“liberal arts”的源与流——古今之变中的审视

“古今之变”是审视liberal arts流变的中心线索。古典liberal arts是具有内在统一性并指向完满品格的整全性知识体系。欧洲三次文艺复兴对liberal arts的再造展现了其历史流变中的不变逻辑,即为特定时代的受教育者提供共同价值。德国古典大学赋予了liberal arts在古典意义上的完美形态,而新人文主义的自我塑造观念孕育了博雅教育的现代转向。科学革命终结了古典学术的内在统一性与道德理想,瓦解了古典liberal arts。美国现代大学则借助古典资源,经由三次改革浪潮重建了liberal arts。然而,古典教育凝聚文明精华的共同价值、塑造意义与学术整合力量,同现代科学的智识自由、价值分殊与学科分化特性相冲突,这是古今之变为现代大学再造liberal arts所深植的困境,liberal arts只能在钟摆的两端之间不断权衡。

医护-社会组织一体化模式对HIV/AIDS患者ART及自我管理能力的影响

探究接受高效抗反转录病毒治疗确诊HIV/AIDS患者接受医护-社会组织一体化模式干预价值。方法 从2022年1月至2022年12月南昌市某定点医院接受抗病毒治疗及随访管理的新确诊HIV/AIDS患者100例,50例接受传统医护合作模式对照组、50例接受医护-社会组织一体化模式观察组,两组各项临床指标差异进行分析对比(从HIV抗体初筛阳性到启动ART治疗时间、抗病毒治疗一年后HIV病毒载量的指标及病毒抑制率、抗病毒治疗一年后自我管理能力)。结果 干预后与对照组比较,观察组HIV抗体初筛阳性到启动ART治疗时间显著偏低,HIV病毒载量指标水平显著偏低,病毒抑制率显著偏高,一年后自我管理能力评分显著偏高,用药依从性显著偏高(P<0.05)。结论 接受抗病毒治疗及随访管理的确诊HIV/AIDS患者接受医护-社会组织一体化模式干预后,可显著提高患者自我管理能力。此外,还能保障高病毒抑制率,缩短患者治疗时间,提升患者用药依从性。

A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods:antioxidant and bile acid-binding capacity

In this study,the structural characters,antioxidant activities and bile acid-binding ability of sea buckthorn polysaccharides(HRPs)obtained by the commonly used hot water(HRP-W),pressurized hot water(HRP-H),ultrasonic(HRP-U),acid(HRP-C)and alkali(HRP-A)assisted extraction methods were investigated.The results demonstrated that extraction methods had significant effects on extraction yield,monosaccharide composition,molecular weight,particle size,triple-helical structure,and surface morphology of HRPs except for the major linkage bands.Thermogravimetric analysis showed that HRP-U with filamentous reticular microstructure exhibited better thermal stability.The HRP-A with the lowest molecular weight and highest arabinose content possessed the best antioxidant activities.Moreover,the rheological analysis indicated that HRPs with higher galacturonic acid content and molecular weight showed higher viscosity and stronger crosslinking network(HRP-C,HRP-W and HRP-U),which exhibited stronger bile acid binding capacity.The present findings provide scientific evidence in the preparation technology of sea buckthorn polysaccharides with good antioxidant and bile acid binding capacity which are related to the structure affected by the extraction methods.

基于ART的集装箱运输防损策略优化探究

本论文结合人工智能运输机器人在港口应用的案例,从问题现象入手,分析急停可能导致的损失,通过对ART急停原因分析,制定出急停改缓停的解决方案,结果显示缓停策略大大地降低了ART急停概率,可为其他自动化集装箱码头水平运输作业或使用自动化车辆的工程项目提供借鉴。

Reliable calculations of nuclear binding energies by the Gaussian process of machine learning

