The inter-city linkage heat data provided by Baidu Migration is employed as a characterization of inter-city linkages in order to facilitate the study of the network linkage characteristics and hierarchical structure ...The inter-city linkage heat data provided by Baidu Migration is employed as a characterization of inter-city linkages in order to facilitate the study of the network linkage characteristics and hierarchical structure of urban agglomeration in the Greater Bay Area through the use of social network analysis method.This is the inaugural application of big data based on location services in the study of urban agglomeration network structure,which represents a novel research perspective on this topic.The study reveals that the density of network linkages in the Greater Bay Area urban agglomeration has reached 100%,indicating a mature network-like spatial structure.This structure has given rise to three distinct communities:Shenzhen-Dongguan-Huizhou,Guangzhou-Foshan-Zhaoqing,and Zhuhai-Zhongshan-Jiangmen.Additionally,cities within the Greater Bay Area urban agglomeration play different roles,suggesting that varying development strategies may be necessary to achieve staggered development.The study demonstrates that large datasets represented by LBS can offer novel insights and methodologies for the examination of urban agglomeration network structures,contingent on the appropriate mining and processing of the data.展开更多
To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the mechanisms.The present study presents a case demonstrating the pre...To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the mechanisms.The present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following chemotherapy.Then network pharmacology was employed to predict the targets of GCBD.Subsequently,a DOX-induced apoptosis model of H9C2 cardiomyocytes was established and co-cultured with serum containing GCBD serum.The viability and myocardial enzyme levels were evaluated using CCK8 assay and ELISA assay,TUNEL was using for apoptosis test.The GCBD effect was confirmed by tests of ROS andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with mitochondria.Furthermore,the expression levels of apoptosis-related molecules were determined via Western blotting.Additionally,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with GCBD.Myocardial enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through HE staining while related proteins were detected using IHC.Network pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related molecules.Initially,we demonstrated the effective amelioration of DIC in cardiomyocyte viability,LDH/CK levels,α-actinin and ROS levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and WB.The efficacy of GCBD in enhancing cardiac function in DIC mice has been validated through animal experiments.Taken together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial apoptosis.The utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.展开更多
To evaluate the effectiveness and safety of Jinye Baidu Granules(金叶败毒颗粒)for acute upper respiratory tract infection(AURTI).Database such as CNKI,Wan-fang,VIP,Sino Med,Web of science,Clinical Trials gov,Medline、...To evaluate the effectiveness and safety of Jinye Baidu Granules(金叶败毒颗粒)for acute upper respiratory tract infection(AURTI).Database such as CNKI,Wan-fang,VIP,Sino Med,Web of science,Clinical Trials gov,Medline、EMBASE,CENTRAL,Cochrane Library were retrieved to collect randomized controlled trials(RCTs)on Jinye Baidu Granules(金叶败毒颗粒)in treating AURTI from the estabslishment of the database to March 2019.A total of 2 reviewers independently screened the literature according to the inclusion and exclusion criteria,and extracted material and the quality evaluation of the included studies.Quality evaluation adopted Cochrane Handbook 5.1 evaluation standards and tools.Rev Man5.3 was used to perform Meta-analysis for the adopted study.Finally a total of 4 RCTs involving 636 patients were included.Meta-analysis results showed that:compared with conventional Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine in the treatment of acute upper respiratory tract infection can improve the total effective rate of clinical efficacy[RR=0.13,95%CI(0.06,0.29),P<0.00001],shorten the time of antipyretic time for acute upper respiratory tract infection[MD=–1.22,95%CI(–1.43,–1.00),P<0.00001],shorten the time of pharyngeal pain[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001]and shorten the cough disappear time[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001].There were 2 papers reporting adverse reactions during the study period,and one of them specifically reported diarrhea,nausea,vomiting and stomachache in the experimental group.In the control group:diarrhea,nausea and adverse reactions disappeared after drug withdrawal;the incidence of adverse reactions was 3.92%in the control group and 5.88%in the observation group.There was no significant difference between the 2 groups(P>0.05).Based on existing data and methods,the systematic evaluation showed that,compared with Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine alone could improve the total effective rate of clinical efficacy,reduce the time of fever,sore throat,and the disappearance of cough with less adverse reactions.However,due to the low quality of the included study,large samples,multicenter,randomized,double-blind trials and trials are still needed to randomized controlled trials with reference to the CONSORT standard and the STRICTA statement.展开更多
