Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

Background:Valid and reliable measures of depressive symptoms are crucial for understanding risk factors,outcomes,and interventions across rural and urban settings.Despite this need,the longitudinal invariance of these measures over time remains understudied.This research explores the structural components of the Center for Epidemiological Studies Depression Scale(CES-D)and examines its consistency across various living environments and temporal stability in a cohort of Chinese teenagers.Method:In the initial phase,1,042 adolescents furnished demographic details and undertook the CES-D assessment.After a three-month interval,967 of these participants repeated the CES-D evaluation.The study employed Confirmatory factor analysis(CFA)to scrutinize the scale’s structural integrity.We investigated factorial invariance by conducting a twopronged CFA:one comparing urban vs.rural backgrounds,and another contrasting the results from the initial assessment with those from the follow-up.Results:The CES-D demonstrated adequate reliability in both rural and urban high school student samples.The preliminary four-factor model applied to the CES-D demonstrated a good fit with the collected data.Invariance tests,including multigroup analyses comparing rural and urban samples and longitudinal assessments,confirmed the scale’s invariance.Conclusions:The results suggest that the CES-D serves as a reliable instrument for evaluating depressive symptoms among Chinese adolescents.Its applicability is consistent across different living environments and remains stable over time.

Study on the Changes of Medical Income Structure in Governmentrun Hospitals of Traditional Chinese Medicine from 2012 to 2021

Objective To study the changing characteristics and trend of medical income structure in the government-run hospitals of traditional Chinese medicine(TCM),evaluate the effects of relevant reform measures,and to put forward corresponding suggestions for further optimizing their income structure.Methods The data related to the average medical income of government-run hospitals of TCM from 2012 to 2021 were sorted out.Then,descriptive analysis method was used to analyze the changes of related indicators.Besides,structural change method was applied to investigate the changes of outpatient income and inpatient income.Results and Conclusion From 2012 to 2021,the growth of medical income in government-run hospitals of TCM tended to be stable,and the proportion of medical service income increased from 22.62%(2012)to 29.38%(2021),but the average annual growth rate was only 0.68%.The main items that caused the change of outpatient income structure were medicine revenue,laboratory tests,diagnosis and treatment,and the cumulative contribution rate was 89.15%.The main items that caused the change of inpatient income structure were medicine revenue,sanitary materials,and auxiliary examinations income,with a cumulative contribution rate of 80.04%.However,the contribution rate of registration,diagnosis,treatment,surgery and nursing income reflecting the value of medical personnel’s technical labor was relatively small.The medical income structure of government-run hospitals of TCM underwent great changes and gradually became reasonable,but the medical service income increased slowly,and not all indicators achieved the expectations.To promote the sustainable development of public hospitals of TCM and enable them to provide high-quality and efficient TCM medical and health services,it is necessary to further improve the relevant policy mechanism.

Structural similarity of lithospheric velocity models of Chinese mainland

Existing lithospheric velocity models exhibit similar structures typically associated with the first-order tectonic features,with dissimilarities due to different data and methods used in model generation.The quantification of model structural similarity can help in interpreting the geophysical properties of Earth's interior and establishing unified models crucial in natural hazard assessment and resource exploration.Here we employ the complex wavelet structural similarity index measure(CW-SSIM)active in computer image processing to analyze the structural similarity of four lithospheric velocity models of Chinese mainland published in the past decade.We take advantage of this method in its multiscale definition and insensitivity to slight geometrical distortion like translation and scaling,which is particularly crucial in the structural similarity analysis of velocity models accounting for uncertainty and resolution.Our results show that the CW-SSIM values vary in different model pairs,horizontal locations,and depths.While variations in the inter-model CW-SSIM are partly owing to different databases in the model generation,the difference of tomography methods may significantly impact the similar structural features of models,such as the low similarities between the full-wave based FWEA18 and other three models in northeastern China.We finally suggest potential solutions for the next generation of tomographic modeling in different areas according to corresponding structural similarities of existing models.

