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Different processing methods and pharmacological effects of Atractylodis Rhizoma
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作者 GUO Dongmei XU Kang +5 位作者 WAN Qianyun YU Songyang MA Chaoyang ZHANG Baohui LIU Yanju QU Linghang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2024年第8期756-768,共13页
Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy... Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy for specific conditions.However,a comprehensive report detailing the changes in chemical composition and pharmacological effects due to these processing methods is currently lacking.This article provides a systematic review of the commonly employed processing techniques for Atractylodis Rhizoma,including raw Atractylodis Rhizoma(SCZ),bran-fried Atractylodis Rhizoma(FCZ),deep-fried Atractylodis Rhizoma(JCZ),and rice water-processed Atractylodis Rhizoma(MCZ).It examines the alterations in chemical constituents and pharmacological activities resulting from these processes and elucidates the mechanisms of action of the primary components in the various processed forms of Atractylodis Rhizoma in the treatment of gastrointestinal diseases. 展开更多
关键词 atractylodis Rhizoma Processing method Pharmacological effect Change in chemical composition Gastrointestinal disease
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Analysis of the influence of processing of bran stir-baking on the main components of Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair by high-performance liquid chromatography 被引量:4
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作者 方新华 吴鑫 +2 位作者 曹岗 蔡皓 蔡宝昌 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第4期231-235,共5页
The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and pr... The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs, a simple, easy, and sensitive high-performance liquid chromatography coupled with diode array detectors was developed for simultaneous determination of nine bioactive components in the herbal pairs. The calibration curve exhibited good linearity(r2≥0.9992). The LODs and LOQs were ≤7.30 and 11.53 μg/m L, respectively. The intra-, inter-day and repeatability RSD values of the nine compounds were less than 3.86%, 2.71%, and 4.29%, respectively. The RSD stability values were less than 3.64%. The recovery of the method was in the range of 96.70%–102.10%, with RSD values less than 3.52%. The developed method can be applied to the intrinsic quality control of crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs. 展开更多
关键词 High-performance liquid chromatography Processing Quantification Paeoniae Radix Alba atractylodis Macrocephalae Rhizoma
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Effect of Baizhu(Rhizoma Atractylodis Macrocephalae)extract on intestinal absorption of brucine and strychnine in vitro and in situ 被引量:4
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作者 Lu Dan Jiang Qieying +3 位作者 Zhang Jing Zeng Ronggui Liao Zhenggen Liang Xinli 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2020年第4期562-570,共9页
OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mech... OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mechanism of these effects.METHODS:The apparent permeability value(Papp)and absorption rate constant(Ka)were chosen as indices.The everted intestinal sac model and in situ single-pass intestinal perfusion model were used to study the effects of the RAM extract on the absorption of brucine and strychnine.To confirm the results,the brucine and strychnine concentrations in hepatic portal venous blood were determined.Western blotting was used to study P-glycoprotein(P-gp)expression in the Caco-2 cell line.RESULTS:Papp and Ka of brucine and strychnine were significantly increased in the presence of a P-gp inhibitor,but no significant increase was noted in the presence of a tight junction regulator.The RAM extract inhibited the absorption of brucine and strychnine and enhanced P-gp expression.CONCLUSION:The primary absorption mechanism for brucine and strychnine is passive transport,which is affected by P-gp. 展开更多
