Mean nocturnal baseline impedance in gastro-esophageal reflux disease diagnosis:Should we strictly follow the Lyon 2 Consensus?

Clinical practice guidelines drive clinical practice and clinicians rely to them when trying to answer their most common questions.One of the most important position papers in the field of gastro-esophageal reflux disease(GERD)is the one produced by the Lyon Consensus.Recently an updated second version has been released.Mean nocturnal baseline impedance(MNBI)was proposed by the first Consensus to act as supportive evidence for GERD diagnosis.Originally a cut-off of 2292 Ohms was proposed,a value revised in the second edition.The updated Consensus recommended that an MNBI<1500 Ohms strongly suggests GERD while a value>2500 Ohms can be used to refute GERD.The proposed cut-offs move in the correct direction by diminishing the original cut-off,nevertheless they arise from a study of normal subjects where cut-offs were provided by measuring the mean value±2SD and not in symptomatic patients.However,data exist that even symptomatic patients with inconclusive disease or reflux hypersensitivity(RH)show lower MNBI values in comparison to normal subjects or patients with functional heartburn(FH).Moreover,according to the data,MNBI,even among symptomatic patients,is affected by age and body mass index.Also,various studies have proposed different cut-offs by using receiver operating characteristic curve analysis even lower than the one proposed.Finally,no information is given for patients submitted to on-proton pump inhibitors pH-impedance studies even if new and extremely important data now exist.Therefore,even if MNBI is an extremely important tool when trying to approach patients with reflux symptoms and could distinguish conclusive GERD from RH or FH,its values should be interpreted with caution.

Gyrokinetic simulations of the kinetic electron effects on the electrostatic instabilities on the ITER baseline scenario

The linear and nonlinear simulations are carried out using the gyrokinetic code NLT for the electrostatic instabilities in the core region of a deuterium plasma based on the International Thermonuclear Experimental Reactor(ITER)baseline scenario.The kinetic electron effects on the linear frequency and nonlinear transport are studied by adopting the adiabatic electron model and the fully drift-kinetic electron model in the NLT code,respectively.The linear simulations focus on the dependence of linear frequency on the plasma parameters,such as the ion and electron temperature gradientsκ_(Ti,e)≡R=L_(Ti,e),the density gradientκ_(n)≡R/L_(n)and the ion-electron temperature ratioτ=T_(e)=T_(i).Here,is the major radius,and T_(e)and T_(i)denote the electron and ion temperatures,respectively.L_(A)=-(δ_(r)lnA)^(-1)is the gradient scale length,with denoting the density,the ion and electron temperatures,respectively.In the kinetic electron model,the ion temperature gradient(ITG)instability and the trapped electron mode(TEM)dominate in the small and large k_(θ)region,respectively,wherek_(θ)is the poloidal wavenumber.The TEMdominant region becomes wider by increasing(decreasing)κ_(T_(e))(κ_(T_(i)))or by decreasingκ_(n).For the nominal parameters of the ITER baseline scenario,the maximum growth rate of dominant ITG instability in the kinetic electron model is about three times larger than that in the adiabatic electron model.The normalized linear frequency depends on the value ofτ,rather than the value of T_(e)or T_(i),in both the adiabatic and kinetic electron models.The nonlinear simulation results show that the ion heat diffusivity in the kinetic electron model is quite a lot larger than that in the adiabatic electron model,the radial structure is finer and the time oscillation is more rapid.In addition,the magnitude of the fluctuated potential at the saturated stage peaks in the ITGdominated region,and contributions from the TEM(dominating in the higher k_(θ)region)to the nonlinear transport can be neglected.In the adiabatic electron model,the zonal radial electric field is found to be mainly driven by the turbulent energy flux,and the contribution of turbulent poloidal Reynolds stress is quite small due to the toroidal shielding effect.However,in the kinetic electron model,the turbulent energy flux is not strong enough to drive the zonal radial electric field in the nonlinear saturated stage.The kinetic electron effects on the mechanism of the turbulence-driven zonal radial electric field should be further investigated.

A New Result on Regular Designs under Baseline Parameterization

The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship between K-aberration and word length pattern is developed.

