The human pharyngeal microbiome, which resides at the juncture of digestive and respiratory tracts, may have an active role in the prevention of respiratory tract infections, similar to the actions of the intestinal m...The human pharyngeal microbiome, which resides at the juncture of digestive and respiratory tracts, may have an active role in the prevention of respiratory tract infections, similar to the actions of the intestinal microbiome against enteric infections. Recent studies have demonstrated that the pharyngeal microbiome comprises an abundance of bacterial species that interacts with the local epithelial and immune cells, and together, they form a unique micro-ecological system. Most of the microbial species in microbiomes are obligate symbionts constantly adapting to their unique surroundings. Indigenous commensal species are capable of both maintaining dominance and evoking host immune responses to eliminate invading species. Temporary damage to the pharyngeal microbiome due to the impaired local epithelia is also considered an important predisposing risk factor for infections. Therefore, reinforcement of microbiome homeostasis to prevent invasion of infection-prone species would provide a novel treatment strategy in addition to antibiotic treatment and vaccination. Hence continued research efforts on evaluating probiotic treatment and developing appropriate procedures are necessary to both prevent and treat respiratory infections.展开更多
Accurate interpretation of clutter seismic reflection is of great significance to make clear the structural geometry and kinematics characteristics.Based on field investigations,boreholes and seismic data,forward mode...Accurate interpretation of clutter seismic reflection is of great significance to make clear the structural geometry and kinematics characteristics.Based on field investigations,boreholes and seismic data,forward modeling is carried out under the trishear model of fault-propagated fold principle,and the activity characteristics of the main faults in the study area are quantitatively analyzed using the balanced restoration technique,which may provide important indication for the potential petroleum exploration and development.The results show that separated by Tuziluoke and Tugerming fault,the structural style of the study area can be divided into the deeply buried forelimb,the kink band and the tiny anticline backlimb section.The Tuziluoke fault has been active with strong intensity since the sedimentary period of the Kuqa Formation and,which controls the formation of the growth strata in the deep buried forelimb of the Tuziluoke anticline.The Tugerming fault has been active intermittently since the end of the Jurassic,causing the strata denudation of the Late Jurassic to Paleogene in varying degrees and the development of series of regulating faults.The multi-stage tectonic activities caused the structural high of the anticline migrated from east to west.展开更多
基金supported by the National High Technology Research and Development Program of China (863 Program, Grant No. 2006AA02Z4A9)the National Basic Research Program of China (973 Program, Grant No. 2011CB944100)
文摘The human pharyngeal microbiome, which resides at the juncture of digestive and respiratory tracts, may have an active role in the prevention of respiratory tract infections, similar to the actions of the intestinal microbiome against enteric infections. Recent studies have demonstrated that the pharyngeal microbiome comprises an abundance of bacterial species that interacts with the local epithelial and immune cells, and together, they form a unique micro-ecological system. Most of the microbial species in microbiomes are obligate symbionts constantly adapting to their unique surroundings. Indigenous commensal species are capable of both maintaining dominance and evoking host immune responses to eliminate invading species. Temporary damage to the pharyngeal microbiome due to the impaired local epithelia is also considered an important predisposing risk factor for infections. Therefore, reinforcement of microbiome homeostasis to prevent invasion of infection-prone species would provide a novel treatment strategy in addition to antibiotic treatment and vaccination. Hence continued research efforts on evaluating probiotic treatment and developing appropriate procedures are necessary to both prevent and treat respiratory infections.
基金The work was supported by the National Natural Science Foundation of China(No.U19B6003-01),National Oil and Gas Major Project(2016ZX05003-002)PetroChina Science Research and Technology Development Project(No.2019B-0504).
文摘Accurate interpretation of clutter seismic reflection is of great significance to make clear the structural geometry and kinematics characteristics.Based on field investigations,boreholes and seismic data,forward modeling is carried out under the trishear model of fault-propagated fold principle,and the activity characteristics of the main faults in the study area are quantitatively analyzed using the balanced restoration technique,which may provide important indication for the potential petroleum exploration and development.The results show that separated by Tuziluoke and Tugerming fault,the structural style of the study area can be divided into the deeply buried forelimb,the kink band and the tiny anticline backlimb section.The Tuziluoke fault has been active with strong intensity since the sedimentary period of the Kuqa Formation and,which controls the formation of the growth strata in the deep buried forelimb of the Tuziluoke anticline.The Tugerming fault has been active intermittently since the end of the Jurassic,causing the strata denudation of the Late Jurassic to Paleogene in varying degrees and the development of series of regulating faults.The multi-stage tectonic activities caused the structural high of the anticline migrated from east to west.