A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and adva...A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and advancing tourism. We systematically analyzed the accessibility of 56 scenic spots in Xi’an City, China, via car and public transport travel modes using the real-time travel function of the Baidu Maps API(Application Programming Interface) along with spatial analysis methods and the modal accessibility gap index of scenic spots. We obtained the following results. First, maximum and minimum travel times using public transport exceeded those using cars. Moreover, the accessibility of scenic spots via cars and public transport presented a circular spatial pattern of increasing travel time from the center to the periphery. Contrasting with travel by public transport, car travel showed a clear time-space compression effect. Second, accessibility of the scenic spots via cars and public transport showed some spatial heterogeneity, with no clear advantages of car accessibility in the central urban area. However, advantages of car accessibility were increasingly evident moving from the center to the periphery. Third, whereas the correlation of the modal accessibility gap index of scenic spots in Xi’an with global space was significantly positive, local spatial interdependence was only evident in some inner city areas and in marginal areas. Moreover, spatial heterogeneity was evident in two regions but was insignificant in other areas, indicating that the spatial interdependence of the modal accessibility gap index in most scenic spots was not apparent in terms of the overall effect of public transport routes, road networks, and the distribution of scenic spots. The improvement of public transport coverage in marginal areas and the optimization of public transport routes in central urban areas are essential tasks for improving travel using public transport in the future.展开更多
This paper incorporates the Baidu Index into various heterogeneous autoregressive type time series models and shows that the Baidu Index is a superior predictor of realized volatility in the SSE 50 Index.Furthermore,t...This paper incorporates the Baidu Index into various heterogeneous autoregressive type time series models and shows that the Baidu Index is a superior predictor of realized volatility in the SSE 50 Index.Furthermore,the predictability of the Baidu Index is found to rise as the forecasting horizon increases.We also find that continuous components enhance predictive power across all horizons,but that increases are only sustained in the short and medium terms,as the long-term impact on volatility is less persistent.Our findings should be expected to influence investors interested in constructing trading strategies based on realized volatility.展开更多
The paper was to establish a simple and sensitive HPLC method for determination of berbefine hydrochloride content in Qingwen Baidu granule. The HPLC system consisted of Stable Bond - C18 column (4.6 × 150 mm, ...The paper was to establish a simple and sensitive HPLC method for determination of berbefine hydrochloride content in Qingwen Baidu granule. The HPLC system consisted of Stable Bond - C18 column (4.6 × 150 mm, 5um) and with a mobile phase of acetonitrile -0.05mol/L potassium dihydrogen phosphate solution (50:50,v:v) mixture. Berberine hydrochloride was detected at the wavelength of 345 nm, with a flow rate of 1.0 ml/min and a column temperature of 30 ℃. The excipients and solvents in the granule could be well separated from the drug under such a designated chromatogram condition and did not interfere with the assay. A good linear relationship was found between peak area and the concentration of berberine hydrochloride in the range of 16.0 -48.0 I^g/mL. The average recovery of berberine hydrochloride was 99.09%. The established approach was specific, accurate, reliable, prompt, sensitive and applicable, and could be used to control the quality of Qingwen Baidu granule.展开更多
A number of studies have investigated the predictability of Chinese stock returns with economic variables.Given the newly emerged dataset from the Internet,this paper investigates whether the Baidu Index can be employ...A number of studies have investigated the predictability of Chinese stock returns with economic variables.Given the newly emerged dataset from the Internet,this paper investigates whether the Baidu Index can be employed to predict Chinese stock returns.The empirical results show that 1)the Search Frequency of Baidu Index(SFBI)can predict next day’s price changes;2)the stock prices go up when individual investors pay less attention to the stocks and go down when individual investors pay more attention to the stocks;3)the trading strategy constructed by shorting on the most SFBI and longing on the least SFBI outperforms the corresponding market index returns without consideration of the transaction costs.These results complement the existing literature on the predictability of Chinese stock returns and have potential implications for asset pricing and risk management.展开更多
