The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping ...The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.展开更多
Exploring new and efficient photocatalysts to boost photocatalytic CO_(2) reduction is of critical importance for solar-to-fuel conversion.In this study,through the in-situ growth method,a series of S-scheme mechanism...Exploring new and efficient photocatalysts to boost photocatalytic CO_(2) reduction is of critical importance for solar-to-fuel conversion.In this study,through the in-situ growth method,a series of S-scheme mechanism Bi_(2)S_(3)/BiVO_(4)/Mn_(0.5)Cd_(0.5)S-DETA nanocomposites with good photocatalytic activity were synthesized.The extremely small size of Mn_(0.5)Cd_(0.5)S-DETA nanoparticles provides more active sites for photocatalytic reactions.In order to solve the serious shortcomings of sulfide photo-corrosion,BiVO_(4) were introduced as oxidation catalyst to consume too many holes and improve the stability of the material.In addition,the in-situ growth method produces the reduction cocatalyst Bi_(2)S_(3) during the BiVO_(4) and Mn_(0.5)Cd_(0.5)S-DETA recombination process,thereby improving the efficiency of charge transfer at their interface contact.The ternary composite unveils a higher CO_(2)-reduction rate(44.74μmol g^(−1) h^(−1))comparing with pristine BiVO_(4)(14.11μmol g^(−1) h^(−1)).The enhanced photocatalytic CO_(2) reduction performance is due to the special interface structure of the S-scheme Bi_(2)S_(3)/BiVO_(4)/Mn_(0.5)Cd_(0.5)S-DETA photocatalyst,which facilitates the charge separation at the interface and improves its photocatalytic activity and stability.展开更多
基金upported in part by the National Natural Science Foundation of China(21475007 and 21675009)the Fundamental Research Funds for the Central Universities(buctrc201608 and buctrc201720)
文摘The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.
基金This work was supported by the National Natural Science Foundation of China(Nos.51572103 and 51973078)the Distinguished Young Scholar of Anhui Province(No.1808085J14)+1 种基金the Major projects of Education Department of Anhui Province(No.KJ2020ZD005)the Key Foundation of Educational Commission of Anhui Province(No.KJ2019A0595).
文摘Exploring new and efficient photocatalysts to boost photocatalytic CO_(2) reduction is of critical importance for solar-to-fuel conversion.In this study,through the in-situ growth method,a series of S-scheme mechanism Bi_(2)S_(3)/BiVO_(4)/Mn_(0.5)Cd_(0.5)S-DETA nanocomposites with good photocatalytic activity were synthesized.The extremely small size of Mn_(0.5)Cd_(0.5)S-DETA nanoparticles provides more active sites for photocatalytic reactions.In order to solve the serious shortcomings of sulfide photo-corrosion,BiVO_(4) were introduced as oxidation catalyst to consume too many holes and improve the stability of the material.In addition,the in-situ growth method produces the reduction cocatalyst Bi_(2)S_(3) during the BiVO_(4) and Mn_(0.5)Cd_(0.5)S-DETA recombination process,thereby improving the efficiency of charge transfer at their interface contact.The ternary composite unveils a higher CO_(2)-reduction rate(44.74μmol g^(−1) h^(−1))comparing with pristine BiVO_(4)(14.11μmol g^(−1) h^(−1)).The enhanced photocatalytic CO_(2) reduction performance is due to the special interface structure of the S-scheme Bi_(2)S_(3)/BiVO_(4)/Mn_(0.5)Cd_(0.5)S-DETA photocatalyst,which facilitates the charge separation at the interface and improves its photocatalytic activity and stability.
