The purpose of this article is to determine the effect of a well-designed combined aerobic,resistance,and extension exercise program on bone mineral density(BMD)in postmenopausal women.The population comprised 45 post...The purpose of this article is to determine the effect of a well-designed combined aerobic,resistance,and extension exercise program on bone mineral density(BMD)in postmenopausal women.The population comprised 45 postmenopausal women,who exercised over 12 months(exercise group),and 36 women who served as a non-training control group.BMD of the hip,and lumbar spine was measured at the baseline and 12th month.Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls.Thirty-six out of 45 persons in the exercise group and 36 controls completed the study.Average compliance was 82.2%for the whole exercise group at the 12th month.All the subjects had decreased BMD,but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip.Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites,we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis.Further,the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.展开更多
BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant ...BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic effect.AIM To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent teeth.METHODS In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two groups.Changes in chewing function and language function were compared between the two groups of patients.Follow-up lasted for 12 mo after repair to observe any adverse reactions in the oral cavity.RESULTS The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group B.After treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions improved.The changes in various indicators in group A were more significant.After treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.展开更多
目的 探讨绝经女性患者骨密度(bone mineral density,BMD)对骨关节炎全膝关节置换术恢复情况的预测价值。方法 选取2019年4月至2021年12月湖州市第一人民医院收治的骨关节炎全膝关节置换术患者78例为研究对象,采用双能X线测量患者的BMD...目的 探讨绝经女性患者骨密度(bone mineral density,BMD)对骨关节炎全膝关节置换术恢复情况的预测价值。方法 选取2019年4月至2021年12月湖州市第一人民医院收治的骨关节炎全膝关节置换术患者78例为研究对象,采用双能X线测量患者的BMD水平,术后6个月采用美国膝关节协会评分(Keen Society score,KSS)对膝关节功能进行评估,根据KSS评分将患者分为恢复良好组(n=41)和恢复不良组(n=37);采用Logistic回归分析对患者术后膝关节功能恢复的影响因素进行评估;利用R软件建立预测列线图模型;绘制受试者操作特征曲线分析构建模型的预测效能。结果 术后6个月,非骨质疏松患者的KSS评分均显著高于骨质疏松患者(P<0.05)。两组患者的年龄、病程、绝经时间、BMD及体质量指数(body mass index,BMI)比较差异均有统计学意义(P<0.05)。多因素Logistic回归分析表明,年龄、BMI、病程、绝经时间及BMD均是影响骨关节炎全膝关节置换术后关节功能恢复的独立危险因素(P<0.05)。列线图构建关节功能恢复预测模型的曲线下面积为0.832 (95%CI:0.762~0.883),预测的敏感度与特异性较高。结论 绝经女性患者BMD对骨关节炎全膝关节置换术后关节功能恢复产生影响,建立的列线图对判断预后具有较高应用价值。展开更多
目的目前,骨关节炎(osteoarthritis,OA)的动物模型多根据某一致病因素而设计,而OA是综合因素的临床过程。文中评价叠加法制作OA模型的可行性,探讨造模后膝关节骨密度(bone mineral density,BMD)改变及软骨基质金属蛋白酶-13(matrixmetal...目的目前,骨关节炎(osteoarthritis,OA)的动物模型多根据某一致病因素而设计,而OA是综合因素的临床过程。文中评价叠加法制作OA模型的可行性,探讨造模后膝关节骨密度(bone mineral density,BMD)改变及软骨基质金属蛋白酶-13(matrixmetalloproteinase,MMP-13)的表达。方法实验组30只兔行结扎股静脉并切断腓肠肌内外侧头造模,术后4、8、12周测量膝关节4个目的区(ROI)BMD后处死动物。对照组10只12周处死。取胫骨髁关节软骨作组织学、免疫组化定量分析。结果造模后4周可见软骨面粗糙。8周有滑膜增生,软骨面纤维化、糜烂,簇聚肥大软骨细胞。12周出现软骨面剥脱,骨质裸露,骨赘形成等。造模后4周R2和R3区BMD增高,R4区于8周BMD下降。4周时软骨MMP-13平均光密度(average optical density,AOD)升高是对照组的4倍,后迅速下降,12周仍较对照组高。结论叠加法制作OA模型,效果确实,简单易行。造模后不同目的区BMD有改变,关节不稳、应力改变是其主要原因。MMP-13早期明显升高,提示MMP-13可能主要在OA早期起作用。展开更多
基金supported by the Science Foundation of Hubei Provincial Department of Education(No.D20081403).