<p style="text-align:justify;"> <b><span style="font-family:Verdana;">Purpose: </span></b><span style="font-family:Verdana;">This work is aimed to expl...<p style="text-align:justify;"> <b><span style="font-family:Verdana;">Purpose: </span></b><span style="font-family:Verdana;">This work is aimed to explain the theoretical basis of “Huashi Baidu Fang” in the treatment of coronavirus disease </span><span style="font-family:Verdana;">20</span><span style="font-family:""><span style="font-family:Verdana;">19 (COVID-19) with western </span><span><span style="font-family:Verdana;">medical theory. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We analyze</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">the “Diagnosis and Treatment Protocol for COVID-19 (Version 1 to Version 7)” made by China, “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV)</span><span style="font-family:""><span style="font-family:Verdana;"> infection is suspected—Interim guidance” made by World Health Organization (WHO), “Therapeutic Guidelines: Respiratory (Version 5)”, “Therapeutic Guidelines: Gastrointestinal (Version 5)” and “Therapeutic Guidelines: Antibiotic (Version 15)” published by Australia, and the origin of classical prescription of “Huashi Baidu Fang”: “Shanghanlun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (The Epidemic Febrile Disease)”. We search the dictionary of traditional Chinese medicine (Version II) manually. And we search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study among the symptoms of TCM formulations in “Huashi Baidu Fang”, the pathogenesis and clinical manifestation of COVID-19 and COPD with acute gastrointestinal inflammation. And we carry out pharmacological inquiry of “Huashi Baidu Fang”. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The clinical manifestations of respiratory symptoms and gastrointestinal tract of syndrome of lung obstruction due to epidemic toxin and acute exacerbation of COPD are almost the same;The formulations used in “Huashi Baidu Fang” are consistent with the pharmacological activity of the drug recommended in the Therapeutic Guidelines. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">“Huashi Baidu Fang” may play a positive role in COVID-19.</span></span> </p>展开更多
文摘The inter-city linkage heat data provided by Baidu Migration is employed as a characterization of inter-city linkages in order to facilitate the study of the network linkage characteristics and hierarchical structure of urban agglomeration in the Greater Bay Area through the use of social network analysis method.This is the inaugural application of big data based on location services in the study of urban agglomeration network structure,which represents a novel research perspective on this topic.The study reveals that the density of network linkages in the Greater Bay Area urban agglomeration has reached 100%,indicating a mature network-like spatial structure.This structure has given rise to three distinct communities:Shenzhen-Dongguan-Huizhou,Guangzhou-Foshan-Zhaoqing,and Zhuhai-Zhongshan-Jiangmen.Additionally,cities within the Greater Bay Area urban agglomeration play different roles,suggesting that varying development strategies may be necessary to achieve staggered development.The study demonstrates that large datasets represented by LBS can offer novel insights and methodologies for the examination of urban agglomeration network structures,contingent on the appropriate mining and processing of the data.
基金supported by the National Natural Science Foundation of China(No.82074348,No.82274491)the innovation and development joint project of Shandong Province Natural Science Foundation(ZR2023LZL009)the Jinan clinical medical science and technology innovation plan(No.202225014,202328072).
文摘To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the mechanisms.The present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following chemotherapy.Then network pharmacology was employed to predict the targets of GCBD.Subsequently,a DOX-induced apoptosis model of H9C2 cardiomyocytes was established and co-cultured with serum containing GCBD serum.The viability and myocardial enzyme levels were evaluated using CCK8 assay and ELISA assay,TUNEL was using for apoptosis test.The GCBD effect was confirmed by tests of ROS andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with mitochondria.Furthermore,the expression levels of apoptosis-related molecules were determined via Western blotting.Additionally,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with GCBD.Myocardial enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through HE staining while related proteins were detected using IHC.Network pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related molecules.Initially,we demonstrated the effective amelioration of DIC in cardiomyocyte viability,LDH/CK levels,α-actinin and ROS levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and WB.The efficacy of GCBD in enhancing cardiac function in DIC mice has been validated through animal experiments.Taken together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial apoptosis.The utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.