基于Baseline模型的刮板输送机健康评估

对刮板输送机进行可靠健康评估是保证工作面高效开采的关键。针对某煤矿综采工作面刮板输送机提出一种基于Baseline模型的健康评估方法。该方法采用长短时记忆(LSTM)深度神经网络建立运行参数的Baseline模型,预测正常的数值和故障发生上、下限阈值。在此基础上建立了真实值与预测值的6种偏差计算方法和设备健康评估机制。最后融合机头电机、机尾电机、机头减速器和机尾减速器的评估结果,完成刮板输送机运行健康综合评估。

Baseline Sensitivity of Botrytis cinerea from Liaoning Province to Boscalid

[Objective] This study aimed to avoid and delay the generation of resis- tance in Botrytis cinerea to boscalid. [Method] The sensitivity of Botrytis cinerea to boscalid was tested by the mycelial growth rate method. The distribution of sensitivity variation of B. cinerea to boscalid in different regions was cleared, and the sen- sitivity baseline of B. cinerea from Liaoning Province to boscalid was established. [Result] The ECso values of B. cinerea strains from Liaoning Province ranged from 0.080 0 to 7.787 2μg/ml, and the highest ECho value was 97.34 times higher than the minimum. The average EC50 value （1.973μg/ml） of the 158 strains was treated as the baseline sensitivity of B. cinerea from Liaoning Province to boscalid. [Conclu- sion] It is essential to conduct a risk assessment of drug resistance in B. cinerea to boscalid.

An Analog Equalizer and Baseline-Wander Cancelle rfor 100/1000Base-TX Transceiver

A frequency-domain equalizer with a mixed-signal adaptive control loop and a novel baseline wander （BLW） canceller are proposed. The equalizer is independent of channel-modeling accuracy,and its control loop is intrinsically stable. An AGC function is incorporated into the equalizer without an extra AGC circuit. The proposed BLW canceller uses a peak detector to monitor the BLW and full feedback method to accomplish BLW canceling. High canceling accuracy and robust performance are achieved. The circuits are tested in 0.25μm CMOS technology. Better performance and smaller silicon area are achieved compared with results in the literature.

Baseline——一种容忍与检测DoS/DDoS攻击的被动方法(英文)

提出一种检测DoS/DDoS攻击(拒绝服务攻击/分布式拒绝服务攻击)的“Baseline”服务体系结构,并实现了其中关键的“Shepherd”检测算法。该体系结构通过把服务及其质量是否受到影响的判断指标交由具体的通信进程来定义而具有较强的适应性,可以与各种现有入侵检测系统很好地结合且不给宿主系统增加过多的开销。同时相比其他DoS/DDoS检测方式,Baseline服务无须对Internet路由基础设施作出更改来提供支持,是一种十分可行的DoS/DDoS检测方案。在理想情况下,Baseline服务可以做到对DoSDDoS入侵零误报。

基于MAX+plusII 10.0 Baseline的数字电路设计

讨论 MAX+plus II10 .0 Baseline的功能和特点 ,提出以 VHDL 设计语言为手段、以 MAX+plus II10 .0Baseline为平台的数字电路的设计方法。

Estimating the Baseline Error of Wide-Swath Altimeters Using Nadir Altimeters via Numerical Simulation

The baseline roll and length errors for wide-swath altimeters are major error sources in sea surface measurements that exhibit strong spatial characteristics in the cross-track direction.These errors can be identified and estimated in accordance with height differences at crossover points generated with nadir altimeters after excluding the interference from other error sources.Most of the wide-swath altimeter baseline estimation methods considered only the roll error in previous studies.A numerical simulation was conducted in this study using nadir altimeters to estimate the roll and length errors simultaneously to provide a selectable scheme for baseline error estimation and correction for future wide-swath altimeters.Results based on the parameters of the surface water and ocean topography mission and Sentinel-3A show that the correlation coefficient of the roll error between the estimated and simulated values is 0.89,while the correlation coefficient of the length error is 0.85.The sea surface height root mean square error(RMSE)can be reduced from 12.18 cm to 6.45 cm based on the two estimated results.The estimation effect can be increased by using multiple nadir altimeters to form an observation constellation.The numerical simulation of the five nadir altimeter constellation shows that the correlation coefficients of the roll and length errors would increase to 0.97,which reduces the sea surface height RMSE to 2.88 cm.In addition,the stability of this method is indicated in simulation experiments,which introduce different degrees of sea state errors.

