Not only a bad guy:potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain

The receptor for advanced glycation endproducts（RAGE）is a receptor of the immunoglobulin superfamily of cell surface molecules which plays important contributions under both physiological and pathological conditions.Over the years extensive research work supported the detrimental role of RAGE in Alzheimer’s disease（AD）pathophysiology,ranging from its involvement in beta amyloid（Aβ）brain influx and clearance,

五轴联动数控激光加工系统的空间曲线B样条插补算法研究

五轴联动计算机数控激光加工系统是多功能综合性的机电一体化设备 ,可进行平面和三维曲面的切割、焊接等激光加工。传统的CNC系统往往只提供直线和圆弧插补功能 ,不能满足CAD系统的曲线和曲面造型能力对CAM系统的要求。本论文针对复杂轮廓零件数控加工的需要 ,提出了一种新的空间曲线B样条插补五轴联动算法 。