Reliable calculations of nuclear binding energies are crucial for advancing the research of nuclear physics. Machine learning provides an innovative approach to exploring complex physical problems. In this study, the nuclear binding energies are modeled directly using a machine-learning method called the Gaussian process. First, the binding energies for 2238 nuclei with Z > 20 and N > 20 are calculated using the Gaussian process in a physically motivated feature space, yielding an average deviation of 0.046 MeV and a standard deviation of 0.066 MeV. The results show the good learning ability of the Gaussian process in the studies of binding energies. Then, the predictive power of the Gaussian process is studied by calculating the binding energies for 108 nuclei newly included in AME2020. The theoretical results are in good agreement with the experimental data, reflecting the good predictive power of the Gaussian process. Moreover, the α-decay energies for 1169 nuclei with 50 ≤ Z ≤ 110 are derived from the theoretical binding energies calculated using the Gaussian process. The average deviation and the standard deviation are, respectively, 0.047 MeV and 0.070 MeV. Noticeably, the calculated α-decay energies for the two new isotopes ^ (204 )Ac(Huang et al. Phys Lett B 834, 137484(2022)) and ^ (207) Th(Yang et al. Phys Rev C 105, L051302(2022)) agree well with the latest experimental data. These results demonstrate that the Gaussian process is reliable for the calculations of nuclear binding energies. Finally, the α-decay properties of some unknown actinide nuclei are predicted using the Gaussian process. The predicted results can be useful guides for future research on binding energies and α-decay properties.

Analysis of RNA Recognition and Binding Characteristics of OsCPPR1 Protein in Rice

Pentatricopeptide repeat(PPR)proteins represent one of the largest protein families in plants and typically localize to organelles like mitochondria and chloroplasts.By contrast,CYTOPLASMLOCALIZED PPR1(OsCPPR1)is a cytoplasm-localized PPR protein that can degrade OsGOLDENLIKE1(OsGLK1)mRNA in the tapetum of rice anther.However,the mechanism,by which OsCPPR1 recognizes and binds to OsGLK1 transcripts,remains unknown.Through protein structure prediction and macromolecular docking experiments,we observed that distinct PPR motif structures of OsCPPR1 exhibited varying binding efficiencies to OsGLK1 RNA.Moreover,RNA-electrophoretic mobility shift assay experiment demonstrated that the recombinant OsCPPR1 can directly recognize and bind to OsGLK1 mRNA in vitro.This further confirmed that the mutations in the conserved amino acids in each PPR motif resulted in loss of activity,while truncation of OsCPPR1 decreased its binding efficiency.These findings collectively suggest that it may require some co-factors to assist in cleavage,a facet that warrants further exploration in subsequent studies.

Application of Modern Construction Art in Landscape Architecture Planning and Design

The continuous progress of urbanization has driven the continuous development and innovation of landscape planning and design.Focused on the important design method of modern construction art,this study analyzed its concepts and characteristics,and made deep exploration to its application in landscape planning and design.The results indicated that modern construction art had a significant impact on landscape spatial planning and layout,spatial design forms,and spatial ornaments.The use of modern construction art concepts could make landscape design more scientific,artistic,and humane,creating higher quality leisure and entertainment venues for audiences.

A Discussion of Artificial Intelligence in Visual Art Education

Since ChatGPT emerged on November 30, 2022, Artificial Intelligence (AI) has been increasingly discussed as a radical force that will change our world. People have become used to AI in which such ubiquitous technologies as Siri, Google, and Netflix deploy AI algorithms to answer questions, impart information, and provide recommendations. However, many individuals including originators and backers of AI have recently expressed grave concerns. In this paper, the authors will assess what is occurring with AI in Visual Arts Education, outline positives and negatives, and provide recommendations addressed specifically for teachers working in the field regarding emerging AI usage from kindergarten to grade twelve levels as well as in higher education.

Evaluating new biomarkers for diabetic nephropathy:Role ofα2-macroglobulin,podocalyxin,α-L-fucosidase,retinol-binding protein-4,and cystatin C

