An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction re...An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α- arylalkanoic acids.展开更多
A general synthesis of diaryl ethers via coupling of aryl halides with substituted phenoxytrimethylsilane in the presence of TBAF is described. The protocol is simple and mild, and gives good to excellent yields.
A series of PVP-Pd-Sn/MontK10 catalysts were prepared by immobilization of PVP[poly(N-vinyl-2-pyrrolidone)] supported bimetallic catalyst using MontK10 as carrier. This catalyst has good catalytic activity for hydroge...A series of PVP-Pd-Sn/MontK10 catalysts were prepared by immobilization of PVP[poly(N-vinyl-2-pyrrolidone)] supported bimetallic catalyst using MontK10 as carrier. This catalyst has good catalytic activity for hydrogen transfer dehalogenation of aryl halides. The catalytic reaction was carried out in aqueous system in the presence of phase transfer catalyst and sodium formate as hydrogen source. The catalyst with loading Pd 0.19wt% and molar ratio of Pd/Dn 8:1 gives the highest activity and good stability. This catalyst is more reducible with NaBH4. It is also found that the catalyst is easily separated from the reaction system.展开更多
The photoinduced reactions of aryl halides with carbazolyl nitrogen anion,in dimethyl sulfoxide,yield the corresponding N-arylated products.These reactions are suggested in terms of the S;Nl mechaism of nucleophilic s...The photoinduced reactions of aryl halides with carbazolyl nitrogen anion,in dimethyl sulfoxide,yield the corresponding N-arylated products.These reactions are suggested in terms of the S;Nl mechaism of nucleophilic substitution.展开更多
Various functionalized asymmetrical biaryls can be synthesized in high to excellent yields via coupling reaction of aryl iodides or bromides with NaBPh4 catalyzed by MCM-41-supported sulfur palladium(0) complex. Thi...Various functionalized asymmetrical biaryls can be synthesized in high to excellent yields via coupling reaction of aryl iodides or bromides with NaBPh4 catalyzed by MCM-41-supported sulfur palladium(0) complex. This palladium complex can be easily recovered and reused many times without loss of activity.展开更多
A novel bisupported bimetal catalyst PVP-PdCl2-FeSO4/Al-Mont-PEG600 was prepared by immobilization of PVP (poly (N-vinyl-2-pyrrolidone)) supported bimetallic catalyst using alumina pillared inartificial montmorill...A novel bisupported bimetal catalyst PVP-PdCl2-FeSO4/Al-Mont-PEG600 was prepared by immobilization of PVP (poly (N-vinyl-2-pyrrolidone)) supported bimetallic catalyst using alumina pillared inartificial montmorillonite as the carrier. This catalyst has good dehalogenation activity and selectivity to aryl halides o-chlorotoluene in aqueous system in the presence of phase transfer catalyst (PEG) and sodium formate as hydrogen source. The catalyst also shows good reusability.展开更多
10 mol% Cul combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-...10 mol% Cul combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.展开更多
Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reactio...Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reaction of aryl halides with electron-deficient olefins. The coupling reaction of awl halide bearig different functional groups with olefin derivatives took place and the corresponding products were isolated in good to excellent yields under optimal conditions. The procedure exhibits good functional group tolerance and wide substrate scope. This Mizoroki-Heck reaction was further achieved using Pd(OAc)2 and 3,5-di-isopropyl-1H-1,2,4-diazaphospholes as combined catalyst, which provide the convenient and alternative method in organic synthesis展开更多
A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substitu...A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substituted atyl chlorides could efficiently react with heterocycles, providing variety of N-arylated products in good to excellent yields. The ligand-free catalyst system was stable in air and could be readily reused.展开更多
Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and phosphites.Only 3—5 mol%CuI and ligands were r...Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and phosphites.Only 3—5 mol%CuI and ligands were required to ensure coupling with a number of(hetero)aryl bromides and iodides to complete at 120 ℃ in 10—20 h.展开更多
The Suzuki-Miyaura type coupling reaction of aryl halides with triphenylborane-pyridine was described. The reaction can be catalyzed by Pd(OAc)2 (5 mol%) in presence of Cs2CO3 at 50 ℃ or 80 ℃, and functionalized...The Suzuki-Miyaura type coupling reaction of aryl halides with triphenylborane-pyridine was described. The reaction can be catalyzed by Pd(OAc)2 (5 mol%) in presence of Cs2CO3 at 50 ℃ or 80 ℃, and functionalized biaryls were obtained in good to excellent yields. This protocol is general and can tolerate a wide range of func- tional groups.展开更多