文摘The purpose of this article is to determine the effect of a well-designed combined aerobic,resistance,and extension exercise program on bone mineral density(BMD)in postmenopausal women.The population comprised 45 postmenopausal women,who exercised over 12 months(exercise group),and 36 women who served as a non-training control group.BMD of the hip,and lumbar spine was measured at the baseline and 12th month.Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls.Thirty-six out of 45 persons in the exercise group and 36 controls completed the study.Average compliance was 82.2%for the whole exercise group at the 12th month.All the subjects had decreased BMD,but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip.Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites,we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis.Further,the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.
基金the Review Committee of General Hospital of Central Theater Command(Approval No.05901).
文摘BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic effect.AIM To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent teeth.METHODS In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two groups.Changes in chewing function and language function were compared between the two groups of patients.Follow-up lasted for 12 mo after repair to observe any adverse reactions in the oral cavity.RESULTS The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group B.After treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions improved.The changes in various indicators in group A were more significant.After treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.
文摘目的 探讨绝经女性患者骨密度(bone mineral density,BMD)对骨关节炎全膝关节置换术恢复情况的预测价值。方法 选取2019年4月至2021年12月湖州市第一人民医院收治的骨关节炎全膝关节置换术患者78例为研究对象,采用双能X线测量患者的BMD水平,术后6个月采用美国膝关节协会评分(Keen Society score,KSS)对膝关节功能进行评估,根据KSS评分将患者分为恢复良好组(n=41)和恢复不良组(n=37);采用Logistic回归分析对患者术后膝关节功能恢复的影响因素进行评估;利用R软件建立预测列线图模型;绘制受试者操作特征曲线分析构建模型的预测效能。结果 术后6个月,非骨质疏松患者的KSS评分均显著高于骨质疏松患者(P<0.05)。两组患者的年龄、病程、绝经时间、BMD及体质量指数(body mass index,BMI)比较差异均有统计学意义(P<0.05)。多因素Logistic回归分析表明,年龄、BMI、病程、绝经时间及BMD均是影响骨关节炎全膝关节置换术后关节功能恢复的独立危险因素(P<0.05)。列线图构建关节功能恢复预测模型的曲线下面积为0.832 (95%CI:0.762~0.883),预测的敏感度与特异性较高。结论 绝经女性患者BMD对骨关节炎全膝关节置换术后关节功能恢复产生影响,建立的列线图对判断预后具有较高应用价值。
文摘目的目前,骨关节炎(osteoarthritis,OA)的动物模型多根据某一致病因素而设计,而OA是综合因素的临床过程。文中评价叠加法制作OA模型的可行性,探讨造模后膝关节骨密度(bone mineral density,BMD)改变及软骨基质金属蛋白酶-13(matrixmetalloproteinase,MMP-13)的表达。方法实验组30只兔行结扎股静脉并切断腓肠肌内外侧头造模,术后4、8、12周测量膝关节4个目的区(ROI)BMD后处死动物。对照组10只12周处死。取胫骨髁关节软骨作组织学、免疫组化定量分析。结果造模后4周可见软骨面粗糙。8周有滑膜增生,软骨面纤维化、糜烂,簇聚肥大软骨细胞。12周出现软骨面剥脱,骨质裸露,骨赘形成等。造模后4周R2和R3区BMD增高,R4区于8周BMD下降。4周时软骨MMP-13平均光密度(average optical density,AOD)升高是对照组的4倍,后迅速下降,12周仍较对照组高。结论叠加法制作OA模型,效果确实,简单易行。造模后不同目的区BMD有改变,关节不稳、应力改变是其主要原因。MMP-13早期明显升高,提示MMP-13可能主要在OA早期起作用。