BACKGROUND The intricate relationship between type 2 diabetes mellitus(T2DM)and diabetic nephropathy(DN)presents a challenge in understanding the significance of various biomarkers in diagnosis.AIM To elucidate the roles and diagnostic values ofα2-macroglobulin(α2-MG),podocalyxin(PCX),α-L-fucosidase(AFU),retinol-binding protein-4(RBP-4),and cystatin C(CysC)in DN.METHODS From December 2018 to December 2020,203 T2DM patients were enrolled in the study.Of these,115 were diagnosed with DN(115 patients),while the remaining 88 patients were classified as non-DN.The urinary levels ofα2-MG,PCX,and AFU and the serum concentrations RBP-4 and CysC were measured in conjunction with other relevant clinical indicators to evaluate their potential correlations and diagnostic utility.RESULTS After adjustments for age and gender,significant positive correlations were observed between the biomarkers CysC,RBP-4,α2-MG/urinary creatinine(UCr),PCX/UCr,and AFU/UCr,and clinical indicators such as urinary albumin-to-creatinine ratio(UACR),serum creatinine,urea,24-h total urine protein,and neutrophil-to-lymphocyte ratio(NLR).Conversely,these biomarkers exhibited negative correlations with the estimated glomerular filtration rate(P<0.05).Receiver operating characteristic(ROC)curve analysis further demonstrated the diagnostic performance of these biomarkers,with UACR showcasing the highest area under the ROC curve(AUC^(ROC))at 0.97.CONCLUSION This study underscores the diagnostic significance ofα2-MG,PCX,and AFU in the development of DN.The biomarkers RBP-4,CysC,PCX,AFU,andα2-MG provide promising diagnostic insights,while UACR is the most potent diagnostic biomarker in assessing DN.

Application of Midjournal and Stable Diffusion in Environmental Art and Design Courses in Higher Education Institutions

This study was aimed to explore the feasibility of introducing two mainstream AI drawing applications,Midjournal and Stable Diffusion,into the environmental art and design courses in higher education institutions.On the basis of introducing the development history of AI drawing technology,the characteristics of Midjournal and Stable Diffusion and their applications in teaching were described in detail.The analysis on its practical application in public space design courses showed that AI drawing technology could significantly improve students’creative efficiency and the possibility of artistic creation,while also enriching the expressive power of design.In spite of the challenges such as technical accuracy,response to complex design requirements,hardware dependencies,and student dependencies,the application of AI drawing technology had an overall positive prospects in the field of education.Finally,the value of AI drawing technology in teaching was emphasized,and the challenges it brought were discussed,as well as how to fully utilize this technology while maintaining teaching objectives and educational principles.

Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients(r=0.58,P=0;r=0.58,P=0;respectively).FABP5high Huh7 cells also expressed higher protein levels of p53,BIRC5,CDK1,CDK2,and CDK4 than FABP5low HepG2 cells.FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.CONCLUSION We discovered that FABP5 gene is frequently amplified in cancer,especially in HCC,leading to its significant elevated expression in HCC.Its high expression correlates well with worse patient outcome,enriched cancer hallmarks and oncogenes in HCC.FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells.All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC.

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways,which are potentially involved in the regulation of thrombopoietin-dependent signaling and further impair proplatelet formation by megakaryocytes(MKs)[11].However,the positive regulators of ANKRD26,which might be associated with THC2 pathology,are still unknown.

Preliminary Investigation of Copper(II) Ion Binding or Complex Coordination in Lysozeme Molecules

Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.

Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer

BACKGROUND Colorectal cancer(CRC)causes many deaths worldwide.Synaptotagmin binding cytoplasmic RNA interacting protein(SYNCRIP)is an RNA-binding protein that plays an important role in multiple cancers by epigenetically targeting some genes.Our study will examine the expression,potential effect,biological function and clinical value of SYNCRIP in CRC.AIM To examine the expression,potential effect,biological function and clinical value METHODS The expression of SYNCRIP was examined by immunohistochemistry arrays and high-throughput data.The effect of SYNCRIP gene in CRC cell growth was evaluated by CRISPR-Cas9 technology.The target genes of SYNCRIP were calculated using various algorithms,and the molecular mechanism of SYNCRIP in CRC was explored by mutation analysis and pathway analysis.The clinical value of SYNCRIP in prognosis and radiotherapy was revealed via evidence-based medicine methods.RESULTS The protein and mRNA levels of SYNCRIP were both highly expressed in CRC samples compared to nontumorous tissue based on 330 immunohistochemistry arrays and 3640 CRC samples.Cells grew more slowly in eleven CRC cell lines after knocking out the SYNCRIP gene.SYNCRIP could epigenetically target genes to promote the occurrence and development of CRC by boosting the cell cycle and affecting the tumor microenvironment.In addition,CRC patients with high SYNCRIP expression are more sensitive to radiotherapy.CONCLUSION SYNCRIP is upregulated in CRC,and highly expressed SYNCRIP can accelerate CRC cell division by exerting its epigenetic regulatory effects.In addition,SYNCRIP is expected to become a potential biomarker to predict the effect of radiotherapy.