Computational investigation on the molecular structure and chemical reactivity of a traditional Chinese medicine extract MK-1 molecule

MK-1 molecule(C_(16)H_(16)O_(2)),the simplest structure of vitamin K(VK)compound family,is an extract from traditional Chinese medicine Cymbopogon distans(Nees ex Steud.)Wats(Chinese name YunXiangCao),which has attracted a great deal of attention in recent years due to its antiasthmatic,antitussives and expectorant effects.To investigate the molecular structure and chemical reactivity of MK-1 molecule,computational investigations on six conformational minima structures were carried out at the MP2/6-311++G(2d,2p)level of theory.Several local reactivity descriptors including condensed Fukui function,average local ionization energy,and molecular electrostatic potential on each individual atom were determined to predict the intrinsic reactivity of MK-1 molecule.

Microsatellite analysis of genetic diversity and population structure of Chinese mitten crab (Eriocheir sinensis)

Chinese mitten crab （Eriocheir sinensis） has higher commercial value as food source than any other species of Eriocheir in China. To evaluate the germplasm resources and characterize the genetic diversity and population structure of the crabs in different water systems, two stocks and two farming populations were assessed with 25 polymorphic microsallite loci available in public GenBank. Basic statistics showed that the average observed heterozygosity （Ho） amongst populations ranged from 0.5789 to 0.6824. However, a remarkable presence of inbreeding and heterozygote deficiencies were observed. To analyze population structure, pairwise FST coefficients explained only -10.3% variability from the subdivision of mitten crab populations, the remaining variability stems from the subdivision within subpopulations. Although the four populations had slight differentiation, different allelic frequencies resulted in distinct population structures. Two stocks and one farming population were clustered together to the phylogenetic branch of Yangtze crab, with an approximate membership of 95%. Whereas, another farming population was clustered singly to the phylogenetic branch of the Liaohe crab, with a membership of 97.1%. The tests for individual admixture showed that Yangtze crab had probably been contaminated with individuals from other water systems. Genetic relationships between populations also supported the conclusion that Yangtze crab and Liaohe crab had different gene pools in spite of the origins of the same species.

Analysis of genetic diversity and population structure of Chinese yak breeds (Bos grunniens) using microsatellite markers

Nine Chinese yak breeds （Maiwa, Tianzhu White, Qinghai Plateau, Sibu, Zhongdian, Pali, Tibetan High Mountain, Jiulong, and Xinjiang） and Gayal were analyzed by means of 16 microsatellite markers to determine the level of genetic variation within populations, genetic relationship between populations, and population structure for each breed. A total of 206 microsatellite alleles were observed. Mean F-statistics （0.056） for 9 yak breeds indicated that 94.4% of the genetic variation was observed within yak breeds and 5.6% of the genetic variation existed amongst breeds. The Neighbor-Joining phylogenetic tree was constructed based on Nei＇s standard genetic distances and two clusters were obtained. The Gayal separated from the yaks far away and formed one cluster and 9 yak breeds were grouped together. The analysis of population structure for 9 yak breeds and the Gayal showed that they resulted in four clusters; one cluster includes yaks from Tibet Autonomous Region and Qinghai Province, one cluster combines Zhongdian, Maiwa, and Tianzhu White, and Jiulong and Xinjiang come into the third cluster. Pali was mainly in the first cluster （90%）, Jiulong was mainly in the second cluster （87.1%）, Zhongdian was primarily in the third cluster （83%）, and the other yak breeds were distributed in two to three clusters. The Gayal was positively left in the fourth cluster （99.3%）.

