Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1（ApoB/ApoA-1） ratio on the incidence of ischemic stroke（IS） or coronary heart disease（CHD） in a...Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1（ApoB/ApoA-1） ratio on the incidence of ischemic stroke（IS） or coronary heart disease（CHD） in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein（CRP） level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios（HRs） and 95% confidence intervals（CIs） for the IS and CHD events in all the subgroups.Results The HRs（95% CI） for IS and CHD were 1.33（0.84-2.12）,1.14（0.69-1.88）,and 1.91（1.17-3.11） in the ‘low CRP level with high ApoB/ApoA-1＇,‘high CRP level with low ApoB/ApoA-1＇,and ‘high CRP level with high ApoB/ApoA-1＇ subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1＇ subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1＇ subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.展开更多
目的:探究C反应蛋白/白蛋白比值(C-reactive protein-to-albumin ratio,CAR)在弥漫大B细胞淋巴瘤(diffuse large Bcell lymphoma,DLBCL)中的预后价值。方法:回顾性分析南京医科大学第一附属医院2009年12月-2018年12月收治的初诊DLBCL患...目的:探究C反应蛋白/白蛋白比值(C-reactive protein-to-albumin ratio,CAR)在弥漫大B细胞淋巴瘤(diffuse large Bcell lymphoma,DLBCL)中的预后价值。方法:回顾性分析南京医科大学第一附属医院2009年12月-2018年12月收治的初诊DLBCL患者的临床资料。使用Kaplan-Meier方法分析影响无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)的因素,使用Cox比例风险回归模型进行单变量及多变量分析。结果:314例患者纳入分析,截至2019年6月,中位随访50个月,中位PFS和OS均未达到。生存分析显示CAR增高具有更差的PFS和OS(P均<0.001),且CAR是影响PFS(P=0.006)及OS(P=0.009)的独立预后因素。此外,将CAR与美国国家综合癌症网络国际预后指数(National Comprehensive Cancer Network International Prognostic Index,NCCN-IPI)结合后对DLBCL的PFS和OS的预测和判别能力优于NCCN-IPI(P=0.010和P=0.002)。结论:CAR为简单易行的参数,可作为预测DLBCL临床预后的良好指标。展开更多
Aims: Small dense LDL (sdLDL) cholesterol is considered a cardiovascular risk. Our purpose in this study was to evaluate the efficacy of rosuvastatin in reducing sdLDL and large buoyant LDL (lbLDL-C) in hypercholester...Aims: Small dense LDL (sdLDL) cholesterol is considered a cardiovascular risk. Our purpose in this study was to evaluate the efficacy of rosuvastatin in reducing sdLDL and large buoyant LDL (lbLDL-C) in hypercholesterolemia. Methods: Fifty-six patients with a mean baseline LDL-cholesterol (LDL-C) concentration of 173.9 ± 40.5 mg/dL were treated with rosuvastatin 2.5 mg/day for 12 weeks. LDL-C, sdLDL-C, and apolipoprotein (apo) B were assessed and l lbLDL-C was calculated (LDL-C minus sdLDL-C). Results: After 12-week treatment with rosuvastatin 2.5mg, sdLDL-C and lbLDL-C were significantly reduced from 62.1 ± 23.8 mg/dL to 34.0 ± 13.4 mg/dL, p <0.001 and 112.7 ± 34.9 mg/dL to 77.2± 29.2 mg/dL, p < 0.001 respectively, and sdLDL-C/lbLDL-C ratio and apo B also decreased significantly, from 0.36 ± 0.02 to 0.32 ± 0.02, p < 0.005 and 134.2 ± 4.3 to 93.6 ± 3.5 mg/dl, p < 0.001, respectively. In diabetic subjects there was significant correlation between percent reductions in the plasma triglyceride and sdLDL-C/ lbLDL-C ratio (r = 0.58, p < 0.005), but not between the percentage decrease in plasma triglyceride and sdLDL-C. Conclusions: Treatment with rosuvastatin is associated with significant reduction in sdLDL, lbLDL and sdLDL/lbLDL ratio.展开更多
Boron nuclei in cosmic rays(CRs)are believed to be mainly produced by the fragmentation of heavier nuclei,such as carbon and oxygen,via collisions with the interstellar matter.Therefore,the boron-tocarbon flux ratio(B...Boron nuclei in cosmic rays(CRs)are believed to be mainly produced by the fragmentation of heavier nuclei,such as carbon and oxygen,via collisions with the interstellar matter.Therefore,the boron-tocarbon flux ratio(B/C)and the boron-to-oxygen flux ratio(B/O)are very essential probes of the CR propagation.The energy dependence of the B/C ratio from previous balloon-borne and space-based experiments can be well described by a single power-law up to about 1 TeV/n within uncertainties.This work reports direct measurements of B/C and B/O in the energy range from 10 Ge V/n to 5.6 TeV/n with 6 years of data collected by the Dark Matter Particle Explorer,with high statistics and well controlled systematic uncertainties.The energy dependence of both the B/C and B/O ratios can be well fitted by a broken power-law model rather than a single power-law model,suggesting the existence in both flux ratios of a spectral hardening at about 100 Ge V/n.The significance of the break is about 5.6σand 6.9σfor the GEANT4 simulation,and 4.4σand 6.9σfor the alternative FLUKA simulation,for B/C and B/O,respectively.These results deviate from the predictions of conventional turbulence theories of the interstellar medium(ISM),which point toward a change of turbulence properties of the ISM at different scales or novel propagation effects of CRs,and should be properly incorporated in the indirect detection of dark matter via anti-matter particles.展开更多
