(c)stinging sensation(SS),(d)tearing sensation(TS),(2)Tear breakup time(TBUT),(3)Schirmer’s test,(4)Central corneal thickness(CCT),and (4)Central Corneal Sensitivity(CCS).Results:Both groups showed reduced CCS values at all postoperative examination points;however,SG participants had significantly better CCS(all p<0.05).SG had better TBUT than CG at the 3rd(p=0.03)and 6th examination points(p=0.04).Moreover,SG had better SDI scores at the 3rd(SDI=9.26±0.55)and 6th weeks(SDI=9.47±0.48)vs.CG participants(p=0.03 and p<0.01,respectively).Conclusion:The increased 0.2%sodium hyaluronate concentration in the artificial tears provided in the COMOD®device seems to address dry-eye-disease symptoms better in patients who underwent phacoemulsification surgery than the 0.1%concentration.Trial registration:ClinicalTrials.gov Identifier:NCT03705949 Oct 15,2018,retrospectively registered.

HypoTear Gel优乐沛人工泪液凝胶治疗眼表疾病的初步临床评价

目的 客观评估HypoTearGel对治疗某些眼表疾病的临床效果。方法 采用前瞻性研究方法将研究对象60例(60只眼)随机分为治疗组(采用HypoTearGel)及对照组(采用人工泪液滴眼液)各30例,分别观察2组患者的临床效果。结果 治疗组显效20例(67%),有效7例(23%),总有效27例(90%);对照组的显效7例(23%),有效10例(33%),总有效17例(56%);经统计学处理有显著性差异(P<0.01),在适应症范围内,HypoTearGel临床疗效明显优于人工泪液。结论 HypoTearGel是一种安全有效、值得推广的新型人工泪液制剂。

Keratograph 5M眼表综合分析仪对丹参注射液离子导入联合人工泪液治疗白内障术后干眼的疗效观察

【目的】应用Keratograph 5M(简称K5M)眼表综合分析仪观察丹参注射液离子导入联合人工泪液治疗白内障术后干眼的效果。【方法】将90例(180眼)白内障手术后干眼症患者随机分为观察组和对照组,每组各45例(90眼)。对照组单纯给予常规人工泪液滴眼治疗,观察组在对照组基础上加用丹参注射液离子导入治疗。7 d为1个疗程,持续治疗2个疗程。使用K5M眼表综合分析仪采集治疗前后第1次泪膜破裂时间(NIBUTf),平均泪膜破裂时间(NIBUTav)、泪河高度(LTMH)和眼表充血评分等评价指标的变化情况。【结果】治疗前,2组患者的NIBUTf、NIBUTav、LTMH、眼表充血评分等各项K5M眼表综合分析仪评价指标比较,差异均无统计学意义(P>0.05)。治疗后,2组患者K5M眼表综合分析仪各项评价指标均较治疗前明显改善(P<0.05),且观察组对NIBUTav、LTMH和眼表充血评分等指标的改善作用均优于对照组,差异均有统计学意义(P<0.05)。【结论】丹参注射液离子导入联合人工泪液治疗白内障手术后干眼,具有较好疗效,能更有效改善患者各项症状,提高患者舒适感;与传统的诊断方法相比,K5M眼表综合分析仪对白内障术后干眼的治疗效果具有更加直观和客观的评价作用。

Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography

AIM:To evaluate the role of medical treatment in the management of inflammatory punctum stenosis guided by spectral domain anterior segment optical coherence tomography(OCT).METHODS:This prospective study included 60 patients complaining of epiphora due to inflammatory punctual stenosis.They were divided into two groups:Group A(30 patients)treated with a combination of preservative free hydrocortisone sodium phosphate 3.35 mg/m L eye drops,and preservative free artificial tears based on sodium hyaluronate,polyethylene and propylene Glycol;Group B(30 patients)treated with the same preservative free artificial tears only.Thirty normal subjects were included for comparison of pre-treatment anatomical parameters.Before starting treatment,all patients underwent anterior segment assessment including slit lamp examination,measurement of intraocular pressure(IOP),fluorescein dye disappearance test,and measurement of the outer punctum diameter(OPD)by Spectral domain anterior segment OCT.All assessments were repeated at each follow up done at 1 and 3 mo later,together with subjective evaluation of patient’s satisfaction of the treatment outcome by simple rating questionnaire.RESULTS:Punctual diameter increased significantly with treatment in both groups(P<0.0001);although the widening was more in Group A as compared to group B(16.2%vs 8%of the original punctual size,mean difference of 28.933μm,P=0.0076).Subjective satisfaction with treatment outcome was also better in group A(70%vs 40%,Chi-square P=0.0397).CONCLUSION:A combination of preservative free steroid eye drops and artificial tears causes significant widening of inflammed stenotic punctae and improvement of the associated epiphora.

疏肝养血润目针灸法治疗水样液缺乏性干眼的疗效观察

目的 观察疏肝养血润目针灸法治疗水样液缺乏性干眼(ATD)的临床疗效及安全性。方法 纳入2021年6月—2023年6月唐山市丰润区人民医院诊治的ATD肝肾阴虚证患者98例(196只眼),采用随机数字表法分成对照组和治疗组,最终每组纳入48例(96只眼)。对照组予1.4%聚乙烯醇滴眼液治疗,治疗组在对照组基础上联合疏肝养血润目针灸法。2组均观察4周。分别于治疗前、后检测受试者的泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、角膜荧光染色(FL)、白细胞介素(IL)-1β、IL-6、金属基质蛋白酶-9(MMP-9)水平及中医证候积分。结果 (1)BUT:治疗前后比较,2组治疗后BUT均较治疗前延长,差异均有统计学意义(t_(治疗组)=50.217、t_(对照组)=40.909,均P=0.000)。治疗组治疗后BUT长于对照组,差异有统计学意义(t=7.349,P=0.000)。(2)SⅠT:治疗前后比较,2组治疗后SⅠT均较治疗前延长,差异均有统计学意义(t_(治疗组)=46.149、t_(对照组)=42.726,均P=0.000)。治疗组治疗后SⅠT长于对照组,差异有统计学意义(t=7.078,P=0.000)。(3)FL:治疗前后比较,2组治疗后FL均较治疗前降低,差异均有统计学意义(t_(治疗组)=50.398、t_(对照组)=42.955,均P=0.000)。治疗组治疗后FL低于对照组,差异有统计学意义(t=8.688,P=0.000)。(4)泪液炎症因子:治疗前后比较,2组治疗后IL-1β、IL-6及MMP-9水平均较治疗前降低,差异均有统计学意义(IL-1β:t_(治疗组)=71.214、t_(对照组)=51.982,均P=0.000;IL-6:t_(治疗组)=83.398、t_(对照组)=70.133,均P=0.000;MMP-9:t_(治疗组)=673.908、t_(对照组)=623.730,均P=0.000)。治疗组治疗后IL-1β、IL-6及MMP-9均低于对照组,差异均有统计学意义(t_(IL-1β)=10.708、t_(IL-6)=9.689、t_(MMP-9)=9.155,均P=0.000)。(5)中医证候积分:治疗前后比较,2组治疗后中医证候积分均较治疗前降低,差异均有统计学意义(t_(治疗组)=54.729、t_(对照组)=46.822,均P=0.000)。治疗组治疗后中医证候积分低于对照组,差异有统计学意义(t=11.622,P=0.000)。(6)临床疗效:治疗组总有效率为92.71%,高于对照组的82.29%,差异有统计学意义(χ~2=4.762,P=0.029)。(7)不良反应:2组不良反应比较,差异无统计学意义(P>0.05)。结论 对ATD患者实施疏肝养血润目针灸法联合人工泪液治疗,可有效缓解症状,明显改善FL等泪膜稳定性指标,且安全性高。

