The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical properties.Previous stud...The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical properties.Previous studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the alloys.In this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%Sc.The results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc addition.The ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.展开更多
目的:总结1例由ADNP基因变异所致的Helsmoortel-Van der Aa综合征(HVDAS)的临床表现及遗传学特点,并进行国内外相关文献复习。方法:对2020年8月于中山大学孙逸仙纪念医院儿科神经专科确诊的1例HVDAS患儿的临床表现、生化检查及基因检测...目的:总结1例由ADNP基因变异所致的Helsmoortel-Van der Aa综合征(HVDAS)的临床表现及遗传学特点,并进行国内外相关文献复习。方法:对2020年8月于中山大学孙逸仙纪念医院儿科神经专科确诊的1例HVDAS患儿的临床表现、生化检查及基因检测等临床资料进行回顾性分析。同时检索国内外数据库中有关ADNP基因变异所致的HVDAS患儿的文献。结果:本例患儿,男,5岁10个月,因“运动、语言发育迟缓5年余,社交障碍2年余”入院。患儿表现为智力障碍、孤独症谱系、发育迟缓、特殊面容、睾丸鞘膜积液、隐睾及睾丸微石症等。基因检测发现该患儿携带一个ADNP杂合致病突变,即ADNP(NM_015339.3)Exon3:c.56_57del TG:p.(Val19fs)基因突变,父母均未发现该基因突变。文献检索到102例患儿(包含本例患儿),平均年龄6.3岁,男女比例为3:2。相关文献报道所有患儿都有轻到重度智力障碍、严重的语言和运动发育迟缓。孤独症谱系障碍、特征性的面部外观也很常见。结论:HVDAS是一种罕见常染色体显性的神经发育障碍性疾病,临床上对于发育迟缓、孤独症谱系障碍、特殊面容的患儿,应考虑到HVDAS的可能性,应及早进行基因检测,基因检测发现ADNP基因变异可明确诊断。展开更多
基金supported by the Key Research&Development Program of Yunnan Province(Grant numbers 202103AA080017,202203AE140011).
文摘The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical properties.Previous studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the alloys.In this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%Sc.The results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc addition.The ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.
文摘目的:总结1例由ADNP基因变异所致的Helsmoortel-Van der Aa综合征(HVDAS)的临床表现及遗传学特点,并进行国内外相关文献复习。方法:对2020年8月于中山大学孙逸仙纪念医院儿科神经专科确诊的1例HVDAS患儿的临床表现、生化检查及基因检测等临床资料进行回顾性分析。同时检索国内外数据库中有关ADNP基因变异所致的HVDAS患儿的文献。结果:本例患儿,男,5岁10个月,因“运动、语言发育迟缓5年余,社交障碍2年余”入院。患儿表现为智力障碍、孤独症谱系、发育迟缓、特殊面容、睾丸鞘膜积液、隐睾及睾丸微石症等。基因检测发现该患儿携带一个ADNP杂合致病突变,即ADNP(NM_015339.3)Exon3:c.56_57del TG:p.(Val19fs)基因突变,父母均未发现该基因突变。文献检索到102例患儿(包含本例患儿),平均年龄6.3岁,男女比例为3:2。相关文献报道所有患儿都有轻到重度智力障碍、严重的语言和运动发育迟缓。孤独症谱系障碍、特征性的面部外观也很常见。结论:HVDAS是一种罕见常染色体显性的神经发育障碍性疾病,临床上对于发育迟缓、孤独症谱系障碍、特殊面容的患儿,应考虑到HVDAS的可能性,应及早进行基因检测,基因检测发现ADNP基因变异可明确诊断。
