Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level. Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis modelswere given Xu...Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level. Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis modelswere given Xueguantong for 30 days. Then, their plasma endothelin and calcitonin gene-related peptide (CGRP) were determined with radioimmunoassay (RIA) and the effects of Xueguantong on plasma endothelin and CGRP in the models were observed. Results: The plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P＜ 0. 05 ) and CGRP increased (P＜ 0. 05) by Xueguantong. Conclusion: One of antiatherogenic mechanisms of Xueguantong was decreasing endothelin and increasing CGRP.展开更多
This paper analyses the anterior descending branch of the arteria coronaria sinistra from the view of hemodynamics.The results show that the branching of the anterior descending branch with an angle of 90?at the openi...This paper analyses the anterior descending branch of the arteria coronaria sinistra from the view of hemodynamics.The results show that the branching of the anterior descending branch with an angle of 90?at the opening and the formation of the mural arteria coronaria are the hemodynamic characteristics.The shearing stress of the turbulent flow, the additional pressure, the formation of the blood vertex, and the impulsive pressure, caused by these characteristics, are hemodynamic reasons that leads to the occurence of atherosclerosis in anterior descending branch.展开更多
文摘Objective: To explore the antiatherogenic mechanism of the action of Xueguantong at molecular level. Methods: After being established by feeding with high fat diet for 12 weeks, the quail atherosis modelswere given Xueguantong for 30 days. Then, their plasma endothelin and calcitonin gene-related peptide (CGRP) were determined with radioimmunoassay (RIA) and the effects of Xueguantong on plasma endothelin and CGRP in the models were observed. Results: The plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P＜ 0. 05 ) and CGRP increased (P＜ 0. 05) by Xueguantong. Conclusion: One of antiatherogenic mechanisms of Xueguantong was decreasing endothelin and increasing CGRP.
文摘This paper analyses the anterior descending branch of the arteria coronaria sinistra from the view of hemodynamics.The results show that the branching of the anterior descending branch with an angle of 90?at the opening and the formation of the mural arteria coronaria are the hemodynamic characteristics.The shearing stress of the turbulent flow, the additional pressure, the formation of the blood vertex, and the impulsive pressure, caused by these characteristics, are hemodynamic reasons that leads to the occurence of atherosclerosis in anterior descending branch.
