期刊文献+
共找到89篇文章
< 1 2 5 >
每页显示 20 50 100
Bioactive compounds in Hericium erinaceus and their biological properties:a review
1
作者 Yue Qiu Genglan Lin +4 位作者 Weiming Liu Fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期1825-1844,共20页
Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing immunity.It is also ... Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing immunity.It is also effective in protecting the digestive system and preventing neurodegenerative diseases.In this review paper,we summarize the sources,structures and efficacies of the main active components in H.erinaceus fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular mechanisms.Based on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of H.erinaceus.Perspectives for future studies and new applications of H.erinaceus are proposed. 展开更多
关键词 Hericium erinaceus bioactive compounds Biological activities ANTIOXIDATION NEUROPROTECTION IMMUNOREGULATION
下载PDF
Nutritional values,bioactive compounds and health benefits of purslane(Portulaca oleracea L.):a comprehensive review
2
作者 Yanxi Li Longgao Xiao +3 位作者 Huan Yan Mingyi Wu Xiaojiang Hao Haiyang Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2480-2501,共22页
Portulaca oleracea L.,commonly known as purslane,is a worldwide weed species belonging to the family Portulacaceae and has been known as“Global Panacea”.As one of the most widely consumed green vegetables and medici... Portulaca oleracea L.,commonly known as purslane,is a worldwide weed species belonging to the family Portulacaceae and has been known as“Global Panacea”.As one of the most widely consumed green vegetables and medicinal plants around the world,it has recently been re-evaluated as a potential“new crop”due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid(α-linolenic acid),as well as a variety of nutrients and phytochemicals.Accordingly,emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory,anti-hyperglycemic,antioxidant,neuroprotective,and immunomodulatory.These findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional medicine.This review systematically summarizes the up-to-date research carried out on purslane,including the nutritional compositions,bioactive compounds,and health benefits it exerts as well as limitations,challenges,and future directions of research.Finally,we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment. 展开更多
关键词 Purslane Nutritional compositions bioactive compounds POLYSACCHARIDES Functional foods
下载PDF
Predicting bioactive compounds and cancer-related molecular targets of lotus seedpod (Receptaculum Nelumbinis) based on network pharmacology and molecular docking
3
作者 Jian-Lin Shen Meng-Tong Zhang +8 位作者 Fei Li Jia-Yu Huang Quan-Sheng Xu Han-Yue Zhang Jun Zhang Jing Li Yan-Ping Li Qi Zou Xiao-Yin Wang 《Food and Health》 2024年第2期14-41,共28页
Background:Lotus seedpod(Receptaculum Nelumbinis)is the abundant by-products produced during lotus seed processing,and the sources are usually considered to be wastes and are abandoned outdoors or incinerated.This stu... Background:Lotus seedpod(Receptaculum Nelumbinis)is the abundant by-products produced during lotus seed processing,and the sources are usually considered to be wastes and are abandoned outdoors or incinerated.This study aims at predicting its bioactive compounds and cancer-related molecular targets against six cancers,including lung cancer,gastric cancer,liver cancer,breast cancer,ovarian cancer and cervical cancer.Methods:Network pharmacology and molecular docking methods were performed.Results:Network pharmacology results indicated that 14 core compounds(liensinine,tetrandrine,lysicamine,tricin,sanleng acid,cireneol G,ricinoleic acid,linolenic acid,5,7-dihydroxycoumarin,apigenin,luteolin,morin,quercetin and isorhamnetin)and 10 core targets(AKT1,ESR1,HSP90AA1,JUN,MAPK1,MAPK3,PIK3CA,PIK3R1,SRC and STAT3)were screened for lotus seedpod against the six cancers.Molecular docking analysis suggested that the binding abilities between the core compounds and the core targets were mostly strong.GO analysis revealed that the intersected targets between the bioactive compounds of lotus seedpod and the six cancers were significantly related to biological processes,cell compositions and molecular functions.KEGG analysis showed that PI3K-Akt,TNF,Ras,MAPK,HIF-1 and C-type lectin receptor signaling pathways were notably involved in the anti-cancer activities of lotus seedpod against the six cancers.Conclusions:14 core compounds and 10 core targets were screened for lotus seedpod against lung cancer,gastric cancer,liver cancer,breast cancer,ovarian cancer and cervical cancer.This study supports the application of lotus seedpod in treating cancers,and promotes the recycling and the high-value utilization. 展开更多
关键词 Lotus seedpod ANTI-CANCER bioactive compounds Molecular targets Network pharmacology Molecular docking.
