BACKGROUND Early identification of metabolic-associated fatty liver disease(MAFLD)is urgent.Atherogenic index of plasma(AIP)is a reference predictor of obesity-related diseases,but its predictive value for MAFLD remai...BACKGROUND Early identification of metabolic-associated fatty liver disease(MAFLD)is urgent.Atherogenic index of plasma(AIP)is a reference predictor of obesity-related diseases,but its predictive value for MAFLD remains unclear.No studies have reported whether its combination with waist circumference(WC)and body mass index(BMI)can improve the predictive performance for MAFLD.AIM To systematically explore the relationship between AIP and MAFLD and evaluate its predictive value for MAFLD and to pioneer a novel noninvasive predictive model combining AIP,WC,and BMI while validating its predictive performance for MAFLD.METHODS This cross-sectional study consecutively enrolled 864 participants.Multivariate logistic regression analysis and receiver operating characteristic curve were used to evaluate the relationship between AIP and MAFLD and its predictive power for MAFLD.The novel prediction model A-W-B combining AIP,WC,and BMI to predict MAFLD was established,and internal verification was completed by magnetic resonance imaging diagnosis.RESULTS Subjects with higher AIP exhibited a significantly increased risk of MAFLD,with an odds ratio of 12.420(6.008-25.675)for AIP after adjusting for various confounding factors.The area under receiver operating characteristic curve of the A-W-B model was 0.833(0.807-0.858),which was significantly higher than that of AIP,WC,and BMI(all P<0.05).Subgroup analysis illustrated that the A-W-B model had significantly higher area under receiver operating characteristic curves in female,young and nonobese subgroups(all P<0.05).The best cutoff values for the A-W-B model to predict MAFLD in males and females were 0.5932 and 0.4105,respectively.Additionally,in the validation set,the area under receiver operating characteristic curve of the A-W-B model to predict MAFLD was 0.862(0.791-0.916).The A-W-B level was strongly and positively associated with the liver proton density fat fraction(r=0.630,P<0.001)and significantly increased with the severity of MAFLD(P<0.05).CONCLUSION AIP was strongly and positively associated with the risk of MAFLD and can be a reference predictor for MAFLD.The novel prediction model A-W-B combining AIP,WC,and BMI can significantly improve the predictive ability of MAFLD and provide better services for clinical prediction and screening of MAFLD.展开更多
为探讨血浆促动脉硬化指数(AIP)在铁路职工健康维护工作中的应用,收集2023年某单位623名职工健康管理信息,以China-PAR(中国动脉粥样硬化性心血管疾病风险预测项目)心血管病终生发病风险评估等级为因变量,以AIP与职工健康维护等级为自...为探讨血浆促动脉硬化指数(AIP)在铁路职工健康维护工作中的应用,收集2023年某单位623名职工健康管理信息,以China-PAR(中国动脉粥样硬化性心血管疾病风险预测项目)心血管病终生发病风险评估等级为因变量,以AIP与职工健康维护等级为自变量建立多元线性回归风险预测模型,并绘制受试者工作特征(Receiver Operating Characteristic,ROC)曲线,通过计算曲线下面积(Area under the Curve,AUC)进一步验证综合指标的预测性能。相关性分析中,职工健康维护等级相关系数高于AIP相关系数;职工健康维护等级、AIP的标准化系数分别为0.333和0.225,提示职工健康维护等级与心脑血管病终生发病风险的关联等级更高。多元线性回归模型预测值的AUC面积显著大于AIP、职工健康维护等级单项指标(P<0.05),但2个单项指标的差异无统计学意义(Z=-0.784,P=0.433)。说明AIP、职工健康维护等级二者联合风险预测模型对个体心脑血管疾病发病风险具备较好预测效果。展开更多
目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内...目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内径狭窄程度≥50%为支架内再狭窄标准,按有无再狭窄分为冠脉再狭窄组(42例)和冠脉未再狭窄组(226例)。比较两组间AIP、直接胆红素、间接胆红素、总胆红素等指标,并进一步研究AIP、血清胆红素与冠脉药物支架术后支架内再狭窄的相关性。结果冠脉血管内再狭窄组AIP值高于无再狭窄组(P<0.05);再狭窄组的总胆红素水平低于无再狭窄组(P<0.05)。结论 AIP促进冠状动脉支架内再狭窄,为其再狭窄的危险因子,而血清总胆红素则是冠状动脉支架内再狭窄的对抗因子,起保护作用。展开更多
基金This study was approved by the Clinical Research Ethics Committee of China-Japan Friendship Hospital(2018-110-K79-1).