普拉洛芬滴眼液联合人工泪液治疗干眼症的临床效果及对睡眠时间的影响

目的:探讨普拉洛芬滴眼液联合人工泪液治疗干眼症的临床效果及对睡眠时间的影响。方法:选取2023年2月至2023年9月安溪县医院干眼症患者120例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组60例。观察组采用普拉洛芬滴眼液+人工泪液治疗,对照组采用人工泪液治疗,比较2组治疗效果、睡眠质量(PSQI)、临床指标。结果:观察组治疗有效率为96.67%,高于对照组的83.33%(P<0.05)。治疗前,2组PSQI评分比较,差异无统计学意义(P>0.05);治疗后,观察组PSQI评分均较对照组低,差异有统计学意义(P<0.05)。视疲劳、眼部干涩、充血红肿、眼部异物感消失时间观察组均较对照组短(P<0.05),泪膜破裂时间观察组较对照组长(P<0.05)。结论:对干眼症者行普拉洛芬滴眼液+人工泪液治疗,调整睡眠时间,利于病情康复,疗效突出,可进一步推广应用。

药物治疗干眼的临床应用及研究进展

干眼又称作干燥性角结膜炎,其临床表现为眼部干涩,有搔痒感、灼烧感、视物模糊等症状,严重影响患者的生活质量。近年来干眼的发病率逐年升高,已成为眼科临床的常见疾病之一。目前治疗干眼的手段主要有药物治疗、手术治疗和临床护理等,其中药物治疗是治疗干眼最为常用的手段。本文对近年来临床上基于渗透通路和炎症通路的药物治疗干眼的应用及研究进展进行归纳总结,为后续干眼的治疗及药物研发提供一些思路。

Analyze interleukin-1β,interleukin-6,and tumor necrosis factor-αlevels in dry eye and the therapeutic effect of cyclosporine A

BACKGROUND Dry eye is a common eye disease.Artificial tears supplements are widely used for the treatment of dry eyes.However,multiple adverse effects have been observed in patients receiving long-term treatment with artificial tears,which may affect the therapeutic effect.AIM To analyze the characteristics of interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-alpha(TNF-α)levels in patients with dry eye and the therapeutic effect of artificial tears combined with cyclosporine A.METHODS A total of 124 dry eye patients treated at The First People’s Hospital of Xining from April 2020 to April 2022 were selected as the observation group,while 20 healthy individuals served as the control group during the same period.Levels of inflammatory markers,including IL-1β,IL-6,and TNF-α,were analyzed.The observation group was further divided into a study group and a control group,each consisting of 62 patients.The control group received artificial tears,whereas the study group received a combination of artificial tears and cyclosporine A.Inflammatory markers,Schirmer’s test(SIT),tear break-up time(TBUT),corneal fluorescein staining(CFS),National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25)scores,and adverse events(AEs)were compared between the two groups.RESULTS The observation group exhibited significantly elevated serum levels of IL-1β,IL-6,and TNF-αin comparison to the healthy group.Following treatment,the study group demonstrated substantial reductions in IL-1β,IL-6,and TNF-αlevels relative to the control group.Moreover,after treatment,the study group experienced a marked decrease in CFS scores and significant increases in both SIT and BUT levels when compared to the control group.Additionally,significant improvements were observed in the primary symptom of dry eye and secondary symptoms such as photophobia,foreign body sensation,fatigue,red eye,and burning sensation within the study group.Furthermore,post-treatment NEI-VFQ-25 scores across all dimensions exhibited significant enhancements in the study group compared to the control group(P<0.05).It is noteworthy that significant AEs were reported in both groups throughout the treatment period.CONCLUSION Cyclosporine A combined with artificial tears is effective in treating dry eye,yielding enhanced outcomes by improving SIT and TBUT levels,reducing CFS scores,and ameliorating vision-related quality of life.

