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The Spine of the Ancient Capital, the Backbone of Development, and the Pillar of Conservation An Analysis of the Cultural Value and Future Development of Beijing Central Axis as a World Cultural Heritage Site
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作者 Wu Liyun Chen Hong 《China & The World Cultural Exchange》 2024年第9期16-25,共10页
Beijing Central Axis is the backbone of the ancient capital,a cultural spine shaped by the passage of time and spatial changes.Its successful inscription as a World Heritage site presents new opportunities for the con... Beijing Central Axis is the backbone of the ancient capital,a cultural spine shaped by the passage of time and spatial changes.Its successful inscription as a World Heritage site presents new opportunities for the conservation of the Central Axis cultural heritage,while also offering a fresh chance to link cultural and tourism sites along the Axis,fostering coordinated development. 展开更多
关键词 backbone offering PASSAGE
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基于Backbone的极值进化算法
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作者 高永超 刘丽梅 +1 位作者 李歧强 王云争 《计算机工程与应用》 CSCD 北大核心 2008年第24期36-39,49,共5页
由于变量的适应度最优与问题的目标函数最优无法达到一致,从而利用极值过程原则的局部搜索算法对TSP问题效果不好,而通过改变变量的适应度,使其与目标函数相关,就能够提高个体解的搜索能力。比较参数取不同值时个体解搜索到的目标函数,... 由于变量的适应度最优与问题的目标函数最优无法达到一致,从而利用极值过程原则的局部搜索算法对TSP问题效果不好,而通过改变变量的适应度,使其与目标函数相关,就能够提高个体解的搜索能力。比较参数取不同值时个体解搜索到的目标函数,可以发现存在使个体解搜索性能最佳的参数取值,且与变量的变异方式无关,这就为参数设置提供了依据。但个体解接近最优解后改善缓慢,无法快速到达最优解,为此引入组合优化问题解的Backbone概念,在种群进入最优解域后固定解中的相同部分,从而保留解中包含的最优解的信息,在减小问题规模后继续进行优化,增强搜索能力,提高搜索性能。 展开更多
关键词 backbone 极值过程 自组织临界模型 旅行商问题
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基于Backbone的空间收缩与划分算法
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作者 高永超 钱恒 +2 位作者 刘丽梅 王云争 王玎 《中国工程科学》 2009年第9期74-77,共4页
搜索空间的规模和复杂程度是决定问题求解难度的重要因素,而解空间的信息往往可以引导搜索找到最优解。在已知JSP空间结构的基础上,提出一种空间收缩与划分算法。算法利用搜索算法获得的较优解,结合组合优化问题解的backbone的概念,将... 搜索空间的规模和复杂程度是决定问题求解难度的重要因素,而解空间的信息往往可以引导搜索找到最优解。在已知JSP空间结构的基础上,提出一种空间收缩与划分算法。算法利用搜索算法获得的较优解,结合组合优化问题解的backbone的概念,将搜索空间收缩并划分为一个或多个优解域,在优解域内再进行小规模问题的优化。该算法不必在求解前或求解过程中进行大量的统计分析工作,可以利用求解信息对解空间的地形进行估计,提高求解速度和解的质量。实验结果也证明了算法的有效性。 展开更多
关键词 车间作业调度问题 解空间 backbone
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A Distributed Virtual Backbone Formation for Wireless Ad Hoc and Sensor Networks 被引量:2
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作者 曹涌涛 何晨 蒋铃鸽 《Journal of Shanghai Jiaotong university(Science)》 EI 2007年第1期23-28,34,共7页
The virtual backbone is an approach for solving routing problems in wireless ad hoc and sensor networks. A connected dominating set (CDS) was proposed as a virtual backbone to improve the performance of wireless netwo... The virtual backbone is an approach for solving routing problems in wireless ad hoc and sensor networks. A connected dominating set (CDS) was proposed as a virtual backbone to improve the performance of wireless networks. The quality of a virtual backbone is measured not only by approximation factor, which is the ratio of its size to that of minimum CDS, but also time complexity and message complexity. In this paper, a distributed algorithm is presented to construct a minimum CDS for ad hoc and sensor networks. By destroying triangular loops in the virtual backbone, the proposed algorithm can effectively construct a CDS with smaller size. Moreover, our algorithm, which is fully localized, has a constant approximation ratio, linear message and time complexity, and low implementation complexity. The simulation results and theoretical analysis show that our algorithm has better efficiency and performance than conventional approaches. 展开更多
关键词 virtual backbone connected dominating sets(CDS) wireless sensor networks
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A Study of Configuration Evolution of an Operational IP Backbone Network 被引量:1
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作者 Fuliang Li Jiahai Yang +3 位作者 Huijing Zhang Xingwei Wang Suogang Li Jianping Wu 《China Communications》 SCIE CSCD 2017年第6期88-97,共10页
Configuration errors are proved to be the main reasons for network interruption and anomalies.Many researchers have paid their attention to configuration analysis and provisioning,but few works focus on understanding ... Configuration errors are proved to be the main reasons for network interruption and anomalies.Many researchers have paid their attention to configuration analysis and provisioning,but few works focus on understanding the configuration evolution.In this paper,we uncover the configuration evolution of an operational IP backbone based on the weekly reports gathered from January 2006 to January 2013.We find that rate limiting and launching routes for new customers are configured most frequently.In addition,we conduct an analysis of network failures and find that link failures are the main causes for network failures.We suggest that we should configure redundant links for the links which are easy to break down.At last,according to the analysis results,we illustrate how to provide semi-automated configuration for rate limiting and adding customers. 展开更多