文摘BACKGROUND Early identification of metabolic-associated fatty liver disease(MAFLD)is urgent.Atherogenic index of plasma(AIP)is a reference predictor of obesity-related diseases,but its predictive value for MAFLD remains unclear.No studies have reported whether its combination with waist circumference(WC)and body mass index(BMI)can improve the predictive performance for MAFLD.AIM To systematically explore the relationship between AIP and MAFLD and evaluate its predictive value for MAFLD and to pioneer a novel noninvasive predictive model combining AIP,WC,and BMI while validating its predictive performance for MAFLD.METHODS This cross-sectional study consecutively enrolled 864 participants.Multivariate logistic regression analysis and receiver operating characteristic curve were used to evaluate the relationship between AIP and MAFLD and its predictive power for MAFLD.The novel prediction model A-W-B combining AIP,WC,and BMI to predict MAFLD was established,and internal verification was completed by magnetic resonance imaging diagnosis.RESULTS Subjects with higher AIP exhibited a significantly increased risk of MAFLD,with an odds ratio of 12.420(6.008-25.675)for AIP after adjusting for various confounding factors.The area under receiver operating characteristic curve of the A-W-B model was 0.833(0.807-0.858),which was significantly higher than that of AIP,WC,and BMI(all P<0.05).Subgroup analysis illustrated that the A-W-B model had significantly higher area under receiver operating characteristic curves in female,young and nonobese subgroups(all P<0.05).The best cutoff values for the A-W-B model to predict MAFLD in males and females were 0.5932 and 0.4105,respectively.Additionally,in the validation set,the area under receiver operating characteristic curve of the A-W-B model to predict MAFLD was 0.862(0.791-0.916).The A-W-B level was strongly and positively associated with the liver proton density fat fraction(r=0.630,P<0.001)and significantly increased with the severity of MAFLD(P<0.05).CONCLUSION AIP was strongly and positively associated with the risk of MAFLD and can be a reference predictor for MAFLD.The novel prediction model A-W-B combining AIP,WC,and BMI can significantly improve the predictive ability of MAFLD and provide better services for clinical prediction and screening of MAFLD.
文摘为探讨血浆促动脉硬化指数(AIP)在铁路职工健康维护工作中的应用,收集2023年某单位623名职工健康管理信息,以China-PAR(中国动脉粥样硬化性心血管疾病风险预测项目)心血管病终生发病风险评估等级为因变量,以AIP与职工健康维护等级为自变量建立多元线性回归风险预测模型,并绘制受试者工作特征(Receiver Operating Characteristic,ROC)曲线,通过计算曲线下面积(Area under the Curve,AUC)进一步验证综合指标的预测性能。相关性分析中,职工健康维护等级相关系数高于AIP相关系数;职工健康维护等级、AIP的标准化系数分别为0.333和0.225,提示职工健康维护等级与心脑血管病终生发病风险的关联等级更高。多元线性回归模型预测值的AUC面积显著大于AIP、职工健康维护等级单项指标(P<0.05),但2个单项指标的差异无统计学意义(Z=-0.784,P=0.433)。说明AIP、职工健康维护等级二者联合风险预测模型对个体心脑血管疾病发病风险具备较好预测效果。
文摘目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内径狭窄程度≥50%为支架内再狭窄标准,按有无再狭窄分为冠脉再狭窄组(42例)和冠脉未再狭窄组(226例)。比较两组间AIP、直接胆红素、间接胆红素、总胆红素等指标,并进一步研究AIP、血清胆红素与冠脉药物支架术后支架内再狭窄的相关性。结果冠脉血管内再狭窄组AIP值高于无再狭窄组(P<0.05);再狭窄组的总胆红素水平低于无再狭窄组(P<0.05)。结论 AIP促进冠状动脉支架内再狭窄,为其再狭窄的危险因子,而血清总胆红素则是冠状动脉支架内再狭窄的对抗因子,起保护作用。