关键词 Strychnos nux-vomica BRUCINE STRYCHNINE ATP binding cassette transporter subfamily B member 1 Baizhu(Rhizoma atractylodis Macrocephalae)
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Structural Elucidation and Antitumor Activity of Polysaccharide AMP-1 from Atractylodis macrocephalae K. 被引量:1
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作者 单俊杰 柯炜 +1 位作者 邓军娥 田庚元 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2003年第1期87-90,共4页
A polysaccharide named as AMP-1 was isolated from the root of Atractylodis macrocephalae Koidz, and purified by ethanol fractionation and gel filtration. The homogeneity of AMP-1 was determined by HPLC and capillary... A polysaccharide named as AMP-1 was isolated from the root of Atractylodis macrocephalae Koidz, and purified by ethanol fractionation and gel filtration. The homogeneity of AMP-1 was determined by HPLC and capillary electrophoresis that gave a single peak. AMP-1 is composed of galactose and mannose in a molar ratio of 1.0∶1.9. Its molecular weight is 3.8×10 3. The structure of glycan was elucidated by IR, 1H NMR, 13C NMR and methylation analysis, and on the basis of the results was suggested that AMP-1 contain a backbone of β-(1→2)-D-galactose residues with branches of single β-D-mannose residue being substituted at the O-6. Bioactivity assay of AMP-1 showed that it could inhibit growth of Sarcoma 180 and Lewis pulmonary carcinoma implanted in mice. 展开更多
关键词 STRUCTURE POLYSACCHARIDE atractylodis macrocephalae K. ANTITUMOR
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Advances in Research of Epidemic Lung Preventive Mixture
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作者 Meiyan QIU Bing QING +1 位作者 Wen ZHONG Jiangcun WEI 《Medicinal Plant》 CAS 2023年第4期106-108,共3页
This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a m... This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a more detailed theoretical basis for its further clinical research and development. 展开更多
关键词 Epidemic Lung Preventive Mixture Preparation process Quality standard Cinnamomi Ramulus(Guizhi) atractylodis Rhizoma(Cangzhu).
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白术多糖的提取、纯化和活性研究 被引量:7
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作者 郭志欣 梁中焕 +1 位作者 娄丽秋 张丽萍 《安徽农业科学》 CAS 2012年第24期12011-12013,共3页
[目的]提取和纯化白术多糖,并探讨多糖中蛋白对小鼠脾淋巴细胞转化的影响。[方法]采用醇沉分级、脱蛋白和Sephadex G-75制备柱从中药白术中提取分离得到cPAM、zPAM和PAM 3种多糖,并对这3种多糖进行体外淋巴细胞转化试验。[结果]3种白术... [目的]提取和纯化白术多糖,并探讨多糖中蛋白对小鼠脾淋巴细胞转化的影响。[方法]采用醇沉分级、脱蛋白和Sephadex G-75制备柱从中药白术中提取分离得到cPAM、zPAM和PAM 3种多糖,并对这3种多糖进行体外淋巴细胞转化试验。[结果]3种白术多糖对ConA诱导的T淋巴细胞增殖均有促进作用;浓度为5μg/ml的zPAM对小鼠脾淋巴细胞增殖有明显的促进作用;浓度为5和10μg/ml的PAM对小鼠脾淋巴细胞增殖有明显的促进作用。[结论]白术多糖的纯化程度与脾淋巴细胞增殖有一定关系;纯化程度高的多糖对小鼠脾淋巴细胞的增殖有促进作用;白术粗多糖中的蛋白对小鼠脾淋巴细胞的增殖没有影响。 展开更多
关键词 白术(RHIZOMA atractylodis MACROCEPHALAE) 多糖 纯化 淋巴细胞转化
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安徽省白术资源及其开发对策 被引量:5
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作者 王宁 《安徽农业科学》 CAS 2012年第14期8157-8158,共2页
研究认为文献记载的古代质量最好的白术应是安徽潜山产的"舒州白术"和"徽州白术",其与浙江的"杭州术"、"越州术"质量相似,均为上品。目前安徽产的"舒州白术"和"徽州白术"... 研究认为文献记载的古代质量最好的白术应是安徽潜山产的"舒州白术"和"徽州白术",其与浙江的"杭州术"、"越州术"质量相似,均为上品。目前安徽产的"舒州白术"和"徽州白术"只有零星野生分布。亳州有较大面积的白术栽培,但名气没有浙江产的白术名气大;白术指纹图谱研究和化学成分研究显示,徽州产白术和浙江产白术的质量相似,而亳州产白术质量略差。需要加强安徽产白术的对外宣传和"舒州白术"种质资源的保护,并提高亳州地区栽培白术的质量,以发掘安徽道地药材,发展安徽经济。 展开更多
关键词 白术(RHIZOMA atractylodis MACROCEPHALAE) 资源 种质 开发研究
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