Brain ischemic stroke is the leading cause of long-lasting injury,disability,and death in adults.Although the brain represents only about 2%of the total body mass,it consumes almost 20%of the body＇s oxygen.As a resul...Brain ischemic stroke is the leading cause of long-lasting injury,disability,and death in adults.Although the brain represents only about 2%of the total body mass,it consumes almost 20%of the body＇s oxygen.As a result,brain cells are extremely sensitive to hypoxia.Once cerebral ischemia occurs.展开更多
BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the eff...BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B (CHB). METHODS: Patients with CHB receiving enticavir for initial antiviral therapy were studied; they were divided into the high CAP group and normal CAP group at baseline according to the CAP values. The effect of the antiviral therapy between the two groups were compared at week 12, 24 and 48. Patients with high CAP value at baseline were divided into three subgroups, mild, moderate and severe elevation; the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP. RESULTS: A total of 153 patients were enrolled. Among them, 63 were in the high CAP group and 90 in the normal CAP group. Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12, 24 and 48. Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24; while the difference was not significant between the patients with normal CAP and those with severely elevated CAP. The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12, 24 and 48. CONCLUSION: CHB patients with high CAP had poor response to antiviral therapy.展开更多
The present drinking water purification system in Egypt uses surface water as a raw water supply without a preliminary filtration process.On the other hand,chlorine gas is added as a disinfectant agent in two steps,pr...The present drinking water purification system in Egypt uses surface water as a raw water supply without a preliminary filtration process.On the other hand,chlorine gas is added as a disinfectant agent in two steps,pre-and post-chlorination.Due to these reasons most of water treatment plants suffer low filtering effectiveness and produce the trihalomethane(THM) species as a chlorination by-product.The Ismailia Canal represents the most distal downstream of the main Nile River.Thus its water contains all the proceeded pollutants discharged into the Nile.In addition,the downstream reaches of the canal act as an agricultural drain during the closing period of the High Dam gates in January and February every year.Moreover,the wide industrial zone along the upstream course of the canal enriches the canal water with high concentrations of heavy metals.The obtained results indicate that the canal gains up to 24.06×106 m3 of water from the surrounding shallow aquifer during the closing period of the High Dam gates,while during the rest of the year,the canal acts as an influent stream losing about 99.6×106 m3 of its water budget.The reduction of total organic carbon(TOC) and suspended particulate matters(SPMs) should be one of the central goals of any treatment plan to avoid the disinfectants by-products.The combination of sedimentation basins,gravel pre-filtration and slow sand filtration,and underground passage with microbiological oxidation-reduction and adsorption criteria showed good removal of parasites and bacteria and complete elimination of TOC,SPM and heavy metals.Moreover,it reduces the use of disinfectants chemicals and lowers the treatment costs.However,this purification system under the arid climate prevailing in Egypt should be tested and modified prior to application.展开更多
文摘Brain ischemic stroke is the leading cause of long-lasting injury,disability,and death in adults.Although the brain represents only about 2%of the total body mass,it consumes almost 20%of the body＇s oxygen.As a result,brain cells are extremely sensitive to hypoxia.Once cerebral ischemia occurs.
基金supported by grants from the National Science and Technology Major Project of China(2012ZX10002007-001-003 and 2013ZX10002005-002-003)the WBE Liver Fibrosis Foundation(XJS20120204)
文摘BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B (CHB). METHODS: Patients with CHB receiving enticavir for initial antiviral therapy were studied; they were divided into the high CAP group and normal CAP group at baseline according to the CAP values. The effect of the antiviral therapy between the two groups were compared at week 12, 24 and 48. Patients with high CAP value at baseline were divided into three subgroups, mild, moderate and severe elevation; the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP. RESULTS: A total of 153 patients were enrolled. Among them, 63 were in the high CAP group and 90 in the normal CAP group. Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12, 24 and 48. Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24; while the difference was not significant between the patients with normal CAP and those with severely elevated CAP. The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12, 24 and 48. CONCLUSION: CHB patients with high CAP had poor response to antiviral therapy.
基金Project supported by the German Academic Exchange Services(Deutcher Akademischer Austausch Dienst (DAAD)
文摘The present drinking water purification system in Egypt uses surface water as a raw water supply without a preliminary filtration process.On the other hand,chlorine gas is added as a disinfectant agent in two steps,pre-and post-chlorination.Due to these reasons most of water treatment plants suffer low filtering effectiveness and produce the trihalomethane(THM) species as a chlorination by-product.The Ismailia Canal represents the most distal downstream of the main Nile River.Thus its water contains all the proceeded pollutants discharged into the Nile.In addition,the downstream reaches of the canal act as an agricultural drain during the closing period of the High Dam gates in January and February every year.Moreover,the wide industrial zone along the upstream course of the canal enriches the canal water with high concentrations of heavy metals.The obtained results indicate that the canal gains up to 24.06×106 m3 of water from the surrounding shallow aquifer during the closing period of the High Dam gates,while during the rest of the year,the canal acts as an influent stream losing about 99.6×106 m3 of its water budget.The reduction of total organic carbon(TOC) and suspended particulate matters(SPMs) should be one of the central goals of any treatment plan to avoid the disinfectants by-products.The combination of sedimentation basins,gravel pre-filtration and slow sand filtration,and underground passage with microbiological oxidation-reduction and adsorption criteria showed good removal of parasites and bacteria and complete elimination of TOC,SPM and heavy metals.Moreover,it reduces the use of disinfectants chemicals and lowers the treatment costs.However,this purification system under the arid climate prevailing in Egypt should be tested and modified prior to application.
