目的探讨北京降压0号治疗原发性高血压的降压效果及安全性。方法将150例在门诊就诊的轻、中度高血压患者随机分为两组,每组75例。北京降压0号治疗组用北京降压0号,1片/d;对照组用长效降压药拉西地平4m g/d。两组服药时间均为晨服。每周...目的探讨北京降压0号治疗原发性高血压的降压效果及安全性。方法将150例在门诊就诊的轻、中度高血压患者随机分为两组,每组75例。北京降压0号治疗组用北京降压0号,1片/d;对照组用长效降压药拉西地平4m g/d。两组服药时间均为晨服。每周随访1次,追踪观察6个月,了解其降压效果及不良反应发生情况;并在治疗前后分别检测血糖、血脂、电解质及肝、肾功能变化。结果用北京降压0号治疗1周、4周和8周后达到正常血压值(<140/90m m H g)者分别为52例(69.33%)、64例(85.33%)和70例(94.66%)。用拉西地平片治疗1周、4周和8周后达到正常血压值者分别为56例(74.67%)、62例(82.67%)和69例(92.67%)。两组降压幅度与疗效无明显差异(P>0.05)。用北京降压0号治疗出现不良反应5例(6.7%),主要为轻度头晕、鼻塞、乏力,继续治疗可自行缓解。对照组出现不良反应6例(8.0%),为头痛、面红、心悸和轻度浮肿。结论应用北京降压0号可显著降低轻、中度高血压患者血压,安全性好,可作为临床推荐使用的高血压一线药物。展开更多
This study aims to evaluate the impact of physical activity (PA) on the prevalence of hypertension among older adults in Beijing community. As economy growing rapidly in China, the occurrence of hypertension increases...This study aims to evaluate the impact of physical activity (PA) on the prevalence of hypertension among older adults in Beijing community. As economy growing rapidly in China, the occurrence of hypertension increases among older people in China as well. Epidemiological studies have shown that physical activity may significantly related to lower risk of hypertension. Taking PA maybe an instructive factor to reduce the risk of being hypertensive. We randomly selected Beijing community residents aged 65 and above (n = 400), collected data comprising level of PA (low, moderate, high), blood pressure, and a host of potentially confounding variables indicated by the literature. Five logistic regression models adjusted for different modifiers were used to estimate the association between hypertension and PA. The prevalence of hypertension was 96.88%, 78.57% and 73.66% among subjects with low, moderate and high level of PA respectively. Lower diastolic BP was observed for elder people with higher level of PA (p<0.01). We observed a strong and statistically significant association between moderate (OR=0.09, 95% CI: 0.01 to 0.74) or high (OR=0.08, 95% CI: 0.01 to 0.57) level of PA and lower risk of hypertension (p < 0.05). PA is a protective factor for hypertension among older Beijing people, which suggests elderly people be encouraged to actively engage in PA, if body conditions permit.展开更多
文摘目的探讨北京降压0号治疗原发性高血压的降压效果及安全性。方法将150例在门诊就诊的轻、中度高血压患者随机分为两组,每组75例。北京降压0号治疗组用北京降压0号,1片/d;对照组用长效降压药拉西地平4m g/d。两组服药时间均为晨服。每周随访1次,追踪观察6个月,了解其降压效果及不良反应发生情况;并在治疗前后分别检测血糖、血脂、电解质及肝、肾功能变化。结果用北京降压0号治疗1周、4周和8周后达到正常血压值(<140/90m m H g)者分别为52例(69.33%)、64例(85.33%)和70例(94.66%)。用拉西地平片治疗1周、4周和8周后达到正常血压值者分别为56例(74.67%)、62例(82.67%)和69例(92.67%)。两组降压幅度与疗效无明显差异(P>0.05)。用北京降压0号治疗出现不良反应5例(6.7%),主要为轻度头晕、鼻塞、乏力,继续治疗可自行缓解。对照组出现不良反应6例(8.0%),为头痛、面红、心悸和轻度浮肿。结论应用北京降压0号可显著降低轻、中度高血压患者血压,安全性好,可作为临床推荐使用的高血压一线药物。
文摘This study aims to evaluate the impact of physical activity (PA) on the prevalence of hypertension among older adults in Beijing community. As economy growing rapidly in China, the occurrence of hypertension increases among older people in China as well. Epidemiological studies have shown that physical activity may significantly related to lower risk of hypertension. Taking PA maybe an instructive factor to reduce the risk of being hypertensive. We randomly selected Beijing community residents aged 65 and above (n = 400), collected data comprising level of PA (low, moderate, high), blood pressure, and a host of potentially confounding variables indicated by the literature. Five logistic regression models adjusted for different modifiers were used to estimate the association between hypertension and PA. The prevalence of hypertension was 96.88%, 78.57% and 73.66% among subjects with low, moderate and high level of PA respectively. Lower diastolic BP was observed for elder people with higher level of PA (p<0.01). We observed a strong and statistically significant association between moderate (OR=0.09, 95% CI: 0.01 to 0.74) or high (OR=0.08, 95% CI: 0.01 to 0.57) level of PA and lower risk of hypertension (p < 0.05). PA is a protective factor for hypertension among older Beijing people, which suggests elderly people be encouraged to actively engage in PA, if body conditions permit.