下载PDF
Nutritional Composition and Bioactive Compounds of Bael (Aegle marmelos) and Development of Functional Food Products
4
作者 Sajon Kumar Biswas Md. Zainul Abedin +3 位作者 Biddut Chandra Dey Md. Sajib Al Reza Luthfunnesa Bari Md. Abu Zubair 《Food and Nutrition Sciences》 CAS 2023年第4期328-340,共13页
Aegle marmelos, widely known as bael, belongs to the Rutaceae family. It is one of the most inexpensive and appealing fruits, considered to be an essential source of natural antioxidants and bioactive components. The ... Aegle marmelos, widely known as bael, belongs to the Rutaceae family. It is one of the most inexpensive and appealing fruits, considered to be an essential source of natural antioxidants and bioactive components. The major purpose of the research study was to investigate the nutritional composition and bioactive constituents of bael pulp, as well as to develop new value-added products that maintain the maximum quantity of nutrients. The developed food products were subjected to evaluate sensory attributes according to a nine-point hedonic scale. It was found that the moisture, protein, fat, crude fiber, and total ash content of bael fruit pulp were 61.20%, 2.48%, 0.47%, 3.04%, and 1.29%, respectively. When compared to the catechin standard, the antioxidant activity of such extract indicated good antioxidant capacity, with an IC<sub>50</sub> value of 75.68 μg/ml for methanol extract. Vitamin C content was about 10.21 mg/100g. Besides, total flavonoid and phenolic contents were found as 140 mg of Quercetin Equivalent (QE)/g and 106.65 mg of Gallic Acid Equivalent (GAE)/g, respectively. Results of sensory attributes revealed that there was a significant difference (P ba and bael bar. The overall acceptability of bael murabba (6.7) and bael bar (7.1) is acceptable in quality, but their specific characteristics were found slightly different by the test panelists. These products might be applicable for the treatment of several diseases like atherosclerosis, diabetes, constipation, irritable bowel syndrome, peptic ulcer, tumor, and osteoporosis. 展开更多
关键词 Bael Aegle marmelos bioactive compounds Antioxidant Activity Bael Murabba and Bar
下载PDF
Assessment of the Level of Metal(loid)s Pollution and Bioactive Compounds Screening of Anthill Soil
5
作者 Graça K. Kandanda Festus S. Shafodino +1 位作者 Simeon I. Ambuga Lamech M. Mwapagha 《Open Journal of Soil Science》 2023年第11期474-489,共16页
The anthill soil is used by hypertensive elderly and teenagers from Oshikoto region (Namibia) and many of them testified stabilization of their blood pressure to normal after consuming the anthill soil-derived aqueous... The anthill soil is used by hypertensive elderly and teenagers from Oshikoto region (Namibia) and many of them testified stabilization of their blood pressure to normal after consuming the anthill soil-derived aqueous extracts. This study therefore investigated and/or assessed the physicochemical parameters, the contents of some metal(loid)s (and their associated potential health risks) and the qualitative composition of bioactive compounds of this anthill soil. The homogenous soil sample collected from various anthill soils in the Oshikoto region was used to obtain the measurements of physiochemical parameters. The elemental contents were determined (using an Inductively Coupled Plasma Optical Emission Spectrophotometer) after acid digestion in accordance with the EPA method 350B and their potential health risk assessments were performed. Methanol, aqueous methanol, and aqueous-based extracts were generated via maceration extraction process prior to the screening of bioactive compounds using standard diagnostic assays. The oxidation reduction potential (164.4 ± 16.6 mV) was the only physicochemical parameter whose value was within the World Health Organization limits for drinking water whereas, total dissolved solids (23 ± 5.5 mg/L), electrical conductivity (44 ± 10.1 uS/cm) and pH (5.35 ± 0.33) were out of specifications. Phenolic compounds, flavonoids, terpenoids, and cardiac glycosides were present in anthill soil (with respect to the extractants used) to which its antihypertensive properties can be attributed in addition to some of the studied mineral components. With respect to the pH, TDS and EC, and the contents of most metal(loid)s in relation to their health risk assessment values, the results suggest that aqueous extracts derived from this anthill soil can be deemed unsuitable for human consumption. 展开更多
