The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms thatregulate the timing and frequency of DNA replication and cell division.The temporal and spatial expressionof the genes is tight...The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms thatregulate the timing and frequency of DNA replication and cell division.The temporal and spatial expressionof the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cellsduring the cycle.Although the genes involved in interphase are well studied,most of the genes which areinvolved in mitotic events still remain unidentified.Since,the discovery of mitosis related genes is stillincomplete,we performed a co-expression and gene ontology analysis for revealing novel mitosis regulatedgenes.In this study,we showed that C12orf48 is co-expressed with well-known mitotic genes.Moreover,it isalso co-expressed with the genes that have roles in interphase such as DNA replication.Furthermore,ourresults showed that C12orf48 is also differentially expressed in various cancers.Therefore,the results pre-sented in this study suggest that C12orf48 may be an important molecule for both interphase and mitosis.Since,the molecules involved in these mechanisms are crucial for proliferation as well as in carcinogenesis,C12orf48 should be considered as a novel cell cycle and carcinogenesis related gene.展开更多
文摘The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms thatregulate the timing and frequency of DNA replication and cell division.The temporal and spatial expressionof the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cellsduring the cycle.Although the genes involved in interphase are well studied,most of the genes which areinvolved in mitotic events still remain unidentified.Since,the discovery of mitosis related genes is stillincomplete,we performed a co-expression and gene ontology analysis for revealing novel mitosis regulatedgenes.In this study,we showed that C12orf48 is co-expressed with well-known mitotic genes.Moreover,it isalso co-expressed with the genes that have roles in interphase such as DNA replication.Furthermore,ourresults showed that C12orf48 is also differentially expressed in various cancers.Therefore,the results pre-sented in this study suggest that C12orf48 may be an important molecule for both interphase and mitosis.Since,the molecules involved in these mechanisms are crucial for proliferation as well as in carcinogenesis,C12orf48 should be considered as a novel cell cycle and carcinogenesis related gene.
