Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease

The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

Evaluation of Generalized Error Function via Fast-Converging Power Series

A generalized form of the error function, Gp(x)=pΓ(1/p)∫0xe−tpdt, which is directly associated with the gamma function, is evaluated for arbitrary real values of p>1and 0x≤+∞by employing a fast-converging power series expansion developed in resolving the so-called Grandi’s paradox. Comparisons with accurate tabulated values for well-known cases such as the error function are presented using the expansions truncated at various orders.

Existence of Monotone Positive Solution for a Fourth-Order Three-Point BVP with Sign-Changing Green’s Function

This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones and iterative technique.

A Set of Almost Automorphic Functions and Applications

For a set S of real numbers, we introduce the concept of S-almost automorphic functions valued in a Banach space. It generalizes in particular the space of Z-almost automorphic functions. Considering the space of S-almost automorphic functions, we give sufficient conditions of the existence and uniqueness of almost automorphic solutions of a differential equation with a piecewise constant argument of generalized type. This is done using the Banach fixed point theorem.

Duality between Bessel Functions and Chebyshev Polynomials in Expansions of Functions

In expansions of arbitrary functions in Bessel functions or Spherical Bessel functions, a dual partner set of polynomials play a role. For the Bessel functions, these are the Chebyshev polynomials of first kind and for the Spherical Bessel functions the Legendre polynomials. These two sets of functions appear in many formulas of the expansion and in the completeness and (bi)-orthogonality relations. The analogy to expansions of functions in Taylor series and in moment series and to expansions in Hermite functions is elaborated. Besides other special expansion, we find the expansion of Bessel functions in Spherical Bessel functions and their inversion and of Chebyshev polynomials of first kind in Legendre polynomials and their inversion. For the operators which generate the Spherical Bessel functions from a basic Spherical Bessel function, the normally ordered (or disentangled) form is found.

基于格林函数法研究分数阶Bessel-Gaussian光束近场传输

为揭示FBG(fractional-order Bessel-Gaussian)光束在近场传输时的光强和相位演化情况,基于光传播的独立性和叠加性原理,通过引入虚光源点,并结合格林函数法,严格推导了FBG光束的非傍轴积分表达式,并进一步利用非傍轴下的各阶修正解,精确计算了FBG光束轴上的光强分布.计算结果表明:对于分数阶Bessel-Gaussian光束的远场传输,利用经典的傍轴近似理论可以得到准确的计算结果,但在近场传输时,傍轴近似理论的计算结果误差很大,只有利用非傍轴修正解才能精确研究FBG光束的近场光学传输.研究结果为将FBG光束更好地应用于近场光学奠定必要的理论基础.

高压管汇材料疲劳性能测试及P-S-N模型曲线的拟合

高压管汇作为压裂设备中的主要易损件之一,其失效危害较大。它的失效原因主要是疲劳、冲蚀、腐蚀或者材料缺陷引起的刺漏和爆裂,其中尤以疲劳失效最不可预估。目前,对于高压管汇材料的疲劳性能研究不够深入,为解决高压管汇材料疲劳寿命的准确描述问题,以某国产高压管汇材料为例,进行了一系列疲劳试验,并基于试验数据,采用多种分布模型和不同S-N模型进行拟合分析,得出综合评价拟合能力最强的P-S-N模型。结果表明,该材料在中长疲劳寿命区,Weibull三参数模型在7级应力水平下综合评价能力最好;在存活率分别为50%、90%、99%、99.9%时,指数S-N模型的拟合系数均大于0.98,拟合能力最好。得出的P-S-N模型曲线可以为高压管汇的疲劳寿命以及安全设计提供依据。