关键词 network measurement configuration evolution backbone network semi-automated configuration
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Gateways Placement in Backbone Wireless Mesh Networks 被引量:2
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作者 Maolin TANG 《International Journal of Communications, Network and System Sciences》 2009年第1期44-50,共7页
This paper presents a novel algorithm for the gateway placement problem in Backbone Wireless Mesh Networks (BWMNs). Different from existing algorithms, the new algorithm incrementally identifies gateways and assigns m... This paper presents a novel algorithm for the gateway placement problem in Backbone Wireless Mesh Networks (BWMNs). Different from existing algorithms, the new algorithm incrementally identifies gateways and assigns mesh routers to identified gateways. The new algorithm can guarantee to find a feasible gateway placement satisfying Quality-of-Service (QoS) constraints, including delay constraint, relay load constraint and gateway capacity constraint. Experimental results show that its performance is as good as that of the best of existing algorithms for the gateway placement problem. But, the new algorithm can be used for BWMNs that do not form one connected component, and it is easy to implement and use. 展开更多
关键词 GATEWAY PLACEMENT backbone WIRELESS MESH Networks
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BIODEGRADABLE POLYMERS WITH A PHOSPHORYL-CONTAINING BACKBONE:TISSUE ENGINEERING AND CONTROLLED DRUG DELIVERY APPLICATIONS 被引量:1
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作者 Kam W.Leong 毛海泉 卓仁禧 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1995年第4期289-314,共26页
This review provides a glimpse of the potential of the biodegradable phos-phoryl-containing polymers in medical applications. Undoubtedly these polymerspossess unique properties that are yet to be fully understood. Ma... This review provides a glimpse of the potential of the biodegradable phos-phoryl-containing polymers in medical applications. Undoubtedly these polymerspossess unique properties that are yet to be fully understood. Many areas warrantfurther investigation and much optimization remains to be done. The fascinatingchemistry of phosphorus poses interesting hurdles but at the same time leavesample room for polymer scientists to exercise their creativity in designinginteresting biomaterials. As the mutual understanding between basic and clinicalscientists on the need of medical devices and the capabilities of these newbiomaterials expands, imaginative application of new biomaterials to other medi-cal applications can be expected. 展开更多
关键词 biodegradable polymers phosphoryl-containing backbone controlled drug delivery
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Parameterless Pruning Algorithms for Similarity-Weight Network and Its Application in Extracting the Backbone of Global Value Chain 被引量:1
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作者 Lizhi Xing Yu Han 《Journal of Data and Information Science》 CSCD 2022年第1期57-75,共19页
Purpose:With the availability and utilization of Inter-Country Input-Output(ICIO)tables,it is possible to construct quantitative indices to assess its impact on the Global Value Chain(GVC).For the sake of visualizatio... Purpose:With the availability and utilization of Inter-Country Input-Output(ICIO)tables,it is possible to construct quantitative indices to assess its impact on the Global Value Chain(GVC).For the sake of visualization,ICIO networks with tremendous low-weight edges are too dense to show the substantial structure.These redundant edges,inevitably make the network data full of noise and eventually exert negative effects on Social Network Analysis(SNA).In this case,we need a method to filter such edges and obtain a sparser network with only the meaningful connections.Design/methodology/approach:In this paper,we propose two parameterless pruning algorithms from the global and local perspectives respectively,then the performance of them is examined using the ICIO table from different databases.Findings:The Searching Paths(SP)method extracts the strongest association paths from the global perspective,while Filtering Edges(FE)method captures the key links according to the local weight ratio.The results show that the FE method can basically include the SP method and become the best solution for the ICIO networks.Research limitations:There are still two limitations in this research.One is that the computational complexity may increase rapidly while processing the large-scale networks,so the proposed method should be further improved.The other is that much more empirical networks should be introduced to testify the scientificity and practicability of our methodology.Practical implications:The network pruning methods we proposed will promote the analysis of the ICIO network,in terms of community detection,link prediction,and spatial econometrics,etc.Also,they can be applied to many other complex networks with similar characteristics.Originality/value:This paper improves the existing research from two aspects,namely,considering the heterogeneity of weights and avoiding the interference of parameters.Therefore,it provides a new idea for the research of network backbone extraction. 展开更多