关键词 Anthill Soil Physicochemical Parameters Metal(loid)s Contamination ANTIHYPERTENSIVE bioactive compounds
下载PDF
A Review of Textile Fabrication Using Bioactive Compounds Derived from Natural Products
6
作者 Deepa Priya R Aishwarya Lakshmi J +1 位作者 Veena H Kirubanandan Shanmugam 《Proceedings of Anticancer Research》 2023年第6期7-12,共6页
Antimicrobial-treated textiles should exhibit efficacy against a broad spectrum of bacterial and fungal species,all while maintaining user safety with a non-toxic profile.Natural antimicrobial compounds play a vital r... Antimicrobial-treated textiles should exhibit efficacy against a broad spectrum of bacterial and fungal species,all while maintaining user safety with a non-toxic profile.Natural antimicrobial compounds play a vital role in textile finishing processes.The proliferation of synthetic antimicrobial agents introduces environmental and consumer safety concerns.Given these potential hazards associated with synthetic agents,the utilization of natural antimicrobial agents is gaining traction,as they tend to have fewer adverse effects on users and are more environmentally sustainable.Numerous natural antimicrobial compounds,sourced from plants such as neem,basil,turmeric,aloe vera,and clove oil,have been developed,showcasing inherent antimicrobial properties.This review article highlights the importance of incorporating bioactive components in the creation of antibacterial textile fabrics. 展开更多
关键词 Antimicrobial-treated textile bioactive compounds Natural products
下载PDF
Bioactive compounds of sea cucumbers and their therapeutic effects 被引量:10
7
作者 时淑娟 冯文静 +3 位作者 胡松 梁世秀 安妮娜 毛拥军 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2016年第3期549-558,共10页
Abstract Sea cucumbers belong to the Class Holothuroidea of marine invertebrates. They are commercially valuable and prized as a food and folk medicine in Asia. Nutritionally, sea cucumbers have an impressive profile ... Abstract Sea cucumbers belong to the Class Holothuroidea of marine invertebrates. They are commercially valuable and prized as a food and folk medicine in Asia. Nutritionally, sea cucumbers have an impressive profile of valuable nutrients such as vitamins, minerals and amino acids. A number of unique biological and pharmacological activities/properties, including anticancer, anticoagulant/antithrombotic, antimicrobial, antioxidant, antihyperlipidemic, antihyperglycemic, anti-inflammatory, antihypertension and radioprotective, have been ascribed to various compounds isolated from sea cucumbers. The therapeutic properties and medicinal benefits of sea cucumbers can be linked to the presence of a wide array ofbioactives, especially triterpene glycosides, acid mucopolysaccharide, sphingoid bases, glycolipids, fucosylated chondroitin sulfate, polysaccharides, phospholipids, cerebrosides, phosphatidylcholines, and other extracts and hydrolysates. This review highlights the valuable bioactive components as well as the multiple therapeutic properties of sea cucumbers with a view to exploring their potential uses as functional foods and a natural source of new multifunctional drugs. 展开更多
关键词 sea cucumber bioactive compounds biological activities pharmacological activities therapeutic effects
下载PDF
Fruits as Prospective Reserves of bioactive Compounds:A Review 被引量:5
8
作者 Marines Marli Gniech Karasawa Chakravarthi Mohan 《Natural Products and Bioprospecting》 CAS 2018年第5期335-346,共12页
Astaxanthin is a value-added ketocarotenoid with great potential in nutraceutical and pharmaceutical industries.Genetic engineering of heterologous hosts for astaxanthin production has attracted great attention.In thi... Astaxanthin is a value-added ketocarotenoid with great potential in nutraceutical and pharmaceutical industries.Genetic engineering of heterologous hosts for astaxanthin production has attracted great attention.In this study,we assessed some key factors,including codon usage of the expressed genes,types of promoters,bacterial strains,and culture media,for engineered Escherichia coli to produce astaxanthin.The effect of codon usage was shown to be related to the types of promoters.E.coli DH5a was superior to other strains for astaxanthin production.Different culture media greatly affected the contents and yields of astaxanthin in engineered E.coli.When the expression cassette containing GadE promoter and its driving genes,HpCHY and CrBKT,was inserted into the plasmid pACCAR16DcrtX and expressed in E.coli DH5a,the engineered strain was able to produce 4.30±0.28 mg/g dry cell weight(DCW)or 24.16±2.03 mg/L of astaxanthin,which was a sevenfold or 40-fold increase over the initial production of 0.62±0.03 mg/g DCW or 0.61±0.05 mg/L. 展开更多