基于哨兵函数和S变换的风力机叶片材料损伤特性研究

利用声发射检测技术研究玻璃纤维增强环氧树脂复合材料的损伤特性,在此过程中,采用哨兵函数来表征该材料的损伤程度,并通过S变换和模糊C均值(FCM)聚类来分析声发射信号,从而获得材料的损伤特征。三点弯曲实验结束后对试件断口进行扫描电子显微镜(SEM)拍照来验证,可得:通过对SEM照片的分析得到基体开裂、纤维脱粘、分层破坏、纤维断裂4种损伤模式;对整个声发射事件进行哨兵函数分析,观察到试件在弯曲过程中哨兵函数曲线呈明显下降趋势;对依据哨兵函数划分的不同阶段的信号进行VMD降噪处理,然后采用S变换进行时频分析得到不同损伤的特征频率,最后采用FCM聚类进行验证。结果表明:哨兵函数值的突变可作为材料断裂的预警信号,材料损伤类型的识别可依据S变换的频率分布结果进行确定。

Continuum Skyrme Hartree-Fock-Bogoliubov theory with Green’s function method for neutron-rich Ca,Ni,Zr,and Sn isotopes

The possible exotic nuclear properties in the neutron-rich Ca,Ni,Zr,and Sn isotopes are examined with the continuum Skyrme Hartree-Fock-Bogoliubov theory in the framework of the Green’s function method.The pairing correlation,the couplings with the continuum,and the blocking effects for the unpaired nucleon in odd-A nuclei are properly treated.The Skyrme interaction SLy4 is adopted for the ph channel and the density-dependentinteraction is adopted for the pp chan-nel,which well reproduce the experimental two-neutron separation energies S_(2n)and one-neutron separation energies Sn.It is found that the criterion S_(n)>0 predicts a neutron drip line with neutron numbers much smaller than those for S_(2n)>0.Owing to the unpaired odd neutron,the neutron pairing energies−E_(pair)in odd-A nuclei are much lower than those in the neighbor-ing even-even nuclei.By investigating the single-particle structures,the possible halo structures in the neutron-rich Ca,Ni,and Sn isotopes are predicted,where sharp increases in the root-mean-square(rms)radii with significant deviations from the traditional rA^(1∕3)rule and diffuse spatial density distributions are observed.Analyzing the contributions of various partial waves to the total neutron densityρlj(r)∕ρ(r)reveals that the orbitals located around the Fermi surface-particularly those with small angular momenta-significantly affect the extended nuclear density and large rms radii.The number of neutrons Nλ(N_(0))occupying above the Fermi surfacen(continuum threshold)is discussed,whose evolution as a function of the mass number A in each isotope is consistent with that of the pairing energy,supporting the key role of the pairing correlation in halo phenomena.

THIRD-ORDER DIFFERENTIAL SUBORDINATION RESULTS FOR ANALYTIC FUNCTIONS INVOLVING THE GENERALIZED BESSEL FUNCTIONS

In the present paper, we derive some third-order differential subordination results for analytic functions in the open unit disk, using the operator Bcκf by means of normalized form of the generalized Bessel functions of the first kind, which is defined as z（Bκ＋1^c f（z））′= κBκ^c f（z）-（κ- 1）Bκ＋1^c f（z）,where b, c, p ∈ C and κ = p ＋（b ＋ 1）/2 ∈ C ／ Z0^-（Z0^-= {0,-1,-2, … }）. The results are obtained by considering suitable classes of admissible functions. Various known or new special cases of our main results are also pointed out.

GREEN'S FUNCTION AND THE POINTWISE BEHAVIORS OF THE VLASOV-POISSON-FOKKER-PLANCK SYSTEM

The pointwise space-time behaviors of the Green’s function and the global solution to the Vlasov-Poisson-Fokker-Planck(VPFP)system in three dimensional space are studied in this paper.It is shown that the Green’s function consists of the diffusion waves decaying exponentially in time but algebraically in space,and the singular kinetic waves which become smooth for all(t,x,v)when t>0.Furthermore,we establish the pointwise space-time behaviors of the global solution to the nonlinear VPFP system when the initial data is not necessarily smooth in terms of the Green’s function.

