Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been establis...Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been established,there are still some challenges.According to the different presentations,the personalized management of patients who suffer from this disease,including those with chronic or acute severe onset,the autoantibody-negative phenotype and cirrhosis are necessarily descriptive.Each subgroup of patients should receive an individualized therapy.Here,we review the recent studies of autoimmune hepatitis,mainly focusing on the epidemiology and genetics,personalized diagnostics,individualized treatment strategies,special subgroups and outcomes.Most of the research in the literature is based on Japanese and Chinese populations.展开更多
基金the National Natural Science Foundation of China(No.81325002,81620108002 to X Ma,81570511,81770564 to QX Wang)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.81421001)the Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai(No.2017YQ037 to QX Wang)
文摘Autoimmune hepatitis has been considered as a relatively rare immunological liver disease,especially in the Asia-Pacific area.Although the diagnosis criteria and immunosuppressive treatment regimens have been established,there are still some challenges.According to the different presentations,the personalized management of patients who suffer from this disease,including those with chronic or acute severe onset,the autoantibody-negative phenotype and cirrhosis are necessarily descriptive.Each subgroup of patients should receive an individualized therapy.Here,we review the recent studies of autoimmune hepatitis,mainly focusing on the epidemiology and genetics,personalized diagnostics,individualized treatment strategies,special subgroups and outcomes.Most of the research in the literature is based on Japanese and Chinese populations.
