Effects of alprostadil combined with Bailing Capsule on residual renal function, renal hemodynamics, immune indexes and nutritional status in patients with chronic renal failure

Objective:To investigate the clinical efficacy and safety of alprostadil combined with Bailing Capsule in the treatment of chronic renal failure,and the influence of alprostadil combined with Bailing Capsule on residual renal function,renal hemodynamics,immune indexes and nutritional status.Methods 86 patients with chronic renal failure(CRF)hospitalized in Wuhan integrated traditional Chinese and Western Medicine Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology from January 2018 to June 2019 were selected as the study objects.They were randomly divided into control group and case group with 43 cases in each group.Two groups were given peritoneal dialysis treatment,the control group was given bailing capsule,the case group was given alprostadil injection on the basis of the control group.To observe the clinical effect of the two groups before and after treatment,and the changes of residual renal function,renal hemodynamics,immune index and nutritional status.Results The total effective rate of the case group was 97.68%,higher than 83.73%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of bun,SCR,GFR,24h urinary protein quantity,resistance index,CRP,IL-6,TNF,CD8+and SGA in the two groups were lower than those before treatment;the levels of renal blood flow,RRF,CD3+,CD4+,ALB,PA,TRF and Hb were higher than those before treatment;moreover,the improvement of serum inflammatory cytokines,residual renal function and renal hemodynamic indexes,immune indexes and nutritional status in the case group were significant The difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 16.28%,higher than 6.98%in the case group,with no significant difference(P>0.05).Conclusion Alprostadil combined with Bailing capsule can significantly improve the residual renal function,hemodynamics,immune index,reduce the degree of inflammatory response in patients with chronic renal failure.

Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy

Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the observation group were randomly assigned. The renal function, oxidative stress, inflammation and immune indexes of two groups of patients with diabetic nephropathy were compared and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared with those before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly compared with those before the treatment;and the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group. Conclusions: Bailing capsule combined with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal function, oxidize inflammatory reaction and enhance the immune function of patients, which has clinical significance.

Effect of Bailing capsule combined with Edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease

Objective:To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD).Methods:160 patients with COPD who received treatment in the department of respiratory medicine of our hospital from March 2016 to March 2018 were randomly divided into control group and observation group, 80 cases in each group. Patients in the control group received edaravone treatment, while patients in the observation group received bailing capsule combined with edaravone treatment. The levels of T lymphocyte, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) were measured and compared before and after treatment.Result: After treatment, the levels of CD3+, CD4+, CD4+ / CD8+, SOD and NO of patients in the control group and the observation group were significantly higher than those before treatment, while the levels of CD8+ and MDA were significantly lower than those before treatment. The change trend of the levels of T lymphocyte and antioxidant enzyme of patients in the observation group were significantly more obvious than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and MMP-9 of patients in the control group and the observation group decreased significantly, and the change trend of the above factors of patients in the observation group was more obvious than that in the control group (P<0.05).Conclusion: Bailing capsule combined with edaravone in the treatment of chronic obstructive pulmonary disease can significantly enhance the immune function and antioxidant function of patients and alleviate inflammation of the body. It has good clinical curative effect.

Effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome

Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods: A total of 108 patients with PCOS who were treated in our hospital between November 2014 and April 2017 were reviewed and divided into routine group (n=67) who received routine therapy and Bailing capsule group (n=41) who received Bailing capsule combined with routine therapy. Routine group received ethinylestradiol and cyproterone acetate and metformin therapy, and Bailing capsule group were treated with Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy. The differences in the levels of lipid metabolism, insulin resistance indexes as well as inflammatory factors were compared between the two groups before and after treatment.Results: There was no statistically significant difference in serum levels of lipid metabolism, insulin resistance-related indexes and inflammatory factors between the two groups before treatment. After treatment, serum HDL-C content of Bailing capsule group was higher than that of routine group whereas LDL-C and TC contents were lower than those of routine group;serum insulin resistance-related indexes FINS and HOMA-IR levels were lower than those of routine group;serum inflammatory cytokines IL-6, TNF-α, APN and LEP contents were lower than those of routine group.Conclusion: Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy can effectively improve the lipid metabolism level and inhibit the insulin resistance in patients with PCOS.

A BRIEF INTRODUCTION TO THE NEWLY APPOINTED VICE PRESIDENT OF THE CAS, PROF. YANG BAILING

Prof. Yang Bailing is a research professor specializing in chemical lasers and aero-dynamics. Born in Shanghai in October 1943, he graduated from the Harbin Institute of Military Engineering in 1966 and was then assigned to work at the CAS-affiliated Dalian Institute of Chemical Physics. In 1980, he

甲基化衍生-高效液相色谱法检测北五味子中的代森锰锌

利用甲基化衍生-高效液相色谱法检测北五味子[Schisandra chinensis(Turcz.)Bail.]中代森锰锌残留量。以BEH C18(2.1 mm×50 mm,1.7μm)为固定相;乙腈∶水(18∶82,V/V)为流动相;检测波长为272nm。结果表明,代森锰锌的平均回收率达97.0%,RSD为1.36%,最低检出限(LOD)为0.02 mg/kg,最低检测浓度(LOQ)为0.05 mg/kg,结果符合农药残留试验准则要求。北五味子样品中均未检出代森锰锌。

