The dichloromethane extract of the air-dried leaves of Ardisia cf.elliptica(subgenus Tinus)afforded a mixture of bauerenol(1a),α-amyrin(1b)andβ-amyrin(1c).Their structures were identified by NMR spectroscopy.Mixture...The dichloromethane extract of the air-dried leaves of Ardisia cf.elliptica(subgenus Tinus)afforded a mixture of bauerenol(1a),α-amyrin(1b)andβ-amyrin(1c).Their structures were identified by NMR spectroscopy.Mixtures of the triterpenes (1a-1c)at ratios of 2:2:1,2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM).All three ratios were found to be effective in restricting inter-capillary length,while 1a-1c(2:2:1)was most effective in reducing branch point density with 100%CAM viability and embryo survivability,suggesting a high impact angio-suppressive potential of 1a-1c(2:2:1).展开更多
基金supported by the grant from the Philippine Council for Health Research and Development (PCHRD) of the Philippines through the Metro Manila Health Research and Development Consortium (MMHRDC)
文摘The dichloromethane extract of the air-dried leaves of Ardisia cf.elliptica(subgenus Tinus)afforded a mixture of bauerenol(1a),α-amyrin(1b)andβ-amyrin(1c).Their structures were identified by NMR spectroscopy.Mixtures of the triterpenes (1a-1c)at ratios of 2:2:1,2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM).All three ratios were found to be effective in restricting inter-capillary length,while 1a-1c(2:2:1)was most effective in reducing branch point density with 100%CAM viability and embryo survivability,suggesting a high impact angio-suppressive potential of 1a-1c(2:2:1).