圆柱结构中的环向SH波及洞体内表面波不存在性讨论

目前有关圆柱结构中的环向SH波研究仅限于实心柱体与圆柱壳体结构。由于无法直接获得圆柱洞体中传播的SH表面波的解析解,对比研究了实心柱体和多种不同类型的圆柱壳体中的环向SH波,从波结构、应变能密度幅值分布与壳体厚度的关系讨论洞体内SH表面波的存在性。建立柱坐标系下均匀弹性材料与功能梯度材料环向SH波的波动方程;分别求得方程的贝塞尔函数解和幂级数渐近解;进一步计算得到其频散曲线、波结构与应变能密度幅值。结果表明:幂级数方法可用于计算圆柱型结构中的变系数波动方程,且具有较高的精度;圆柱型结构中环向SH波的能量集中在外表面或次外表面,并随着壳体厚度的增加,能量集中现象更为明显;通过应变能密度幅值分布规律推论出圆柱洞体内表面无法传播环向SH表面波。最后,针对均质结构和梯度结构,采用反证法证明了无法得到满足洞体内SH表面波衰减条件的解析解,从而证明了该推论。

Common Properties of Riemann Zeta Function, Bessel Functions and Gauss Function Concerning Their Zeros

The behavior of the zeros in finite Taylor series approximations of the Riemann Xi function (to the zeta function), of modified Bessel functions and of the Gaussian (bell) function is investigated and illustrated in the complex domain by pictures. It can be seen how the zeros in finite approximations approach to the genuine zeros in the transition to higher-order approximation and in case of the Gaussian (bell) function that they go with great uniformity to infinity in the complex plane. A limiting transition from the modified Bessel functions to a Gaussian function is discussed and represented in pictures. In an Appendix a new building stone to a full proof of the Riemann hypothesis using the Second mean-value theorem is presented.

Quantifyingα-diversity as a continuous function of location——a case study of a temperate forest

α-diversity describes species diversity at local scales.The Simpson’s and Shannon-Wiener indices are widely used to characterizeα-diversity based on species abundances within a fixed study site(e.g.,a quadrat or plot).Although such indices provide overall diversity estimates that can be analyzed,their values are not spatially continuous nor applicable in theory to any point within the study region,and thus they cannot be treated as spatial covariates for analyses of other variables.Herein,we extended the Simpson’s and Shannon-Wiener indices to create point estimates ofα-diversity for any location based on spatially explicit species occurrences within different bandwidths(i.e.,radii,with the location of interest as the center).For an arbitrary point in the study region,species occurrences within the circle plotting the bandwidth were weighted according to their distance from the center using a tri-cube kernel function,with occurrences closer to the center having greater weight than more distant ones.These novel kernel-basedα-diversity indices were tested using a tree dataset from a 400 m×400 m study region comprising a 200 m×200 m core region surrounded by a 100-m width buffer zone.Our newly extendedα-diversity indices did not disagree qualitatively with the traditional indices,and the former were slightly lower than the latter by<2%at medium and large band widths.The present work demonstrates the feasibility of using kernel-basedα-diversity indices to estimate diversity at any location in the study region and allows them to be used as quantifiable spatial covariates or predictors for other dependent variables of interest in future ecological studies.Spatially continuousα-diversity indices are useful to compare and monitor species trends in space and time,which is valuable for conservation practitioners.

Green's functions of two-dimensional piezoelectric quasicrystal in half-space and bimaterials

In this paper,we obtain Green’s functions of two-dimensional(2D)piezoelectric quasicrystal(PQC)in half-space and bimaterials.Based on the elastic theory of QCs,the Stroh formalism is used to derive the general solutions of displacements and stresses.Then,we obtain the analytical solutions of half-space and bimaterial Green’s functions.Besides,the interfacial Green’s function for bimaterials is also obtained in the analytical form.Before numerical studies,a comparative study is carried out to validate the present solutions.Typical numerical examples are performed to investigate the effects of multi-physics loadings such as the line force,the line dislocation,the line charge,and the phason line force.As a result,the coupling effect among the phonon field,the phason field,and the electric field is prominent,and the butterfly-shaped contours are characteristic in 2D PQCs.In addition,the changes of material parameters cause variations in physical quantities to a certain degree.

