Teaching Reform of Basic Medicine Curriculum by Integrating the Perspective of Curriculum Civics and Politics in the Context of Healthy China

Basic medicine is the foundation of basic knowledge of medical science,life science,and natural science,and is the basis for training medical talents.It can help students correctly understand the relationship between disease and health,and is of great significance under the perspective of the Healthy China strategy.However,there are still some deficiencies in the current teaching,and insufficient attention has been paid to civics and politics.Thus,it is necessary to carry out curriculum reform in order to enable students to better understand medical knowledge and master medical skills,to ensure the development of medical education,and to play an important role in basic medicine.This study combines the necessity of curriculum reform under the perspective of civics and politics and puts forward a teaching reform strategy suitable for the development of contemporary medicine to provide a direction for the educational development of basic medicine.

Exploration on the Reform of PBL Mode of Course:Comprehensive Experiment of Basic Medicine for Nursing Undergraduates in Colleges and Universities of Traditional Chinese Medicine

The undergraduate education of nursing science produces higher practical operational talents to the society,and the importance of experimental teaching cannot be ignored in the training of nursing students.The basic experimental teaching method of undergraduate nursing has been explored and reformed by the College of Basic Medicine of Guangxi University of Chinese Medicine.After the reform,the experimental teaching adopts the teaching method of PBL mode,and the experimental course is composed of several specific and important medical problems.The specific tasks involved in each problem include relevant morphological knowledge,functional knowledge,diagnostic and laboratory knowledge,and clinical medical knowledge.It makes the teaching content of experimental course more comprehensive,and leads to the transition from basic medicine to clinical medicine.This has gradually and effectively improved the practical ability,scientific research thinking,clinical comprehensive ability and learning interest of undergraduate nursing students.

The 3rd Symposium on Animal Models of Primates——The Application of Non-Human Primates to Basic Research and Translational Medicine

In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues： （1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.

New Solution and Application of the Theory of "Acting According to Time"

From the perspective of theoretical analysis,based on the annotation of ancient doctors on the theory of"acting according to time,"this article puts forward the view of "time";that is,the impact of the social environment on the occurrence and development of diseases.In addition,it points out that the characteristics of modem diseases are of"multiple heat syndromes and multiple repletion pattern."Based on this characteristic,the use of heat-clearing drugs in the clinical stage would have a good eflect.It has been suggested that contemporary doctors should not only inherit the theories from predecessors,but also think diligently and innovate bravely along with the current environment in order to ensure that the theories ofTCM are constantly full of vitality to better serve the clinical aspect.

Effect of Bushen Yisui Capsule(补肾益髓胶囊) on Oligodendrocyte Lineage Genes 1 and 2 in Mice with Experimental Autoimmune Encephalomyelitis

Objective： To study the effects of Bushen Yisui Capsule（补肾益髓胶囊, BSYSC） on the oligodendrocyte lineage genes（Olig） 1 and Olig2 in C57BL/6 mice with experimental autoimmune encephalomyelitis（EAE） in order to explore the remyelination effect of BSYSC. Methods： The mice were randomly divided into normal control（NC）, EAE model（EAE-M）, prednisone acetate（PA, 6 mg/kg）, BSYSC high-dose（3.02 g/kg） and BSYSC low-dose（1.51 g/kg） groups. The mice were induced by immunization with myelin oligodendrocyte glycoprotein（MOG） 35-55. The neurological function scores were assessed once daily. The pathological changes in mice brains were observed with hematoxylin-eosin（HE） staining and transmission electron microscope（TEM）. The protein expressions of myelin basic protein（MBP）, Olig1 and Olig2 in brains were measured by immunohistochemistry. The m RNA expressions of Olig1 and Olig 2 was also determined by quantitative real-time polymerase chain reaction. Results： Compared with the EAE-M mice,（1） the neurological function scores were significantly decreased in BSYSC-treated mice on days 22 to 40（P〈0.01）;（2） the inflammatory cells and demyelination in brains were reduced in BSYSC-treated EAE mice;（3） the protein expression of MBP was markedly increased in BSYSC-treated groups on day 18 and 40 respectively（P〈0.05 or P〈0.01）;（4） the protein expression of Olig1 was increased in BSYSC（3.02 g/kg）-treated EAE mice on day 40（P〈0.01）. Protein and m RNA expression of Olig2 was increased in BSYSC-treated EAE mice on day 18 and 40（P〈0.01）. Conclusion： The effects of BSYSC on reducing demyelination and promoting remyelination might be associated with the increase of Olig1 and Olig2.