Construction method of Chinese sentential semantic structure

A new method is proposed for constructing the Chinese sentential semantic structure in this paper. The method adopts the features including predicates, relations between predicates and basic arguments, relations between words, and case types to train the models of CRF ＋ ＋ and de- pendency parser. On the basis of the data set in Beijing Forest Studio-Chinese Tagged Corpus （ BFS- CTC）, the proposed method obtains precision value of 73.63% in open test. This result shows that the formalized computer processing can construct the sentential semantic structure absolutely. The features of predicates, topic and comment extracted with the method can be applied in Chinese in- formation processing directly for promoting the development of Chinese semantic analysis. The method makes the analysis of sentential semantic analysis based on large scale of data possible. It is a tool for expanding the corpus and has certain theoretical research and practical application value.

Research on the Impact of Chinese Digital Inclusive Finance on Industrial Structure Upgrade—Based on Spatial Dubin Model

Based on the panel data of 30 provinces, municipalities, and autonomous regions in China from 2011 to 2018, this paper uses the digital inclusive financial index and industrial structure upgrading coefficient of the Internet Research Center of Peking University as the core explanatory and explained variables to construct a spatial panel. Bin model performs regression analysis on the effect of digital inclusive finance in the upgrading of industrial structure. The results prove that the development of digital inclusive finance in this province and city has significantly promoted the upgrading of the regional industrial structure, and it has a positive overall effect on the upgrading of industrial structure.

Receiver functions of CCDSN and crustal structure of Chinese mainland

The teleseismic receiver functions of 48 stations belonging to the CCDSN are used to invert the crustal structure beneath each station with the neighborhood algorithm. Thin layers with low velocity have been found beneath eight stations with ＂abnormal＂ observed receiver functions. Unreasonable results of few stations have been adjusted lightly with the trial-and-error method. The final result indicates that the crust in the western China is relatively thicker than the eastern China. The crust thickness beneath the Tibetan plateau is very large, which reaches 84 km at the station LSA. Double-crust structure exists below the stations LSA and CAD in Tibet, which might imply the collision between the Indian and Eurasian plates. A pronounced low velocity zone in the lower crust beneath the station TNC of Yunnan province might relate to the high temperature or emergence of partially molten material caused by Quaternary volcano, magma and geothermal activities in this area. The Moho is a transitional zone made up of thin layers instead of simple sharp discontinuity beneath several stations. The Conrad discontinuity is clearly identified beneath 20 stations mainly in the southeastern China, whereas it is blurry beneath 14 stations and uncertain beneath remaining stations.

Reflections on Chinese Culture from the Perspective of Chinese Conversation Structure

Though Chinese conversation structure has some overlap with the English conversation structure, it has many differences in the details because of the in? uence of unique Chinese culture. This thesis analyses every part of the Chinese conversation structure by listing many concrete examples which reflects how Chinese culture in? uence the Chinese conversation structure.

Changes of Wage Structures in Chinese Public and Private Sectors： 1995-2007

Using CHIP （Chinese Household Income Project Survey） data and the sample selection bias corrected wage function model, this paper estimated changes in wage structure in China by ownership types （SOEs, COEs, FEs, and PEs） in 1995 and 2007. The major conclusions are as follows. First, effects of education on wage levels in SOEs and FEs become greater, while education effects decrease in SOEs and PEs under economic transition periods; firm-specific human capital becomes more important in the wage determination mechanism along with market-oriented reforms in SOEs, PEs, and FEs; age effect decreases in SOEs and COEs, but it becomes greater in PEs and FEs. Second, there exist wage structure differences between sectors by wage distributions. For example, in 2007, in SOEs, education return rates are higher for the low-wage and middle-wage groups, and the effect is the highest at the 40th percentile. However in COEs and FEs, education return rates are higher for the high-wage groups, and the effect is the highest at the 70th percentile in COEs and at the 70th percentile in FEs. Tenure effects are greater in the middle-wage groups （40th-80th） in SOEs, COEs, and FEs, and age effects are greater in the low-wage groups （5th-30th） in SOEs, FEs, and PEs.

Chinese Conversation Structure

This paper aims to describe the features of Chinese conversation structure. Specifically speaking, the structure will be analyzed from the following four aspects: openings and pre-sequence, adjacency pairs, pre-closing and closing. Generally speaking, Chinese conversation structure is similar to English conversation structure. But still a lot of differences are found due to cultural factors.