文摘To evaluate the effectiveness and safety of Jinye Baidu Granules(金叶败毒颗粒)for acute upper respiratory tract infection(AURTI).Database such as CNKI,Wan-fang,VIP,Sino Med,Web of science,Clinical Trials gov,Medline、EMBASE,CENTRAL,Cochrane Library were retrieved to collect randomized controlled trials(RCTs)on Jinye Baidu Granules(金叶败毒颗粒)in treating AURTI from the estabslishment of the database to March 2019.A total of 2 reviewers independently screened the literature according to the inclusion and exclusion criteria,and extracted material and the quality evaluation of the included studies.Quality evaluation adopted Cochrane Handbook 5.1 evaluation standards and tools.Rev Man5.3 was used to perform Meta-analysis for the adopted study.Finally a total of 4 RCTs involving 636 patients were included.Meta-analysis results showed that:compared with conventional Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine in the treatment of acute upper respiratory tract infection can improve the total effective rate of clinical efficacy[RR=0.13,95%CI(0.06,0.29),P<0.00001],shorten the time of antipyretic time for acute upper respiratory tract infection[MD=–1.22,95%CI(–1.43,–1.00),P<0.00001],shorten the time of pharyngeal pain[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001]and shorten the cough disappear time[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001].There were 2 papers reporting adverse reactions during the study period,and one of them specifically reported diarrhea,nausea,vomiting and stomachache in the experimental group.In the control group:diarrhea,nausea and adverse reactions disappeared after drug withdrawal;the incidence of adverse reactions was 3.92%in the control group and 5.88%in the observation group.There was no significant difference between the 2 groups(P>0.05).Based on existing data and methods,the systematic evaluation showed that,compared with Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine alone could improve the total effective rate of clinical efficacy,reduce the time of fever,sore throat,and the disappearance of cough with less adverse reactions.However,due to the low quality of the included study,large samples,multicenter,randomized,double-blind trials and trials are still needed to randomized controlled trials with reference to the CONSORT standard and the STRICTA statement.
基金Under the auspices of National Natural Science Foundation of China(No.41831284,41501120)Special Scientific Research Project of Education Department of Shaanxi Provincial Government(No.18JK0649)Scientific Research Project of Xi’an International Studies University(No.18XWC24)
文摘A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and advancing tourism. We systematically analyzed the accessibility of 56 scenic spots in Xi’an City, China, via car and public transport travel modes using the real-time travel function of the Baidu Maps API(Application Programming Interface) along with spatial analysis methods and the modal accessibility gap index of scenic spots. We obtained the following results. First, maximum and minimum travel times using public transport exceeded those using cars. Moreover, the accessibility of scenic spots via cars and public transport presented a circular spatial pattern of increasing travel time from the center to the periphery. Contrasting with travel by public transport, car travel showed a clear time-space compression effect. Second, accessibility of the scenic spots via cars and public transport showed some spatial heterogeneity, with no clear advantages of car accessibility in the central urban area. However, advantages of car accessibility were increasingly evident moving from the center to the periphery. Third, whereas the correlation of the modal accessibility gap index of scenic spots in Xi’an with global space was significantly positive, local spatial interdependence was only evident in some inner city areas and in marginal areas. Moreover, spatial heterogeneity was evident in two regions but was insignificant in other areas, indicating that the spatial interdependence of the modal accessibility gap index in most scenic spots was not apparent in terms of the overall effect of public transport routes, road networks, and the distribution of scenic spots. The improvement of public transport coverage in marginal areas and the optimization of public transport routes in central urban areas are essential tasks for improving travel using public transport in the future.
基金This work is supported by the National Natural Science Foundation of China(71790594,71701150,and U1811462).