Chemical vapor deposition is an important method for the preparation of boron carbide.Knowledge of the correlation between the phase composition of the deposit and the deposition conditions (temperature,inlet gas comp...Chemical vapor deposition is an important method for the preparation of boron carbide.Knowledge of the correlation between the phase composition of the deposit and the deposition conditions (temperature,inlet gas composition,total pressure,reactor configuration,and total flow rate) has not been completely determined.In this work,a novel approach to identify the kinetic mechanisms for the deposit composition is presented.Machine leaning (ML) and computational fluid dynamic (CFD) techniques are utilized to identify core factors that influence the deposit composition.It has been shown that ML,combined with CFD,can reduce the prediction error from about 25% to 7%,compared with the ML approach alone.The sensitivity coefficient study shows that BHCl_(2 )and BCl_(3) produce the most boron atoms,while C_(2)H_(4) and CH_(4) are the main sources of carbon atoms.The new approach can accurately predict the deposited boron-carbon ratio and provide a new design solution for other multi-element systems.展开更多
基金supported by the National Natural Science Foundation of China(grant Nos.30972531 and 81320108026)a project of the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1（ApoB/ApoA-1） ratio on the incidence of ischemic stroke（IS） or coronary heart disease（CHD） in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein（CRP） level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios（HRs） and 95% confidence intervals（CIs） for the IS and CHD events in all the subgroups.Results The HRs（95% CI） for IS and CHD were 1.33（0.84-2.12）,1.14（0.69-1.88）,and 1.91（1.17-3.11） in the ‘low CRP level with high ApoB/ApoA-1＇,‘high CRP level with low ApoB/ApoA-1＇,and ‘high CRP level with high ApoB/ApoA-1＇ subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1＇ subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1＇ subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.
文摘目的:探究C反应蛋白/白蛋白比值(C-reactive protein-to-albumin ratio,CAR)在弥漫大B细胞淋巴瘤(diffuse large Bcell lymphoma,DLBCL)中的预后价值。方法:回顾性分析南京医科大学第一附属医院2009年12月-2018年12月收治的初诊DLBCL患者的临床资料。使用Kaplan-Meier方法分析影响无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)的因素,使用Cox比例风险回归模型进行单变量及多变量分析。结果:314例患者纳入分析,截至2019年6月,中位随访50个月,中位PFS和OS均未达到。生存分析显示CAR增高具有更差的PFS和OS(P均<0.001),且CAR是影响PFS(P=0.006)及OS(P=0.009)的独立预后因素。此外,将CAR与美国国家综合癌症网络国际预后指数(National Comprehensive Cancer Network International Prognostic Index,NCCN-IPI)结合后对DLBCL的PFS和OS的预测和判别能力优于NCCN-IPI(P=0.010和P=0.002)。结论:CAR为简单易行的参数,可作为预测DLBCL临床预后的良好指标。
文摘Aims: Small dense LDL (sdLDL) cholesterol is considered a cardiovascular risk. Our purpose in this study was to evaluate the efficacy of rosuvastatin in reducing sdLDL and large buoyant LDL (lbLDL-C) in hypercholesterolemia. Methods: Fifty-six patients with a mean baseline LDL-cholesterol (LDL-C) concentration of 173.9 ± 40.5 mg/dL were treated with rosuvastatin 2.5 mg/day for 12 weeks. LDL-C, sdLDL-C, and apolipoprotein (apo) B were assessed and l lbLDL-C was calculated (LDL-C minus sdLDL-C). Results: After 12-week treatment with rosuvastatin 2.5mg, sdLDL-C and lbLDL-C were significantly reduced from 62.1 ± 23.8 mg/dL to 34.0 ± 13.4 mg/dL, p <0.001 and 112.7 ± 34.9 mg/dL to 77.2± 29.2 mg/dL, p < 0.001 respectively, and sdLDL-C/lbLDL-C ratio and apo B also decreased significantly, from 0.36 ± 0.02 to 0.32 ± 0.02, p < 0.005 and 134.2 ± 4.3 to 93.6 ± 3.5 mg/dl, p < 0.001, respectively. In diabetic subjects there was significant correlation between percent reductions in the plasma triglyceride and sdLDL-C/ lbLDL-C ratio (r = 0.58, p < 0.005), but not between the percentage decrease in plasma triglyceride and sdLDL-C. Conclusions: Treatment with rosuvastatin is associated with significant reduction in sdLDL, lbLDL and sdLDL/lbLDL ratio.