关键词 Inter-Country Input-Output Table Global Production System Global Value Chain Network backbone Extraction
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Software-Defined Space-Air-Ground Integrated Network Architecture with the Multi-Layer Satellite Backbone Network 被引量:1
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作者 Chao Guo Cheng Gong +3 位作者 Juan Guo Zhanzhen Wei Yanyan Han Sher Zaman Khan 《Computers, Materials & Continua》 SCIE EI 2020年第7期527-540,共14页
Under the background of the rapid development of ground mobile communication,the advantages of high coverage,survivability,and flexibility of satellite communication provide air support to the construction of space in... Under the background of the rapid development of ground mobile communication,the advantages of high coverage,survivability,and flexibility of satellite communication provide air support to the construction of space information network.According to the requirements of the future space information communication,a software-defined Space-Air-Ground Integrated network architecture was proposed.It consisted of layered structure satellite backbone network,deep space communication network,the stratosphere communication network and the ground network.The Space-Air-Ground Integrated network was supported by the satellite backbone network.It provided data relay for the missions such as deep space exploration and controlled the deep-space spacecraft when needed.In addition,it safeguarded the anti-destructibility of stratospheric communication and assisted the stratosphere to supplement ground network communication.In this paper,algorithm requirements of the congestion control and routing of satellite backbone protocols for heterogeneous users’services were proposed.The algorithm requirements of distinguishing different service objects for the deep space communication and stratospheric communication network protocols were described.Considering the realistic demand for the dynamic coverage of the satellite backbone network and node cost,the multi-layer satellite backbone network architecture was constructed.On this basis,the proposed Software-defined Space-Air-Ground Integrated network architecture could be built as a large,scalable and efficient communication network that could be integrated into space,air,and ground. 展开更多
关键词 Space-Air-Ground integrated network network architecture software-defined network multi-layer satellite backbone network
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Backbone formulation algorithm in wireless sensor network based on cross-entropy method 被引量:8
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作者 SHI Weiren JIANG Yisong ZHAO Ying 《Instrumentation》 2014年第1期38-48,共11页
In wireless sensor network,virtual backbone is a cost effective broadcasting method.Connected dominating set formation is proposed to construct a virtual backbone.However,it is NP-Hard to find a minimum connected domi... In wireless sensor network,virtual backbone is a cost effective broadcasting method.Connected dominating set formation is proposed to construct a virtual backbone.However,it is NP-Hard to find a minimum connected dominating set in an arbitrary graph.In this paper,based on cross-entropy method,we present a novel backbone formulation algorithm(BFA-CE)in wireless sensor network.In BFA-CE,a maximal independent set is got at first and nodes in the independent set are required to get their action sets.Based on those action sets,a backbone is generated with the cross-entropy method.Simulation results show that our algorithm can effectively reduce the size of backbone network within a reasonable message overhead,and it has lower average node degree.This approach can be potentially used in designing efficient broadcasting strategy or working as a backup routing of wireless sensor network. 展开更多
关键词 wireless sensor network backbone connected dominated set cross-entropy method
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Selective Acid Hydrolysis Condition for the Composition and Linkage with a Fructofuranosyl Backbone of a Polysaccharide from Angelica sinensis (Oliv) Diels
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作者 Gui Yun XU Yang CHEN Ru Xian CHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第10期1369-1372,共4页