关键词 ANTICANCER Antioxidant bioactive compounds Flavones FRUITS Medicinal uses
下载PDF
Effect of microwave pre-treatment on physical quality,bioactive compounds,safety risk factor,and storage stability of peanut butter 被引量:7
9
作者 Jefferson G.Degon Chang Zheng +3 位作者 Abdeen Elkhedir Bo Yang Qi Zhou Wenlin Li 《Oil Crop Science》 CSCD 2021年第3期137-144,共8页
Microwave,as a new heat treatment technology,has the characteristics of uniform and fast heating speed.It is an energy-saving technology known for improving oilseed product quality.Its efficiency mainly depends on the... Microwave,as a new heat treatment technology,has the characteristics of uniform and fast heating speed.It is an energy-saving technology known for improving oilseed product quality.Its efficiency mainly depends on the roasting power and time.However,the production of high-quality peanut butter using short-time roasting con-ditions are limited.Herein,we determined an appropriate microwave roasting power and time for peanuts and evaluated its impacts on the quality of peanut butter.Different roasting powers(400 W,800 W and 1200 W)and times(4,4.5,5,and 5.5 min)were preliminarily tested.Among them,800 W at 5 min was the most suitable.The roasting efficiency was further evaluated using color,sensory,bioactive compounds,storage stability,and safety risk factors of peanut butter produced from four peanut cultivars(Silihong,Baisha-1016,Yuanza-9102,and Yuhua-9414).The pre-treated butter obtained from three cultivars(Silihong,Yuanza-9102,and Yuhua-9414)with moisture content between 5%and 7.2%had a similar sensory score(6-7)as the commercial on a 9-point hedonic scale compare to the other.The color of the pre-treated peanut butter varies statistically with the commercial but remained in the recommended range of Hunter L*values of 51-52,respectively,for high initial moisture peanut cultivars.The total polyphenol(35.20-31.59±0.59μmol GAE/g)and tocopherol(19.05±0.35 mg/100 g)content in the butter obtained from three cultivars(Yuahua-9102,Yuhua,and Baisha-1016)and Silihong respectively,were significantly(P<0.05)higher than those in the commercial butter.The induction times of all pre-treated butter(19.80±0.99-7.84±0.07 h)were significantly(P<0.05)longer during storage at accelerated temperature than commercial samples.In addition,no benzo[a]pyrene was found in the pre-treated samples.Collectively,the microwave pretreated peanut butter was superior to the commercial one.These findings provided data support and a reference basis to promote microwave use for peanut butter production. 展开更多
关键词 Microwave pre-treatment Peanut butter SENSORY Storage stability:bioactive compounds
下载PDF
Nanostructured food proteins as efficient systems for the encapsulation of bioactive compounds 被引量:4
10
作者 Mehdi Mohammadian Mostafa I.Waly +3 位作者 Maryam Moghadam Zahra Emam-Djomeh Maryam Salami Ali Akbar Moosavi-Movahedi 《Food Science and Human Wellness》 SCIE 2020年第3期199-213,共15页
Recently,nanoencapsulation was introduced as an efficient and promising approach for the protection,delivery,and site-specific liberation of the nutraceuticals and bioactive ingredients.Food proteins are attractive ma... Recently,nanoencapsulation was introduced as an efficient and promising approach for the protection,delivery,and site-specific liberation of the nutraceuticals and bioactive ingredients.Food proteins are attractive materials for developing nanocarriers to protect and deliver bioactives due to their unique functional and biological properties.Food proteins extracted from animals and plants have the ability to form different nanostructures including nanoparticles,hollow particles,nanogels,nanofibrillar aggregates,electrospun nanofibers,nanotubular structures,and nanocomplexes.These nanostructured food proteins have been widely used as nanocarriers for the biologically active compounds and drugs.The release of bioactive compounds from nanocarriers depends mainly on pH as well as swelling and the degradation behavior of nanostructure in the simulated physiological conditions.This review presents the applications of the nanostructured food proteins for the encapsulation of bioactive compounds.The major techniques for the fabrication of nanocarriers are described.The encapsulation,protection,and release of bioactive compounds in different nanostructured food proteins were also discussed. 展开更多