A High-Speed Baseline Restorer for Neutron Flux Detection in ITER

A neutron flux monitor .（NFM） is a key diagnostic system in the International Ther- monuclear Experimental Reactor （ITER）, and may provide readings of a series of important parameters in fusion reaction processes. As a valuable part of the main electronics system of the NFM, the high-speed baseline restorer we designed is an important signal conversion plug-in which can restore the input signal baseline offset to a zero level, while keeping the output pulse signal waveform from the preamplifier basically unchanged.

IMPROVED CALIBRATION METHOD FOR AIRBORNE ATI-SAR BASELINE

Airborne Along-Track Interferometric Synthetic Aperture Radar (ATI-SAR) baseline error is a main error resource affecting the precision of velocity measurement of moving objects and therefore should be calibrated externally. The Jet Propulsion Laboratory (JPL) has proposed a calibration scheme for tasks of PacRim98 and PacRim2000 based on several static objects on the ground. In this paper, the influence of phase center uncertainty on baseline determination by using PacRim method proposed by JPL is analyzed. According to the analysis, the phase center uncertainty can cause a constant part of error to the result of baseline calibration. In order to deal with this problem, an improved calibration method on the basis of sensitivity equations and some ground moving targets, whose velocities are already known, is proposed in this paper. The simulation results show that our proposed calibration method has improved the accuracy of baseline calibration and has obviously prohibited the effect of antennas' phase center uncertainty.

基于Baseline SVD主动学习算法的推荐系统

推荐系统是一种解决信息过载的新型技术,为了解决推荐系统中新用户带来的冷启动问题,提出一种基于主动学习的推荐系统。主动学习方法能有效减少需要标记的样本数量,快速建立模型,在此选择将主动学习方法和Baseline SVD推荐算法结合起来,通过记录模型训练得到的预估评价的改变程度,认为改变最大的样例即是最具有信息量的样例,供新用户标记,并重新训练模型。通过与其他选择策略进行实验比较,证实了该方法确实有效解决了新用户带来的冷启动问题。

Baseline JPEG压缩器在Xilinx FPGA上的设计与实现

由于近年来胶囊内窥镜需求的发展,以及FPGA在小型化和低功耗的技术进步,在内窥镜系统中应用FPGA为核心的解决方案已经成为可能。在目前的FPGA数字胶囊系统,以及未来用于胶囊窥镜的专用集成电路中,图像数据压缩都是重要组成部分。本文使用Verilog对普遍应用的Baseline JPEG压缩核进行封装并在FPGA进行实现和验证,并给出了电路设计和测试结果。在Xilinx Spartan LX9 FPGA上,所实现的Baseline JPEG压缩器达到最高166 MHz的时钟频率。

Baseline characterization of patients aged 70 years and above with hepatocellular carcinoma

AIM: To characterize the baseline profiles of patients aged 70 years and above with hepatocellular carcinoma (HCC).METHODS: A series of 127 consecutive patients with HCC were enrolled between 2000 and 2004, and none of them had been diagnosed as having HCC previously. Baseline profiles, including parameters of hepatic function such as serum transaminase and prothrombin time [PT (% activity)] were compared between patients aged ≥70 and ＜70 years.RESULTS: Patients ≥70 years old showed significantly lower levels of aspartate aminotransferase (P = 0.04)and alanine aminotransferase (P = 0.01), and significantly higher PTs (P= 0.04) and platelet counts (P = 0.02).Concomitantly, among ≥70-year-old patients, HCC was more common in non-cirrhotics, whereas among patients ＜70 years old, HCC was more common in cirrhotics. There was no significant difference between the groups in the number or size of tumors.CONCLUSION: Older HCC patients showed less inflammation and better preservation of hepatic function, indicating that not only cirrhotic patients but also noncirrhotic patients should be considered as a high-risk group among the elderly.