文摘This paper incorporates the Baidu Index into various heterogeneous autoregressive type time series models and shows that the Baidu Index is a superior predictor of realized volatility in the SSE 50 Index.Furthermore,the predictability of the Baidu Index is found to rise as the forecasting horizon increases.We also find that continuous components enhance predictive power across all horizons,but that increases are only sustained in the short and medium terms,as the long-term impact on volatility is less persistent.Our findings should be expected to influence investors interested in constructing trading strategies based on realized volatility.
基金Supported by Technology Innovation Project of Shandong Province(201210916001)
文摘The paper was to establish a simple and sensitive HPLC method for determination of berbefine hydrochloride content in Qingwen Baidu granule. The HPLC system consisted of Stable Bond - C18 column (4.6 × 150 mm, 5um) and with a mobile phase of acetonitrile -0.05mol/L potassium dihydrogen phosphate solution (50:50,v:v) mixture. Berberine hydrochloride was detected at the wavelength of 345 nm, with a flow rate of 1.0 ml/min and a column temperature of 30 ℃. The excipients and solvents in the granule could be well separated from the drug under such a designated chromatogram condition and did not interfere with the assay. A good linear relationship was found between peak area and the concentration of berberine hydrochloride in the range of 16.0 -48.0 I^g/mL. The average recovery of berberine hydrochloride was 99.09%. The established approach was specific, accurate, reliable, prompt, sensitive and applicable, and could be used to control the quality of Qingwen Baidu granule.
基金This work is supported by the National Natural Science Foundation of China(71320107003 and 71532009).
文摘A number of studies have investigated the predictability of Chinese stock returns with economic variables.Given the newly emerged dataset from the Internet,this paper investigates whether the Baidu Index can be employed to predict Chinese stock returns.The empirical results show that 1)the Search Frequency of Baidu Index(SFBI)can predict next day’s price changes;2)the stock prices go up when individual investors pay less attention to the stocks and go down when individual investors pay more attention to the stocks;3)the trading strategy constructed by shorting on the most SFBI and longing on the least SFBI outperforms the corresponding market index returns without consideration of the transaction costs.These results complement the existing literature on the predictability of Chinese stock returns and have potential implications for asset pricing and risk management.
文摘<p style="text-align:justify;"> <b><span style="font-family:Verdana;">Purpose: </span></b><span style="font-family:Verdana;">This work is aimed to explain the theoretical basis of “Huashi Baidu Fang” in the treatment of coronavirus disease </span><span style="font-family:Verdana;">20</span><span style="font-family:""><span style="font-family:Verdana;">19 (COVID-19) with western </span><span><span style="font-family:Verdana;">medical theory. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We analyze</span></span></span><span style="font-family:""> </span><span style="font-family:Verdana;">the “Diagnosis and Treatment Protocol for COVID-19 (Version 1 to Version 7)” made by China, “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV)</span><span style="font-family:""><span style="font-family:Verdana;"> infection is suspected—Interim guidance” made by World Health Organization (WHO), “Therapeutic Guidelines: Respiratory (Version 5)”, “Therapeutic Guidelines: Gastrointestinal (Version 5)” and “Therapeutic Guidelines: Antibiotic (Version 15)” published by Australia, and the origin of classical prescription of “Huashi Baidu Fang”: “Shanghanlun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (The Epidemic Febrile Disease)”. We search the dictionary of traditional Chinese medicine (Version II) manually. And we search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study among the symptoms of TCM formulations in “Huashi Baidu Fang”, the pathogenesis and clinical manifestation of COVID-19 and COPD with acute gastrointestinal inflammation. And we carry out pharmacological inquiry of “Huashi Baidu Fang”. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The clinical manifestations of respiratory symptoms and gastrointestinal tract of syndrome of lung obstruction due to epidemic toxin and acute exacerbation of COPD are almost the same;The formulations used in “Huashi Baidu Fang” are consistent with the pharmacological activity of the drug recommended in the Therapeutic Guidelines. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">“Huashi Baidu Fang” may play a positive role in COVID-19.</span></span> </p>