关键词 Food proteins NANOCARRIERS bioactive compounds NANOENCAPSULATION Release properties
下载PDF
Bioactive compounds and probiotics-a ray of hope in COVID-19 management 被引量:3
11
作者 Indu Bhushan Mahima Sharma +5 位作者 Malvika Mehta Shivi Badyal Varun Sharma Indu Sharma Hemender Singh Srinivas Sistla 《Food Science and Human Wellness》 SCIE 2021年第2期131-140,共10页
The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with pro... The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time.Anti-viral,anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity.This review highlights some of the important bioactive compounds and probiotic bacteria,suggesting them as a ray of hope in the milieu of the COVID-19 management. 展开更多
关键词 PROBIOTICS bioactive compounds COVID FOOD METABOLITES
下载PDF
A Clinical and Animal Experiment Integrated Platform for Small-Molecule Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the Therapeutic Efficacy of Yinchenhao Tang for Jaundice Syndrome 被引量:2
12
作者 Hui Xiong Ai-Hua Zhang +6 位作者 Ya-Jing Guo Xiao-Hang Zhou Hui Sun Le Yang Heng Fang Guang-Li Yan Xi-Jun Wang 《Engineering》 SCIE EI 2021年第9期1293-1305,共13页
A herbal prescription in traditional Chinese medicine(TCM)has great complexity,with multiple components and multiple targets,making it extremely challenging to determine its bioactive compounds.Yinchenhao Tang(YCHT)ha... A herbal prescription in traditional Chinese medicine(TCM)has great complexity,with multiple components and multiple targets,making it extremely challenging to determine its bioactive compounds.Yinchenhao Tang(YCHT)has been extensively used for the treatment of jaundice disease.Although many studies have examined the efficacy and active ingredients of YCHT,there is still a lack of an in-depth systematic analysis of its effective components,mechanisms,and potential targets—especially one based on clinical patients.This study established an innovative strategy for discovering the potential targets and active compounds of YCHT based on an integrated clinical and animal experiment platform.The serum metabolic profiles and constituents of YCHT in vivo were determined by ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry(UPLC-Q-ToF-MS)-based metabolomics combined with a serum pharmacochemistry method.Moreover,a compound–target–pathway network was constructed and analyzed by network pharmacology and ingenuity pathway analysis(IPA).We found that eight active components could modulate five key targets.These key targets were further verified by enzyme-linked immunosorbent assay(ELISA),which indicated that YCHT exerts therapeutic effects by targeting cholesterol 7a-hydroxylase(CYP7A1),multidrug-resistance-associated protein 2(ABCC2),multidrug-resistance-associated protein 3(ABCC3),uridine diphosphate glucuronosyl transferase 1A1(UGT1A1),and farnesoid X receptor(FXR),and by regulating metabolic pathways including primary bile acid biosynthesis,porphyrin and chlorophyll metabolism,and biliary secretion.Eight main effective compounds were discovered and correlated with the key targets and pathways.In this way,we demonstrate that this integrated strategy can be successfully applied for the effective discovery of the active compounds and therapeutic targets of an herbal prescription. 展开更多
关键词 Efficacy bioactive compound Small molecule TARGETS Herbal medicine Metabolomics
下载PDF
Structural Features and Biological Activities of Bioactive Compounds from Fortunella margarita(Lour.) Swingle:A Review 被引量:2
13
作者 曾红亮 陈培琳 +4 位作者 黄灿灿 沈瑾烨 常青 郑宝东 张怡 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第12期2123-2132,共10页