The structure features of stick-slip mechanism of the strike-slip earthquake generating structure in the interior of the Chinese mainland

This is the third one of the paper series on the strike slip earthquake generating structure in the interior of the Chinese mainland. The features of the tectonic stress field of strike slip earthquake generating structure were discussed in the first paper (Huan et al ., 1994), and the features of the deformation field of strike slip earthquake were presented in the second paper (Hun et al ., 1994). In the first section of this paper, through the analysis of the strike slip earthquake generating structure of several dozen large earthquakes with magnitude greater than 6.0, it is concluded that almost all strike slip earthquake generating faults are characterized by the oblique arranged distribution, and the barrier structure mode about the adhesive slip movement of strike slip is put forward; then in the second section, its four types, due to the different fracture form of the barrier at the ends, are also discussed; finally in the third section, the fracture terminating scale of the barrier of strike slip earthquake generating fault is also discussed.

On Chinese Conversation Structure

With the aim of introducing Chinese conversational communication characteristics in Chinese cultural,this paper lists the Chinese conversation structure and describes the characteristics of its components "setting up","pragmatic acts","uptakes" and "pre-closing".By giving some specific examples,the paper also explains how the components work according to Chinese social conventions in Chinese society.

Structural Carpentry in Qing Dynasty-A Framework for the Hierarchically Modularized Chinese Timber Structural Design

This article, by using mathematical expressions, offers a scientific framework for understanding how the grading system of Qing′s structural carpentry determines the design and construction in the grand style timber architecture.The Qing′s grand style timber structure, which is ready for prefabrication and assembly, is extremely hierarchical oriented and significantly standardized. The general procedure in designing a grand style timber structure is to start with the grade that defines the basic module (dou kou); next comes with the number of bracket set (cuan), the number of longitudinal bays and the number of purlins which affect its plan and cross section; thirdly choose a roof type that determines its longitudinal section and the facade as well. A series of formulae are conducted to help depict the layout, cross sectional roof curvature and special longitudinal treatments in 4 sloped and 9 spined roofs respectively.

Comparison between English and Chinese Repeated References to the Same Thing and Parallel Structure

Chinese and English are two very different languages; the former belongs to the Sino-Tibetan Language Family and the latter the Indo-European Language Family. In terms of textual organization, they show substantial differences. Chinese is mainly a pragmatic, paratactic and topic-prominent language, while English a grammatical, hypotactic and subject-prominent language. This thesis gives a contrastive study of two problems in English and Chinese. They are repeated references to the same thing and parallel structure. In this way, the translation work will be more succinct and smooth.

Translation of Four-Chinese-Character Structures——With the Report at the 19^(th) National Congress of the Communist Party of China as Case Study

Chinese is featured with four-Chinese-character structures.These forms are typical in pattern,sound and meaning delivery.The thesis,therefore,with classifications of the four-Chinese-character structures in the latest 19^(th)National Congress of the Communist Party of China,attempts to analyze translation methods such as literal translation and liberal translation as well as translation techniques such as combination,shift,addition and omission.It is concluded that dominant methods or techniques are adopted in translating corresponding types of four-Chinese-character structures.In this sense,not only guidance for translation practice in political regard is offered but also a further understanding of translation methods and techniques can be gained.

The Comparative Study of Two Translated Texts on Huangdirent Translating Styles o'n s Internal Classics——Simple Analysis on the Diffe Culture-Specific Lexicon, Figure of Speech and Four-Chinese-Character Structures

Huangdi's Internal Classics(Neijin) is one of the most important ancient medical classics, which plays far-reaching influence in medical field. More and more domestic and overseas scholars published their translated texts on Neijing. Due to the diversity of editions and different understanding, the translating styles and contents are widely different. This study will focus on the different translating styles on culture-specific lexicon、figure of speech and four-Chinese-character structures in Neijin.