CuO-CeO_(2)nanocomposite as a green recyclable catalyst,catalyzed amination of aryl halides with aqueous am-monia in water.This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive ru...CuO-CeO_(2)nanocomposite as a green recyclable catalyst,catalyzed amination of aryl halides with aqueous am-monia in water.This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive runs with consistent activity.The procedure provides some advantages such as simple work-up,clean procedure,relatively short reaction times and high yields of the products.展开更多
Deuterated compounds are valuable in synthetic,pharmaceutical,and analytical chemistry.The deuteration of halides is a widespread method for highly site-selective deuterium installation.However,the facile,efficient,an...Deuterated compounds are valuable in synthetic,pharmaceutical,and analytical chemistry.The deuteration of halides is a widespread method for highly site-selective deuterium installation.However,the facile,efficient,and economical deuterium incorporation remains challenging.In this work,we introduced a practical deuteration of(hetero)aryl halides through an electrochemical reduction method.This transformation proceeded smoothly at room temperature without metal catalysts,external reductants,or toxic or dangerous reagents.Remarkably,low-cost and chemically equivalent D2O was the sole deuterium source in this reaction.Professional electrosynthesis equipment was not essential because we demonstrated common batteries and electrodes were enough for this reaction.展开更多
Suzuki cross-coupling reaction of phenylboronic acid with aryl halides catalyzed by cyclopalladated complexes of tertiary arylamines immobilized in ionic liquid [Bmim]^+BF4^- was reported. The catalytic system proved...Suzuki cross-coupling reaction of phenylboronic acid with aryl halides catalyzed by cyclopalladated complexes of tertiary arylamines immobilized in ionic liquid [Bmim]^+BF4^- was reported. The catalytic system proved to be efficient and be reused at least 3 times without significant loss of activity.展开更多
A fast and convenient C―S bond formation reaction was achieved catalyzed by CuI/L-proline in aqueous two-phase system providing a simple method for synthesis of aryl sulfides in good yields in short time.
Suzuki-Miyaura(S-M)is regarded the most powerful way for synthesis biaryls,triaryls,or incorporating of substituted aryl moieties in organic preparation by the cross-coupling of aryl boronic acid with aryl halides usi...Suzuki-Miyaura(S-M)is regarded the most powerful way for synthesis biaryls,triaryls,or incorporating of substituted aryl moieties in organic preparation by the cross-coupling of aryl boronic acid with aryl halides using the Pd catalyst.This work reports the combining of the hydrothermal and microwaveassisted protocol to convert the glucose to magnetic carbon spheres(Fe_(3)O_(4)-CSPs)decorated with Pd nanoparticles(NPs)as the catalyst for Suzuki-Miyaura cross-coupling reactions.The physicochemical properties in the produced composite were examined using FESEM,HRTEM,nitrogen isotherms,Raman spectroscopy,FTIR,XPS,and XRD.The as-fabricated composite Pd/Fe_(3)O_(4)-CSPs is mostly spherical with a core–shell structure and possesses a great surface area of 253.2 m^(2).g^(-1).Its catalytic performance demonstrates that the composite has excellent stability and high tolerance Suzuki-Miyaura crosscoupling reactions in 30 min at 80℃.Both activated and deactivated aryl halides provided excellent yield.The as-fabricated catalyst was recycled for up to four catalytic cycles without a substantial decline in performance.Moreover,this research offers a facile roadmap for synthesizing Pd/Fe_(3)O_(4)-CSPs composites and promoting the practical implementation of Pd/Fe_(3)O_(4)-CSPs catalysts for organic transformation processes.展开更多
The possibility of carrying out a purely heterogeneous Heck reaction in practice without Pd leaching has been previously considered by a number of research groups but no general consent has yet arrived. Here, the reac...The possibility of carrying out a purely heterogeneous Heck reaction in practice without Pd leaching has been previously considered by a number of research groups but no general consent has yet arrived. Here, the reaction was, for the first time, evaluated by a simple computational approach. Modelling experiments were performed on one of the initial catalytic steps: phenyl halides attachment on Pd (111) to (100) and (111) to (111) ridges of a Pd crystal. Three surface structures of resulting were identified as possible reactive intermediates. Following potential energy minimisation calculations based on a universal force field, the relative stabilities of these surface species were then determined. Results showed the most stable species to be one in which a Pd ridge atom is removed from the Pd crystal structure, suggesting Pd leaching induced by phenyl halides is energetically favourable.展开更多
A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with sec...A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene.展开更多
文摘An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α- arylalkanoic acids.
