Objective To investigate the variation of auditory evoked potential P50 in first-episode schizo- phrenia. Methods P50 was recorded from 66 schizophrenics and 92 normal controls with American Brova instrument, and asse...Objective To investigate the variation of auditory evoked potential P50 in first-episode schizo- phrenia. Methods P50 was recorded from 66 schizophrenics and 92 normal controls with American Brova instrument, and assessing their psychotic symptoms with PANSS. Results Compared with NC, schizophrenics showed sensory gating deficit, reflecting by increased S2/S1 ratio (NC: 42±21% , Sch:81±40% ,P <0. 01). No significant correlation was found between PANSS score and the three markers for assessing the sensory gating, such as the S2/S1 ratio, S2-S1, and 100 (1 -S2/S1) (P > 0. 05). Schizophrenics showed no differences with P50 markers between the 5 weeks and 12 weeks of treatment. Conclusion P50 might be biological trait marker of schizophrenia.展开更多
Objective: Patients with Chronic Low Back Pain (CLBP) show arousal, attentiona l and cognitive disturbances. The sleep state dependent P50 midlatency auditory evoked potential was used to determine if patients with CL...Objective: Patients with Chronic Low Back Pain (CLBP) show arousal, attentiona l and cognitive disturbances. The sleep state dependent P50 midlatency auditory evoked potential was used to determine if patients with CLBP [with and without c o-morbid depression (DEP)] show quantitative disturbances in the manifestation of the P50 potential. Methods: P50 potential latency,amplitude and habituation t o repetitive stimuli at 250,500and 1000 ms interstimulus intervals (ISIs) was re corded, along with the McGill Pain Questionnaire-Short Form (MPQ-SF).CLBP subj ects (n=42) were compared with Controls (n=43), and with subjects with DEP only (n=6). Of the CLBP subjects, 20/42 had clinical depression (CLBP+DEP); 8/20 wer e taking anti-depressant medication (CLBP+DEP+med), the others were not (CLBP +DEP-med). Results: There were no differences (ANOVA) in age, sex or P50 poten tial latency, although there was a trend towards increased latencies in CLBP gro ups. P50 potential amplitude was lower in CLBP groups, but not in sub-groups, a gain indicating a trend. P50 potential habituation was decreased in the DEP only subjects at the 250 m ISI, and decreased in CLBP+DEPmed subjects at the 500 ms ISI. This difference was not present in CLBP+DEP+med subjects. The MPQ-SF re vealed that patients with CLBP and CLBP+DEP-med showed lower pain scores than CLBP+DEP+med patients. Conclusions: There is decreased habituation of the P50 potential habituation in unmedicated patients with CLBP+DEP compared to C ontrols.Significance: Patients with CLBP+DEP-med may be less able to disregard incoming sensory information, including painful sensations, but anti-depressan t medications help correct this deficit. However, their perception of pain may b e increased by medication.展开更多
The aim of this research was to investigate the variations of P50 auditory sensory gating(P50)in normal healthy adults and the first onset schizophrenics.By using the American Nicolet Bravo electromyography/evoked pot...The aim of this research was to investigate the variations of P50 auditory sensory gating(P50)in normal healthy adults and the first onset schizophrenics.By using the American Nicolet Bravo electromyography/evoked potential(EMG/EP)system,P50 was measured with conditioning-testing paradigm(paired-click stimuli S1 and S2 were used)in 58 first onset schizophrenics and 108 healthy adults,and the Positive and Negative Syndrome Scale(PANSS)was applied.The following three conclusions have been reached.(1)In normal control(NC)group,measured from central,anterior and posterior zone(Cz,Fz and Pz respectively),there were no statistical differences(P>0.05)between S1 and S2 evoked P50 peak latencies(S1-P50 and S2-P50);the ampli-tudes of S2-P50[(2.2P1.4),(2.3P1.5)and(2.1P1.4)μV respectively]reduced significantly as compared with S1-P50[(5.6P3.3),(5.6P3.9)and(4.9P2.8)μV respectively](P<0.01);the S2/S1 ration,S1-S2 difference,and 100(1-S2/S1)had no statistical differences(P>0.05).(2)Compared with NC,the schizophrenic group significantly showed lower S1-P50 amplitudes(P<0.01,except at Pz in whichZ=2.030,P=0.042),higher S2-P50 amplitudes,higher S2/S1 ratio,lower S1-S2 difference,and more decreased 100(1-S2/S1)(P<0.01)at Cz,Fz and Pz.(3)No significant correlations were found among S2/S1 ratio,S1-S2,100(1-S2/S1)of sen-sory gating and PANSS(P>0.05)in schizophrenic group.The first onset schizophrenics had sensory gating deficits,which could be quantified by P50.展开更多
基金Supported by the National Nature Science Foundation of China (30470626)
文摘Objective To investigate the variation of auditory evoked potential P50 in first-episode schizo- phrenia. Methods P50 was recorded from 66 schizophrenics and 92 normal controls with American Brova instrument, and assessing their psychotic symptoms with PANSS. Results Compared with NC, schizophrenics showed sensory gating deficit, reflecting by increased S2/S1 ratio (NC: 42±21% , Sch:81±40% ,P <0. 01). No significant correlation was found between PANSS score and the three markers for assessing the sensory gating, such as the S2/S1 ratio, S2-S1, and 100 (1 -S2/S1) (P > 0. 05). Schizophrenics showed no differences with P50 markers between the 5 weeks and 12 weeks of treatment. Conclusion P50 might be biological trait marker of schizophrenia.