Measurement of Optical Fiber Geometry Parameters with Bessel Function Fitting Method

Geometry parameters of optical fiber are crucial in evaluating the quality of the optical fiber.Near⁃field light distribution method is recommended in GB15972.20-2008 for the measurement of geometry parameters.To distinguish the boundary between fiber core and cladding,it is necessary to illuminate the fiber.The end face of the core is a bright spot with unclear edge,so the true edge of the core and the cladding cannot be accurately judged.A method is proposed in this paper to measure the geometry parameters of optical fiber by Bessel function fitting.Theoretically,the solution to the electromagnetic vector of mode field satisfies Bessel function,and the boundary between the core and the cladding can be precisely extracted by Bessel function fitting.Edges of the fiber were fitted by elliptical curves,and the geometry parameters of the fibers could be calculated.Results show that the maximum deviations of the diameters and the average differences of the fibers were decreased under normal and abnormal conditions respectively.The proposed method is an efficient way to obtain edge data and can improve the accuracy and stability of geometry parameters of optical fibers.

Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including microglia.To examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 months.We conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain tissue.We confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-βdeposition.The expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed group.Subsequently,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated group.Both radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by PLX3397.These results showed that radiofrequency electromagnetic fields ameliorated amyloid-βpathology and cognitive impairment by suppressing amyloid-βdeposition-induced microgliosis and their key regulator,CSF1R.

基于S函数的调节阀粘滞特性检测方法

调节阀粘滞特性引起的振荡是工业控制回路性能恶化的最常见来源。目前虽然已有许多检测调节阀粘滞特性的方法,但这些方法的复杂性或存在的缺陷限制着其在实际工况中的具体应用。本文提出了一种检测过程控制回路中调节阀粘滞故障的新方法。该方法将控制器输出(OP)和过程变量(PV)的变化(ΔPV)在相平面图中所构成变化趋势与标准S函数进行对比,根据实际函数趋势与标准S函数间的差异计算相关系数,通过相关系数的数值具体得出调节阀中是否存在粘滞特性。仿真实例和实际工业数据分析实验验证了提出方法的有效性。

A Probabilistic Trust Model and Control Algorithm to Protect 6G Networks against Malicious Data Injection Attacks in Edge Computing Environments

Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential infrastructures.The provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and unsupervised.While full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and vulnerabilities.In particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control loops.Additionally,Denialof-Service attacks can be executed by inundating the network with valueless noise.Current anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical models.Solutions based on an exhaustive data collection to detect anomalies are precise but extremely slow.Standard models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors transparently.This paper introduces a probabilistic trust model and control algorithm designed to address this gap.The model determines the probability of any node to be trustworthy.Communication channels are pruned for those nodes whose probability is below a given threshold.The trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and combined.Initially,anomalous nodes are identified using Gaussian mixture models and clustering technologies.Next,traffic patterns are studied using digital Bessel functions and the functional scalar product.Finally,the information coherence and content are analyzed.The noise content and abnormal information sequences are detected using a Volterra filter and a bank of Finite Impulse Response filters.An experimental validation based on simulation tools and environments was carried out.Results show the proposed solution can successfully detect up to 92%of malicious data injection attacks.

SIMPLIFICATION OF FREQUENCY EQUATION OF MULTILAYERED CYLINDERS AND SOME RECURSION FORMULAE OF BESSEL FUNCTIONS

In this paper the axially symmetric, radial vibration frequency equation of multilayered cylinders made of the same materials in plain strain state is studied. It is proved in this paper that the frequency equation of:several contact hallow cylinders can be replaced by the frequency equation of a single hollow cylinder, so that the solving process is greatly simplified. Some recursion formulae of Bessel functions are derived from such practical problems as well.