文摘A general synthesis of diaryl ethers via coupling of aryl halides with substituted phenoxytrimethylsilane in the presence of TBAF is described. The protocol is simple and mild, and gives good to excellent yields.
文摘A series of PVP-Pd-Sn/MontK10 catalysts were prepared by immobilization of PVP[poly(N-vinyl-2-pyrrolidone)] supported bimetallic catalyst using MontK10 as carrier. This catalyst has good catalytic activity for hydrogen transfer dehalogenation of aryl halides. The catalytic reaction was carried out in aqueous system in the presence of phase transfer catalyst and sodium formate as hydrogen source. The catalyst with loading Pd 0.19wt% and molar ratio of Pd/Dn 8:1 gives the highest activity and good stability. This catalyst is more reducible with NaBH4. It is also found that the catalyst is easily separated from the reaction system.
文摘The photoinduced reactions of aryl halides with carbazolyl nitrogen anion,in dimethyl sulfoxide,yield the corresponding N-arylated products.These reactions are suggested in terms of the S;Nl mechaism of nucleophilic substitution.
基金National Natural Science Foundation of China (Project 20462002) Natural Science Foundation of Jiangxi Province (Project 0420015) for financial support.
文摘Various functionalized asymmetrical biaryls can be synthesized in high to excellent yields via coupling reaction of aryl iodides or bromides with NaBPh4 catalyzed by MCM-41-supported sulfur palladium(0) complex. This palladium complex can be easily recovered and reused many times without loss of activity.
文摘A novel bisupported bimetal catalyst PVP-PdCl2-FeSO4/Al-Mont-PEG600 was prepared by immobilization of PVP (poly (N-vinyl-2-pyrrolidone)) supported bimetallic catalyst using alumina pillared inartificial montmorillonite as the carrier. This catalyst has good dehalogenation activity and selectivity to aryl halides o-chlorotoluene in aqueous system in the presence of phase transfer catalyst (PEG) and sodium formate as hydrogen source. The catalyst also shows good reusability.
基金supported by the National Natural Science Foundation of China (No.21102036)Plan for Scientific Innovation Talent of Henan University of Technology (No.11CXRC02)startup fund from HAUT (No.2010BS042)
文摘10 mol% Cul combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.
基金Financial support from Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No. 2015157)Teaching Reform Project of Shanxi Normal University(No. SD2014JGKT-52)Undergraduate Training Programs for Innovation and Entrepreneurship of Modern College of Arts and Sciences, Shanxi Normal University(No. WL2015CXCY-YJ-26)
文摘Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reaction of aryl halides with electron-deficient olefins. The coupling reaction of awl halide bearig different functional groups with olefin derivatives took place and the corresponding products were isolated in good to excellent yields under optimal conditions. The procedure exhibits good functional group tolerance and wide substrate scope. This Mizoroki-Heck reaction was further achieved using Pd(OAc)2 and 3,5-di-isopropyl-1H-1,2,4-diazaphospholes as combined catalyst, which provide the convenient and alternative method in organic synthesis
基金This work was supported by the National Natural Science Foundation of China (No. 20802049).
文摘A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substituted atyl chlorides could efficiently react with heterocycles, providing variety of N-arylated products in good to excellent yields. The ligand-free catalyst system was stable in air and could be readily reused.
基金The authors are grateful to Chinese Academy of Sciences(supported by the Strategic Priority Research Program,grant XDB20020200&QYZDJ-SSW-SLH029)the National Natural Science Foundation of China(grant 21621002,21831009 and 21991110)for their financial support.
文摘Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and phosphites.Only 3—5 mol%CuI and ligands were required to ensure coupling with a number of(hetero)aryl bromides and iodides to complete at 120 ℃ in 10—20 h.
基金This work was supported by the Natural Science Foundation of Zhejiang Province (No. Y407081) andthe Research Foundation of Education Department of Zhejiang Province (No. YZ01018492).
