Advanced strategies for 3D-printed neural scaffolds:materials,structure,and nerve remodeling

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor functions.The potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human health.Three-dimensional(3D)printing offers versatility and precision in the fabrication of neural scaffolds.Complex neural structures such as neural tubes and scaffolds can be fabricated via 3Dprinting.This reviewcomprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their design.It highlights therapeutic strategies and structural design involving neural materials and stem cells.First,nerve regeneration materials and their fabrication techniques are outlined.The applications of conductive materials in neural scaffolds are reviewed,and their potential to facilitate neural signal transmission and regeneration is highlighted.Second,the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated,and their potential to restore neural function and promote the recovery of different nervous systems is emphasized.In addition,various applications of 3D-printed neural scaffolds in peripheral and neurological diseases,as well as the design strategies of multifunctional biomimetic scaffolds,are discussed.

Geographic Drone-based Route Optimization Approach for Emergency Area Ad-Hoc Network

Wireless sensor Mobile ad hoc networks have excellent potential in moving and monitoring disaster area networks on real-time basis.The recent challenges faced in Mobile Ad Hoc Networks(MANETs)include scalability,localization,heterogeneous network,self-organization,and self-sufficient operation.In this background,the current study focuses on specially-designed communication link establishment for high connection stability of wireless mobile sensor networks,especially in disaster area network.Existing protocols focus on location-dependent communications and use networks based on typically-used Internet Protocol(IP)architecture.However,IP-based communications have a few limitations such as inefficient bandwidth utilization,high processing,less transfer speeds,and excessive memory intake.To overcome these challenges,the number of neighbors(Node Density)is minimized and high Mobility Nodes(Node Speed)are avoided.The proposed Geographic Drone Based Route Optimization(GDRO)method reduces the entire overhead to a considerable level in an efficient manner and significantly improves the overall performance by identifying the disaster region.This drone communicates with anchor node periodically and shares the information to it so as to introduce a drone-based disaster network in an area.Geographic routing is a promising approach to enhance the routing efficiency in MANET.This algorithm helps in reaching the anchor(target)node with the help of Geographical Graph-Based Mapping(GGM).Global Positioning System(GPS)is enabled on mobile network of the anchor node which regularly broadcasts its location information that helps in finding the location.In first step,the node searches for local and remote anticipated Expected Transmission Count(ETX),thereby calculating the estimated distance.Received Signal Strength Indicator(RSSI)results are stored in the local memory of the node.Then,the node calculates the least remote anticipated ETX,Link Loss Rate,and information to the new location.Freeway Heuristic algorithm improves the data speed,efficiency and determines the path and optimization problem.In comparison with other models,the proposed method yielded an efficient communication,increased the throughput,and reduced the end-to-end delay,energy consumption and packet loss performance in disaster area networks.

Synthesis and manufacture of photocrosslinkable poly(caprolactone)-based three-dimensional scaffolds for tissue engineering applications

It is known that the body can efficiently repair hard tissue (bone) micro fractures by suturing the defect through the deposition of minerals resulting in an area that is stronger post-injury. Larger defects, however, generally cause more trouble since the body is incapable of repairing them. Bone defects can occur as a result of congenital abnormalities, trauma, or disease. Traditional methods for addressing these defects have involved the use of acellular cadaverous bone or autologous bone. Both contain innate prob- lems associated with them;the former method can result in disease transmission, as well as very low integration with the host due to the lack of viable cells while the latter is associated with two surgical sites and morbidity at the donor site. Alternative methods have been developed, but no method has yet provided a satisfactory solution. As a result, resear- chers and the medical community are turning toward the promising fields of biomaterial development and tissue engineering to develop new materials and me- thods of bone regeneration. In this work, a design of experiments (DOE) approach was performed to ren- der commercially available biodegradable polymers (Poly(caprolactone)-diol/triol) photocrosslinkable and resultantly manufacturable using stereolithography (SL), a rapid prototyping technology. To perform the investigations, a commercial SL system (Viper HA, 3D Systems, Valencia, CA) equipped with a solid state laser system (355 nm wavelength) was used to manu-facture synthesized poly(caprolactone) trifuma- rate (PCLtF) 3D porous constructs. Results of the work conducted produced constructs which provided pro- mising chemical and biological results for the in- tended application.

Pressureless all-solid-state Na/S batteries with self-supporting Na_(5)YSi_(4)O_(12) scaffolds

The development of reliable and affordable all-solid-state sodium metal batteries(ASS-SMBs)requires suitable solid-state electrolytes with cost-efficient processing and stabilized electrode/electrolyte interfaces.Here,an integrated porous/dense/porous Na_(5)YSi_(4)O_(12)(NYS)trilayered scaffold is designed and fabricated by tape casting using aqueous slurries.In this template-based NYS scaffold,the dense layer in the middle serves as a separator and the porous layers on both sides accommodate the active materials with their volume changes during the charge/discharge processes,increasing the contact area and thus enhancing the utilization rate and homogenizing the current distribution.The Na/NYS/Na symmetric cells with the Pb-coated NYS scaffold exhibit significantly reduced interfacial impedance and superior critical current density of up to 3.0 mA cm^(-2)against Na metal owing to enhanced wettability.Furthermore,the assembled Na/NYS/S full cells operated without external pressure at room temperature showed a high initial discharge capacity of 970 mAh g^(-1)and good cycling stability with a capacity of 600 mAh g^(-1)after 150 cycles(based on the mass of sulfur).This approach paves the way for the realization of economical and practical ASS-SMBs from the perspective of ceramic manufacturing.

Urban Construction Land Suitability Evaluation Based on Improved Multi-criteria Evaluation Based on GIS(MCE-GIS): Case of New Hefei City,China

Urban construction land suitability evaluation （UCLSE） is a complex system engineering and the basis for rational use of the limited urban land resources in China. It has an important practical value on urban construction land use planning and management from the angle of methodology. As a widely used technique, traditional multi-criteria evaluation based on GIS （MCE-GIS）, is not suitable for UCLSE. This study develops an improved MCE-GIS method which could be more suitable for UCLSE based on urban complex ecological system theory and the summary of the shortcomings of traditional MCE-GIS. The improvements include three aspects： a composite evaluation index system rather than natural indexes alone, an index weight calculated by using fuzzy Analytic Hierarchy Process （AHP） method rather than the common AHP method, and the integrated overlay rule, which includes selecting the minimum value, weighted linear combination （WLC） and simple summation. The main advantage of this improved technique is that it can make UCLSE more comprehensive, more operational and more reasonable. It can provide a scientific basis for decision making in the planning and management of urban construction land use. The improved MCE-GIS system has been adopted in the New Hefei City, Anhui Province, China. Based on the results of UCLSE in New Hefei, three functional areas including construction-appropriate areas, construction-restricted areas and construction-forbidden areas could be worked out, in which 36.90% of the total study area could be developed as urban construction land and the remaining 63.10% should be protected as reserves land or as ecological land. Furthermore, the results can orovide scientific decision suooort for spatial planning and eco-environment nrotection in New Hefei.

Mathematical Model of Natural Gas Desulfurization Based on Membrane Absorption

Models of mass transfer kinetics combined with mass transfer differential equation and mass transfer resistance equation were established on the basis of double-film theory. Mass transfer process of H2 S absorption by means of polypropylene hydrophobic microporous hollow fiber membrane contactor was simulated using MDEA(N-methyldiethanolamine) as the absorption liquid and corresponding experiments of natural gas desulfurization were performed. The simulation results indicated that the removal rate of hydrogen sulfide showed positive dependence on the absorption liquid concentration and gas pressure. However, the desulfurization rate showed negative dependence on gas flow. The simulated values were in good agreement with the experimental results. The in-tube concentration of hydrogen sulfide at the same point increased with increase in the gas velocity. Axial concentration of hydrogen sulfide decreased rapidly at the beginning, and the decrease saw a slowdown during the latter half period. Hydrogen sulfide concentration dropped quickly in the radial direction, and the reduction in the radial direction was weakened with the increase of axial length due to the gradual reduction of hydrogen sulfide concentration along the tube. The desulfurization rate under given operating conditions can be predicted by this model, and the theoretical basis for membrane module design can also be provided.

Alzheimer’s Disease Diagnosis Based on a Semantic Rule-Based Modeling and Reasoning Approach

Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The risks and barriers to detecting AD are huge as pathological events begin decades before appearing clinical symptoms.Therapies for AD are likely to be more helpful if the diagnosis is determined early before the final stage of neurological dysfunction.In this regard,the need becomes more urgent for biomarker-based detection.A key issue in understanding AD is the need to solve complex and high-dimensional datasets and heterogeneous biomarkers,such as genetics,magnetic resonance imaging(MRI),cerebrospinal fluid(CSF),and cognitive scores.Establishing an interpretable reasoning system and performing interoperability that achieves in terms of a semantic model is potentially very useful.Thus,our aim in this work is to propose an interpretable approach to detect AD based on Alzheimer’s disease diagnosis ontology(ADDO)and the expression of semantic web rule language(SWRL).This work implements an ontology-based application that exploits three different machine learning models.These models are random forest(RF),JRip,and J48,which have been used along with the voting ensemble.ADNI dataset was used for this study.The proposed classifier’s result with the voting ensemble achieves a higher accuracy of 94.1%and precision of 94.3%.Our approach provides effective inference rules.Besides,it contributes to a real,accurate,and interpretable classifier model based on various AD biomarkers for inferring whether the subject is a normal cognitive(NC),significant memory concern(SMC),early mild cognitive impairment(EMCI),late mild cognitive impairment(LMCI),or AD.