A new polysaccharide was extracted and purified from the roots of Angelica sinensis (Oliv) Diels (ASD). Its composition and linkage was elucidated by selective hydrolysis and GC/MS analysis of its derivatives. The... A new polysaccharide was extracted and purified from the roots of Angelica sinensis (Oliv) Diels (ASD). Its composition and linkage was elucidated by selective hydrolysis and GC/MS analysis of its derivatives. The polysaccharide was made of → 1) Fruf(2→and→6) Glcp (l→as its backbone with highly branched structure. To our best knowledge, this is the first report of the fructose residue in polysaccharides from the roots of the ASD. 展开更多
关键词 Selective hydrolysis fructofuranosyl backbone GC/MS
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MODELLING THE POLYALANINE BACKBONE STARTING FROM ALPHA-CARBON GUIDE POSITIONS
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作者 Yu LUO Xu Liang JIANG Lu Hua LAI Chun Xu QU Xiao Jie XU You Qi TANG Institute of Physical Chemistry,Peking University,Beijing 100871 《Chinese Chemical Letters》 SCIE CAS CSCD 1990年第1期87-90,共4页
An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,198... An automatic procedure for building a protein polyalanine backbone from guiding alpha-carbon positions is presented here,which is different from a previously developed'spare parts'approach(Jones and Thirup,1986;Claessens et al.,1989). In our procedure,the geometric restraint of angle N-CA-C is used to generate a list of polypeptide chains,and several filters are used later to select the best conformer.The most important filter is based upon the Ramachandran scatter plot of mainchain dihedral angles PHI and PSI.Results for all test cases are satisfactory,with more than 95%of peptide planes correctly reconstructed and the overall root-mean-square deviation less than 0.5 angstrom compared with the refined X-ray coordinates. 展开更多
关键词 Bank MODELLING THE POLYALANINE backbone STARTING FROM ALPHA-CARBON GUIDE POSITIONS length maps
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Fractals of Protein Backbone Structures
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作者 Huang Jingfei Liu Ciquan(Laboratory of Cellular and Molecular Evolution,Kunming Institute of Zoology,The Chinese Academy of Sciences,Kunming,Yunnan 650223) 《生物数学学报》 CSCD 1997年第S1期385-392,共8页
Ths paper,based on the principles of geometric self-similarity of fractal theory and some research results of rotein chemistry,improved the method of comput-ing protein fractal dimensions,and computed fractal dime... Ths paper,based on the principles of geometric self-similarity of fractal theory and some research results of rotein chemistry,improved the method of comput-ing protein fractal dimensions,and computed fractal dimensions of some protein back bone,secondary and assumed folding structures.The relationship between protein back-bone strucrural fractal dimensions and its spatial structures was investigated.The results indicated that protein backbone fractal dimensions not only have a close relation with protein secondary structure,but also with its folding.In addition,the folding of protein Polypeptide chains in 3-D space may be similar to the other macromolecular chain be haviour described by the self-avoiding walks(SAW)model. 展开更多
关键词 FRACTAL DIMENSION protein backbone STRUCTURE SECONDARY STRUCTURE FOLDING
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Molecular and Crystal Structure of Hexacobalt Carbonyl Cluster Containg Twin Co_3S(CO)_7 Fragments Linked by a Novel Phosphido-Thiolato Ligand as Backbone
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作者 Zhi Rong ZHAO Xiang HU Shu Tang LIU and Qi Wang LIU(Department of Chedristry, Inner Mongolia University, Huhhot 010021) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第5期461-464,共4页
Reaction of dimers of (R) thionophosphine sulfide (R = P - C6H4OMe,SMe ) with Co, (CO), yields the novel hexacobalt cluster [Co'(μ3, -S)2, (CO) 14 (μ4 -μ4- and the trinuclear clusterPSCH,)J 2' In 1, tw0 Co3... Reaction of dimers of (R) thionophosphine sulfide (R = P - C6H4OMe,SMe ) with Co, (CO), yields the novel hexacobalt cluster [Co'(μ3, -S)2, (CO) 14 (μ4 -μ4- and the trinuclear clusterPSCH,)J 2' In 1, tw0 Co3S(C0)7 units linked by a novel phosphido-thio1ato bifunc-tiona1 bridging p'-SPR ligand as backbone. 展开更多
关键词 TWIN CO CO Fragments Linked by a Novel Phosphido-Thiolato Ligand as backbone Molecular and Crystal Structure of Hexacobalt Carbonyl Cluster Containg Twin Co3S
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Method of Distribution Network Resources after Restoration, the Networks MPLS-TE Use of Various Telecommunications Technologies to Construct Backbone Networks
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作者 Mohammad Alhihi 《International Journal of Communications, Network and System Sciences》 2017年第11期251-260,共10页