Fortunella margarita(Lour.) Swingle, commonly known as kumquat, is the smallest citrus fruit. It thrives in southeastern China and is widely cultivated and consumed in the world due to its multiple health benefits. ... Fortunella margarita(Lour.) Swingle, commonly known as kumquat, is the smallest citrus fruit. It thrives in southeastern China and is widely cultivated and consumed in the world due to its multiple health benefits. It has been used as an important herbal medicine in traditional Chinese medicine and also as one of the most popular fruits. There are various kinds of bioactive compounds in F. margarita, such as polysaccharides, limonoids, essential oils, flavonoids, phenolic acids, vitamins, dietary fiber, etc. In addition, many studies have reported that these bioactive compounds can be used as antioxidant, antimicrobial, hypolipidemic, drosophila lure components in functional foods, pharmaceuticals and daily chemical products due to their biological activities. This review focuses on the structural features and biological activities of polysaccharides, limonoids, essential oils and flavonoids and other bioactive substances from F. margarita and their potential applications in food, daily chemical and pharmaceutical industries. 展开更多
关键词 FortuneUa margarita (Lour.) Swingle bioactive compounds structural features biological activities APPLICATION
下载PDF
Antialgal and Antilarval Activities of Bioactive Compounds Extracted from the Marine Dinoflagellate Amphidinium carterae 被引量:1
14
作者 KONG Xianyu HAN Xiurong +4 位作者 GAO Min SU Rongguo WANG Ke LI Xuzhao LU Wei 《Journal of Ocean University of China》 SCIE CAS 2016年第6期1014-1020,共7页
Abstract With the global ban on the application of organotin-based marine coatings by the International Maritime Organization, the development of environmentally friendly, low-toxic and nontoxic antifouling compounds ... Abstract With the global ban on the application of organotin-based marine coatings by the International Maritime Organization, the development of environmentally friendly, low-toxic and nontoxic antifouling compounds for marine industries has become an urgent need. Marine microorganisms have been considered as a potential source of natural antifoulants. In this study, the antifouling potential of marine dinoflagellate Amphidinium carterae, the toxic and red-tide microalgae, was investigated. We performed a series of operations to extract the bioactive substances from Amphidinium carterae and tested their antialgal and antilarval activities. The crude extract of Amphidinium carterae showed significant antialgal activity and the ECs0 value against Skeletonema costatum was 55.4 ~tg mL-1. After purification, the isolated bioactive substances (the organic extract C) exhibited much higher antialgal and antilar- val activities with ECso of 12.9μgmL-1 against Skeletonema costatum and LC50 of 15.1 μmL-1 against Amphibalanus amphitrite larvae. Subsequently, IR, Q-TOFMS, and GC-MS were utilized for the structural elucidation of the bioactive compounds, and a series of unsaturated and saturated 16- to 22-carbon fatty acids were detected. The data suggested the bioactive compounds isolated from Amphidinium carterae exhibited a significant inhibiting effect against the diatom Skeletonema costatum and Amphibalanus amphi- trite larvae, and could be substitutes for persistent, toxic antifouling compounds. 展开更多
关键词 marine dinoflagellate bioactive compounds antialgal activity antilarval activity ANTIFOULING
下载PDF
Functional mechanism on stem cells by tea(Camellia sinensis)bioactive compounds 被引量:1
15
作者 Yao Cheng Jiachen Sun +2 位作者 Hui Zhao Hongxing Guo Jianying Li 《Food Science and Human Wellness》 SCIE 2022年第3期579-586,共8页
Camellia sinensis(tea),one of the most popular commercial crops,is commonly applied in all parts of the world.The main active ingredients of tea include polyphenols,alkaloids,polysaccharides,amino acids,aroma and vola... Camellia sinensis(tea),one of the most popular commercial crops,is commonly applied in all parts of the world.The main active ingredients of tea include polyphenols,alkaloids,polysaccharides,amino acids,aroma and volatile constitutes,all of which are potentially responsible for the activities of tea.Stem cells(SCs)are the immature and undifferentiated cells by a varying capacity for proliferation,self-renewal and the capability to differentiate into one or more different derivatives with specialized function or maintain their stem cell phenotype.Herein,a thorough review is conducted of the functional mechanism on SCs by tea bioactive compounds. 展开更多
