Study on Traditional Chinese Medicine theory of lung being connected with large intestine

OBJECTIVE:The theory of lung being connected with large intestine,which is a major topic in Traditional Chinese Medicine(TCM),has guided clinical practice for thousands of years in China.METHODS:In this study,we analyzed the history,main contents,clinical application,and material basis of the theory,to attempt to improve the potential clinical significance of "lung being connected with large intestine" in China.RESULTS:The lung being connected with large intestine was first described in "Huang Di Nei Jing",and formed one of the basic theories of TCM.For thousands of years,the majority of TCM practitioners explored this theory continuously,leading to its development and use as an important theory in the guidance of TCM clinics In the last decade,researchers in the field of integrated TCM and Western medicine have studied clinical applications and biomedical mechanisms with experimental methods to explore the implications of the theory.CONCLUSION:With the further development of science and technology,research concerning the theory of lung being connected with large intestine will be greatly stimulated and contribute to the modernization of TCM.

Literature-based analysis on relationship of symptoms,drugs and therapies in treatment of intestinal diseases

OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid management.METHODS:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal diseases.RESULTS:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the intestine.Among these agents,Kuxingren(Semen Armeniacae Amarum)was used most frequently.Clearing Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red tongue.Clearing Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key agent.CONCLUSION:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,abdominal fullness),drugs[Gualou(Fructus et Semen Trichosanthis),Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)]and therapies(moistening the intestine,clearing Fu-organs,invigorating Qi,ventilating the lungs).

Analysis on clinically drug-used law for lung-intestine related diseases

OBJECTIVE： To analyze the application laws of clini- cal drugs by descriptive statistical method with the clinical literatures guided by ＂lung being connect- ed with large intestine＂ used as the object. METHODS： Retrieve publicly published clinical litera- tures about ＂lung being connected with large intes- tine＂ in recent 30 years, establish the data base of clini- cal literature, and study on the clinically drug-used laws by descriptive statistical analytic method. RESULTS： The common high frequent drugs used for the lung-intestine related diseases were Gualou （Ructus Trichsanthis）, Dahuang （Radix et Rhizoma）, Kuxingren （Semen Armeniacae Amarum）, Gancao （Radix Glycyrrhizae）, Houpu （Cortex Magnoliae Offi- cinalis）, Zhishi （Fructus Aurantii Immaturus）. For the different clinical syndrome types, in the commonly used drugs there were different characteristics, re- flecting the principle of TCM syndrome differentia- tion treatment.CONCLUSION： The common high frequent drugs used for the lung-intestine related diseases are Gua- Iou （Fructus Trichsantffis）, Dahuang （Radix et Rhi- zoma）, Kuxingren （Semen Armeniacae Amarum）, Gancao （Radix Glycyrrhizae）, Houpu （Cortex Mag- noliae Officinalis）, Zhishi （Fructus Aurantii Immatu- rus）, which are commonly-used drugs for the lung-intestine related diseases ,with differences for different syndrome types.