文摘Objective: Patients with Chronic Low Back Pain (CLBP) show arousal, attentiona l and cognitive disturbances. The sleep state dependent P50 midlatency auditory evoked potential was used to determine if patients with CLBP [with and without c o-morbid depression (DEP)] show quantitative disturbances in the manifestation of the P50 potential. Methods: P50 potential latency,amplitude and habituation t o repetitive stimuli at 250,500and 1000 ms interstimulus intervals (ISIs) was re corded, along with the McGill Pain Questionnaire-Short Form (MPQ-SF).CLBP subj ects (n=42) were compared with Controls (n=43), and with subjects with DEP only (n=6). Of the CLBP subjects, 20/42 had clinical depression (CLBP+DEP); 8/20 wer e taking anti-depressant medication (CLBP+DEP+med), the others were not (CLBP +DEP-med). Results: There were no differences (ANOVA) in age, sex or P50 poten tial latency, although there was a trend towards increased latencies in CLBP gro ups. P50 potential amplitude was lower in CLBP groups, but not in sub-groups, a gain indicating a trend. P50 potential habituation was decreased in the DEP only subjects at the 250 m ISI, and decreased in CLBP+DEPmed subjects at the 500 ms ISI. This difference was not present in CLBP+DEP+med subjects. The MPQ-SF re vealed that patients with CLBP and CLBP+DEP-med showed lower pain scores than CLBP+DEP+med patients. Conclusions: There is decreased habituation of the P50 potential habituation in unmedicated patients with CLBP+DEP compared to C ontrols.Significance: Patients with CLBP+DEP-med may be less able to disregard incoming sensory information, including painful sensations, but anti-depressan t medications help correct this deficit. However, their perception of pain may b e increased by medication.
基金supported by the National Natural Science Foundation of China(Grant No.0470626).
文摘The aim of this research was to investigate the variations of P50 auditory sensory gating(P50)in normal healthy adults and the first onset schizophrenics.By using the American Nicolet Bravo electromyography/evoked potential(EMG/EP)system,P50 was measured with conditioning-testing paradigm(paired-click stimuli S1 and S2 were used)in 58 first onset schizophrenics and 108 healthy adults,and the Positive and Negative Syndrome Scale(PANSS)was applied.The following three conclusions have been reached.(1)In normal control(NC)group,measured from central,anterior and posterior zone(Cz,Fz and Pz respectively),there were no statistical differences(P>0.05)between S1 and S2 evoked P50 peak latencies(S1-P50 and S2-P50);the ampli-tudes of S2-P50[(2.2P1.4),(2.3P1.5)and(2.1P1.4)μV respectively]reduced significantly as compared with S1-P50[(5.6P3.3),(5.6P3.9)and(4.9P2.8)μV respectively](P<0.01);the S2/S1 ration,S1-S2 difference,and 100(1-S2/S1)had no statistical differences(P>0.05).(2)Compared with NC,the schizophrenic group significantly showed lower S1-P50 amplitudes(P<0.01,except at Pz in whichZ=2.030,P=0.042),higher S2-P50 amplitudes,higher S2/S1 ratio,lower S1-S2 difference,and more decreased 100(1-S2/S1)(P<0.01)at Cz,Fz and Pz.(3)No significant correlations were found among S2/S1 ratio,S1-S2,100(1-S2/S1)of sen-sory gating and PANSS(P>0.05)in schizophrenic group.The first onset schizophrenics had sensory gating deficits,which could be quantified by P50.