Geochemical baseline determination and contamination of heavy metals in the urban topsoil of Fuxin City,China

Urban topsoil is the most frequent interface between human society and natural environment.The accumulation of heavy metals in the urban topsoil has a direct effect on residents'life and health.The geochemical baseline of heavy metals is an objective description of the general level of heavy metals in the urban topsoil.Meanwhile,the determination of geochemical baseline is necessary for regional environmental management,especially in coal cities prone to heavy metal pollution.Heavy metal pollution has become an environmental problem in Fuxin City,China for a long time.To establish the geochemical baseline of heavy metals in the topsoil of Fuxin City and to evaluate the ecological risk of the topsoil,we collected 75 topsoil samples(0–20 cm)and analyzed the concentrations of Cu,Ni,Zn,Pb,Cr,Cd,Hg and As through X-ray fluorescence spectrometry,atomic absorption spectrometry and inductively coupled plasma optical emission spectrometry.We determined the geochemical baseline of heavy metals in the topsoil of Fuxin City by using iteration removal,box-whisker plot,cumulative frequency curve and reference metal normalization;evaluated the contamination risk and ecological risk of the topsoil by using the baseline factor index,Nemerow index and Hakanson potential ecological risk index;and identified the source category of heavy metals in the topsoil by using a pedigree clustering heatmap.Results showed that the geochemical baseline values were 42.86,89.34,92.23,60.55,145.21,0.09,0.08 and 4.17 mg/kg for Cu,Ni,Zn,Pb,Cr,Cd,Hg and As,respectively.The results of Nemerow index and Hakanson potential ecological risk index indicated that the urban topsoil in the study area was slightly contaminated and suffering low potential ecological risk.The main contaminated areas dominated in the middle part and northeast part of the study area,especially in the western Haizhou Strip Mine.The result of baseline factor index indicated that Hg and Cd were the major pollution elements.Using a pedigree clustering heatmap,we divided the sources of these heavy metals into three types:type I for Ni and Cr,largely represented the enrichment of heavy metals from natural sources;type II for Cu,Pb,Zn,Cd and As,mainly represented the enrichment of heavy metals from anthropogenic sources;and type III for Hg,represented the form of both natural and anthropogenic inputs.

Baseline HBsAg predicts response to pegylated interferon-α2b in HBeAg-positive chronic hepatitis B patients

AIM: To evaluate the predictive effect of baseline hepatitis B surface antigen (HBsAg) on response to pegylated interferon (PEG-IFN)-&#x003b1;2b in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients.

The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years

Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin （OCN） in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen （CTX） and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant （NGT） women at baseline were invited for follow-up. The incidence of diabetes and prediabetes （collectively defined as dysglycemia） was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3% （95% confidence interval （CI）, 6.8%-30.70/0）] compared with the lower [31.0% （95% CI, 17.2%-46.1%）] and upper [46.5% （95% CI, 31.2%-62.6%）] tertiles of CTX, with a significant difference seen between the middle and upper tertiles （P = 0.002 5）. After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09 （95% CI, 1.73-28.99） when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia.

GPS dynamic cycle slip detection and correction with baseline constraint

When the cycle slips take place in the attitude determination of a moving platform, the precision of the attitude will be impaired badly. A method of cycle slip detection and correction is proposed, which is suitable to the dynamic measurement using GPS carrier phase： the cycle slips detection is first achieved by triple difference observables, then the cycle slips correction is performed with baseline length constraint. The simulation results show that the proposed method is effective to the dynamic cycle slips problem.

Joint adaptive waveform and baseline range design for bistatic radar

The problems of joint adaptive waveform design and baseline range design for bistatic radar to maximize the practical radar resolution were considered.Distinguishing from the conventional ambiguity function(AF)-based resolution which is only related with the transmitted waveform and bistatic geometry and could be regarded as the potential resolution of a bistatic radar system,the practical resolution involves the effect of waveform,signal-to-noise ratio(SNR)as well as the measurement model.Thus,it is more practical and will have further significant application in target detection and tracking.The constraint optimization procedure of joint adaptive waveform design and baseline range design for maximizing the practical resolution of bistatic radar system under dynamic target scenario was devised.Simulation results show that the range and velocity resolution are enhanced according to the adaptive waveform and bistatic radar configuration.