干眼患者泪液相关检测指标及技术的研究进展

泪液质和量的检查是诊断干眼的重要指标。临床常用诊断干眼的检查方法主要包括对泪液量及泪膜稳定性的检测以评估其严重程度,而实验室条件下对泪液成分进行分析标记以诊断临床分型,也指导临床对相关成分进行补充以有针对地对其进行治疗。准确评估泪液的产生和成分的变化使临床医生能够有效监测干眼的严重程度并评估治疗措施的有效性。随着近年来光学成像技术及人工智能的发展,临床泪液的相关指标及检查技术方法与其相结合,一些新的检测手段得以应用,可提供更为方便快捷精准的检测,极大提高了临床上干眼的诊断和治疗水平。

有晶状体眼后房型人工晶状体植入术对患者眼表泪膜影响临床研究

目的:探究有晶状体眼后房型人工晶状体(ICL)植入术对眼表泪膜的影响,为临床防治ICL术后干眼症提供科学依据。方法:纳入行ICl手术矫正治疗的患者76例149眼为研究对象,根据术后3个月是否发生干眼症分为干眼组和对照组,比较两组术前3 d、术后7 d、术后1个月泪河高度(TMH)、首次泪膜破裂时间(NIF-BUT)、平均泪膜破裂时间(NIAvg-BUT)、睑板腺成像评分、脂质层评分、视觉质量评分(QoV)、眼表疾病指数(OSDI)的差异。结果:两组患者术前膜染色评分、睑缘形态评分、NIF-BUT评分、NIAvg-BUT评分、OSDI评分低于术后7 d与术后1个月(均P<0.05);干眼组术前OSDI评分高于对照组(P<0.05);干眼组术后7 d角膜染色评分、睑缘形态评分、NIF-BUT、NIAvg-BUT、Qov评分、OSDI评分高于对照组,TMH低于对照组(均P<0.05);干眼组术后1个月角膜染色评分、睑缘形态评分、睑板腺成像评分、NIF-BUT、NIAvg-BUT、QoV评分、OSD评分高于对照组,TMH低于对照组(均P<0.05)。Logistic回归分析结果显示,术后7 d、术后1个月角膜染色评分、睑缘形态评分、NIF-BUT、NIAvg-BUT、QOV评分及术后1个月睑板成像评分偏高是干眼症发生的独立危险因素,较高的TMH评分是干眼症发生的独立保护因素(均P<0.05)。结论:ICL植入术对患者眼表泪膜稳定性同样存在影响,应当注意术前评估及术后复查,给予针对性的术前预防性治疗和术后干预性治疗措施。

人工泪液联合普拉洛芬治疗白内障超声乳化术后干眼症的效果分析

目的:分析人工泪液联合普拉洛芬治疗白内障超声乳化术后干眼症的效果。方法:选取2022年1月—2023年4月山东省青岛市崂山区社区卫生服务中心收治的100例白内障超声乳化术后干眼症患者作为研究对象,依据随机数字表法分为对照组和观察组,各50例。对照组采取人工泪液治疗,观察组在对照组基础上应用普拉洛芬,比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.019)。治疗后,两组泪膜破裂时间长于治疗前,且观察组长于对照组,两组泪液分泌长度大于治疗前,且观察组大于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P=0.856)。结论:人工泪液联合普拉洛芬治疗白内障超声乳化术后干眼症的效果较好,治疗后,患者泪膜破裂时间、泪液分泌长度较优,不良反应发生较少。

雷火灸联合人工泪液治疗泪液生成不足型干眼症的临床效果观察

目的:分析雷火灸联合人工泪液治疗泪液生成不足型干眼症的临床效果。方法:选取2023年1—12月西安市中医医院眼科收治的106例泪液生成不足型干眼症患者作为研究对象,按照随机数字表法分为试验组和对照组,各53例。对照组实施人工泪液治疗,试验组在对照组基础上给予雷火灸治疗。比较两组泪液分泌试验、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分结果及临床疗效。结果:治疗前,两组滤纸润湿长度、BUT、FL评分比较,差异无统计学意义(P>0.05);治疗后,两组滤纸润湿长度、BUT长于治疗前,且试验组长于对照组,FL评分低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.001)。试验组治疗有效率高于对照组,差异有统计学意义(P=0.034)。结论:雷火灸联合人工泪液可有效改善泪液生成不足型干眼症患者临床症状,增加泪液分泌量,延长泪膜破裂时间。

