IM To study the influence of fever on biliary elements and gallstone formation in guinea pigs. METHODS Sixty guinea pigs were divided into lithogenic (group B) and normal diet (group A) groups, and each group was ...IM To study the influence of fever on biliary elements and gallstone formation in guinea pigs. METHODS Sixty guinea pigs were divided into lithogenic (group B) and normal diet (group A) groups, and each group was further divided into control and fever subgroups. The animals in the fever groups were injected subcutaneously with boiled defat milk 1ml/kg, once a week for 4 times to run fever. After 45 days, all the animals were killed. Among them the guinea pigs in the fever groups were injected subcutaneously with turpentine 1ml/kg 36 hours before they were killed, and kept in fever condition. Their gallbladder lumens were examined and bile samples were analyzed. RESULTS The gallstone incidence of the fever group fed with lithogenic diet was the highest, accounting for 40% (6/15). All the animals in fever group had significantly higher concentration of total bile protein and bilirubin than that of the control groups. CONCLUSION The effect of fever on biliary elements plays an important role in the gallstone formation in guinea pigs.展开更多
文摘IM To study the influence of fever on biliary elements and gallstone formation in guinea pigs. METHODS Sixty guinea pigs were divided into lithogenic (group B) and normal diet (group A) groups, and each group was further divided into control and fever subgroups. The animals in the fever groups were injected subcutaneously with boiled defat milk 1ml/kg, once a week for 4 times to run fever. After 45 days, all the animals were killed. Among them the guinea pigs in the fever groups were injected subcutaneously with turpentine 1ml/kg 36 hours before they were killed, and kept in fever condition. Their gallbladder lumens were examined and bile samples were analyzed. RESULTS The gallstone incidence of the fever group fed with lithogenic diet was the highest, accounting for 40% (6/15). All the animals in fever group had significantly higher concentration of total bile protein and bilirubin than that of the control groups. CONCLUSION The effect of fever on biliary elements plays an important role in the gallstone formation in guinea pigs.