The modern telecommunication system is characterized by the rapid improvement of information and communication technologies, such as the improvement in the data rate, power consumption and Quality of Service (QoS). Ba... The modern telecommunication system is characterized by the rapid improvement of information and communication technologies, such as the improvement in the data rate, power consumption and Quality of Service (QoS). Based on this development, the next generation network (NGN) is shaped. The NGN is represented by a packet transport network demarcated functions and services. To provide transport functions in NGN, using Multi-Protocol Label Switching (MPLS) technology, there are two main problems, which are multipath routing and traffic distribution, which are what this paper works with. Accordingly, this paper proposes a solution to these two problems using optimization procedures to find the shortest path Dijkstra and Bellman-Ford, which is characterized by a high-speed-oriented selection of a single shortest path between the source and the destination, based on several selected criteria related to the optimal use of the network resources. Solving the information flow distribution problems in large number of nodes network applying salesman procedure or having NP-completeness, causes significant time delay, which means that the proposed solution is not suitable for real time applications. Accordingly, for real time applications, there is a need to move to other methods based on the use of several independent shortest paths. 展开更多
关键词 QoS NGN MPLS Routing Protocols backbone NETWORKS BER PEP
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LOAD AWARE ADAPTIVE BACKBONE SYNTHESIS IN WIRELESS MESH NETWORKS
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作者 Yuan Yuan Zheng Baoyu 《Journal of Electronics(China)》 2009年第3期366-373,共8页
Wireless Mesh Networks(WMNs) are envisioned to support the wired backbone with a wireless Backbone Networks(BNet) for providing internet connectivity to large-scale areas.With a wide range of internet-oriented applica... Wireless Mesh Networks(WMNs) are envisioned to support the wired backbone with a wireless Backbone Networks(BNet) for providing internet connectivity to large-scale areas.With a wide range of internet-oriented applications with different Quality of Service(QoS) requirement, the large-scale WMNs should have good scalability and large bandwidth.In this paper, a Load Aware Adaptive Backbone Synthesis(LAABS) algorithm is proposed to automatically balance the traffic flow in the WMNs.The BNet will dynamically split into smaller size or merge into bigger one according to statistic load information of Backbone Nodes(BNs).Simulation results show LAABS generates moderate BNet size and converges quickly, thus providing scalable and stable BNet to facilitate traffic flow. 展开更多
关键词 Wireless Mesh Networks (WMNs) backbone synthesis Load aware
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Provider Backbone Transport Technology
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作者 Zhang Zailong 1,Fang Jun 2,Yu Jinghai 2(1.Institute of Information and Network Technologies,Nanjing University of Posts and Telecommunications,Nanjing 210003,P.R.China 2.ZTE Corporation,Shenzhen 518057,P.R.China) 《ZTE Communications》 2009年第1期25-29,共5页
The Metro Ethernet Forum(MEF) put forward the concept of Carrier Ethernet(CE) to improve Ethernet technology and make it a transmission convergence layer solution for Next Generation Network(NGN).Provider Backbone Tra... The Metro Ethernet Forum(MEF) put forward the concept of Carrier Ethernet(CE) to improve Ethernet technology and make it a transmission convergence layer solution for Next Generation Network(NGN).Provider Backbone Transport(PBT) is the result of the enhancement and improvement of the early Ethernet technologies and it is the new version of CE implementation technology and standard which is promising.Through studying the PBT-related technologies,PBT network structure,PBT advantages as the transmission convergence layer solution and its trend of future development,it is concluded that PBT can be used as the preferred technology of the transmission convergence layer in the NGN,though there are some problems to be solved for PBT. 展开更多
关键词 PBT PBB Provider backbone Transport Technology MAC
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The need analysis of backbone civilian nurses post-oriented education training in China
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作者 CHEN zhaoyun 张银玲 +2 位作者 GE Wei XU Lulu YANG Qian 《中西医结合护理(中英文)》 2016年第8期1-6,共6页