BIODRILL S合成基钻井液在垦利区块首次应用

渤海油田垦利9-1区块地层岩性复杂,且存在断层带,钻井过程中易发生泥岩水化分散和砂岩层井眼缩径等问题,井壁垮塌风险极大。针对该区块地层岩性特点和技术难题并结合环保要求,制备了一种复合型封堵材料PFMOSHIELD,构建了BIODRILL S合成基钻井液体系。该体系流变性能良好,抗钙、抗岩屑污染达26%和15%,封堵性、沉降稳定性、润滑性优异,高温高压砂盘滤失量3.2 mL,静置7 d沉降因子为0.53,极压润滑系数0.082。BIODRILL S首次在渤海湾垦利9-1区块进行了现场应用,结果表明:该体系解决了垦利9-1区块泥页岩水化和砂岩层井眼缩径问题,垦利9-1北-3定向探井三开井段上部地层钻屑完整,钻屑达4~7 cm;井眼清洁性能良好,钻井液动塑比超过0.59 Pa/mPa·s,φ6和φ3读数均超过9,剪切稀释性强,提高了井眼净化效率,有效避免形成“岩屑床”;润滑性能优异,在大井斜段(55°、70°、67°)可实现直接起钻。

Individualized music for dementia:Evolution and application of evidence-based protocol

The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research.

Biased Random Number Generator Based on Bell's Theorem

We propose a biased random number generation protocol whose randomness is based on the violation of the Clauser Home inequality. Non-maximally entangled state is used to maximize the Bell violation. Due to the rotational asymmetry of the quantum state, the ratio of Os to ls varies with the measurement bases. The experimental partners can then use their measurement outcomes to generate the biased random bit string. The bias of their bit string can be adjusted by altering their choices of measurement bases. When this protocol is implemented in a device-independent way, we show that the bias of the bit string can still be ensured under the collective attack.

COVID-19 mortality paradox(United States vs Africa):Mass vaccination vs early treatment

The coronavirus disease 2019(COVID-19)mortality rate in 55 African countries is almost 4.5 times lower than in the coronavirus disease 2019(COVID-19)despite Africa having over 4.2 times more people.This mortality paradox is also evident when comparing Nigeria,a heavily populated,poorly vaccinated and weakly mandated country to Israel,a small,highly vaccinated and strictly mandated country.Nigeria has almost 4 times lower COVID mortality than Israel.In this Field of Vision perspective,I explain how this paradox has evolved drawing upon my academic,clinical and social experience.Since April 2020,I’ve developed and been using the Egyptian immune-modulatory Kelleni’s protocol to manage COVID-19 patients including pediatric,geriatric,pregnant,immune-compromised and other individuals suffering from multiple comorbidities.It’s unfortunate that severe acute respiratory syndrome coronavirus 2 is still evolving accompanied by more deaths.However in Africa,we’ve been able to live without anxiety or mandates throughout the pandemic because we trust science and adopted early treatment using safe,and effective repurposed drugs that have saved the majority of COVID-19 patients.This article represents an African and Egyptian tale of honor.

观察基于Watson人性照顾理论的干预对重症肺炎合并呼吸衰竭患者的应用效果

目的:观察基于Watson人性照顾理论的干预对重症肺炎合并呼吸衰竭患者的应用效果。方法:选取2021年6月至2023年6月泉州市第一医院呼吸与危重症医学科收治的重症肺炎合并呼吸衰竭患者94例作为研究对象,按照随机数字表法分为对照组和观察组,每组47例。对照组给予常规护理干预,观察组在对照组基础上给予Watson人性照顾理论的干预。采用匹兹堡睡眠质量指数量表(PSQI)比较2组患者干预前后睡眠质量的变化,采用阿森斯失眠量表(AIS)评估2组患者干预前后失眠的改善效果,并通过2组患者护理后的呼吸困难缓解时间、机械通气时间、重症监护室住院时间,以判断恢复情况。结果:干预后,观察组患者PSQI评分、AIS评分均显著低于对照组,观察组呼吸困难缓解时间、机械通气时间及重症监护室住院时间均显著短于对照组,差异均有统计学意义(均P<0.05)。结论:对重症肺炎合并呼吸衰竭患者应用基于Watson人性照顾理论的护理干预可有效改善其睡眠质量,促进病情恢复,值得临床推广应用。