氯替泼诺联合人工泪液对白内障术后干眼症患者Toll样受体-核因子κB信号通路相关因子的影响

目的分析氯替泼诺联合人工泪液对白内障术后干眼症患者Toll样受体(TLR)-核因子κB(NF-κB)信号通路相关因子的影响。方法回顾性分析2020年12月至2023年12月赣州启明星眼科医院收治的110例白内障术后干眼症患者的临床资料,根据治疗方法的不同分为对照组(n=55)与试验组(n=55)。对照组给予人工泪液治疗,试验组给予氯替泼诺联合人工泪液治疗,比较两组患者的治疗总有效率、角膜荧光素染色(FL)评分、美国国家眼科研究所视觉相关生命质量量表(NEI-VFQ-25)评分、泪液肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平及血清TLR4、NF-κB水平。结果对照组、试验组患者治疗总有效率分别为74.55%、90.91%,试验组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的FL评分均低于同组治疗前,且试验组的FL评分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的TNF-α、IL-1β水平均低于同组治疗前,且试验组的TNF-α、IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的TLR4、NF-κB水平均低于同组治疗前,且试验组的TLR4、NF-κB水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的生活质量各项评分均高于同组治疗前,且试验组的生活质量各项评分均高于对照组,差异有统计学意义(P<0.05)。结论氯替泼诺联合人工泪液治疗白内障术后干眼症患者效果较好,可有效提高泪膜稳定性,可提高患者生活质量,与氯替泼诺联合人工泪液治疗通过介导TLR-NF-κB信号通路降低眼表炎症状态有关,可推广应用。

溴芬酸钠联合人工泪液治疗干眼症对视功能、症状及体征的影响

目的探讨溴芬酸钠和人工泪液联合应用对干眼症患者视功能、症状及体征的影响。方法选取2022年1月—2023年1月云南省红河哈尼族彝族自治州第三人民医院收治的88例干眼症患者为研究对象,根据随机数表法分为两组,对照组(n=44)采用单一人工泪液治疗,观察组(n=44)在对照组的基础上+溴芬酸钠治疗,治疗周期为2周。对比两组治疗效果。结果治疗2周后,观察组临床总有效率高于对照组(97.73%vs81.82%),差异有统计学意义(χ^(2)=4.389,P=0.036);治疗后,两组自觉症状及体征、角膜荧光素染色、视觉功能评分均降低,泪液分泌量均增多,泪膜破裂时间均延长,且观察组均优于对照组,差异有统计学意义(P均<0.05);治疗后,两组视觉相关生命质量各项评分均升高,且观察组高于对照组,差异有统计学意义(P均<0.05)。结论干眼症患者采用溴芬酸钠和人工泪液联合治疗,能够减少角膜损伤,促进泪液分泌,增加泪膜稳定性,提高视功能,缓解干眼症状,改善生活质量,疗效显著,安全性较高。

中药超声雾化联合人工泪液治疗泪液蒸发过快型干眼症临床观察

目的:观察中药超声雾化联合人工泪液治疗泪液蒸发过快型干眼症的临床疗效。方法:86例按随机数字表法分为研究组和参照组各43例。两组均用人工泪液治疗,研究组加用中药超声雾化治疗。结果:研究组总有效率高于参照组(P<0.05)。治疗后研究组症状(异物感、疲劳感、干燥感、烧灼感、视力波动)、FL评分低于参照组而SIT、BUT评分高于参照组(P<0.05)。治疗后研究组IL-17、IL-1β、MMP-9、MMP-2水平低于参照组(P<0.05)。研究组不良反应发生率与参照组比较差异无统计学意义(P>0.05)。结论:中药超声雾化联合人工泪液治疗泪液蒸发过快型干眼症疗效较好。