Binding Number and Fractional k-Factors of Graphs

In this paper, we consider the relationship between the binding number and the existence of fractional k-factors of graphs. The binding number of G is defined by Woodall as bind(G)=min{ | NG(X) || X |:∅≠X⊆V(G) }. It is proved that a graph G has a fractional 1-factor if bind(G)≥1and has a fractional k-factor if bind(G)≥k−1k. Furthermore, it is showed that both results are best possible in some sense.

Binding Energy, Root Mean Square Radius and Magnetic Dipole Moment of the Triton Nucleus

The basis functions of the translation invariant shell model are used to construct the ground state nuclear wave functions of 3H. The used residual two-body interactions consist of central, tensor, spin orbit and quadratic spin orbit terms with Gaussian radial dependence. The parameters of these interactions are so chosen in such a way that they represent the long-range attraction and the short-range repulsion of the nucleon-nucleon interactions. These parameters are so chosen to reproduce good agreement between the calculated values of the binding energy, the root mean-square radius, the D-state probability, the magnetic dipole moment and the electric quadrupole moment of the deuteron nucleus. The variation method is then used to calculate the binding energy of triton by varying the oscillator parameter which exists in the nuclear wave function. The obtained nuclear wave functions are then used to calculate the root mean-square radius and the magnetic dipole moment of the triton.

The Path to Healthy Development for Chinese Art in the New Era

This topic is closely centered on exploring how Chinese fine arts can take the road to the healthy development of art,which is of great guiding significance.It is clear that the road of national art development is to carry forward the main theme,promote social justice,guide and infect people with correct public opinion,and better serve the people with excellent works.

Analysis of Color and Artistic Conception in Painting Art

The charm of painting,as a bright pearl in the treasure house of culture,lies in its visual language constructed through colors and lines,which conveys the artist’s unique perception of life and profound emotions.Color,as the most intuitive and expressive language in painting,is not only a simple reproduction of material colors but also a projection of the artist’s inner world.Artistic conception,as a core concept in traditional Chinese painting theory,refers to the emotional atmosphere and spiritual mood embedded in paintings.The purpose of this paper is to discuss the interaction between color and mood in painting art,to analyze the techniques of using color in different painting styles and their influence on the creation of mood,and to provide new perspectives and methods for the creation of paintings.

Research on the Cultivation of Aesthetics among Art Students under the New Era Background

Through understanding the history and current situation of aesthetic education in China,this paper explains some misunderstandings in the aesthetics of contemporary university art students,such as the insufficiency of aesthetic value and ability,as well as the inadequacy of students’creativity due to traditional art education.It is also pointed out that the cultivation of core literacy of art students is a multidimensional and comprehensive process,and these problems need to be solved by schools,teachers,and students,so as to strengthen the inner aesthetic education of students and improve their aesthetic awareness and ability.Aesthetic education is not only an important part of the art classroom but also a key part of fostering students’all-round development and enhancing their humanistic literacy.It is necessary to cultivate students’observation,imagination,image-thinking ability,and creativity,so that they can become artistic talents with independent thinking and innovation.

Digital Art as Urban Communication

As mobility and migration become the norm,citizens in modern cities live among people who remain strangers to each other.This creates new opportunities and challenges for urban social life.Public space is a critical forum in which strangers encounter each other and have the opportunity to develop social protocols for coexisting in diversity.New media technologies have huge impact on the form and quality of public space.Digital art can create experimental public spaces in which mediated connections and embodied presence are combined in new ways.Through the practice and research of digital art,we can imagine a communicative city in which urban digital media is less about spectacle,and more about promoting new forms of public speech and social encounter between people.