The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice we...The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice werecomposed of 6 waves,waves Ⅰ to Ⅵ.The mean threshold was 35.12±8.03 dB ,whichwas significantly different from the 22.63 dB of ABR found in guinea pigs.Thelatency of ABR waves Ⅰ to Ⅵizn the mice was found to be 1.30±8.03 ms ;2.02±0.24ms ;2.90±0.27 ms ;3.80±0.24 ms ;4.87±0.42 ms and 5.83±0.40 ms respectively.Nosex or strain differences were found.The MLR waveform of the mice were similar tothose of human and the latency was found to be P0 3.94±1.76 ms;P8.38±1.57ms;Na 14.98±2.54 ms;Pa 24.56±3.15 ms rcspectively.It is suggested that mice can beused for hearing research.Since the Na and Pa waves of MLR were unstable under anes-thesia,testing conditions for determining MLR in mice need further study.展开更多
Objective To explore the effect of acupuncture at ＂Jing Jiaji＂ （颈夹背） on sudden hearing loss by observing the changes of the threshold of auditory brainstem response （ABR） of deaf guinea pigs. Methods Sixty he...Objective To explore the effect of acupuncture at ＂Jing Jiaji＂ （颈夹背） on sudden hearing loss by observing the changes of the threshold of auditory brainstem response （ABR） of deaf guinea pigs. Methods Sixty healthy guinea pigs were selected, with computer randomization, 20 were randomly divided into a normal control group （group A）, while the rest were randomly and equally divided into a model group （group B） and an acupuncture group （group C） when turned deaf after gentamycin sulfate and furosemide were administered. No treatment was administered for either the group A or the group B, while acupuncture at ＂Jing Jiaji＂ was given for the group C for 30 days. The ABR thresholds of each group were observed and recorded separately after the treatment for 15 days and 30 days. Results The ABR threshold in the group C was lower than that in the group B after the treatment of 15 days （P〈O.05）. After the treatment of 30 days, the ABR threshold in the group C was obviously lower than that in the group B （P〈0.01）, and was obviously lower than that before acupuncture （P〈0.01）. Conclusion Acupuncture at ＂Jing Jiaji＂ has definite effect on improving the hearing of deaf guinea pigs.展开更多
目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特...目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特点。方法回顾性研究22例（42耳）极重度听力损失的大前庭水管综合征（LVAS）婴幼儿，另选择28例（56耳）极重度听力损失的非LVAS的感音神经性耳聋婴幼儿作为对照组，研究其ABR及ASSR相关性。结果①LVAS婴幼儿组ABR测试中，36耳（85．7％）记录到AsNR，在109．6 dB nHL刺激强度引出的ASNR平均潜伏期在3．04±0．22msT对照组中婴幼儿无一例记录到ASNR。②LVAS婴幼儿组ASSRNI]试在250、500和1000Hz引出率明显高于对照组，两组间差异有统计学意义（P〈0．01）。结论相比于普通的极重度感音神经性耳聋患儿，极重度听损LVAS患儿进行听力学检查时，ABR容易出现ASNR负向波，ASSR测试结果显示较高的中低频的电位反应引出率，此结果可用于临床辅助诊断大前庭水管综合征。展开更多
文摘The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice werecomposed of 6 waves,waves Ⅰ to Ⅵ.The mean threshold was 35.12±8.03 dB ,whichwas significantly different from the 22.63 dB of ABR found in guinea pigs.Thelatency of ABR waves Ⅰ to Ⅵizn the mice was found to be 1.30±8.03 ms ;2.02±0.24ms ;2.90±0.27 ms ;3.80±0.24 ms ;4.87±0.42 ms and 5.83±0.40 ms respectively.Nosex or strain differences were found.The MLR waveform of the mice were similar tothose of human and the latency was found to be P0 3.94±1.76 ms;P8.38±1.57ms;Na 14.98±2.54 ms;Pa 24.56±3.15 ms rcspectively.It is suggested that mice can beused for hearing research.Since the Na and Pa waves of MLR were unstable under anes-thesia,testing conditions for determining MLR in mice need further study.
基金Supported by Yanbian University on Scientific Development and Application:No.36,yanda kehe zi[2013]
文摘Objective To explore the effect of acupuncture at ＂Jing Jiaji＂ （颈夹背） on sudden hearing loss by observing the changes of the threshold of auditory brainstem response （ABR） of deaf guinea pigs. Methods Sixty healthy guinea pigs were selected, with computer randomization, 20 were randomly divided into a normal control group （group A）, while the rest were randomly and equally divided into a model group （group B） and an acupuncture group （group C） when turned deaf after gentamycin sulfate and furosemide were administered. No treatment was administered for either the group A or the group B, while acupuncture at ＂Jing Jiaji＂ was given for the group C for 30 days. The ABR thresholds of each group were observed and recorded separately after the treatment for 15 days and 30 days. Results The ABR threshold in the group C was lower than that in the group B after the treatment of 15 days （P〈O.05）. After the treatment of 30 days, the ABR threshold in the group C was obviously lower than that in the group B （P〈0.01）, and was obviously lower than that before acupuncture （P〈0.01）. Conclusion Acupuncture at ＂Jing Jiaji＂ has definite effect on improving the hearing of deaf guinea pigs.
文摘目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特点。方法回顾性研究22例（42耳）极重度听力损失的大前庭水管综合征（LVAS）婴幼儿，另选择28例（56耳）极重度听力损失的非LVAS的感音神经性耳聋婴幼儿作为对照组，研究其ABR及ASSR相关性。结果①LVAS婴幼儿组ABR测试中，36耳（85．7％）记录到AsNR，在109．6 dB nHL刺激强度引出的ASNR平均潜伏期在3．04±0．22msT对照组中婴幼儿无一例记录到ASNR。②LVAS婴幼儿组ASSRNI]试在250、500和1000Hz引出率明显高于对照组，两组间差异有统计学意义（P〈0．01）。结论相比于普通的极重度感音神经性耳聋患儿，极重度听损LVAS患儿进行听力学检查时，ABR容易出现ASNR负向波，ASSR测试结果显示较高的中低频的电位反应引出率，此结果可用于临床辅助诊断大前庭水管综合征。