基金funded by the Strategic Priority Science and Technology Projects in Space Science of Chinese Academy of Sciences(CAS)supported by the National Natural Science Foundation of China(11921003,11903084,12003076,12022503,12103094,and 12220101003)+7 种基金the Strategic Priority Science and Technology Projects of CAS(XDA15051100)the CAS Project for Young Scientists in Basic Research(YSBR-061)the Youth Innovation Promotion Association of CASthe Natural Science Foundation of Jiangsu Province(BK20201107)the Program for Innovative Talents and Entrepreneur in Jiangsusupported by the Swiss National Science Foundation(SNSF),Switzerlandthe National Institute for Nuclear Physics(INFN),Italythe European Research Council(ERC)under the European Unions Horizon 2020 research and innovation programme(851103)。
文摘Boron nuclei in cosmic rays(CRs)are believed to be mainly produced by the fragmentation of heavier nuclei,such as carbon and oxygen,via collisions with the interstellar matter.Therefore,the boron-tocarbon flux ratio(B/C)and the boron-to-oxygen flux ratio(B/O)are very essential probes of the CR propagation.The energy dependence of the B/C ratio from previous balloon-borne and space-based experiments can be well described by a single power-law up to about 1 TeV/n within uncertainties.This work reports direct measurements of B/C and B/O in the energy range from 10 Ge V/n to 5.6 TeV/n with 6 years of data collected by the Dark Matter Particle Explorer,with high statistics and well controlled systematic uncertainties.The energy dependence of both the B/C and B/O ratios can be well fitted by a broken power-law model rather than a single power-law model,suggesting the existence in both flux ratios of a spectral hardening at about 100 Ge V/n.The significance of the break is about 5.6σand 6.9σfor the GEANT4 simulation,and 4.4σand 6.9σfor the alternative FLUKA simulation,for B/C and B/O,respectively.These results deviate from the predictions of conventional turbulence theories of the interstellar medium(ISM),which point toward a change of turbulence properties of the ISM at different scales or novel propagation effects of CRs,and should be properly incorporated in the indirect detection of dark matter via anti-matter particles.
基金the National Key R&D Program of China(Grant No.2017YFB0703200)National Natural Science Foundation of China(Grant Nos.51702100 and 51972268)China Postdoctoral Science Foundation(Grant No.2018M643075)for the financial support.
文摘Chemical vapor deposition is an important method for the preparation of boron carbide.Knowledge of the correlation between the phase composition of the deposit and the deposition conditions (temperature,inlet gas composition,total pressure,reactor configuration,and total flow rate) has not been completely determined.In this work,a novel approach to identify the kinetic mechanisms for the deposit composition is presented.Machine leaning (ML) and computational fluid dynamic (CFD) techniques are utilized to identify core factors that influence the deposit composition.It has been shown that ML,combined with CFD,can reduce the prediction error from about 25% to 7%,compared with the ML approach alone.The sensitivity coefficient study shows that BHCl_(2 )and BCl_(3) produce the most boron atoms,while C_(2)H_(4) and CH_(4) are the main sources of carbon atoms.The new approach can accurately predict the deposited boron-carbon ratio and provide a new design solution for other multi-element systems.