关键词 Functional mechanism Stem cell Camellia sinensis bioactive compounds
下载PDF
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment
16
作者 Waseem Mohammed Abdul Nahid H.Hajrah +5 位作者 Jamal S.M.Sabir Saleh M.Al-Garni Meshaal J.Sabir Saleh A.Kabli Kulvinder Singh Saini Roop Singh Bora 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2018年第3期177-185,共9页
Ricinus communis L.(R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studi... Ricinus communis L.(R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studies have revealed the presence of diverse phytochemicals such as alkaloids.flavonoids, terpenes, saponins,phenolic compounds such as kaempferol, gallic acid, ricin, rutin, lupeol, ricinoleic acid, pinene, thujone and gentisic acid.These phytochemicals have been responsible for pharmacological and therapeutic effects,including anticancer, antimicrobial, insecticidal, antioxidant, anti-diabetic, antinociceptive,anti-inflammatory. bone regenerative, analgesic, and anticonvulsant activity. R. communis harbours phytochemicals which have been shown to target peroxisome proliferator activated receptor(PPAR), nuclear factor NF-κ-B, cytochrome p450, P38 mitogen-activated protein kinases kinase(p38 MAPK), tumor protein P53, B-cell lymphoma-extra-large(Bcl-xL) and vascular endothelial growth factor receptor-2(VEGFR-2). Considering its wide variety of phytochemicals, its pharmacological activity and the subsequent clinical trials, R. communis could be a good candidate for discovering novel complementary drugs. Further experimental and advanced clinical studies are required to explore the pharmaceutical, beneficial therapeutic and safety prospects of R. communis with its phytochemicals as a herbal and complementary medicine for combating various diseases and disorders. 展开更多
关键词 Ricinus communis bioactive compounds ETHNOMEDICINE Molecular targets ANTI-CANCER PHARMACOLOGY
下载PDF
Target specificity of selective bioactive compounds in blocking α-dystroglycan receptor to suppress Lassa virus infection: an in silico approach
17
作者 Adittya Arefin Tanzila Ismail Ema +13 位作者 Tamnia Islam MdSaddam Hossen Tariqul Islam Salauddin Al Azad MdNasir Uddin Badal MdAminul Islam Partha Biswas Nafee Ul Alam Enayetul Islam Maliha Anjum Afsana Masud MdShaikh Kamran Ahsab Rahman Parag Kumar Paul 《The Journal of Biomedical Research》 CAS CSCD 2021年第6期459-473,共15页
Lassa hemorrhagic fever,caused by Lassa mammarenavirus(LASV)infection,accumulates up to 5000 deaths every year.Currently,there is no vaccine available to combat this disease.In this study,a library of 200 bioactive co... Lassa hemorrhagic fever,caused by Lassa mammarenavirus(LASV)infection,accumulates up to 5000 deaths every year.Currently,there is no vaccine available to combat this disease.In this study,a library of 200 bioactive compounds was virtually screened to study their drug-likeness with the capacity to block theα-dystroglycan(α-DG)receptor and prevent LASV influx.Following rigorous absorption,distribution,metabolism,and excretion(ADME)and quantitative structure-activity relationship(QSAR)profiling,molecular docking was conducted with the top ligands against theα-DG receptor.The compounds chrysin,reticuline,and 3-caffeoylshikimic acid emerged as the top three ligands in terms of binding affinity.Post-docking analysis revealed that interactions with Arg76,Asn224,Ser259,and Lys302 amino acid residues of the receptor protein were important for the optimum binding affinity of ligands.Molecular dynamics simulation was performed comprehensively to study the stability of the protein-ligand complexes.In-depth assessment of root-mean-square deviation(RMSD),root mean square fluctuation(RMSF),polar surface area(PSA),B-Factor,radius of gyration(Rg),solvent accessible surface area(SASA),and molecular surface area(MolSA)values of the protein-ligand complexes affirmed that the candidates with the best binding affinity formed the most stable protein-ligand complexes.To authenticate the potentialities of the ligands as target-specific drugs,an in vivo study is underway in real time as the continuation of the research. 展开更多