文摘The Suzuki-Miyaura type coupling reaction of aryl halides with triphenylborane-pyridine was described. The reaction can be catalyzed by Pd(OAc)2 (5 mol%) in presence of Cs2CO3 at 50 ℃ or 80 ℃, and functionalized biaryls were obtained in good to excellent yields. This protocol is general and can tolerate a wide range of func- tional groups.
基金We are thankful to the Behbahn Khatam Alanbia University of Technology for the support of this work.
文摘CuO-CeO_(2)nanocomposite as a green recyclable catalyst,catalyzed amination of aryl halides with aqueous am-monia in water.This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive runs with consistent activity.The procedure provides some advantages such as simple work-up,clean procedure,relatively short reaction times and high yields of the products.
基金supported by the National Natural Science Foundation of China(no.21520102003)the Hubei Province Natural Science Foundation of China(no.2017CFA010)The Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.
文摘Deuterated compounds are valuable in synthetic,pharmaceutical,and analytical chemistry.The deuteration of halides is a widespread method for highly site-selective deuterium installation.However,the facile,efficient,and economical deuterium incorporation remains challenging.In this work,we introduced a practical deuteration of(hetero)aryl halides through an electrochemical reduction method.This transformation proceeded smoothly at room temperature without metal catalysts,external reductants,or toxic or dangerous reagents.Remarkably,low-cost and chemically equivalent D2O was the sole deuterium source in this reaction.Professional electrosynthesis equipment was not essential because we demonstrated common batteries and electrodes were enough for this reaction.
基金Project supported by the National Natural Science Foundation of China(No.20172016)Shanghai Science&Technology Council(04JC14032).
文摘Suzuki cross-coupling reaction of phenylboronic acid with aryl halides catalyzed by cyclopalladated complexes of tertiary arylamines immobilized in ionic liquid [Bmim]^+BF4^- was reported. The catalytic system proved to be efficient and be reused at least 3 times without significant loss of activity.
基金Supported by the Zhejiang Province Natural Science Foundation, China(No.407240)
文摘A fast and convenient C―S bond formation reaction was achieved catalyzed by CuI/L-proline in aqueous two-phase system providing a simple method for synthesis of aryl sulfides in good yields in short time.
文摘Suzuki-Miyaura(S-M)is regarded the most powerful way for synthesis biaryls,triaryls,or incorporating of substituted aryl moieties in organic preparation by the cross-coupling of aryl boronic acid with aryl halides using the Pd catalyst.This work reports the combining of the hydrothermal and microwaveassisted protocol to convert the glucose to magnetic carbon spheres(Fe_(3)O_(4)-CSPs)decorated with Pd nanoparticles(NPs)as the catalyst for Suzuki-Miyaura cross-coupling reactions.The physicochemical properties in the produced composite were examined using FESEM,HRTEM,nitrogen isotherms,Raman spectroscopy,FTIR,XPS,and XRD.The as-fabricated composite Pd/Fe_(3)O_(4)-CSPs is mostly spherical with a core–shell structure and possesses a great surface area of 253.2 m^(2).g^(-1).Its catalytic performance demonstrates that the composite has excellent stability and high tolerance Suzuki-Miyaura crosscoupling reactions in 30 min at 80℃.Both activated and deactivated aryl halides provided excellent yield.The as-fabricated catalyst was recycled for up to four catalytic cycles without a substantial decline in performance.Moreover,this research offers a facile roadmap for synthesizing Pd/Fe_(3)O_(4)-CSPs composites and promoting the practical implementation of Pd/Fe_(3)O_(4)-CSPs catalysts for organic transformation processes.
文摘The possibility of carrying out a purely heterogeneous Heck reaction in practice without Pd leaching has been previously considered by a number of research groups but no general consent has yet arrived. Here, the reaction was, for the first time, evaluated by a simple computational approach. Modelling experiments were performed on one of the initial catalytic steps: phenyl halides attachment on Pd (111) to (100) and (111) to (111) ridges of a Pd crystal. Three surface structures of resulting were identified as possible reactive intermediates. Following potential energy minimisation calculations based on a universal force field, the relative stabilities of these surface species were then determined. Results showed the most stable species to be one in which a Pd ridge atom is removed from the Pd crystal structure, suggesting Pd leaching induced by phenyl halides is energetically favourable.
基金We gratefully thank the National Natural Science Foundation of China (No. 31071720) for generous fi- nancial support.
文摘A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene.