An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadswort...An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography（HPLC） was identical to that of Japanese Pharmacopoeia（16th）. This development will be used for the industrial synthesis of beraprost sodium.展开更多
目的探讨贝前列素钠联合他克莫司治疗肾病综合征的效果及对肾功能、超声肾血流状态的影响。方法选取2021年3月至2023年6月收治的80例肾病综合征患者为研究对象,将其随机分为对照组和观察组,各40例。对照组给予他克莫司治疗,观察组在对...目的探讨贝前列素钠联合他克莫司治疗肾病综合征的效果及对肾功能、超声肾血流状态的影响。方法选取2021年3月至2023年6月收治的80例肾病综合征患者为研究对象,将其随机分为对照组和观察组,各40例。对照组给予他克莫司治疗,观察组在对照组基础上加用贝前列素钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率为95.00%,高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗前,两组的血肌酐(Scr)、胱抑素-C(Cys-C)、血尿素氮(BUN)、白蛋白(ALB)水平及24 h尿蛋白定量(24 h UPQ)比较,差异无统计学意义(P>0.05);治疗后,观察组的Scr、Cys-C、BUN水平及24 h UPQ低于对照组,ALB水平高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的肾动脉收缩期峰值血流速度(PSV)、搏动指数(PI)及阻力指数(RI)比较,差异无统计学意义(P>0.05);治疗后,观察组的肾动脉PSV高于对照组,PI、RI低于对照组(P<0.05)。结论贝前列素钠联合他克莫司治疗肾病综合征的效果显著,其能改善患者肾功能,调节肾血流状态,值得推广。展开更多
文摘An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography（HPLC） was identical to that of Japanese Pharmacopoeia（16th）. This development will be used for the industrial synthesis of beraprost sodium.
文摘目的探讨贝前列素钠联合他克莫司治疗肾病综合征的效果及对肾功能、超声肾血流状态的影响。方法选取2021年3月至2023年6月收治的80例肾病综合征患者为研究对象,将其随机分为对照组和观察组,各40例。对照组给予他克莫司治疗,观察组在对照组基础上加用贝前列素钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率为95.00%,高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗前,两组的血肌酐(Scr)、胱抑素-C(Cys-C)、血尿素氮(BUN)、白蛋白(ALB)水平及24 h尿蛋白定量(24 h UPQ)比较,差异无统计学意义(P>0.05);治疗后,观察组的Scr、Cys-C、BUN水平及24 h UPQ低于对照组,ALB水平高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的肾动脉收缩期峰值血流速度(PSV)、搏动指数(PI)及阻力指数(RI)比较,差异无统计学意义(P>0.05);治疗后,观察组的肾动脉PSV高于对照组,PI、RI低于对照组(P<0.05)。结论贝前列素钠联合他克莫司治疗肾病综合征的效果显著,其能改善患者肾功能,调节肾血流状态,值得推广。