关键词 LASV infection α-dystroglycan receptor bioactive compounds target specificity molecular docking molecular dynamic simulations
下载PDF
Biorefinery of Rice Husk to Obtain Functionalized Bioactive Compounds
18
作者 M.Lopretti N.Lecot +6 位作者 A.Rodriguez G.Lluberas F.Orozco L.Bolaños G.Montes De Oca H.Cerecetto J.Vega-Baudrit 《Journal of Renewable Materials》 SCIE 2019年第4期313-324,共12页
The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities,rendering new higher-value products... The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities,rendering new higher-value products with a concomitant solution to waste accumulation issues.To that end,in this work we describe and characterise bioactive compounds generation from rice husk by semisolid fermentation,obtained from 500 g of the material at room temperature and 60%humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum trabeum.The extract was evaluated in different situations:murine mammary tumour cells(4T1),normal cells(NIH 3T3)and in Lactobacillus acidophilus,and Trichoderma harzianum.The results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20μg/mL,but did not inhibit normal cells,and displayed germicide activity after 3 days incubations.We propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste. 展开更多
关键词 BIOREFINERY rice husk bioactive compounds valorisation of biomass veratryl alcohol
下载PDF
A comprehensive review of bioactive compounds and processing technology of sesame seed
19
作者 Xuan Ma Zhi Wang +1 位作者 Chang Zheng Changsheng Liu 《Oil Crop Science》 CSCD 2022年第2期88-94,共7页
Sesame seeds are promulgated as traditional high-quality edible oil crops,rich in lipid(40–65%),protein(19–35%),and bioactive compounds.The review starts with bioactive components(fatty acid,tocopherol,phytosterol,s... Sesame seeds are promulgated as traditional high-quality edible oil crops,rich in lipid(40–65%),protein(19–35%),and bioactive compounds.The review starts with bioactive components(fatty acid,tocopherol,phytosterol,sesamin,sesamolin,and sesamol)of sesame seeds.It considers processing techniques for extracting oil(aqueous extraction and pressing)from seeds.Novel technologies,such as enzyme-assisted aqueous,supercritical CO_(2),and microwave-assisted solvent extraction,are also discussed.The methods of utilization of sesame seed cake are also analyzed.In the future,the processing technology of sesame seed will be further developed in the direction of improving comprehensive utilization rate to meet new consumption demand. 展开更多
关键词 Sesame seed bioactive compound Nutritional properties Processing technology BY-PRODUCT
下载PDF
Bioactive Compounds and Insecticidal Activity of Hysterionica pinifolia, a Native South American Plant
20
作者 Ingrid M. Cufre Lucas E. Fabián +2 位作者 Sandra V. Clemente Arnaldo L. Bandoni Adriana M. Broussalis 《American Journal of Plant Sciences》 2022年第6期815-832,共18页
Phytochemical investigation of the purified fractions of the active dichloromethane extract of Hysterionica pinifolia (Poir.) Baker led to the identification of five compounds. New acetylenic alcohol (E)-undec-3-en-5,... Phytochemical investigation of the purified fractions of the active dichloromethane extract of Hysterionica pinifolia (Poir.) Baker led to the identification of five compounds. New acetylenic alcohol (E)-undec-3-en-5,7-diyne-1-ol (1) and three other compounds (3), (4), and (5) were reported for the first time in this species. Furthermore, forty-six components from the volatile fraction of H. pinifolia were identified. These compounds were elucidated using 1D and 2D NMR spectroscopy as well as MS-ESI and GC-FID-MS experiments. The dichloromethane extract, its fractions, and the methanolic extract were tested for insecticidal activity against Tribolium castaneum under laboratory conditions. The dichloromethane extract and the fraction F2 were found to be active, showing high larval mortality. The dichloromethane extract was also active against T. castaneum adults. The results have shown that H. pinifolia could be considered, in a near future, as a potential source for the development of a botanical insecticide for pest control. 展开更多
关键词 Hysterionica pinifolia bioactive compounds Polyacetylene compounds (E)-undec-3-en-5 7-diyne-1-ol Insecticidal Activity
下载PDF
上一页 1 2 5 下一页 到第
使用帮助 返回顶部