To learn about the need of post-oriented education training of backbone civilian nurses,and to provide scientific evidence for the promotion of training. Methods The convenience sampling method was performed,and an an... To learn about the need of post-oriented education training of backbone civilian nurses,and to provide scientific evidence for the promotion of training. Methods The convenience sampling method was performed,and an anonymous survey on 324 nurses who participated in the "backbone civilian nurses training program"from September 2013 to October 2015 was carried out by using self-made questionnaire.Results(1)Among the 324 nurses,12. 04% of them volunteered to participate in the training and 87. 96%were sent by their departments.(2)More than 90% of training contents met their needs.(3)The training methods in demand included theoretical classroom teaching,clinical observation and probation,seminars,clinical management practice,clinical problem discussion and clinical nursing practice(4)The training period suggested by most nurses was about 2 to 4 weeks. Conclusion It is important to strengthen the significance of post-oriented education training and to improve the quality and capacity of civilian through scientific education design and practical training programs. 展开更多
关键词 civilian nurse backbone continuing education training need
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Essential Topics on Constructing WCDS-based Virtual Backbone in Wireless Sensor/Mesh Networks
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作者 Chie Dou Yung-Han Hsiao 《Communications and Network》 2013年第2期1-7,共7页
Clustering or connected dominating set (CDS) both approaches can establish a virtual backbone (VB) in wireless sensor networks (WSNs) or wireless mesh networks (WMNs). Each cluster consisting of a cluster head (CH) an... Clustering or connected dominating set (CDS) both approaches can establish a virtual backbone (VB) in wireless sensor networks (WSNs) or wireless mesh networks (WMNs). Each cluster consisting of a cluster head (CH) and its neighboring nodes can form a dominating set. After some bridging nodes were selected, cluster heads (CHs) connected through these bridging nodes naturally formed a CDS. Although CDS provides obvious backbone architecture, however, the number of cluster heads and bridging nodes may be too large, this may cause the loss of advantages of virtual backbone. When we effectively reduce their numbers, more effectively WCDS (Weakly Connected Dominating Set) can be fining out. Some essential topics on constructing WCDS-based VB in WSN/WMN are discussed in this paper. From the point of view of three different protocol layers, including network (NWK) layer, MAC layer, and physical (PHY) layer, we explore their cross-layer research topics and design algorithms. For NWK layer, area-based WCDS algorithms and routing strategies including via VB and not via VB are discussed. For MAC layer, a WCDS-based energy-efficient MAC protocol is presented. For PHY layer, battery-aware alternative VB selections and sensor nodes with different transmission ranges are addressed. 展开更多
关键词 WEAKLY Connected Dominating Set Wireless Sensor/Mesh Networks Virtual backbone CROSS-LAYER Design
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More precise model of <i>α</i>-helix and transmembrane <i>α</i>-helical peptide backbone structure
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作者 Walter F. Schmidt Clayton G. Thomas 《Journal of Biophysical Chemistry》 2012年第4期295-303,共9页
The 3-D structure of the β-adrenergic receptor with a molecular weight of 55,000 daltons is available from crystallographic data. Within one of the seven transmembrane ion channel helices in the β2-receptor, one loo... The 3-D structure of the β-adrenergic receptor with a molecular weight of 55,000 daltons is available from crystallographic data. Within one of the seven transmembrane ion channel helices in the β2-receptor, one loop of a helix ACADL has previously been proposed as the site that explains β2 activity (fights acute bronchitis) whereas ASADL in the β1-receptor at the corresponding site explains β1-activity (cardiac stimulation). The α-agonist responsible for this selective reaction is only 0.5% of the receptor molecular weight, and only 1.5% of the weight of the trans-membrane portion of the receptor. The understanding of the mechanism by which a small molecule on binding to a site on one single loop of a helix produces a specific agonist activity on an entire transmembrane ion channel is uncertain. A model of an α-helix is presented in which of pitch occurs at angles both smaller and larger than 180° n. Consequently, atomic coordinates in a peptide backbone α-helix match the data points of individual atom (and atom types) in the backbone. More precisely, eleven atoms in peptide backbone routinely equal one loop of a helix, instead of eleven amino acid residues equaling three loops of a helix;therefore, an α-helix can begin (or end) at any specific atom in a peptide backbone, not just at any specific amino acid. Wavefront Topology System and Finite Element Methods calculate this specific helical shape based only upon circumference, pitch, and phase. Only external forces which specifically affect circumference, pitch and/or phase (e.g. from agonist binding) can/will alter the shape of an α-helix. 展开更多
关键词 HELIX ALPHA-HELIX CIRCUMFERENCE Pitch phase peptide backbone Wavefront Topology System Finite Element Method
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