A Content-Based Parallel Image Retrieval System on Cluster Architectures

We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based image retrieval. It adopts the Browser/Server (B/S) mode. The users could visit our system though web pages. It uses the symmetrical color-spatial features (SCSF) to represent the content of an image. The SCSF is effective and efficient for image matching because it is independent of image distortion such as rotation and flip as well as it increases the matching accuracy. The SCSF was organized by M-tree, which could speedup the searching procedure. Our experiments show that the image matching is quickly and efficiently with the use of SCSF. And with the support of several retrieval servers, the system could respond to many users at mean time. Key words content-based image retrieval - cluster architecture - color-spatial feature - B/S mode - task parallel - WWW - Internet CLC number TP391 Foundation item: Supported by the National Natural Science Foundation of China (60173058)Biography: ZHOU Bing (1975-), male, Ph. D candidate, reseach direction: data mining, content-based image retrieval.

Scaffolding Information of Learner’s Dictionaries for L2 Writing: A User Perspective

As a major resource and tool of language learning, learner’s dictionaries have provided sufficient information forL2 writing, which serves as a good guide of peer feedback. Hence, learner’s dictionaries are an indispensable partof scaffolding in the L2 writing feedback system. However, the effects of dictionary use in L2 writing have longbeen ignored either in L2 writing pedagogy or in learner lexicography. By applying the concept of “scaffolding” topeer feedback as the theoretical framework, this study first clarifies three distinct types of scaffolding informationpresented in current English learner’s dictionaries, and then makes an investigation into EFL learners’ perceptionand practical use of scaffolding information in their English writing. Results show that most EFL learners havepositive attitudes towards scaffolding information and its role in motivating effective feedback in English writing.But their practical use of such information is not satisfactory owing to their inadequate skills and knowledge ofdictionary use. This reflects a high demand of a dictionary use course in universities, which will help to raise EFLlearners’ dictionary use efficiency as well as improve English teachers’ lexicographical expertise in English writingpedagogy.

Ab Initio Calculation of Dielectric Function in Wurtzite GaN Based on Walter's Model

The wavelength-dependent and frequency-dependent dielectric function of wurtzite-GaN is cMculated totally from fundamental parameters such as the lattice constant using Waiter＇s ab initio model. The errors occurring in the cMculation are carefully reduced by/inear interpolation of energy data. The Kramers-Kronig transform of the real part of greater range is obtained by extrapolation of the reM part. The calculation is time-consuming but meaningful The long-wave results are similar to the experimental data of the photon and are useful for related investigation of properties of wide-gap semiconductors such as electron scattering like the Auger recombination and impact ionization.

GRAPHICAL COMPUTING METHOD ON FOUR-BAR LINKAGE(1)——Inflexion Circle,Focal Axis,Ball's Point,Centering-point Curve and Circling-point Curve For Four ISPs,Coupler Curves Based on Ball's Points——

By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.

载铜地质聚合物微球的制备及其催化降解双酚S的性能

传统的芬顿反应因在废水处理过程中会产生大量富含金属污泥而应用受限。本研究采用悬浮固化法得到了一种低成本、易回收、绿色的多孔地质聚合物微球(GM),将其作为载体通过浸渍法制备了载铜地质聚合物微球(Cu-GM),作为类芬顿反应催化剂,催化H_(2)O_(2)降解水中的双酚S(BPS)。SEM、XRD、BET和XPS等一系列表征结果表明,Cu^(+/2+)被稳定固定在GM表面。进一步探究了Cu-GM用量、H_(2)O_(2)用量、BPS浓度和溶液初始p H对催化降解的影响。结果表明,在优化条件下,Cu-GM在480min内对BPS的去除率可达99.3%,催化降解过程符合一级反应动力学。通过自由基淬灭实验发现,在催化降解过程中·OH和^(1)O_(2)是主要活性物质。循环实验表明Cu-GM具有良好的重复利用性,在去除水中有机污染物方面有着极大的应用潜力。

ZTE Showcases World's First VoLTE Call Based on IMS with Existing Mobile Networks at Mobile Asia Congress 2010

ZTE Corporation, a leading global provider of telecommunications equipment and network solutions, demonstrated successful IMS based Voice over LTE （VoLTE） calls on CSL Limited （CSL）＇s LTE network and its existing mobile networks at Mobile Asia Congress 2010 （MAC 2010）.

Introduction of Simulating the Motion of Rigid Ellipsoidal Objects in Ductile Shear Zone Based on the Jeffery's Theory

Rigid ellipsoidal objects(gravels and porphyroclasts)in ductile zone is an important factor to indicate the kinematics and dynamics.Jeffery’s theory(Jeffery G,1922),a quantitative research method,for the rotation ofthe rigid objects(no deformation)in the Newtonian fluid of the simple deformation field has been widely applied by geologists to the study of fabrics in rocks.The theory