Tumorigenesis are closely associated with the immune function of the human body.Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century.Traditional Chinese me...Tumorigenesis are closely associated with the immune function of the human body.Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century.Traditional Chinese medicine(TCM)has been extensively used for cancer treatment in China and surrounding countries for it exerts efficient therapeutic effects with few side effects.In recent years,studies have demonstrated that TCM plays a unique and reliable role in regulating tumor immunity.TCM can enhance the antitumor immune response function by regulating the secretion of cytokines,reshaping the balance of immune cells,and regulating immune checkpoints to relieve the immunosuppression.In addition,TCM can reduce the side effects(e.g.,cytokine storm)of cancer immunotherapy.Based on the current research of active immunotherapy and passive immunotherapy,this review summarizes the potential applications and existing problems of TCM in tumor immunotherapy.This review may be helpful in illuminating the scientific basis of TCM in tumor immunotherapy,promoting its internationalization,as well as shedding innovating new strategies for the development of tumor immunotherapy.展开更多
基金supported by the National Natural Science Foundation of China(82074165,81873306,81973526,81703749,81703764)Guangdong Science and Technology Department(2016A030306025)+7 种基金Guangdong High-level Personnel of Special Support Program(A1-3002-16-111-003)Department of Education of Guangdong Province(2018KZDXM022,A1-2606-19-111-009)the Ph.D.Start-up Fund of Natural Science Foundation of Guangdong Province(2017A030310213)Science and Technology Planning Project of Guangdong Province(2017B030314166)Guangzhou science and technology project(201904010407)the Specific Research Fund for TCM Science and Technology of Guangdong provincial Hospital of Chinese Medicine(YN2018MJ07)and the Foundation for Young Scholars of Guangzhou University of Chinese Medicine(QNYC20190101)Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research(2020B1212030006).
文摘Tumorigenesis are closely associated with the immune function of the human body.Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century.Traditional Chinese medicine(TCM)has been extensively used for cancer treatment in China and surrounding countries for it exerts efficient therapeutic effects with few side effects.In recent years,studies have demonstrated that TCM plays a unique and reliable role in regulating tumor immunity.TCM can enhance the antitumor immune response function by regulating the secretion of cytokines,reshaping the balance of immune cells,and regulating immune checkpoints to relieve the immunosuppression.In addition,TCM can reduce the side effects(e.g.,cytokine storm)of cancer immunotherapy.Based on the current research of active immunotherapy and passive immunotherapy,this review summarizes the potential applications and existing problems of TCM in tumor immunotherapy.This review may be helpful in illuminating the scientific basis of TCM in tumor immunotherapy,promoting its internationalization,as well as shedding innovating new strategies for the development of tumor immunotherapy.