脑特异性新生血管抑制因子1(BAI1)与肿瘤的研究现状

脑特异性新生血管抑制因子1,即BAI1,是近年来在脑胶质瘤中发现的重要的抑制血管生成的基因。本文将对BAI1的分子生物学特点、作用机制、与肿瘤关系等方面的研究现状作一简要综述。

The experimental study of the granulation process

This paper deals with a comparative research between two processes of granulation, namely mini-pelletized sintering （MPS） and hybrid pelletized sintering （HPS）, focusing on aspects such as the balling effect, production, quality, and mineralography and metallurgical performance of sinter. The results indicate that both methods can result in a satisfying capability in balling effect and metallurgical performance of sinter, qualified to meet the plant production requirements, but when the granulation time and granulating moisture are set to around 6 minutes and 7.0% respectively, MPS is better than HPS.

焦炭塔吊装新方法

国外超大件设备吊装,设备一般在大件招投标之前已制作完成,吊耳设计由总承包商与设备制造厂设计制作,这一过程吊装公司基本上没有参与,由于总承包与制造厂对吊装的理解不一样,导致很多设备到场给吊装单位造成一定的吊装难度,焦炭塔作为焦炭装置关键设备,主吊设计有两个管式吊耳,主吊采用专用吊具连接吊耳吊装,溜尾设计了专用吊具吊架,本文主要介绍焦炭塔吊具设计及吊装工艺,并对其进行简要论述.

Catalysis performance comparison of a Br?nsted acid H_2SO_4 and a Lewis acid Al_2(SO_4)_3 in methyl levulinate production from biomass carbohydrates

An experimental investigation was conducted to understand the roles of the Br？nsted acid H2SO4 and Lewis acid Al2（SO4）3 in methyl levulinate（ML） production from biomass carbohydrates, including glucose,fructose and cellulose. The product distributions with different catalysts revealed that the Lewis acid was responsible for the isomerization of methyl glucoside（MG）, producing a significant amount of the subsequent product 5-methoxymethylfurfural（MMF）, while the Br？nsted acid facilitated the production of ML from MMF. Al2（SO4）3 was efficient for monosaccharide conversion but not for cellulose. Using ball-milled cellulose with Al2（SO4）3 resulted in a desired ML yield within a reasonable reaction time. The significant catalysis performances of two types of acids will guide the design of efficient catalytic processes for the selective conversion of biomass into levulinate esters.

Facile Aldol Reaction Between Unmodified Aldehydes and Ketones in Bronsted Acid Ionic Liquids

A series of condensation reactions of unmodified ketones and aromatic aldehydes to prepare α,β-unsaturated carbonyl compounds by means of Aldol reactions in Bronsted acid ionic liquids（BAILs）was explored.1-Butyl-3-methylimidazolium hydrogen sulphate（BMImHSO4）acting as an effective media and catalyst in aldol reactions was compared with other BAILs,with the advantages of high conversion and selectivity.The product was easily isolated and the left ionic liquid can be readily recovered and reused at least 3 times with almost the same efficiency.The scope and limitation of the present method were explored and the possible catalytic mechanism was speculated.

珙桐Davidia involucrata Bail.

落叶乔木,高15～20m;树皮灰褐色,不规则片状剥落。芽鳞覆瓦状排列。叶宽卵形,长9～15cm,宽2.5～4.5cm,基部心形,先端渐尖,叶边缘具明显锯齿;叶面近无毛。

Non-formal Education Bails Out Impoverished Ethnic Youth

On a hot summer day in August 2006, Lamao Cering crouched in a windy field in west China＇s Qinghai Province murmuring to herself. ＂I want to go to school,＂ she chanted quietly over and over in an almost mantra-like trance, oblivious to her father＇s call to come back and tend the sheep.

Hydrothermal synthesis of ABi_(2)Ta_(2)O_(9)Aurivillius phase:A comparative study of A-site cation size on structure,dielectric,optical properties

In this study,the double-layered Aurivillius phases CaBi_(2)Ta_(2)O_(9)(CBT)and PbBi_(2)Ta_(2)O_(9)(PBT)were prepared through a hydrother-mal route with NaOH as a mineralizer.XRD analysis confirmed that the CBT and PBT compounds were successfully formed and adopted an orthorhombic crystal structure with an A21am symmetry.Le Bail refinements of XRD data indicated that the unit cell volume of CBT was smaller than PBT and is associated with the smaller ionic radius of Ca^(2+)compared to Pb^(2+).The surface mor-phology of both samples,as determined using SEM,demonstrated plate-like grains with anisotropic grain growth.It was found that the different ionic radii of A-site cations(Ca^(2+)and Pb^(2+))strongly affected the structural,optical and electrical properties of the Aurivillius phase.The occupation of smaller Ca^(2+)cations induced a higher structural distortion,which resulted in higher bandgap(Eg)energy and ferroelectric transition temperature(Tc)of CBT,compared to those of PBT.

Should Government Bail Out Farmers in Tough Times?

In the face of a struggling tomato market,the government of Guiyang City’s Baiyun District, in southwest China’s Guizhou Province, issued a circular demanding all local government staff buy tomatoes. It wasn’t long before local residents were being